DK557277A - Fremgangsmaade til fremstilling af piperazinderivater eller syreaddttionssalte eller kvarternaere ammoniumsalte deraf - Google Patents
Fremgangsmaade til fremstilling af piperazinderivater eller syreaddttionssalte eller kvarternaere ammoniumsalte derafInfo
- Publication number
- DK557277A DK557277A DK557277A DK557277A DK557277A DK 557277 A DK557277 A DK 557277A DK 557277 A DK557277 A DK 557277A DK 557277 A DK557277 A DK 557277A DK 557277 A DK557277 A DK 557277A
- Authority
- DK
- Denmark
- Prior art keywords
- salts
- quarternide
- procedure
- preparation
- piperazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB52223/76A GB1545094A (en) | 1976-12-14 | 1976-12-14 | Piperazine derivatives |
GB5222376 | 1976-12-14 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK557277A true DK557277A (da) | 1978-06-15 |
DK147421B DK147421B (da) | 1984-07-30 |
DK147421C DK147421C (da) | 1985-02-11 |
Family
ID=10463103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK557277A DK147421C (da) | 1976-12-14 | 1977-12-14 | Analogifremgangsmaade til fremstilling af piperazinderivater eller syreadditionssalte eller kvaternaere ammoniumsalte deraf |
Country Status (22)
Country | Link |
---|---|
US (2) | US4202896A (da) |
JP (1) | JPS5382789A (da) |
AT (1) | AT363090B (da) |
AU (1) | AU516920B2 (da) |
BE (1) | BE861853A (da) |
DE (1) | DE2755752A1 (da) |
DK (1) | DK147421C (da) |
ES (6) | ES465047A1 (da) |
FI (1) | FI69839C (da) |
GB (1) | GB1545094A (da) |
HU (1) | HU177999B (da) |
IE (1) | IE46278B1 (da) |
IL (1) | IL53597A0 (da) |
IT (1) | IT1093045B (da) |
LU (1) | LU78686A1 (da) |
NL (1) | NL7713817A (da) |
NO (1) | NO148150C (da) |
NZ (1) | NZ185981A (da) |
PT (1) | PT67400B (da) |
SE (1) | SE435378B (da) |
YU (1) | YU295877A (da) |
ZA (1) | ZA777452B (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU546260B2 (en) * | 1980-06-16 | 1985-08-22 | Ferrosan A.B. | Diphenylbutyl-1-acylpiperazines |
NL8202636A (nl) * | 1982-06-29 | 1984-01-16 | Gist Brocades Nv | Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. |
DE3600390A1 (de) * | 1986-01-09 | 1987-07-16 | Hoechst Ag | Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel |
US5162537A (en) * | 1986-04-17 | 1992-11-10 | Monsanto Company | Benzhydryl compounds as herbicide antidotes |
HU196194B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds |
HU196195B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds |
HU196196B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds |
FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
FR2636946B1 (fr) * | 1988-09-23 | 1990-11-02 | Lipha | ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant |
US5153198A (en) * | 1989-03-15 | 1992-10-06 | Santen Pharmaceutical Co., Ltd. | Agent for treatment of disorders of the cerebro-neural transmission system |
US5087627A (en) * | 1989-03-15 | 1992-02-11 | Santen Pharmaceutical Co., Ltd. | Agent for treatment of disorders of the cerebro-neural transmission system |
FR2661176B1 (fr) * | 1990-04-20 | 1992-06-12 | Adir | Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive. |
US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
DK178490D0 (da) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
WO1993000811A1 (en) * | 1991-07-01 | 1993-01-21 | The General Hospital Corporation | Invertebrate phenylethanolamine transporter and the use thereof |
ES2157258T3 (es) * | 1993-06-25 | 2001-08-16 | Pola Chem Ind Inc | Inhibidores de la reincorporacion de dopamina destinados para el tratamiento del sindrome de parkinson. |
CA2396956C (en) * | 2000-01-11 | 2010-10-26 | Biostream Therapeutics, Inc. | Polypharmacophoric agents |
US6743797B2 (en) | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
FR2884712B1 (fr) * | 2005-04-21 | 2007-06-15 | Oreal | Compositions cosmetiques comprenant des derives de piperazine |
AU2006264966B2 (en) | 2005-07-04 | 2013-02-21 | High Point Pharmaceuticals, Llc | Histamine H3 receptor antagonists |
EP2038256A1 (en) * | 2006-05-23 | 2009-03-25 | TransTech Pharma, Inc | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament |
CA2659570C (en) * | 2006-05-29 | 2015-10-06 | High Point Pharmaceuticals, Llc | 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
EP2014656A3 (en) * | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
US20120028992A1 (en) * | 2010-08-02 | 2012-02-02 | Brown Arthur M | Pharmaceutical compositions for terminating acute episodes of cardiac arrhythmia, restoring sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm in mammals |
CN104529942B (zh) * | 2014-12-10 | 2018-05-15 | 天津孚音生物科技发展有限公司 | 一种伐诺司林的合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB837986A (en) | 1956-07-10 | 1960-06-22 | Henri Morren | New piperazine derivatives and process for the preparation thereof |
US2953568A (en) * | 1958-03-03 | 1960-09-20 | Ciba Pharm Prod Inc | Derivatives of piperazine |
CH410961A (de) * | 1961-02-22 | 1966-04-15 | Yoshitomi Pharmaceutical | Verfahren zur Herstellung N-substituierter Piperazinderivate |
DE1445692A1 (de) | 1963-03-25 | 1969-03-20 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur Herstellung von Piperazinderivaten |
DE1795375A1 (de) * | 1968-09-21 | 1972-01-05 | Boehringer Mannheim Gmbh | Basische AEther und Verfahren zur Herstellung derselben |
JPS504086A (da) * | 1973-01-18 | 1975-01-16 |
-
1976
- 1976-12-14 GB GB52223/76A patent/GB1545094A/en not_active Expired
-
1977
- 1977-12-13 IL IL53597A patent/IL53597A0/xx not_active IP Right Cessation
- 1977-12-14 DE DE19772755752 patent/DE2755752A1/de active Granted
- 1977-12-14 ZA ZA00777452A patent/ZA777452B/xx unknown
- 1977-12-14 AT AT0891177A patent/AT363090B/de not_active IP Right Cessation
- 1977-12-14 NO NO774307A patent/NO148150C/no unknown
- 1977-12-14 JP JP15038477A patent/JPS5382789A/ja active Granted
- 1977-12-14 US US05/860,460 patent/US4202896A/en not_active Expired - Lifetime
- 1977-12-14 DK DK557277A patent/DK147421C/da not_active IP Right Cessation
- 1977-12-14 LU LU78686A patent/LU78686A1/xx unknown
- 1977-12-14 AU AU31573/77A patent/AU516920B2/en not_active Expired
- 1977-12-14 PT PT67400A patent/PT67400B/pt unknown
- 1977-12-14 NZ NZ185981A patent/NZ185981A/xx unknown
- 1977-12-14 HU HU77GI266A patent/HU177999B/hu unknown
- 1977-12-14 BE BE183456A patent/BE861853A/xx not_active IP Right Cessation
- 1977-12-14 ES ES465047A patent/ES465047A1/es not_active Expired
- 1977-12-14 FI FI773786A patent/FI69839C/fi not_active IP Right Cessation
- 1977-12-14 SE SE7714184A patent/SE435378B/sv not_active IP Right Cessation
- 1977-12-14 YU YU02958/77A patent/YU295877A/xx unknown
- 1977-12-14 NL NL7713817A patent/NL7713817A/xx not_active Application Discontinuation
- 1977-12-14 IE IE2541/77A patent/IE46278B1/en not_active IP Right Cessation
- 1977-12-14 IT IT69793/77A patent/IT1093045B/it active
-
1978
- 1978-09-29 ES ES473818A patent/ES473818A1/es not_active Expired
- 1978-09-29 ES ES473816A patent/ES473816A1/es not_active Expired
- 1978-09-29 ES ES473817A patent/ES473817A1/es not_active Expired
- 1978-09-29 ES ES473814A patent/ES473814A1/es not_active Expired
- 1978-09-29 ES ES473815A patent/ES473815A1/es not_active Expired
-
1979
- 1979-11-01 US US06/090,257 patent/US4265894A/en not_active Expired - Lifetime
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |