ES473816A1 - Procedimiento para preparar derivados de piperazina. - Google Patents

Procedimiento para preparar derivados de piperazina.

Info

Publication number
ES473816A1
ES473816A1 ES473816A ES473816A ES473816A1 ES 473816 A1 ES473816 A1 ES 473816A1 ES 473816 A ES473816 A ES 473816A ES 473816 A ES473816 A ES 473816A ES 473816 A1 ES473816 A1 ES 473816A1
Authority
ES
Spain
Prior art keywords
group
benzhydryloxyethyl
piperazines
phenylpropyl
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES473816A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of ES473816A1 publication Critical patent/ES473816A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para preparar derivados de piperazina, de fórmula general: **(Fórmula)** en la que los radicales R1 a R9, que son iguales o diferentes, representan cada uno un átomo de hidrógeno o halógeno o un grupo alquilo o alcoxi inferior, n es 2 ó 3 y X representa un grupo (CH2)m en donde m es 1, 2, 3 ó 4, ó un grupo -CH2-CH=CH-, teniendo un grupo metileno enlazado al grupo piperazina; y sus sales de adición de ácido y de amonio cuaternario.
ES473816A 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina. Expired ES473816A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52223/76A GB1545094A (en) 1976-12-14 1976-12-14 Piperazine derivatives

Publications (1)

Publication Number Publication Date
ES473816A1 true ES473816A1 (es) 1979-04-16

Family

ID=10463103

Family Applications (6)

Application Number Title Priority Date Filing Date
ES465047A Expired ES465047A1 (es) 1976-12-14 1977-12-14 Procedimiento para preparar derivados de piperazina
ES473818A Expired ES473818A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473816A Expired ES473816A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473817A Expired ES473817A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473814A Expired ES473814A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473815A Expired ES473815A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES465047A Expired ES465047A1 (es) 1976-12-14 1977-12-14 Procedimiento para preparar derivados de piperazina
ES473818A Expired ES473818A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES473817A Expired ES473817A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473814A Expired ES473814A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473815A Expired ES473815A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.

Country Status (22)

Country Link
US (2) US4202896A (es)
JP (1) JPS5382789A (es)
AT (1) AT363090B (es)
AU (1) AU516920B2 (es)
BE (1) BE861853A (es)
DE (1) DE2755752A1 (es)
DK (1) DK147421C (es)
ES (6) ES465047A1 (es)
FI (1) FI69839C (es)
GB (1) GB1545094A (es)
HU (1) HU177999B (es)
IE (1) IE46278B1 (es)
IL (1) IL53597A0 (es)
IT (1) IT1093045B (es)
LU (1) LU78686A1 (es)
NL (1) NL7713817A (es)
NO (1) NO148150C (es)
NZ (1) NZ185981A (es)
PT (1) PT67400B (es)
SE (1) SE435378B (es)
YU (1) YU295877A (es)
ZA (1) ZA777452B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU546260B2 (en) * 1980-06-16 1985-08-22 Ferrosan A.B. Diphenylbutyl-1-acylpiperazines
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
US5162537A (en) * 1986-04-17 1992-11-10 Monsanto Company Benzhydryl compounds as herbicide antidotes
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
FR2636946B1 (fr) * 1988-09-23 1990-11-02 Lipha ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant
US5153198A (en) * 1989-03-15 1992-10-06 Santen Pharmaceutical Co., Ltd. Agent for treatment of disorders of the cerebro-neural transmission system
US5087627A (en) * 1989-03-15 1992-02-11 Santen Pharmaceutical Co., Ltd. Agent for treatment of disorders of the cerebro-neural transmission system
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
ES2157258T3 (es) * 1993-06-25 2001-08-16 Pola Chem Ind Inc Inhibidores de la reincorporacion de dopamina destinados para el tratamiento del sindrome de parkinson.
CA2396956C (en) * 2000-01-11 2010-10-26 Biostream Therapeutics, Inc. Polypharmacophoric agents
US6743797B2 (en) 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
US20050054010A1 (en) * 2003-07-15 2005-03-10 Brown Arthur M. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050208595A1 (en) * 2004-03-19 2005-09-22 Brown Arthur M High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
FR2884712B1 (fr) * 2005-04-21 2007-06-15 Oreal Compositions cosmetiques comprenant des derives de piperazine
AU2006264966B2 (en) 2005-07-04 2013-02-21 High Point Pharmaceuticals, Llc Histamine H3 receptor antagonists
EP2038256A1 (en) * 2006-05-23 2009-03-25 TransTech Pharma, Inc 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament
CA2659570C (en) * 2006-05-29 2015-10-06 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
US20120028992A1 (en) * 2010-08-02 2012-02-02 Brown Arthur M Pharmaceutical compositions for terminating acute episodes of cardiac arrhythmia, restoring sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm in mammals
CN104529942B (zh) * 2014-12-10 2018-05-15 天津孚音生物科技发展有限公司 一种伐诺司林的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB837986A (en) 1956-07-10 1960-06-22 Henri Morren New piperazine derivatives and process for the preparation thereof
US2953568A (en) * 1958-03-03 1960-09-20 Ciba Pharm Prod Inc Derivatives of piperazine
CH410961A (de) * 1961-02-22 1966-04-15 Yoshitomi Pharmaceutical Verfahren zur Herstellung N-substituierter Piperazinderivate
DE1445692A1 (de) 1963-03-25 1969-03-20 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von Piperazinderivaten
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
JPS504086A (es) * 1973-01-18 1975-01-16

Also Published As

Publication number Publication date
PT67400A (en) 1978-01-01
NZ185981A (en) 1980-02-21
DK147421B (da) 1984-07-30
AU516920B2 (en) 1981-07-02
JPS6215546B2 (es) 1987-04-08
ATA891177A (de) 1980-12-15
NO148150C (no) 1983-08-24
AU3157377A (en) 1979-06-21
JPS5382789A (en) 1978-07-21
GB1545094A (en) 1979-05-02
ZA777452B (en) 1978-10-25
FI773786A (fi) 1978-06-15
ES473815A1 (es) 1979-05-01
ES473817A1 (es) 1979-04-16
DK147421C (da) 1985-02-11
US4265894A (en) 1981-05-05
ES473818A1 (es) 1979-04-16
BE861853A (fr) 1978-06-14
IE46278B1 (en) 1983-04-20
SE7714184L (sv) 1978-06-15
PT67400B (en) 1979-05-21
IE46278L (en) 1978-06-14
SE435378B (sv) 1984-09-24
DE2755752A1 (de) 1978-06-15
NO774307L (no) 1978-06-15
ES465047A1 (es) 1979-01-01
IT1093045B (it) 1985-07-19
LU78686A1 (es) 1978-04-17
YU295877A (en) 1983-01-21
DK557277A (da) 1978-06-15
IL53597A0 (en) 1978-03-10
HU177999B (en) 1982-02-27
NL7713817A (nl) 1978-06-16
FI69839B (fi) 1985-12-31
AT363090B (de) 1981-07-10
ES473814A1 (es) 1979-04-16
DE2755752C2 (es) 1991-12-05
FI69839C (fi) 1986-05-26
US4202896A (en) 1980-05-13
NO148150B (no) 1983-05-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503