CA1039282A - 1-(3-(naphth-1-yloxy)-2-hydroxy-propyl)-piperazine derivatives - Google Patents

1-(3-(naphth-1-yloxy)-2-hydroxy-propyl)-piperazine derivatives

Info

Publication number
CA1039282A
CA1039282A CA219,883A CA219883A CA1039282A CA 1039282 A CA1039282 A CA 1039282A CA 219883 A CA219883 A CA 219883A CA 1039282 A CA1039282 A CA 1039282A
Authority
CA
Canada
Prior art keywords
formula
piperazine
process according
reacting
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA219,883A
Other languages
English (en)
French (fr)
Other versions
CA219883S (en
Inventor
Egon Roesch
Gisbert Sponer
Max Thiel
Kurt Stach
Ernst-Christian Witte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of CA1039282A publication Critical patent/CA1039282A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA219,883A 1974-02-23 1975-02-12 1-(3-(naphth-1-yloxy)-2-hydroxy-propyl)-piperazine derivatives Expired CA1039282A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2408804A DE2408804C2 (de) 1974-02-23 1974-02-23 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Publications (1)

Publication Number Publication Date
CA1039282A true CA1039282A (en) 1978-09-26

Family

ID=5908286

Family Applications (1)

Application Number Title Priority Date Filing Date
CA219,883A Expired CA1039282A (en) 1974-02-23 1975-02-12 1-(3-(naphth-1-yloxy)-2-hydroxy-propyl)-piperazine derivatives

Country Status (20)

Country Link
US (1) US3997666A (en, 2012)
JP (1) JPS6029712B2 (en, 2012)
AR (1) AR206339A1 (en, 2012)
AT (1) AT340937B (en, 2012)
BE (1) BE825755A (en, 2012)
CA (1) CA1039282A (en, 2012)
CH (2) CH612958A5 (en, 2012)
DE (1) DE2408804C2 (en, 2012)
DK (1) DK135124C (en, 2012)
ES (1) ES434829A1 (en, 2012)
FI (1) FI59248C (en, 2012)
FR (1) FR2261770B1 (en, 2012)
GB (1) GB1445548A (en, 2012)
IE (1) IE40678B1 (en, 2012)
NL (2) NL175059B (en, 2012)
PL (1) PL92131B1 (en, 2012)
SE (1) SE405601B (en, 2012)
SU (2) SU549085A3 (en, 2012)
YU (2) YU37156B (en, 2012)
ZA (1) ZA751031B (en, 2012)

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DE3918543A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
DE3918542A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Hydroxylierte 1-phenyl-4-(3-(napthth-1-yl-oxy)-2-hydroxy -propyl)-piperazine, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) * 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
EP0972766A4 (en) 1997-01-30 2000-05-03 Senju Pharma Co HYDROQUINONE DERIVATIVES
KR100639543B1 (ko) 1998-09-30 2006-10-31 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
ATE502635T1 (de) 2002-08-19 2011-04-15 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
BR0316572A (pt) 2002-12-13 2005-10-04 Warner Lambert Co Ligando alfa-2-delta para o tratamento de sintomas do trato variáveis inferior, utilização e produto deste
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
GEP20084406B (en) 2003-05-30 2008-06-25 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
WO2006100557A1 (en) 2005-03-21 2006-09-28 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
CA2618103A1 (en) * 2005-08-10 2007-02-15 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
AU2006313430B2 (en) 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2008050732A1 (fr) 2006-10-23 2008-05-02 Takeda Pharmaceutical Company Limited Dérivé de l'iminopyridine et son utilisation
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
US20110039892A1 (en) 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
CN101671317B (zh) * 2009-10-09 2011-04-27 蚌埠丰原涂山制药有限公司 一种萘哌地尔的制备方法
CN101747293B (zh) * 2009-12-29 2011-12-07 蚌埠丰原涂山制药有限公司 萘哌地尔的制备方法
JP5807423B2 (ja) * 2011-07-21 2015-11-10 大日本印刷株式会社 ナフトピジルの製造方法
CN102816136A (zh) * 2012-09-18 2012-12-12 通化吉通药业有限公司 萘哌地尔制备方法
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
US9272980B2 (en) 2014-06-06 2016-03-01 Ktn Biotec, Inc. Anticancer agent
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JOP20210193A1 (ar) 2019-01-18 2023-01-30 Astrazeneca Ab مثبطات pcsk9 وطرق استخدامها

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Publication number Priority date Publication date Assignee Title
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
GB1317479A (en) * 1970-11-10 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
DE2235597A1 (de) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
YU37156B (en) 1984-08-31
FI750449A7 (en, 2012) 1975-08-24
DK58175A (en, 2012) 1975-10-20
GB1445548A (en) 1976-08-11
AU7826875A (en) 1976-08-19
NL175059B (nl) 1984-04-16
AT340937B (de) 1978-01-10
FR2261770A1 (en, 2012) 1975-09-19
SE405601B (sv) 1978-12-18
DE2408804A1 (de) 1975-09-04
ES434829A1 (es) 1976-12-01
YU37157B (en) 1984-08-31
CH609342A5 (en, 2012) 1979-02-28
NL175059C (nl)
CH612958A5 (en, 2012) 1979-08-31
YU38275A (en) 1983-04-27
SU549085A3 (ru) 1977-02-28
IE40678B1 (en) 1979-08-01
BE825755A (fr) 1975-08-20
DK135124C (da) 1977-08-15
AR206339A1 (es) 1976-07-15
FR2261770B1 (en, 2012) 1978-08-04
SE7501911L (en, 2012) 1975-08-25
ATA132375A (de) 1977-05-15
US3997666A (en) 1976-12-14
FI59248C (fi) 1981-07-10
PL92131B1 (en, 2012) 1977-03-31
DK135124B (da) 1977-03-07
ZA751031B (en) 1976-02-25
DE2408804C2 (de) 1983-09-22
NL7501877A (nl) 1975-08-26
SU561514A3 (ru) 1977-06-05
YU104481A (en) 1983-04-27
JPS6029712B2 (ja) 1985-07-12
IE40678L (en) 1975-08-23
FI59248B (fi) 1981-03-31
JPS50121286A (en, 2012) 1975-09-23

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