DE2264657C2 - 5-Phenoxy-2-(1H)pyrimidinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel - Google Patents

5-Phenoxy-2-(1H)pyrimidinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE2264657C2
DE2264657C2 DE2264657A DE2264657A DE2264657C2 DE 2264657 C2 DE2264657 C2 DE 2264657C2 DE 2264657 A DE2264657 A DE 2264657A DE 2264657 A DE2264657 A DE 2264657A DE 2264657 C2 DE2264657 C2 DE 2264657C2
Authority
DE
Germany
Prior art keywords
acid
pyrimidinones
solution
hours
phenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2264657A
Other languages
German (de)
English (en)
Other versions
DE2264657A1 (de
Inventor
Gerald George Wilton Conn. De Angelis
Hans-Jürgen Ernst Old Lyme Conn. Hess
Christopher Andrew Groton Conn. Lipinski
John Gerritt Lyme Conn. Stam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE2264657A1 publication Critical patent/DE2264657A1/de
Application granted granted Critical
Publication of DE2264657C2 publication Critical patent/DE2264657C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE2264657A 1971-10-29 1972-10-05 5-Phenoxy-2-(1H)pyrimidinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel Expired DE2264657C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19400671A 1971-10-29 1971-10-29

Publications (2)

Publication Number Publication Date
DE2264657A1 DE2264657A1 (de) 1974-06-20
DE2264657C2 true DE2264657C2 (de) 1982-09-16

Family

ID=22715935

Family Applications (3)

Application Number Title Priority Date Filing Date
DE2248741A Expired DE2248741C3 (de) 1971-10-29 1972-10-05 5-Phenoxy-und 5-Thlophenoxy-2(1 H)pyrimldinone
DE2264657A Expired DE2264657C2 (de) 1971-10-29 1972-10-05 5-Phenoxy-2-(1H)pyrimidinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2264374A Expired DE2264374C3 (de) 1971-10-29 1972-10-05 4-Hydroxy-5-phenoxy-pyrimidine, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE2248741A Expired DE2248741C3 (de) 1971-10-29 1972-10-05 5-Phenoxy-und 5-Thlophenoxy-2(1 H)pyrimldinone

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2264374A Expired DE2264374C3 (de) 1971-10-29 1972-10-05 4-Hydroxy-5-phenoxy-pyrimidine, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat

Country Status (25)

Country Link
JP (2) JPS5337870B2 (pl)
AR (2) AR198798A1 (pl)
AT (2) AT321308B (pl)
AU (1) AU467600B2 (pl)
BE (1) BE790125A (pl)
CA (1) CA980778A (pl)
CH (2) CH555832A (pl)
DE (3) DE2248741C3 (pl)
DK (1) DK131465B (pl)
EG (1) EG11013A (pl)
ES (2) ES407730A1 (pl)
FI (1) FI55503C (pl)
FR (1) FR2157865B1 (pl)
GB (2) GB1377720A (pl)
IE (1) IE37043B1 (pl)
IL (2) IL40458A (pl)
LU (1) LU66304A1 (pl)
NL (1) NL166470C (pl)
NO (1) NO136574C (pl)
PH (2) PH10129A (pl)
PL (2) PL84634B1 (pl)
SE (2) SE393376B (pl)
SU (2) SU498908A3 (pl)
YU (2) YU35125B (pl)
ZA (1) ZA727362B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151912U (pl) * 1979-04-17 1980-11-01
JPS5752409Y2 (pl) * 1979-11-05 1982-11-15
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPH0655686B2 (ja) * 1988-08-30 1994-07-27 宇部興産株式会社 ｐ−ブロモフェノキシアセトアルデヒドジアルキルアセタール類の製造方法
NZ565955A (en) 2005-08-22 2011-08-26 Melior Pharmaceuticals I Inc Methods and formulations for modulating lyn kinase activity and treating related disorders
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
US20130158055A1 (en) 2010-05-28 2013-06-20 Andrew G. Reaume Prevention Of Pancreatic Beta Cell Degeneration
NZ758966A (en) 2017-04-10 2024-08-30 Board Of Supervisors Of Louisiana State Univ And Agricultural And Mechanical College Treatment of adipocytes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913462A (en) * 1959-11-17 Eahl h
GB951432A (en) * 1959-03-17 1964-03-04 Wellcome Found Pyrimidine derivatives and the manufacture thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
FI55503C (fi) 1979-08-10
NO136574C (no) 1977-09-28
JPS5422995B2 (pl) 1979-08-10
NL166470B (nl) 1981-03-16
DE2248741C3 (de) 1975-06-26
DE2264374A1 (de) 1973-05-24
LU66304A1 (pl) 1973-05-03
AU467600B2 (en) 1975-12-04
GB1377720A (en) 1974-12-18
SE397090B (sv) 1977-10-17
AR198798A1 (es) 1974-07-24
JPS4852780A (pl) 1973-07-24
AT321308B (de) 1975-03-25
GB1377308A (en) 1974-12-11
DE2248741A1 (de) 1973-05-03
PL89852B1 (pl) 1976-12-31
IL40458A (en) 1976-05-31
ES407730A1 (es) 1976-01-16
IL48790A (en) 1976-05-31
DK131465C (pl) 1975-12-08
FR2157865A1 (pl) 1973-06-08
PH11594A (en) 1978-03-31
IE37043B1 (en) 1977-04-27
BE790125A (fr) 1973-04-16
AT320656B (de) 1975-02-25
NL166470C (nl) 1981-08-17
SE7505279L (sv) 1975-05-06
JPS5337870B2 (pl) 1978-10-12
FR2157865B1 (pl) 1975-10-31
NO136574B (pl) 1977-06-20
PL84634B1 (pl) 1976-04-30
DK131465B (da) 1975-07-21
YU255172A (en) 1980-03-15
PH10129A (en) 1976-09-02
DE2264374C3 (de) 1981-07-23
SU498908A3 (ru) 1976-01-05
YU35125B (en) 1980-09-25
IL40458A0 (en) 1972-11-28
EG11013A (en) 1976-11-30
IL48790A0 (en) 1976-03-31
DE2264657A1 (de) 1974-06-20
SE393376B (sv) 1977-05-09
ES436624A1 (es) 1977-02-01
CA980778A (en) 1975-12-30
YU99179A (en) 1981-08-31
ZA727362B (en) 1973-11-28
DE2264374B2 (de) 1980-08-07
DE2248741B2 (de) 1974-11-14
AU4722872A (en) 1974-04-04
CH549579A (fr) 1974-05-31
IE37043L (en) 1973-04-29
JPS53116386A (en) 1978-10-11
NL7213959A (pl) 1973-05-02
AR196263A1 (es) 1973-12-10
CH555832A (fr) 1974-11-15
YU36295B (en) 1982-06-18
FI55503B (fi) 1979-04-30
SU505362A3 (ru) 1976-02-28

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