DE2212854C3 - Verfahren zur Herstellung des Antibiotikums Heliomyzin - Google Patents
Verfahren zur Herstellung des Antibiotikums HeliomyzinInfo
- Publication number
- DE2212854C3 DE2212854C3 DE2212854A DE2212854A DE2212854C3 DE 2212854 C3 DE2212854 C3 DE 2212854C3 DE 2212854 A DE2212854 A DE 2212854A DE 2212854 A DE2212854 A DE 2212854A DE 2212854 C3 DE2212854 C3 DE 2212854C3
- Authority
- DE
- Germany
- Prior art keywords
- mycelium
- weight
- heliomycin
- percent
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ABLACSIRCKEUOB-UHFFFAOYSA-N Resistomycin Chemical compound O=C1C(C)(C)C2=CC(O)=C3C(C)=CC(O)=C4C3=C2C2=C1C(O)=CC(O)=C2C4=O ABLACSIRCKEUOB-UHFFFAOYSA-N 0.000 title claims description 14
- 229950011491 heliomycin Drugs 0.000 title claims description 14
- 230000003115 biocidal effect Effects 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 241000946738 Streptomyces variabilis Species 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 244000005700 microbiome Species 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 description 19
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000284 extract Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 238000000605 extraction Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 238000011081 inoculation Methods 0.000 description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 238000000855 fermentation Methods 0.000 description 4
- 230000004151 fermentation Effects 0.000 description 4
- 235000013312 flour Nutrition 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 241000186046 Actinomyces Species 0.000 description 3
- 241000283222 Physeter catodon Species 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000010698 whale oil Substances 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000006311 Pyoderma Diseases 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001058 brown pigment Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1626871A SU350364A1 (ru) | 1971-03-17 | 1971-03-17 | Продуцент гелиомицина |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2212854A1 DE2212854A1 (de) | 1972-11-02 |
| DE2212854B2 DE2212854B2 (de) | 1974-04-25 |
| DE2212854C3 true DE2212854C3 (de) | 1974-11-28 |
Family
ID=20467153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2212854A Expired DE2212854C3 (de) | 1971-03-17 | 1972-03-16 | Verfahren zur Herstellung des Antibiotikums Heliomyzin |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH568387A5 (enExample) |
| DE (1) | DE2212854C3 (enExample) |
| FR (1) | FR2130267B1 (enExample) |
| GB (1) | GB1355163A (enExample) |
| SU (1) | SU350364A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2777568B1 (fr) | 1998-04-15 | 2002-10-31 | Rhone Poulenc Agrochimie | Gene codant pour l'heliomicine, proteine obtenue, vecteur le contenant, organismes transformes obtenus et procede de preparation |
-
1971
- 1971-03-17 SU SU1626871A patent/SU350364A1/ru active
-
1972
- 1972-03-15 FR FR7209002A patent/FR2130267B1/fr not_active Expired
- 1972-03-15 GB GB1195972A patent/GB1355163A/en not_active Expired
- 1972-03-16 DE DE2212854A patent/DE2212854C3/de not_active Expired
- 1972-03-17 CH CH395472A patent/CH568387A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2212854B2 (de) | 1974-04-25 |
| SU350364A1 (ru) | 1973-10-19 |
| DE2212854A1 (de) | 1972-11-02 |
| CH568387A5 (enExample) | 1975-10-31 |
| FR2130267B1 (enExample) | 1975-04-25 |
| GB1355163A (en) | 1974-06-05 |
| FR2130267A1 (enExample) | 1972-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| EHJ | Ceased/non-payment of the annual fee |