DE19581489T1 - Mit Energieübertragungs-gekuppelten Farbstoffen markierte Sonden - Google Patents

Mit Energieübertragungs-gekuppelten Farbstoffen markierte Sonden

Info

Publication number
DE19581489T1
DE19581489T1 DE19581489T DE19581489T DE19581489T1 DE 19581489 T1 DE19581489 T1 DE 19581489T1 DE 19581489 T DE19581489 T DE 19581489T DE 19581489 T DE19581489 T DE 19581489T DE 19581489 T1 DE19581489 T1 DE 19581489T1
Authority
DE
Germany
Prior art keywords
acceptor
donor
pairs
energy transfer
probes labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19581489T
Other languages
English (en)
Other versions
DE19581489B4 (de
Inventor
Richard A Mathies
Alexander Glazer
Jingyue Ju
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Original Assignee
University of California
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, University of California Berkeley filed Critical University of California
Publication of DE19581489T1 publication Critical patent/DE19581489T1/de
Application granted granted Critical
Publication of DE19581489B4 publication Critical patent/DE19581489B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
DE19581489T 1994-02-01 1995-01-30 Mit Energieübertragungs-gekuppelten Farbstoffen markierte Sonden Expired - Lifetime DE19581489B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/189,924 US5654419A (en) 1994-02-01 1994-02-01 Fluorescent labels and their use in separations
US189924 1994-02-01
PCT/US1995/001205 WO1995021266A1 (en) 1994-02-01 1995-01-30 Probes labelled with energy transfer coupled dyes

Publications (2)

Publication Number Publication Date
DE19581489T1 true DE19581489T1 (de) 1997-01-02
DE19581489B4 DE19581489B4 (de) 2004-07-15

Family

ID=22699330

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19581489T Expired - Lifetime DE19581489B4 (de) 1994-02-01 1995-01-30 Mit Energieübertragungs-gekuppelten Farbstoffen markierte Sonden
DE69530286T Expired - Lifetime DE69530286T2 (de) 1994-02-01 1995-01-30 Mit energieübertragungsvermittelnden verbindungen markierte proben
DE29521620U Expired - Lifetime DE29521620U1 (de) 1994-02-01 1995-01-30 Fluoreszierende Marker und diese enthaltender Reagenzsatz

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69530286T Expired - Lifetime DE69530286T2 (de) 1994-02-01 1995-01-30 Mit energieübertragungsvermittelnden verbindungen markierte proben
DE29521620U Expired - Lifetime DE29521620U1 (de) 1994-02-01 1995-01-30 Fluoreszierende Marker und diese enthaltender Reagenzsatz

Country Status (9)

Country Link
US (3) US5654419A (de)
EP (1) EP0743987B1 (de)
JP (2) JP3895369B2 (de)
AT (1) ATE236994T1 (de)
AU (1) AU692230B2 (de)
CA (1) CA2182516C (de)
DE (3) DE19581489B4 (de)
ES (1) ES2197193T3 (de)
WO (1) WO1995021266A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19811730A1 (de) * 1998-03-18 1999-09-23 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Identifizieren einer Markierung

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