DE1288610B - Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepinen - Google Patents

Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepinen

Info

Publication number
DE1288610B
DE1288610B DEH41139A DEH0041139A DE1288610B DE 1288610 B DE1288610 B DE 1288610B DE H41139 A DEH41139 A DE H41139A DE H0041139 A DEH0041139 A DE H0041139A DE 1288610 B DE1288610 B DE 1288610B
Authority
DE
Germany
Prior art keywords
oxo
dihydro
molecular weight
benzodiazepine
low molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEH41139A
Other languages
German (de)
English (en)
Inventor
Reeder Earl
Sternbach Leo Henryk
Keller Oscar
Steiger Norbert
Fryer Rodney Ian
Metlesics Werner J
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE1288610B publication Critical patent/DE1288610B/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DEH41139A 1959-12-10 1960-12-07 Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepinen Pending DE1288610B (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
DE1288610B true DE1288610B (de) 1969-02-06

Family

ID=27485190

Family Applications (5)

Application Number Title Priority Date Filing Date
DEH41139A Pending DE1288610B (de) 1959-12-10 1960-12-07 Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepinen
DEH41138A Pending DE1290143B (de) 1959-12-10 1960-12-07 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepinderivate
DEH41137A Pending DE1288609B (de) 1959-12-10 1960-12-07 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepine
DE19601445073 Pending DE1445073A1 (de) 1959-12-10 1960-12-19 Verfahren zur Herstellung von fluorhaltigen Benzodiazepin-Derivaten
DE19641445908 Pending DE1445908A1 (de) 1959-12-10 1964-09-10 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten

Family Applications After (4)

Application Number Title Priority Date Filing Date
DEH41138A Pending DE1290143B (de) 1959-12-10 1960-12-07 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepinderivate
DEH41137A Pending DE1288609B (de) 1959-12-10 1960-12-07 2-Oxo-1, 2-dihydro-3H-1, 4-benzodiazepine
DE19601445073 Pending DE1445073A1 (de) 1959-12-10 1960-12-19 Verfahren zur Herstellung von fluorhaltigen Benzodiazepin-Derivaten
DE19641445908 Pending DE1445908A1 (de) 1959-12-10 1964-09-10 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten

Country Status (11)

Country Link
BE (4) BE598013A (https=)
BR (1) BR6024755D0 (https=)
CH (9) CH408029A (https=)
CY (1) CY324A (https=)
DE (5) DE1288610B (https=)
ES (2) ES263123A1 (https=)
GB (13) GB972962A (https=)
MY (1) MY6500178A (https=)
NL (2) NL6412251A (https=)
OA (7) OA00817A (https=)
SE (2) SE310887B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795231C3 (de) * 1963-05-29 1978-07-13 American Home Products Corp., New York, N.Y. (V.St.A.) Verfahren zur Herstellung von 5-Aryl-1,2-dihydro -3H-1,4-benzodiazepin-2-on-4-oxyden
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA2446696A1 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
NZ566263A (en) * 2002-05-24 2009-09-25 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
BE598015A (fr) 1961-06-09
SE310887B (https=) 1969-05-19
OA00959A (fr) 1968-03-22
GB972973A (en) 1964-10-21
CH414652A (de) 1966-06-15
GB972961A (en) 1964-10-21
DE1290143B (de) 1969-03-06
GB972962A (en) 1964-10-21
BE598013A (fr) 1961-06-09
GB972967A (en) 1964-10-21
GB972964A (en) 1964-10-21
NL6412251A (https=) 1966-01-25
GB972976A (en) 1964-10-21
GB972966A (en) 1964-10-21
ES263123A1 (es) 1961-06-01
BE598008A (fr) 1961-06-09
OA00953A (fr) 1968-03-22
CH411910A (de) 1966-04-30
GB972965A (en) 1964-10-21
GB972970A (en) 1964-10-21
BR6024755D0 (pt) 1973-05-24
CH408045A (de) 1966-02-28
CY324A (en) 1965-11-03
GB972963A (en) 1964-10-21
DE1288609B (de) 1969-02-06
OA02385A (fr) 1970-05-05
CH396016A (de) 1965-07-31
BE598012A (fr) 1961-06-09
CH414653A (de) 1966-06-15
CH418342A (de) 1966-08-15
CH418341A (de) 1966-08-15
OA00817A (fr) 1967-11-15
NL6412250A (https=) 1966-01-25
CH408940A (de) 1966-03-15
MY6500178A (en) 1965-12-31
DE1445908A1 (de) 1969-04-17
GB972969A (en) 1964-10-21
DE1445073A1 (de) 1968-10-31
CH408029A (de) 1966-02-28
SE318283B (https=) 1969-12-08
OA02384A (fr) 1970-05-05
GB972972A (en) 1964-10-21
ES263124A1 (es) 1961-06-01
GB972968A (en) 1964-10-21
OA00958A (fr) 1968-03-22
OA00816A (fr) 1967-11-15

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