DE10145044A1 - Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel - Google Patents

Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Info

Publication number
DE10145044A1
DE10145044A1 DE10145044A DE10145044A DE10145044A1 DE 10145044 A1 DE10145044 A1 DE 10145044A1 DE 10145044 A DE10145044 A DE 10145044A DE 10145044 A DE10145044 A DE 10145044A DE 10145044 A1 DE10145044 A1 DE 10145044A1
Authority
DE
Germany
Prior art keywords
hydrogen
butyl
compounds
dichlorophenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10145044A
Other languages
German (de)
English (en)
Inventor
Daniel Jasserand
Ulf Preuschoff
Jochen Antel
Samuel David
Holger Sann
Reinhard Brueckner
Dania Reiche
Christian Eeckout
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Pharmaceuticals GmbH
Original Assignee
Solvay Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DZ020227A priority Critical patent/DZ3292A1/fr
Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Priority to DE10145044A priority patent/DE10145044A1/de
Priority to TW091118380A priority patent/TWI254046B/zh
Priority to ARP020103153A priority patent/AR036487A1/es
Priority to ZA200206731A priority patent/ZA200206731B/xx
Priority to IL151497A priority patent/IL151497A/en
Priority to NZ521154A priority patent/NZ521154A/en
Priority to KR1020020053771A priority patent/KR100909746B1/ko
Priority to DE50204379T priority patent/DE50204379D1/de
Priority to PT02020115T priority patent/PT1293506E/pt
Priority to EP02020115A priority patent/EP1293506B1/de
Priority to ES02020115T priority patent/ES2250561T3/es
Priority to AT02020115T priority patent/ATE305464T1/de
Priority to SI200230195T priority patent/SI1293506T1/sl
Priority to DK02020115T priority patent/DK1293506T3/da
Priority to MXPA02008789A priority patent/MXPA02008789A/es
Priority to HU0202967A priority patent/HU227612B1/hu
Priority to UA2002097386A priority patent/UA75590C2/uk
Priority to CNB021315566A priority patent/CN1232513C/zh
Priority to JP2002265969A priority patent/JP4353684B2/ja
Priority to RU2002124199/04A priority patent/RU2301807C2/ru
Priority to BR0203716-5A priority patent/BR0203716A/pt
Priority to AU2002301141A priority patent/AU2002301141B2/en
Priority to NO20024351A priority patent/NO324867B1/no
Priority to PL02356018A priority patent/PL356018A1/xx
Priority to CA2403139A priority patent/CA2403139C/en
Priority to US10/242,678 priority patent/US6770649B2/en
Publication of DE10145044A1 publication Critical patent/DE10145044A1/de
Priority to HK03105680.1A priority patent/HK1053648B/xx
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
DE10145044A 2001-09-13 2001-09-13 Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel Withdrawn DE10145044A1 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DZ020227A DZ3292A1 (fr) 2001-09-13 2000-09-14 Nouveaux composes de type 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]piperazine, methodes pour les preparer et medicaments renfermant cescomposes
DE10145044A DE10145044A1 (de) 2001-09-13 2001-09-13 Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
TW091118380A TWI254046B (en) 2001-09-13 2002-08-15 Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds
ARP020103153A AR036487A1 (es) 2001-09-13 2002-08-22 Nuevos compuestos de 1-[1-(hetero)aril-1-perhidroxialquilmetil]-piperazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos
ZA200206731A ZA200206731B (en) 2001-09-13 2002-08-22 1-[1-(hetero) aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds.
IL151497A IL151497A (en) 2001-09-13 2002-08-27 Compounds 1–] 1– (Hetero) Aryl – 1– Prehydroxyalkylmethyl] –Piprazine, the process of attenuation and pharmaceutical preparations containing these compounds
NZ521154A NZ521154A (en) 2001-09-13 2002-09-03 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds and pharmaceuticals thereof, and the use of these compounds for the treatment or prevention of a functional or inflammatory disorder in the lower intestinal tract in mammals
KR1020020053771A KR100909746B1 (ko) 2001-09-13 2002-09-06 신규의 1-[1-(헤테로)아릴-1-퍼히드록시알킬메틸]-피페라진 화합물들과 이들의 제조방법 및 이 화합물들을 포함하는 약제들
SI200230195T SI1293506T1 (sl) 2001-09-13 2002-09-07 Nove 1-(1-(hetero)aril-1-perhidroksialkilmetil)-piperazinove spojine, postopek za njihovo izdelavo in zdravila, ki te spojine vsebujejo
PT02020115T PT1293506E (pt) 2001-09-13 2002-09-07 Novos compostos de 1-[1-(hetero)aril-1-perhydroxialquilmetil]-piperazina , processo para sua preparacao e medicamentos que contem estes compostos
EP02020115A EP1293506B1 (de) 2001-09-13 2002-09-07 Neue 1-(1-(Hetero)aryl-1-perhydroxyalkylmethyl)-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
ES02020115T ES2250561T3 (es) 2001-09-13 2002-09-07 Nuevos compuestos de 1-(1-(hetero)aril-1-perhidroxialquilmetil)-piperazina, procedimiento para su preparacion y medicamentos que contienen estos compuestos.
AT02020115T ATE305464T1 (de) 2001-09-13 2002-09-07 Neue 1-(1-(hetero)aryl-1-perhydroxyalkylmethyl)- piperazinverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE50204379T DE50204379D1 (de) 2001-09-13 2002-09-07 Neue 1-(1-(Hetero)aryl-1-perhydroxyalkylmethyl)-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DK02020115T DK1293506T3 (da) 2001-09-13 2002-09-07 Nye 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazin forbindelser, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser
MXPA02008789A MXPA02008789A (es) 2001-09-13 2002-09-09 Compuestos de 1-(-(hetero)aril-1-perhidroxialquilmetil)-piperazina, procedimientos para su preparacion y medicamentos que contienen estos compuestos.
HU0202967A HU227612B1 (en) 2001-09-13 2002-09-09 Novel 1-[1-(hetero)-aril-1-perhydroxy-alkyl-methyl]-piperazine compounds, process for their preparation and pharmaceutical compositions containing them
JP2002265969A JP4353684B2 (ja) 2001-09-13 2002-09-11 １−［１−（ヘテロ）アリール−１−ペルヒドロキシアルキルメチル］−ピペラジン化合物、その製法、薬学的組成物を製造するための該化合物の使用、および該化合物を製造するための出発化合物
CNB021315566A CN1232513C (zh) 2001-09-13 2002-09-11 新的1－[1－(杂)芳基－1－全羟基烷基甲基]－哌嗪化合物、其制备方法和含有该化合物的药物
UA2002097386A UA75590C2 (en) 2001-09-13 2002-09-11 1-(1-(hetero)aryl-1-perhydroxyalkylmethyl)-piperazine compounds, process for their preparation and medicaments containing these compounds
RU2002124199/04A RU2301807C2 (ru) 2001-09-13 2002-09-12 1-[1-(гетеро)арил-1-пергидроксиалкилметил]пиперазиновые соединения, способ их получения и содержащие эти соединения лекарственные средства
BR0203716-5A BR0203716A (pt) 2001-09-13 2002-09-12 Compostos 1-[1-(hetero)aril-1-perhidroxi-alquilmetil]-piperazin a, processo para a sua preparação e medicamentos que contêm estes compostos
AU2002301141A AU2002301141B2 (en) 2001-09-13 2002-09-12 Novel 1-[-(hetero)aryl-1-perhydroxyalkylmethyl])-piperazine compounds, process for their preparation and medicaments containing these compounds
NO20024351A NO324867B1 (no) 2001-09-13 2002-09-12 Nye 1-[1-(hetero)aryl-1-perhydroksyalkylmetyl]-piperazinforbindelser, fremgangsmate for deres fremstilling, legemidler som inneholder disse forbindelsene, anvendelse av forbindelsene til fremstilling av farmasoytiske preparater, samt mellomprodukter i fremgangsmaten
PL02356018A PL356018A1 (en) 2001-09-13 2002-09-12 Novel 1-[1(hetero)aryl-1-perhydroxyalkymethyl] piperazines, method of obtaining them and drugs containing them
CA2403139A CA2403139C (en) 2001-09-13 2002-09-13 Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and medicaments containing these compounds
US10/242,678 US6770649B2 (en) 2001-09-13 2002-09-13 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and pharmaceutical compositions containing them
HK03105680.1A HK1053648B (en) 2001-09-13 2003-08-08 Novel 1-(1-(hetero)aryl-1-perhydroxyalkylmethyl)-piperazine compounds, process for their preparation and medicaments containing these compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10145044A DE10145044A1 (de) 2001-09-13 2001-09-13 Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
DE10145044A1 true DE10145044A1 (de) 2003-04-03

Family

ID=7698848

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10145044A Withdrawn DE10145044A1 (de) 2001-09-13 2001-09-13 Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE50204379T Expired - Lifetime DE50204379D1 (de) 2001-09-13 2002-09-07 Neue 1-(1-(Hetero)aryl-1-perhydroxyalkylmethyl)-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50204379T Expired - Lifetime DE50204379D1 (de) 2001-09-13 2002-09-07 Neue 1-(1-(Hetero)aryl-1-perhydroxyalkylmethyl)-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Country Status (26)

Country Link
US (1) US6770649B2 (cg-RX-API-DMAC7.html)
EP (1) EP1293506B1 (cg-RX-API-DMAC7.html)
JP (1) JP4353684B2 (cg-RX-API-DMAC7.html)
KR (1) KR100909746B1 (cg-RX-API-DMAC7.html)
CN (1) CN1232513C (cg-RX-API-DMAC7.html)
AR (1) AR036487A1 (cg-RX-API-DMAC7.html)
AT (1) ATE305464T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002301141B2 (cg-RX-API-DMAC7.html)
BR (1) BR0203716A (cg-RX-API-DMAC7.html)
CA (1) CA2403139C (cg-RX-API-DMAC7.html)
DE (2) DE10145044A1 (cg-RX-API-DMAC7.html)
DK (1) DK1293506T3 (cg-RX-API-DMAC7.html)
DZ (1) DZ3292A1 (cg-RX-API-DMAC7.html)
ES (1) ES2250561T3 (cg-RX-API-DMAC7.html)
HU (1) HU227612B1 (cg-RX-API-DMAC7.html)
IL (1) IL151497A (cg-RX-API-DMAC7.html)
MX (1) MXPA02008789A (cg-RX-API-DMAC7.html)
NO (1) NO324867B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ521154A (cg-RX-API-DMAC7.html)
PL (1) PL356018A1 (cg-RX-API-DMAC7.html)
PT (1) PT1293506E (cg-RX-API-DMAC7.html)
RU (1) RU2301807C2 (cg-RX-API-DMAC7.html)
SI (1) SI1293506T1 (cg-RX-API-DMAC7.html)
TW (1) TWI254046B (cg-RX-API-DMAC7.html)
UA (1) UA75590C2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200206731B (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2603030C (en) 2005-03-31 2013-11-19 Nippon Zoki Pharmaceutical Co., Ltd. Benzyloxypropylamine derivative
EP1954678B1 (en) * 2005-11-30 2012-03-21 Abbott Products GmbH Novel nk1 and nk2 antagonists
US7592344B2 (en) 2005-11-30 2009-09-22 Solvay Pharmaceuticals Gmbh NK1 and NK2-antagonists and compositions and methods of using the same
CN103387549A (zh) * 2012-05-10 2013-11-13 广州医学院 三个苯并三氮唑类芳基哌嗪化合物的消旋体和光学异构体及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575904A (en) * 1976-04-23 1980-10-01 Lilly Industries Ltd Phenyl piperazines
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
DE69534213T2 (de) * 1994-10-25 2006-01-12 Astrazeneca Ab Therapeutisch wirksame Heterocyclen
ATE308513T1 (de) * 2000-04-06 2005-11-15 Naphthamid-neurokinin antagonisten zur verwendung als medikamente

Also Published As

Publication number Publication date
NO20024351L (no) 2003-03-14
NZ521154A (en) 2004-02-27
HUP0202967A3 (en) 2004-04-28
CA2403139C (en) 2011-02-22
EP1293506A1 (de) 2003-03-19
TWI254046B (en) 2006-05-01
PT1293506E (pt) 2005-11-30
KR100909746B1 (ko) 2009-07-29
ES2250561T3 (es) 2006-04-16
US20030125557A1 (en) 2003-07-03
HU0202967D0 (cg-RX-API-DMAC7.html) 2002-10-28
RU2301807C2 (ru) 2007-06-27
AU2002301141B2 (en) 2008-11-06
HU227612B1 (en) 2011-09-28
IL151497A (en) 2011-10-31
DZ3292A1 (fr) 2005-05-14
NO20024351D0 (no) 2002-09-12
ZA200206731B (en) 2003-04-11
MXPA02008789A (es) 2003-03-18
CN1232513C (zh) 2005-12-21
NO324867B1 (no) 2007-12-17
DK1293506T3 (da) 2005-10-17
ATE305464T1 (de) 2005-10-15
UA75590C2 (en) 2006-05-15
RU2002124199A (ru) 2004-03-20
KR20030023500A (ko) 2003-03-19
HUP0202967A2 (hu) 2003-06-28
CN1406937A (zh) 2003-04-02
SI1293506T1 (sl) 2005-12-31
EP1293506B1 (de) 2005-09-28
IL151497A0 (en) 2003-04-10
JP2003113160A (ja) 2003-04-18
BR0203716A (pt) 2003-06-03
US6770649B2 (en) 2004-08-03
DE50204379D1 (de) 2006-02-09
AR036487A1 (es) 2004-09-15
HK1053648A1 (en) 2003-10-31
JP4353684B2 (ja) 2009-10-28
CA2403139A1 (en) 2003-03-13
PL356018A1 (en) 2003-03-24

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