NO20024351L - Nye 1-[1-(hetero)aryl-1-perhydroksyalkylmetyl]- piperazinforbindelser, fremgangsmåte for deres fremstilling og legemidler som inneholder disseforbindelsene - Google Patents

Nye 1-[1-(hetero)aryl-1-perhydroksyalkylmetyl]- piperazinforbindelser, fremgangsmåte for deres fremstilling og legemidler som inneholder disseforbindelsene

Info

Publication number
NO20024351L
NO20024351L NO20024351A NO20024351A NO20024351L NO 20024351 L NO20024351 L NO 20024351L NO 20024351 A NO20024351 A NO 20024351A NO 20024351 A NO20024351 A NO 20024351A NO 20024351 L NO20024351 L NO 20024351L
Authority
NO
Norway
Prior art keywords
compounds
new
perhydroxyalkylmethyl
hetero
aryl
Prior art date
Application number
NO20024351A
Other languages
English (en)
Other versions
NO20024351D0 (no
NO324867B1 (no
Inventor
Daniel Jasserand
Jochen Antel
Holger Sann
Dania Reiche
Ulf Preuschoff
Samuel David
Reinhard Brueckner
Christian Eeckhout
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of NO20024351D0 publication Critical patent/NO20024351D0/no
Publication of NO20024351L publication Critical patent/NO20024351L/no
Publication of NO324867B1 publication Critical patent/NO324867B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Det beskrives nye, tachykinin-reseptorantagonistisk aktive 1-[1- (hetero)aryl-l-perhydroksyalkylmetyl]- piperazinforbindelser med den generelle formel I. hvor RR, A og Z har de i beskrivelsen angitte betydninger, samt legemidler som inneholder disse forbindelsene. Videre beskrives fremgangsmåte for fremstilling av de nye forbindelsene og mellomprodukter ved denne fremgangsmåten.
NO20024351A 2001-09-13 2002-09-12 Nye 1-[1-(hetero)aryl-1-perhydroksyalkylmetyl]-piperazinforbindelser, fremgangsmate for deres fremstilling, legemidler som inneholder disse forbindelsene, anvendelse av forbindelsene til fremstilling av farmasoytiske preparater, samt mellomprodukter i fremgangsmaten NO324867B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10145044A DE10145044A1 (de) 2001-09-13 2001-09-13 Neue 1-[1-(Hetero)aryl-1-perhydroxyalkylmethyl]-Piperazinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (3)

Publication Number Publication Date
NO20024351D0 NO20024351D0 (no) 2002-09-12
NO20024351L true NO20024351L (no) 2003-03-14
NO324867B1 NO324867B1 (no) 2007-12-17

Family

ID=7698848

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024351A NO324867B1 (no) 2001-09-13 2002-09-12 Nye 1-[1-(hetero)aryl-1-perhydroksyalkylmetyl]-piperazinforbindelser, fremgangsmate for deres fremstilling, legemidler som inneholder disse forbindelsene, anvendelse av forbindelsene til fremstilling av farmasoytiske preparater, samt mellomprodukter i fremgangsmaten

Country Status (27)

Country Link
US (1) US6770649B2 (no)
EP (1) EP1293506B1 (no)
JP (1) JP4353684B2 (no)
KR (1) KR100909746B1 (no)
CN (1) CN1232513C (no)
AR (1) AR036487A1 (no)
AT (1) ATE305464T1 (no)
AU (1) AU2002301141B2 (no)
BR (1) BR0203716A (no)
CA (1) CA2403139C (no)
DE (2) DE10145044A1 (no)
DK (1) DK1293506T3 (no)
DZ (1) DZ3292A1 (no)
ES (1) ES2250561T3 (no)
HK (1) HK1053648A1 (no)
HU (1) HU227612B1 (no)
IL (1) IL151497A (no)
MX (1) MXPA02008789A (no)
NO (1) NO324867B1 (no)
NZ (1) NZ521154A (no)
PL (1) PL356018A1 (no)
PT (1) PT1293506E (no)
RU (1) RU2301807C2 (no)
SI (1) SI1293506T1 (no)
TW (1) TWI254046B (no)
UA (1) UA75590C2 (no)
ZA (1) ZA200206731B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4918031B2 (ja) * 2005-03-31 2012-04-18 日本臓器製薬株式会社 ベンジルオキシプロピルアミン誘導体
JP2009517443A (ja) * 2005-11-30 2009-04-30 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のｎｋ１およびｎｋ２拮抗薬
US7592344B2 (en) 2005-11-30 2009-09-22 Solvay Pharmaceuticals Gmbh NK1 and NK2-antagonists and compositions and methods of using the same
CN103387549A (zh) * 2012-05-10 2013-11-13 广州医学院 三个苯并三氮唑类芳基哌嗪化合物的消旋体和光学异构体及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
EP0709375B1 (en) * 1994-10-25 2005-05-18 AstraZeneca AB Therapeutic heterocycles
AU2001244999A1 (en) * 2000-04-06 2001-10-23 Astrazeneca Ab Naphthamide neurokinin antagonists for use as medicaments

Also Published As

Publication number Publication date
BR0203716A (pt) 2003-06-03
MXPA02008789A (es) 2003-03-18
US20030125557A1 (en) 2003-07-03
CN1406937A (zh) 2003-04-02
PL356018A1 (en) 2003-03-24
DE10145044A1 (de) 2003-04-03
KR20030023500A (ko) 2003-03-19
NO20024351D0 (no) 2002-09-12
CA2403139C (en) 2011-02-22
TWI254046B (en) 2006-05-01
ES2250561T3 (es) 2006-04-16
NZ521154A (en) 2004-02-27
DK1293506T3 (da) 2005-10-17
PT1293506E (pt) 2005-11-30
CN1232513C (zh) 2005-12-21
RU2301807C2 (ru) 2007-06-27
HUP0202967A2 (hu) 2003-06-28
RU2002124199A (ru) 2004-03-20
SI1293506T1 (sl) 2005-12-31
ZA200206731B (en) 2003-04-11
AU2002301141B2 (en) 2008-11-06
HUP0202967A3 (en) 2004-04-28
NO324867B1 (no) 2007-12-17
EP1293506B1 (de) 2005-09-28
JP2003113160A (ja) 2003-04-18
CA2403139A1 (en) 2003-03-13
IL151497A (en) 2011-10-31
ATE305464T1 (de) 2005-10-15
DE50204379D1 (de) 2006-02-09
IL151497A0 (en) 2003-04-10
HU227612B1 (en) 2011-09-28
UA75590C2 (en) 2006-05-15
KR100909746B1 (ko) 2009-07-29
US6770649B2 (en) 2004-08-03
HU0202967D0 (no) 2002-10-28
EP1293506A1 (de) 2003-03-19
AR036487A1 (es) 2004-09-15
DZ3292A1 (fr) 2005-05-14
JP4353684B2 (ja) 2009-10-28
HK1053648A1 (en) 2003-10-31

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