DD265627A5 - Verfahren zur herstellung von 1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3-benzodiazepin - Google Patents

Verfahren zur herstellung von 1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3-benzodiazepin Download PDF

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Publication number
DD265627A5
DD265627A5 DD87306060A DD30606087A DD265627A5 DD 265627 A5 DD265627 A5 DD 265627A5 DD 87306060 A DD87306060 A DD 87306060A DD 30606087 A DD30606087 A DD 30606087A DD 265627 A5 DD265627 A5 DD 265627A5
Authority
DD
German Democratic Republic
Prior art keywords
hydride
benzodiazepine
aminophenyl
methyl
dihydro
Prior art date
Application number
DD87306060A
Other languages
German (de)
English (en)
Inventor
Jenoe Koeroesi
Tibor Lang
Ferenc Andrasi
Pal Berzsenyi
Peter Botka
Tamas Hamori
Katalin Goldschmidt
Jozsef Borsy
Istvan Elekes
Zsuzsa Lang
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �����@������������������k�� filed Critical �����@������������������k��
Publication of DD265627A5 publication Critical patent/DD265627A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DD87306060A 1986-08-15 1987-08-14 Verfahren zur herstellung von 1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3-benzodiazepin DD265627A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
DD265627A5 true DD265627A5 (de) 1989-03-08

Family

ID=10964707

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87306060A DD265627A5 (de) 1986-08-15 1987-08-14 Verfahren zur herstellung von 1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-3,4-dihydro-5h-2,3-benzodiazepin

Country Status (23)

Country Link
US (1) US4835152A (es)
JP (1) JPS6399073A (es)
AT (1) ATA202187A (es)
AU (1) AU596206B2 (es)
BE (1) BE1002415A4 (es)
CA (1) CA1284322C (es)
CH (1) CH673652A5 (es)
CS (1) CS264150B2 (es)
DD (1) DD265627A5 (es)
DE (1) DE3727226A1 (es)
DK (1) DK164555C (es)
ES (1) ES2004985A6 (es)
FI (1) FI85706C (es)
FR (1) FR2602773B1 (es)
GB (1) GB2194236B (es)
HU (1) HU198494B (es)
IT (1) IT1222508B (es)
NL (1) NL8701909A (es)
NO (1) NO164656C (es)
PL (1) PL148535B1 (es)
RU (1) RU1779251C (es)
SE (1) SE467357B (es)
YU (1) YU46223B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
TR199501071A2 (tr) 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US7745431B2 (en) * 2002-12-03 2010-06-29 Vela Acquisition Corporation Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
JP2006514084A (ja) * 2002-12-03 2006-04-27 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３−ヒドロキシ−４−メトキシフェニル）−４−メチル−５−エチル−７，８−ジメトキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
JP4611308B2 (ja) * 2003-05-16 2011-01-12 ヴェラ アクイジション コーポレイション 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US20050096464A1 (en) * 2003-10-30 2005-05-05 Heikki Heikkila Separation process
EP4197536A1 (en) * 2021-12-20 2023-06-21 Universitat de València Haloperidol for use in the treatment of spinal muscular atrophy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
DE3319491A1 (de) * 1982-06-19 1983-10-13 Alps Electric Co., Ltd., Tokyo Papierfuehrungsmechanismus fuer schreibgeraete
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
SE467357B (sv) 1992-07-06
NO164656B (no) 1990-07-23
HU198494B (en) 1989-10-30
ES2004985A6 (es) 1989-02-16
NO873426D0 (no) 1987-08-14
PL148535B1 (en) 1989-10-31
IT8721667A0 (it) 1987-08-14
AU596206B2 (en) 1990-04-26
FI85706C (fi) 1992-05-25
CS600787A2 (en) 1988-08-16
RU1779251C (ru) 1992-11-30
HUT47287A (en) 1989-02-28
GB8719265D0 (en) 1987-09-23
DE3727226A1 (de) 1988-02-18
SE8703169L (sv) 1988-02-16
DK164555C (da) 1992-11-30
CA1284322C (en) 1991-05-21
CS264150B2 (en) 1989-06-13
BE1002415A4 (fr) 1991-02-05
JPS6399073A (ja) 1988-04-30
GB2194236B (en) 1990-03-21
FI873525A (fi) 1988-02-16
SE8703169D0 (sv) 1987-08-14
FI873525A0 (fi) 1987-08-14
US4835152A (en) 1989-05-30
NO873426L (no) 1988-02-16
NO164656C (no) 1990-10-31
DK424887D0 (da) 1987-08-14
NL8701909A (nl) 1988-03-01
IT1222508B (it) 1990-09-05
CH673652A5 (es) 1990-03-30
AU7688087A (en) 1988-02-18
GB2194236A (en) 1988-03-02
YU46223B (sh) 1993-05-28
DK164555B (da) 1992-07-13
YU151487A (en) 1988-12-31
FR2602773B1 (fr) 1990-11-02
FI85706B (fi) 1992-02-14
FR2602773A1 (fr) 1988-02-19
ATA202187A (de) 1993-06-15
DK424887A (da) 1988-02-16

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