DD264614A5 - Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums - Google Patents

Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums Download PDF

Info

Publication number
DD264614A5
DD264614A5 DD87310253A DD31025387A DD264614A5 DD 264614 A5 DD264614 A5 DD 264614A5 DD 87310253 A DD87310253 A DD 87310253A DD 31025387 A DD31025387 A DD 31025387A DD 264614 A5 DD264614 A5 DD 264614A5
Authority
DD
German Democratic Republic
Prior art keywords
zwitterion
chloride
salt
sodium
calcium
Prior art date
Application number
DD87310253A
Other languages
German (de)
English (en)
Inventor
Murray A Kaplan
Joseph B Bogardus
Nageswara R Palepu
Original Assignee
�������`�����@�������k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �������`�����@�������k�� filed Critical �������`�����@�������k��
Publication of DD264614A5 publication Critical patent/DD264614A5/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
DD87310253A 1987-01-09 1987-12-10 Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums DD264614A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/001,945 US4808617A (en) 1985-12-18 1987-01-09 Lyophilized or precipitated cephalosporin zwitterion and salt combination

Publications (1)

Publication Number Publication Date
DD264614A5 true DD264614A5 (de) 1989-02-08

Family

ID=21698538

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87310253A DD264614A5 (de) 1987-01-09 1987-12-10 Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums

Country Status (33)

Country Link
US (1) US4808617A (it)
JP (1) JP2568226B2 (it)
KR (1) KR950010154B1 (it)
AR (1) AR243501A1 (it)
AT (1) AT388672B (it)
AU (1) AU606361B2 (it)
BE (1) BE1002114A3 (it)
CA (1) CA1307464C (it)
CH (1) CH676202A5 (it)
CS (1) CS265249B2 (it)
CY (1) CY1679A (it)
DD (1) DD264614A5 (it)
DE (1) DE3740588C2 (it)
DK (1) DK166404B1 (it)
ES (1) ES2008951A6 (it)
FI (1) FI89006C (it)
FR (1) FR2609396B1 (it)
GB (1) GB2199746B (it)
GR (1) GR871860B (it)
HK (1) HK5593A (it)
HU (1) HU199686B (it)
IE (1) IE61238B1 (it)
IL (1) IL84346A (it)
IT (1) IT1215666B (it)
LU (1) LU87102A1 (it)
NL (1) NL193266C (it)
OA (1) OA08796A (it)
PT (1) PT86157B (it)
SE (1) SE467910B (it)
SG (1) SG114792G (it)
SU (1) SU1575942A3 (it)
YU (1) YU46689B (it)
ZA (1) ZA88114B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
WO2005094800A2 (en) * 2004-03-31 2005-10-13 Lupin Ltd. A co-precipitated cefepime composition and process for preparation thereof
WO2006109324A2 (en) * 2005-04-13 2006-10-19 Lupin Limited Processes for preparation of amorphous cefepime acid addition salts
JP5491119B2 (ja) * 2009-10-02 2014-05-14 日東電工株式会社 薬物含有微粒子を含む医薬組成物およびその製造方法
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
WO2016035846A1 (ja) 2014-09-04 2016-03-10 塩野義製薬株式会社 カテコール基を有するセファロスポリン類を含有する製剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953439A (en) * 1973-08-01 1976-04-27 Smithkline Corporation Substituted phenylglycylcephalosporins
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
US4604386A (en) * 1984-07-09 1986-08-05 Eli Lilly And Company 3-(alkynylalkyloxy) cephalosporins
JPS61130223A (ja) * 1984-11-28 1986-06-18 Shionogi & Co Ltd 抗菌性凍結乾燥製剤
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables

Also Published As

Publication number Publication date
IL84346A0 (en) 1988-04-29
GB2199746A (en) 1988-07-20
FI875122A0 (fi) 1987-11-19
YU2388A (en) 1989-10-31
IE61238B1 (en) 1994-10-19
PT86157A (en) 1987-12-01
CS265249B2 (en) 1989-10-13
DE3740588A1 (de) 1988-07-21
GB8725875D0 (en) 1987-12-09
AU606361B2 (en) 1991-02-07
SE8800036L (sv) 1988-07-10
SE8800036D0 (sv) 1988-01-08
NL193266C (nl) 1999-05-06
YU46689B (sh) 1994-04-05
FI89006C (fi) 1993-08-10
US4808617A (en) 1989-02-28
OA08796A (fr) 1989-03-31
FR2609396B1 (fr) 1993-01-29
DK166404B1 (da) 1993-05-17
SU1575942A3 (ru) 1990-06-30
ATA341687A (de) 1989-01-15
NL8800025A (nl) 1988-08-01
KR880008811A (ko) 1988-09-13
IE872970L (en) 1988-07-09
CY1679A (en) 1993-10-10
IT1215666B (it) 1990-02-22
DE3740588C2 (de) 1996-07-11
FI89006B (fi) 1993-04-30
ZA88114B (it) 1988-06-27
HUT46223A (en) 1988-10-28
HU199686B (en) 1990-03-28
SG114792G (en) 1992-12-24
PT86157B (pt) 1991-02-08
JPS63208522A (ja) 1988-08-30
ES2008951A6 (es) 1989-08-16
IT8819013A0 (it) 1988-01-07
LU87102A1 (fr) 1988-08-23
AU8085687A (en) 1989-05-11
BE1002114A3 (fr) 1990-07-10
DK577387A (da) 1988-07-10
AR243501A1 (es) 1993-08-31
GR871860B (en) 1988-05-10
KR950010154B1 (ko) 1995-09-11
NL193266B (nl) 1999-01-04
DK577387D0 (da) 1987-11-03
AT388672B (de) 1989-08-10
CS15888A2 (en) 1989-01-12
SE467910B (sv) 1992-10-05
GB2199746B (en) 1990-10-24
CA1307464C (en) 1992-09-15
HK5593A (en) 1993-02-05
FI875122A (fi) 1988-07-10
CH676202A5 (it) 1990-12-28
IL84346A (en) 1992-05-25
JP2568226B2 (ja) 1996-12-25
FR2609396A1 (fr) 1988-07-15

Similar Documents

Publication Publication Date Title
DE69014141T2 (de) Verwendung von Benzimidazol-Derivaten als antibakterielle Mittel.
EP0219784B1 (de) Infusionslösungen der 1-Cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-chinolon-3-carbonsäure
DE2738712C2 (it)
DE2332878C2 (de) Salze von Cephalosporinen mit Arginin und Lysin, ihre Herstellung und injizierbare pharmazeutische Zubereitungen
CH671157A5 (de) Stabiles pharmazeutisches praeparat, enthaltend granulocytkolonie stimulierender faktor, und verfahren zur herstellung desselben.
DE3037102A1 (de) Verbesserungen bei cephalosporinantibiotika
DD264614A5 (de) Verfahren zur herstellung eines temperaturstabilen breitband-antibiotikums
DE2323187C2 (de) Verfahren zur Herstellung einer stabilisierten, pulverförmigen Secretinzubereitung
CH644609A5 (de) Cephalosporinantibiotikum.
EP0864579B1 (de) Wismutsalze von Antibiotika der Moenomycin-Gruppe, Verfahren zu ihrer Herstellung, ihre Verwendung und solche Salze enthaltende Arzneimittel
DE2506622C2 (de) Antibiotisch wirksames Arzneimittel
DE69323568T2 (de) Antimikrobielle Zusammensetzungen und pharmazeutische Präparate hiervon
EP0655249B1 (de) Moenomycin als Arzneimittel zur Behandlung von Magengeschwüren
DE69004921T2 (de) Injizierbare Cephalosporinpräparate und ihre Anwendung.
EP0711774A1 (de) Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung
EP0122585B1 (de) Neue Kristallmodifikation von Ceftazidim
EP0004925B1 (de) Synergistische Mischungen von Antibiotika und Verfahren zu ihrer Herstellung
DE2718730A1 (de) Cephalosporin-antibiotika
AT395943B (de) Pharmazeutische waessrige formulierungen, die ein piperidinylcyclopentylheptensaeure-derivat enthalten
EP0462506B1 (de) Pharmazeutische Kombinationspräparate enthaltend Cefotaxim und Xanthinderivate und deren Verwendung
DE3618813A1 (de) Pharmazeutische zubereitung zur behandlung bakterieller infektionen
DE2508443C2 (de) Pharmazeutisches Mischpräparat mit antibiotischer Wirkung
AT314087B (de) Verfahren zur Herstellung von neuen Cephalosporinverbindungen
DE2711223A1 (de) Thienamycinsulfoxid und thienamycinsulfon
CH638679A5 (en) Solid antibiotic composition

Legal Events

Date Code Title Description
IF04 In force in the year 2004

Expiry date: 20071211