IT1215666B - Combinazione liofilizzata o precipitata di una forma bipolare di un composto cefalosporinico e di sali. - Google Patents

Combinazione liofilizzata o precipitata di una forma bipolare di un composto cefalosporinico e di sali.

Info

Publication number
IT1215666B
IT1215666B IT8819013A IT1901388A IT1215666B IT 1215666 B IT1215666 B IT 1215666B IT 8819013 A IT8819013 A IT 8819013A IT 1901388 A IT1901388 A IT 1901388A IT 1215666 B IT1215666 B IT 1215666B
Authority
IT
Italy
Prior art keywords
cephalosporinic
lyophilized
salt
compound
bipolar form
Prior art date
Application number
IT8819013A
Other languages
English (en)
Other versions
IT8819013A0 (it
Inventor
Murray Arthur Kaplan
Joseph Ballard Bogardus
Nageswara R Palepu
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8819013A0 publication Critical patent/IT8819013A0/it
Application granted granted Critical
Publication of IT1215666B publication Critical patent/IT1215666B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
IT8819013A 1987-01-09 1988-01-07 Combinazione liofilizzata o precipitata di una forma bipolare di un composto cefalosporinico e di sali. IT1215666B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/001,945 US4808617A (en) 1985-12-18 1987-01-09 Lyophilized or precipitated cephalosporin zwitterion and salt combination

Publications (2)

Publication Number Publication Date
IT8819013A0 IT8819013A0 (it) 1988-01-07
IT1215666B true IT1215666B (it) 1990-02-22

Family

ID=21698538

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8819013A IT1215666B (it) 1987-01-09 1988-01-07 Combinazione liofilizzata o precipitata di una forma bipolare di un composto cefalosporinico e di sali.

Country Status (33)

Country Link
US (1) US4808617A (it)
JP (1) JP2568226B2 (it)
KR (1) KR950010154B1 (it)
AR (1) AR243501A1 (it)
AT (1) AT388672B (it)
AU (1) AU606361B2 (it)
BE (1) BE1002114A3 (it)
CA (1) CA1307464C (it)
CH (1) CH676202A5 (it)
CS (1) CS265249B2 (it)
CY (1) CY1679A (it)
DD (1) DD264614A5 (it)
DE (1) DE3740588C2 (it)
DK (1) DK166404B1 (it)
ES (1) ES2008951A6 (it)
FI (1) FI89006C (it)
FR (1) FR2609396B1 (it)
GB (1) GB2199746B (it)
GR (1) GR871860B (it)
HK (1) HK5593A (it)
HU (1) HU199686B (it)
IE (1) IE61238B1 (it)
IL (1) IL84346A (it)
IT (1) IT1215666B (it)
LU (1) LU87102A1 (it)
NL (1) NL193266C (it)
OA (1) OA08796A (it)
PT (1) PT86157B (it)
SE (1) SE467910B (it)
SG (1) SG114792G (it)
SU (1) SU1575942A3 (it)
YU (1) YU46689B (it)
ZA (1) ZA88114B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
WO2005094800A2 (en) * 2004-03-31 2005-10-13 Lupin Ltd. A co-precipitated cefepime composition and process for preparation thereof
WO2006109324A2 (en) * 2005-04-13 2006-10-19 Lupin Limited Processes for preparation of amorphous cefepime acid addition salts
JP5491119B2 (ja) * 2009-10-02 2014-05-14 日東電工株式会社 薬物含有微粒子を含む医薬組成物およびその製造方法
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
EP3100732A1 (en) 2013-03-15 2016-12-07 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
KR101935186B1 (ko) 2014-09-04 2019-01-03 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세팔로스포린류를 함유하는 제제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953439A (en) * 1973-08-01 1976-04-27 Smithkline Corporation Substituted phenylglycylcephalosporins
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
US4604386A (en) * 1984-07-09 1986-08-05 Eli Lilly And Company 3-(alkynylalkyloxy) cephalosporins
JPS61130223A (ja) * 1984-11-28 1986-06-18 Shionogi & Co Ltd 抗菌性凍結乾燥製剤
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables

Also Published As

Publication number Publication date
DK577387D0 (da) 1987-11-03
US4808617A (en) 1989-02-28
HU199686B (en) 1990-03-28
LU87102A1 (fr) 1988-08-23
NL193266B (nl) 1999-01-04
FR2609396A1 (fr) 1988-07-15
DD264614A5 (de) 1989-02-08
AT388672B (de) 1989-08-10
SE8800036L (sv) 1988-07-10
AU8085687A (en) 1989-05-11
SG114792G (en) 1992-12-24
DK577387A (da) 1988-07-10
FI89006C (fi) 1993-08-10
IL84346A (en) 1992-05-25
JPS63208522A (ja) 1988-08-30
ZA88114B (it) 1988-06-27
YU46689B (sh) 1994-04-05
AU606361B2 (en) 1991-02-07
DE3740588C2 (de) 1996-07-11
ATA341687A (de) 1989-01-15
CH676202A5 (it) 1990-12-28
PT86157B (pt) 1991-02-08
ES2008951A6 (es) 1989-08-16
NL8800025A (nl) 1988-08-01
AR243501A1 (es) 1993-08-31
HUT46223A (en) 1988-10-28
IE61238B1 (en) 1994-10-19
HK5593A (en) 1993-02-05
CS15888A2 (en) 1989-01-12
KR880008811A (ko) 1988-09-13
YU2388A (en) 1989-10-31
GB8725875D0 (en) 1987-12-09
GR871860B (en) 1988-05-10
SE8800036D0 (sv) 1988-01-08
GB2199746A (en) 1988-07-20
CS265249B2 (en) 1989-10-13
FI89006B (fi) 1993-04-30
GB2199746B (en) 1990-10-24
FR2609396B1 (fr) 1993-01-29
IL84346A0 (en) 1988-04-29
FI875122A0 (fi) 1987-11-19
SU1575942A3 (ru) 1990-06-30
DK166404B1 (da) 1993-05-17
PT86157A (en) 1987-12-01
FI875122A (fi) 1988-07-10
BE1002114A3 (fr) 1990-07-10
SE467910B (sv) 1992-10-05
CA1307464C (en) 1992-09-15
JP2568226B2 (ja) 1996-12-25
DE3740588A1 (de) 1988-07-21
OA08796A (fr) 1989-03-31
IT8819013A0 (it) 1988-01-07
CY1679A (en) 1993-10-10
KR950010154B1 (ko) 1995-09-11
IE872970L (en) 1988-07-09
NL193266C (nl) 1999-05-06

Similar Documents

Publication Publication Date Title
DE3689314T2 (de) Peptidasehemmungsmittel.
DE3878589T2 (de) Buerstendichtungen.
DE3861315D1 (de) Servobetaetigtes schloss mit rotationssperre.
DE3879305T2 (de) Magnetkopf.
IT1215666B (it) Combinazione liofilizzata o precipitata di una forma bipolare di un composto cefalosporinico e di sali.
DE3886569T2 (de) Magnetkopf.
DE3679657D1 (de) Magnetkopf.
DE3879799D1 (de) Magnetkopf.
IT8621409A0 (it) Sali di cefalosporina e composizioni iniettabili.
DE3688983T2 (de) Faktor IX-Protein.
FI881972A (fi) Anvaendning av en ace-inhibitor foer inhibitering av foerlusten av kognitiva funktioner.
DE68910615T2 (de) Magnetkopf.
FI854074L (fi) Peptid-substituerade heterocykliska immunostimulanter.
DE3865176D1 (de) Kehrfahrzeuge.
IT8422442A0 (it) Sali policationici di 4-0sottolineato-poliesaosio-tio-ari len solfati e relativo procedimento di preparazione.
DE68923010T2 (de) Schwebender Verbundmagnetkopf.
FI900075A (fi) Medvaexthormon bindande peptid.
DE68924994T2 (de) Magnetkopf.
NO885576D0 (no) Trometaminsalt av 1-metyl-beta-okso-alfa-(fenyl-karbamoyl)-2-pyrrolpropionitril.
IT1199841B (it) Procedimento per l'estrazione di mn metallico e biossido di manganese da soluzioni di sali di mn bivalente
IT8620828A0 (it) Procedimento per la produzione di una l-aspartil-l-fenilalanina n-protetta.
KR880021124U (ko) 개량 김 발장
DE3881652T2 (de) Tripeptid-derivate.
IT1205850B (it) Proiettile per la creazione di sbarramento
IT8722861A0 (it) Pendaglio luminoso.

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960129