DD229410A5 - Verfahren zur herstellung von kristallinem cephalexinhydrochloridmonohydrat - Google Patents

Verfahren zur herstellung von kristallinem cephalexinhydrochloridmonohydrat Download PDF

Info

Publication number
DD229410A5
DD229410A5 DD84269940A DD26994084A DD229410A5 DD 229410 A5 DD229410 A5 DD 229410A5 DD 84269940 A DD84269940 A DD 84269940A DD 26994084 A DD26994084 A DD 26994084A DD 229410 A5 DD229410 A5 DD 229410A5
Authority
DD
German Democratic Republic
Prior art keywords
cephalexin
crystalline
monohydrate
hydrochloride monohydrate
solvate
Prior art date
Application number
DD84269940A
Other languages
German (de)
English (en)
Inventor
Gary L Engel
Joseph M Indelicato
Harry A Rose
Lawrence J Mcshane
Kuo S Yang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD229410A5 publication Critical patent/DD229410A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DD84269940A 1983-12-01 1984-11-27 Verfahren zur herstellung von kristallinem cephalexinhydrochloridmonohydrat DD229410A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/556,887 US4600773A (en) 1983-12-01 1983-12-01 Crystalline cephalexin hydrochloride monohydrate

Publications (1)

Publication Number Publication Date
DD229410A5 true DD229410A5 (de) 1985-11-06

Family

ID=24223233

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84269940A DD229410A5 (de) 1983-12-01 1984-11-27 Verfahren zur herstellung von kristallinem cephalexinhydrochloridmonohydrat

Country Status (46)

Country Link
US (1) US4600773A (fr)
EP (1) EP0143658B1 (fr)
JP (1) JPS60132990A (fr)
KR (1) KR870000527B1 (fr)
AT (1) AT390616B (fr)
AU (1) AU566080B2 (fr)
BE (1) BE901142A (fr)
BG (1) BG40966A3 (fr)
BR (1) BR8406037A (fr)
CH (1) CH661732A5 (fr)
CS (1) CS248725B2 (fr)
CY (1) CY1505A (fr)
DD (1) DD229410A5 (fr)
DE (1) DE3443065A1 (fr)
DK (1) DK158354C (fr)
ES (1) ES538019A0 (fr)
FI (1) FI80274C (fr)
FR (1) FR2555990B1 (fr)
GB (1) GB2150566B (fr)
GR (1) GR81043B (fr)
GT (1) GT198400146A (fr)
HK (1) HK92089A (fr)
HU (1) HU192516B (fr)
IE (1) IE57886B1 (fr)
IL (1) IL73639A (fr)
IN (1) IN163078B (fr)
IT (1) IT1177329B (fr)
JO (1) JO1347B1 (fr)
LU (1) LU85650A1 (fr)
MA (1) MA20279A1 (fr)
MX (1) MX159670A (fr)
MY (1) MY102966A (fr)
NL (1) NL8403588A (fr)
NO (1) NO844711L (fr)
NZ (1) NZ210357A (fr)
OA (1) OA07876A (fr)
PH (1) PH20849A (fr)
PL (1) PL146014B1 (fr)
PT (1) PT79553B (fr)
SE (1) SE464026B (fr)
SG (1) SG59789G (fr)
SU (1) SU1251807A3 (fr)
YU (1) YU45680B (fr)
ZA (1) ZA849224B (fr)
ZM (1) ZM6384A1 (fr)
ZW (1) ZW19084A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2555989B1 (fr) * 1983-12-06 1987-02-20 Bristol Myers Sa Monohydrate de chlorocephadroxyle
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE3485860T2 (de) * 1983-12-29 1993-01-14 Mochida Pharm Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US5721229A (en) * 1995-12-26 1998-02-24 Veterinary Pharmacy Corporation Soluble forms of cephalosporins and treatment of animals
GB9717629D0 (en) 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
AT413282B (de) * 2002-02-01 2006-01-15 Sandoz Ag Kristalline salze der 7-(((5-amino-1,2,4-thiadiazol-3-yl) (fluoromethoxy-imino)acetyl)amino)-3- ((imino-1-piperazinylmethyl)
US20040033262A1 (en) * 2002-08-19 2004-02-19 Orchid Health Care Sustained release pharmaceutical composition of a cephalosporin antibiotic

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507861A (en) * 1966-09-14 1970-04-21 Lilly Co Eli Certain 3-methyl-cephalosporin compounds
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
DE2317179C2 (de) * 1973-04-05 1982-11-25 Bristol-Myers Co., 10154 New York, N.Y. Verfahren zur Herstellung der relativ wasserunlöslichen kristallinen Form von Cefalexinmonohydrat
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
JPS50151890A (fr) * 1974-05-30 1975-12-06
CH642850A5 (it) * 1978-10-20 1984-05-15 Ausonia Farma Srl Composizioni farmaceutiche ad attivita antibatterica contro infezioni da germi gram-positivi e gram-negativi.
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device

Also Published As

Publication number Publication date
AU566080B2 (en) 1987-10-08
SE464026B (sv) 1991-02-25
DK561284D0 (da) 1984-11-27
JPH0548234B2 (fr) 1993-07-20
PL146014B1 (en) 1988-12-31
BR8406037A (pt) 1985-08-27
ATA373284A (de) 1989-11-15
US4600773A (en) 1986-07-15
GR81043B (en) 1985-03-27
PL250593A1 (en) 1985-07-30
PH20849A (en) 1987-05-08
YU199684A (en) 1987-02-28
GB2150566B (en) 1987-08-26
CY1505A (en) 1990-08-03
SU1251807A3 (ru) 1986-08-15
OA07876A (fr) 1986-11-20
PT79553B (en) 1986-12-15
BE901142A (fr) 1985-05-28
NZ210357A (en) 1988-05-30
KR870000527B1 (ko) 1987-03-14
BG40966A3 (en) 1987-03-14
MY102966A (en) 1993-03-31
JO1347B1 (en) 1986-11-30
DK158354C (da) 1990-10-01
EP0143658A2 (fr) 1985-06-05
HUT35685A (en) 1985-07-29
AT390616B (de) 1990-06-11
FI844631L (fi) 1985-06-02
MA20279A1 (fr) 1985-07-01
ZW19084A1 (en) 1985-06-12
EP0143658A3 (en) 1986-02-12
ZM6384A1 (en) 1985-07-22
GB8430073D0 (en) 1985-01-09
SE8405954D0 (sv) 1984-11-26
DE3443065A1 (de) 1985-06-20
ES8602011A1 (es) 1985-11-01
CH661732A5 (de) 1987-08-14
IL73639A (en) 1988-06-30
YU45680B (sh) 1992-07-20
FI80274C (fi) 1990-05-10
EP0143658B1 (fr) 1989-03-22
FR2555990B1 (fr) 1986-12-26
IE843033L (en) 1985-06-01
SE8405954L (sv) 1985-06-02
PT79553A (en) 1984-12-01
HU192516B (en) 1987-06-29
SG59789G (en) 1989-12-29
LU85650A1 (fr) 1985-07-17
DE3443065C2 (fr) 1989-03-23
DK158354B (da) 1990-05-07
KR850004765A (ko) 1985-07-27
FI80274B (fi) 1990-01-31
IT8423746A0 (it) 1984-11-27
ES538019A0 (es) 1985-11-01
IT8423746A1 (it) 1986-05-27
ZA849224B (en) 1986-07-30
FI844631A0 (fi) 1984-11-26
IL73639A0 (en) 1985-02-28
FR2555990A1 (fr) 1985-06-07
IT1177329B (it) 1987-08-26
NL8403588A (nl) 1985-07-01
AU3589784A (en) 1985-06-06
GB2150566A (en) 1985-07-03
IN163078B (fr) 1988-08-06
DK561284A (da) 1985-06-02
GT198400146A (es) 1986-05-20
MX159670A (es) 1989-08-02
HK92089A (en) 1989-11-24
IE57886B1 (en) 1993-05-05
NO844711L (no) 1985-06-03
CS248725B2 (en) 1987-02-12
JPS60132990A (ja) 1985-07-16

Similar Documents

Publication Publication Date Title
DE3143219C2 (fr)
DE69814378T2 (de) Salz von naphthylidincarbonsäure-derivaten
DD201139A5 (de) Verfahren zur herstellung von (-)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamin und seinen pharmazeutisch unbedenklichen salzen
DE3500179C2 (fr)
DE19546249A1 (de) Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE3443065C2 (fr)
EP0550895B1 (fr) Dérivés de 4,13-dioxabicyclo[8.2.1]tridecenon, leur procédé et les intermédiaires de préparation et médicaments les renfermant
DD202573A5 (de) Verfahren zur herstellung von 1-aethyl-6-fluor-1,4dihydro-4-oxo-7-(1-piperazinyl)-1,8 naphthyridin-3-carbonsaeure
CH654004A5 (de) Kristallmodifikationen des monohydrats und der wasserfreien form von (+)-catechin, verfahren zu deren herstellung und die sie enthaltenden pharmazeutischen zusammensetzungen.
DD213212A5 (de) Verfahren zur herstellung von 4-methyl-6-phenyl-pyridazin-derivaten
DE60131416T2 (de) Chirale fluochinolon-argininsalzformen
DD273634A5 (de) Verfahren zur herstellung eines kristallinen monohydrats eines 1-carbacephalosporins
DE3212882C2 (fr)
DE1811518B2 (de) Daunorubicinderivale, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE69015834T2 (de) 6-Chlor-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzodiazepin-carbamate als Pro-Arzneimittel.
AT403162B (de) Neue kristallform von morphin-6-glucuronid
DE3139554C2 (fr)
DE69121807T2 (de) 3-[(5-Methyl-2-furanyl)methyl]-N-(4-piperidinyl)-3H-imidazo[4,5-b]-pyridin-2-amin-2-hydroxy-1,2,3-propantricarboxylat
DE2655130C3 (de) Eine praktisch lösungsmittelfreie Kristallform des Cefacetril-Natriumsalzes
DE1911240C3 (de) Antibioticum 20 798 RP, Verfahren zu seiner Gewinnung und Arzneimittel, die dieses enthalten
DD200404A5 (de) Verfahren zur herstellung eines synergistisch wirkenden mittels
DE2858813C2 (fr)
EP0192098B1 (fr) Utilisation de 2-amino-6-allyl-5,6,7,8-tétrahydro-4H-thiazolo[4,5-d]azépine pour la production d'un médicament pour le traitement de la maladie de Parkinson, respectivement du parkinsonisme
DE69929315T2 (de) Kristalline formen von 1s-ä1alpha(2s*,3r*),9alphaü-6,10-dioxo-n- (2-ethoxy-5-oxo-tetrahydro-3-furanyl)-9-ää(1-isochinolyl)carbonylü- aminoüoctahydro-6h-piridazinoä1,2-aüä1,2üdiazepin-1-carboxyamid
DE19541921A1 (de) Neue Kristallform von Morphin-6-glucuronid

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee