KR850004765A - 세팔렉신 염산염 일수화물의 제조방법 - Google Patents

세팔렉신 염산염 일수화물의 제조방법 Download PDF

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Publication number
KR850004765A
KR850004765A KR1019840007392A KR840007392A KR850004765A KR 850004765 A KR850004765 A KR 850004765A KR 1019840007392 A KR1019840007392 A KR 1019840007392A KR 840007392 A KR840007392 A KR 840007392A KR 850004765 A KR850004765 A KR 850004765A
Authority
KR
South Korea
Prior art keywords
solvate
hydrochloride monohydrate
cephalexin hydrochloride
preparing
preparing cephalexin
Prior art date
Application number
KR1019840007392A
Other languages
English (en)
Other versions
KR870000527B1 (ko
Inventor
로우웰 엥겔 게리 (외 4)
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR850004765A publication Critical patent/KR850004765A/ko
Application granted granted Critical
Publication of KR870000527B1 publication Critical patent/KR870000527B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

세팔렉신 염산염 일수화물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 결정성 세팔렉신 염산염 C1-4알칸올 용매화합물을 수화시킴을 특징으로하여 결정성 세팔렉신 염산염 일수화물을 제조하는 방법.
  2. 제1항에 있어서, 결정성 염산염 C1-2알칸올 용매화합물을 수화시키는 방법.
  3. 제1항 또는 제2항에 있어서, 용매화합물을 상대습도가 약 10 내지 50인 대기에 노출시킴으로써 수화시키는 방법.
  4. 제3항에 있어서, 용매화합물이 에탄올 용매화합물인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007392A 1983-12-01 1984-11-26 세팔렉신 염산염 일수화물의 제조방법 KR870000527B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US556887 1983-12-01
US556,887 1983-12-01
US06/556,887 US4600773A (en) 1983-12-01 1983-12-01 Crystalline cephalexin hydrochloride monohydrate

Publications (2)

Publication Number Publication Date
KR850004765A true KR850004765A (ko) 1985-07-27
KR870000527B1 KR870000527B1 (ko) 1987-03-14

Family

ID=24223233

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007392A KR870000527B1 (ko) 1983-12-01 1984-11-26 세팔렉신 염산염 일수화물의 제조방법

Country Status (46)

Country Link
US (1) US4600773A (ko)
EP (1) EP0143658B1 (ko)
JP (1) JPS60132990A (ko)
KR (1) KR870000527B1 (ko)
AT (1) AT390616B (ko)
AU (1) AU566080B2 (ko)
BE (1) BE901142A (ko)
BG (1) BG40966A3 (ko)
BR (1) BR8406037A (ko)
CH (1) CH661732A5 (ko)
CS (1) CS248725B2 (ko)
CY (1) CY1505A (ko)
DD (1) DD229410A5 (ko)
DE (1) DE3443065A1 (ko)
DK (1) DK158354C (ko)
ES (1) ES8602011A1 (ko)
FI (1) FI80274C (ko)
FR (1) FR2555990B1 (ko)
GB (1) GB2150566B (ko)
GR (1) GR81043B (ko)
GT (1) GT198400146A (ko)
HK (1) HK92089A (ko)
HU (1) HU192516B (ko)
IE (1) IE57886B1 (ko)
IL (1) IL73639A (ko)
IN (1) IN163078B (ko)
IT (1) IT1177329B (ko)
JO (1) JO1347B1 (ko)
LU (1) LU85650A1 (ko)
MA (1) MA20279A1 (ko)
MX (1) MX159670A (ko)
MY (1) MY102966A (ko)
NL (1) NL8403588A (ko)
NO (1) NO844711L (ko)
NZ (1) NZ210357A (ko)
OA (1) OA07876A (ko)
PH (1) PH20849A (ko)
PL (1) PL146014B1 (ko)
PT (1) PT79553B (ko)
SE (1) SE464026B (ko)
SG (1) SG59789G (ko)
SU (1) SU1251807A3 (ko)
YU (1) YU45680B (ko)
ZA (1) ZA849224B (ko)
ZM (1) ZM6384A1 (ko)
ZW (1) ZW19084A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2555989B1 (fr) * 1983-12-06 1987-02-20 Bristol Myers Sa Monohydrate de chlorocephadroxyle
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US5721229A (en) * 1995-12-26 1998-02-24 Veterinary Pharmacy Corporation Soluble forms of cephalosporins and treatment of animals
GB9717629D0 (en) 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
AT413282B (de) * 2002-02-01 2006-01-15 Sandoz Ag Kristalline salze der 7-(((5-amino-1,2,4-thiadiazol-3-yl) (fluoromethoxy-imino)acetyl)amino)-3- ((imino-1-piperazinylmethyl)
US20040033262A1 (en) * 2002-08-19 2004-02-19 Orchid Health Care Sustained release pharmaceutical composition of a cephalosporin antibiotic

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507861A (en) * 1966-09-14 1970-04-21 Lilly Co Eli Certain 3-methyl-cephalosporin compounds
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
DE2317179C2 (de) * 1973-04-05 1982-11-25 Bristol-Myers Co., 10154 New York, N.Y. Verfahren zur Herstellung der relativ wasserunlöslichen kristallinen Form von Cefalexinmonohydrat
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
JPS50151890A (ko) * 1974-05-30 1975-12-06
CH642850A5 (it) * 1978-10-20 1984-05-15 Ausonia Farma Srl Composizioni farmaceutiche ad attivita antibatterica contro infezioni da germi gram-positivi e gram-negativi.
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device

Also Published As

Publication number Publication date
DD229410A5 (de) 1985-11-06
IT8423746A0 (it) 1984-11-27
BE901142A (fr) 1985-05-28
ZW19084A1 (en) 1985-06-12
DK561284A (da) 1985-06-02
JO1347B1 (en) 1986-11-30
ES538019A0 (es) 1985-11-01
US4600773A (en) 1986-07-15
AT390616B (de) 1990-06-11
SE8405954D0 (sv) 1984-11-26
PL250593A1 (en) 1985-07-30
CS248725B2 (en) 1987-02-12
MY102966A (en) 1993-03-31
NO844711L (no) 1985-06-03
IT8423746A1 (it) 1986-05-27
NL8403588A (nl) 1985-07-01
BG40966A3 (en) 1987-03-14
DK561284D0 (da) 1984-11-27
HUT35685A (en) 1985-07-29
MX159670A (es) 1989-08-02
JPH0548234B2 (ko) 1993-07-20
ZA849224B (en) 1986-07-30
DE3443065A1 (de) 1985-06-20
ES8602011A1 (es) 1985-11-01
DE3443065C2 (ko) 1989-03-23
GR81043B (en) 1985-03-27
EP0143658A3 (en) 1986-02-12
BR8406037A (pt) 1985-08-27
AU566080B2 (en) 1987-10-08
DK158354C (da) 1990-10-01
FR2555990B1 (fr) 1986-12-26
HK92089A (en) 1989-11-24
IE57886B1 (en) 1993-05-05
LU85650A1 (fr) 1985-07-17
GT198400146A (es) 1986-05-20
FI80274C (fi) 1990-05-10
IL73639A (en) 1988-06-30
IL73639A0 (en) 1985-02-28
GB2150566B (en) 1987-08-26
AU3589784A (en) 1985-06-06
OA07876A (fr) 1986-11-20
EP0143658A2 (en) 1985-06-05
IE843033L (en) 1985-06-01
FI80274B (fi) 1990-01-31
SE464026B (sv) 1991-02-25
FI844631A0 (fi) 1984-11-26
ATA373284A (de) 1989-11-15
PT79553A (en) 1984-12-01
SE8405954L (sv) 1985-06-02
CH661732A5 (de) 1987-08-14
NZ210357A (en) 1988-05-30
YU45680B (sh) 1992-07-20
GB8430073D0 (en) 1985-01-09
SG59789G (en) 1989-12-29
IN163078B (ko) 1988-08-06
EP0143658B1 (en) 1989-03-22
PT79553B (en) 1986-12-15
IT1177329B (it) 1987-08-26
JPS60132990A (ja) 1985-07-16
PL146014B1 (en) 1988-12-31
SU1251807A3 (ru) 1986-08-15
GB2150566A (en) 1985-07-03
FR2555990A1 (fr) 1985-06-07
FI844631L (fi) 1985-06-02
HU192516B (en) 1987-06-29
YU199684A (en) 1987-02-28
KR870000527B1 (ko) 1987-03-14
PH20849A (en) 1987-05-08
MA20279A1 (fr) 1985-07-01
ZM6384A1 (en) 1985-07-22
DK158354B (da) 1990-05-07
CY1505A (en) 1990-08-03

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