CS248725B2 - Production method of the crystalic monohydrate of cefalexin hydrochloride - Google Patents

Production method of the crystalic monohydrate of cefalexin hydrochloride Download PDF

Info

Publication number
CS248725B2
CS248725B2 CS849120A CS912084A CS248725B2 CS 248725 B2 CS248725 B2 CS 248725B2 CS 849120 A CS849120 A CS 849120A CS 912084 A CS912084 A CS 912084A CS 248725 B2 CS248725 B2 CS 248725B2
Authority
CS
Czechoslovakia
Prior art keywords
monohydrate
crystalline
hydrochloride
solvate
cephalexin
Prior art date
Application number
CS849120A
Other languages
Czech (cs)
English (en)
Inventor
Gary L Engel
Joseph M Indelicato
Harry A Rose
Lawrence J Mcshane
Kuo S Yang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS248725B2 publication Critical patent/CS248725B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CS849120A 1983-12-01 1984-11-28 Production method of the crystalic monohydrate of cefalexin hydrochloride CS248725B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/556,887 US4600773A (en) 1983-12-01 1983-12-01 Crystalline cephalexin hydrochloride monohydrate

Publications (1)

Publication Number Publication Date
CS248725B2 true CS248725B2 (en) 1987-02-12

Family

ID=24223233

Family Applications (1)

Application Number Title Priority Date Filing Date
CS849120A CS248725B2 (en) 1983-12-01 1984-11-28 Production method of the crystalic monohydrate of cefalexin hydrochloride

Country Status (46)

Country Link
US (1) US4600773A (ko)
EP (1) EP0143658B1 (ko)
JP (1) JPS60132990A (ko)
KR (1) KR870000527B1 (ko)
AT (1) AT390616B (ko)
AU (1) AU566080B2 (ko)
BE (1) BE901142A (ko)
BG (1) BG40966A3 (ko)
BR (1) BR8406037A (ko)
CH (1) CH661732A5 (ko)
CS (1) CS248725B2 (ko)
CY (1) CY1505A (ko)
DD (1) DD229410A5 (ko)
DE (1) DE3443065A1 (ko)
DK (1) DK158354C (ko)
ES (1) ES538019A0 (ko)
FI (1) FI80274C (ko)
FR (1) FR2555990B1 (ko)
GB (1) GB2150566B (ko)
GR (1) GR81043B (ko)
GT (1) GT198400146A (ko)
HK (1) HK92089A (ko)
HU (1) HU192516B (ko)
IE (1) IE57886B1 (ko)
IL (1) IL73639A (ko)
IN (1) IN163078B (ko)
IT (1) IT1177329B (ko)
JO (1) JO1347B1 (ko)
LU (1) LU85650A1 (ko)
MA (1) MA20279A1 (ko)
MX (1) MX159670A (ko)
MY (1) MY102966A (ko)
NL (1) NL8403588A (ko)
NO (1) NO844711L (ko)
NZ (1) NZ210357A (ko)
OA (1) OA07876A (ko)
PH (1) PH20849A (ko)
PL (1) PL146014B1 (ko)
PT (1) PT79553B (ko)
SE (1) SE464026B (ko)
SG (1) SG59789G (ko)
SU (1) SU1251807A3 (ko)
YU (1) YU45680B (ko)
ZA (1) ZA849224B (ko)
ZM (1) ZM6384A1 (ko)
ZW (1) ZW19084A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2555989B1 (fr) * 1983-12-06 1987-02-20 Bristol Myers Sa Monohydrate de chlorocephadroxyle
DE3485860T2 (de) * 1983-12-29 1993-01-14 Mochida Pharm Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US5721229A (en) * 1995-12-26 1998-02-24 Veterinary Pharmacy Corporation Soluble forms of cephalosporins and treatment of animals
GB9717629D0 (en) 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
AT413282B (de) * 2002-02-01 2006-01-15 Sandoz Ag Kristalline salze der 7-(((5-amino-1,2,4-thiadiazol-3-yl) (fluoromethoxy-imino)acetyl)amino)-3- ((imino-1-piperazinylmethyl)
US20040033262A1 (en) * 2002-08-19 2004-02-19 Orchid Health Care Sustained release pharmaceutical composition of a cephalosporin antibiotic

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507861A (en) * 1966-09-14 1970-04-21 Lilly Co Eli Certain 3-methyl-cephalosporin compounds
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
DE2317179C2 (de) * 1973-04-05 1982-11-25 Bristol-Myers Co., 10154 New York, N.Y. Verfahren zur Herstellung der relativ wasserunlöslichen kristallinen Form von Cefalexinmonohydrat
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
JPS50151890A (ko) * 1974-05-30 1975-12-06
CH642850A5 (it) * 1978-10-20 1984-05-15 Ausonia Farma Srl Composizioni farmaceutiche ad attivita antibatterica contro infezioni da germi gram-positivi e gram-negativi.
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device

Also Published As

Publication number Publication date
GB2150566A (en) 1985-07-03
KR870000527B1 (ko) 1987-03-14
DE3443065C2 (ko) 1989-03-23
AU566080B2 (en) 1987-10-08
DK158354C (da) 1990-10-01
FR2555990A1 (fr) 1985-06-07
GR81043B (en) 1985-03-27
AT390616B (de) 1990-06-11
NL8403588A (nl) 1985-07-01
US4600773A (en) 1986-07-15
MY102966A (en) 1993-03-31
JO1347B1 (en) 1986-11-30
MA20279A1 (fr) 1985-07-01
ZW19084A1 (en) 1985-06-12
DK158354B (da) 1990-05-07
FR2555990B1 (fr) 1986-12-26
BG40966A3 (en) 1987-03-14
CY1505A (en) 1990-08-03
DE3443065A1 (de) 1985-06-20
ES8602011A1 (es) 1985-11-01
PL146014B1 (en) 1988-12-31
EP0143658A3 (en) 1986-02-12
GT198400146A (es) 1986-05-20
JPS60132990A (ja) 1985-07-16
HU192516B (en) 1987-06-29
NO844711L (no) 1985-06-03
JPH0548234B2 (ko) 1993-07-20
SE8405954D0 (sv) 1984-11-26
FI844631A0 (fi) 1984-11-26
EP0143658B1 (en) 1989-03-22
SU1251807A3 (ru) 1986-08-15
KR850004765A (ko) 1985-07-27
OA07876A (fr) 1986-11-20
ZA849224B (en) 1986-07-30
YU45680B (sh) 1992-07-20
SE8405954L (sv) 1985-06-02
IT8423746A1 (it) 1986-05-27
NZ210357A (en) 1988-05-30
IN163078B (ko) 1988-08-06
LU85650A1 (fr) 1985-07-17
ES538019A0 (es) 1985-11-01
IE843033L (en) 1985-06-01
GB8430073D0 (en) 1985-01-09
HUT35685A (en) 1985-07-29
IT1177329B (it) 1987-08-26
FI80274C (fi) 1990-05-10
GB2150566B (en) 1987-08-26
DK561284D0 (da) 1984-11-27
PT79553A (en) 1984-12-01
DK561284A (da) 1985-06-02
FI80274B (fi) 1990-01-31
PT79553B (en) 1986-12-15
FI844631L (fi) 1985-06-02
MX159670A (es) 1989-08-02
YU199684A (en) 1987-02-28
AU3589784A (en) 1985-06-06
EP0143658A2 (en) 1985-06-05
DD229410A5 (de) 1985-11-06
CH661732A5 (de) 1987-08-14
IL73639A (en) 1988-06-30
SE464026B (sv) 1991-02-25
PH20849A (en) 1987-05-08
BE901142A (fr) 1985-05-28
ATA373284A (de) 1989-11-15
IT8423746A0 (it) 1984-11-27
SG59789G (en) 1989-12-29
PL250593A1 (en) 1985-07-30
ZM6384A1 (en) 1985-07-22
BR8406037A (pt) 1985-08-27
HK92089A (en) 1989-11-24
IE57886B1 (en) 1993-05-05
IL73639A0 (en) 1985-02-28

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