DD157344A5 - Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren - Google Patents

Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren Download PDF

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Publication number
DD157344A5
DD157344A5 DD80221832A DD22183280A DD157344A5 DD 157344 A5 DD157344 A5 DD 157344A5 DD 80221832 A DD80221832 A DD 80221832A DD 22183280 A DD22183280 A DD 22183280A DD 157344 A5 DD157344 A5 DD 157344A5
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DD
German Democratic Republic
Prior art keywords
compounds
iii
compound
medium
flask
Prior art date
Application number
DD80221832A
Other languages
German (de)
English (en)
Inventor
Richard L Monaghan
Alfred W Alberts
Carl H Hoffmann
George Albers-Schonberg
Henry Joshua
Maria B Lopez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD157344(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/048,946 external-priority patent/US4231938A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DD157344A5 publication Critical patent/DD157344A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD80221832A 1979-06-15 1980-06-13 Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren DD157344A5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/048,946 US4231938A (en) 1979-06-15 1979-06-15 Hypocholesteremic fermentation products and process of preparation
US7780779A 1979-09-21 1979-09-21
US11445980A 1980-01-23 1980-01-23

Publications (1)

Publication Number Publication Date
DD157344A5 true DD157344A5 (de) 1982-11-03

Family

ID=27367450

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80221832A DD157344A5 (de) 1979-06-15 1980-06-13 Verfahren zur herstellung von polyhydro-3,7-dimethyl-8-2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-aethyl-1-napthtylenyl-2-methylbutanoaten und deren entsprechenden saeuren

Country Status (20)

Country Link
EP (1) EP0022478B1 (fr)
AR (1) AR224008A1 (fr)
AT (1) ATE2620T1 (fr)
AU (1) AU535944B2 (fr)
CA (1) CA1161380A (fr)
DD (1) DD157344A5 (fr)
DE (1) DE3062122D1 (fr)
DK (1) DK149003C (fr)
EG (1) EG16957A (fr)
ES (1) ES492384A0 (fr)
FI (1) FI67231C (fr)
GR (1) GR69216B (fr)
IE (1) IE49685B1 (fr)
IL (1) IL60219A (fr)
NO (1) NO155699C (fr)
NZ (1) NZ193922A (fr)
PL (1) PL125843B1 (fr)
PT (1) PT71371B (fr)
RO (1) RO79487A (fr)
ZW (1) ZW13480A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4395515T1 (de) * 1992-11-04 1994-12-01 Biogal Gyogyszergyar Verfahren zur Isolierung und Reinigung von Mevinolin

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
DE8533814U1 (de) * 1985-11-30 1986-01-16 Beiersdorf Ag, 2000 Hamburg Vorrichtung zum Spülen des Darmes
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
DE3739882A1 (de) * 1987-11-25 1989-06-08 Bayer Ag Substituierte hydroxylamine
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
AU618158B2 (en) * 1989-01-07 1991-12-12 Bayer Aktiengesellschaft New substituted pyrido(2,3-d)pyrimidines
DE3911064A1 (de) * 1989-04-06 1990-10-11 Bayer Ag Substituierte 1,8-naphthyridine
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
CA2062023A1 (fr) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Nouvelles souches fongiques et leur utilisation pour la production d'antibiotiques
JPH07504568A (ja) * 1992-03-04 1995-05-25 藤沢薬品工業株式会社 ＨＭＧ−ＣｏＡレダクターゼ阻害物質としてのテトラリン誘導体
DE4244029A1 (de) * 1992-12-24 1994-06-30 Bayer Ag Neue substituierte Pyridine
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
RU2158607C2 (ru) * 1995-07-03 2000-11-10 Санкио Компани Лимитед Лечение артериосклероза и ксантомы
US6221637B1 (en) 1996-03-05 2001-04-24 Takeda Chemical Industries, Ltd. Xanthene derivatives, their production and use
CZ299290B6 (cs) * 1997-02-20 2008-06-11 Dsm Ip Assets B.V. Zpusob výroby beta-laktamové slouceniny, zpusob prípravy a/nebo zlepšení vláknitého mikrobiálního kmene a použití chemicky definovaného fermentacníhomédia
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CN101484166B (zh) 2006-07-05 2012-09-05 奈科明有限责任公司 用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4395515T1 (de) * 1992-11-04 1994-12-01 Biogal Gyogyszergyar Verfahren zur Isolierung und Reinigung von Mevinolin
DE4395515C2 (de) * 1992-11-04 1999-06-17 Biogal Gyogyszergyar Verfahren zur Isolierung und Reinigung von Mevinolin

Also Published As

Publication number Publication date
PL125843B1 (en) 1983-06-30
IE49685B1 (en) 1985-11-27
DK149003B (da) 1985-12-16
IL60219A (en) 1985-05-31
PT71371A (en) 1980-07-01
DK254180A (da) 1980-12-16
DE3062122D1 (en) 1983-03-31
AU535944B2 (en) 1984-04-12
ZW13480A1 (en) 1982-02-03
DK149003C (da) 1986-08-18
FI67231C (fi) 1985-02-11
NO801775L (no) 1980-12-16
CA1161380A (fr) 1984-01-31
FI67231B (fi) 1984-10-31
AU5901780A (en) 1980-12-18
PT71371B (en) 1981-10-21
ATE2620T1 (de) 1983-03-15
IL60219A0 (en) 1980-09-16
NZ193922A (en) 1982-05-25
ES8105389A1 (es) 1981-06-01
RO79487A (fr) 1982-07-06
AR224008A1 (es) 1981-10-15
EG16957A (en) 1990-06-30
NO155699B (no) 1987-02-02
EP0022478B1 (fr) 1983-02-23
FI801857A (fi) 1980-12-16
GR69216B (fr) 1982-05-07
EP0022478A1 (fr) 1981-01-21
NO155699C (no) 1987-05-13
IE801232L (en) 1980-12-15
ES492384A0 (es) 1981-06-01
PL224920A1 (fr) 1981-03-27

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