AR224008A1 - Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutirato - Google Patents

Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutirato

Info

Publication number
AR224008A1
AR224008A1 AR281295A AR28129580A AR224008A1 AR 224008 A1 AR224008 A1 AR 224008A1 AR 281295 A AR281295 A AR 281295A AR 28129580 A AR28129580 A AR 28129580A AR 224008 A1 AR224008 A1 AR 224008A1
Authority
AR
Argentina
Prior art keywords
polyhidro
naftil
tetrahidro
dimetil
hidroxi
Prior art date
Application number
AR281295A
Other languages
English (en)
Spanish (es)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR224008(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/048,946 external-priority patent/US4231938A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of AR224008A1 publication Critical patent/AR224008A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AR281295A 1979-06-15 1980-06-04 Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutirato AR224008A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/048,946 US4231938A (en) 1979-06-15 1979-06-15 Hypocholesteremic fermentation products and process of preparation
US7780779A 1979-09-21 1979-09-21
US11445980A 1980-01-23 1980-01-23

Publications (1)

Publication Number Publication Date
AR224008A1 true AR224008A1 (es) 1981-10-15

Family

ID=27367450

Family Applications (1)

Application Number Title Priority Date Filing Date
AR281295A AR224008A1 (es) 1979-06-15 1980-06-04 Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutirato

Country Status (20)

Country Link
EP (1) EP0022478B1 (fr)
AR (1) AR224008A1 (fr)
AT (1) ATE2620T1 (fr)
AU (1) AU535944B2 (fr)
CA (1) CA1161380A (fr)
DD (1) DD157344A5 (fr)
DE (1) DE3062122D1 (fr)
DK (1) DK149003C (fr)
EG (1) EG16957A (fr)
ES (1) ES8105389A1 (fr)
FI (1) FI67231C (fr)
GR (1) GR69216B (fr)
IE (1) IE49685B1 (fr)
IL (1) IL60219A (fr)
NO (1) NO155699C (fr)
NZ (1) NZ193922A (fr)
PL (1) PL125843B1 (fr)
PT (1) PT71371B (fr)
RO (1) RO79487A (fr)
ZW (1) ZW13480A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
DE8533814U1 (de) * 1985-11-30 1986-01-16 Beiersdorf Ag, 2000 Hamburg Vorrichtung zum Spülen des Darmes
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
DE3739882A1 (de) * 1987-11-25 1989-06-08 Bayer Ag Substituierte hydroxylamine
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
AU618158B2 (en) * 1989-01-07 1991-12-12 Bayer Aktiengesellschaft New substituted pyrido(2,3-d)pyrimidines
DE3911064A1 (de) * 1989-04-06 1990-10-11 Bayer Ag Substituierte 1,8-naphthyridine
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
CA2062023A1 (fr) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Nouvelles souches fongiques et leur utilisation pour la production d'antibiotiques
WO1993017991A1 (fr) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. DERIVES DE TETRALINE EN TANT QU'INHIBITEURS D'HMG-CoA REDUCTASE
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
DE4244029A1 (de) * 1992-12-24 1994-06-30 Bayer Ag Neue substituierte Pyridine
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
AU706628B2 (en) * 1995-07-03 1999-06-17 Sankyo Company Limited Treatment of arteriosclerosis and xanthoma
CA2199104A1 (fr) 1996-03-05 1997-09-05 Tsuneaki Hida Derives du xanthene, leur production et leur utilisation
EP2256211A3 (fr) * 1997-02-20 2011-02-16 DSM IP Assets B.V. Production par fermentationr à l'échelle industrielle de composés de valeur en utilisant des milieux définis chimiquement.
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
RS53461B (en) 2006-07-05 2014-12-31 Takeda Gmbh COMBINATION OF HMG-COA REDUCTASE INHIBITOR OR SIMVASTATIN WITH PHOSPHODIESTERASE 4 INHIBITOR AS A ROFLUMILAST FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent

Also Published As

Publication number Publication date
DK254180A (da) 1980-12-16
GR69216B (fr) 1982-05-07
CA1161380A (fr) 1984-01-31
IL60219A0 (en) 1980-09-16
AU5901780A (en) 1980-12-18
IE801232L (en) 1980-12-15
PL224920A1 (fr) 1981-03-27
DD157344A5 (de) 1982-11-03
NZ193922A (en) 1982-05-25
ZW13480A1 (en) 1982-02-03
EP0022478B1 (fr) 1983-02-23
EP0022478A1 (fr) 1981-01-21
RO79487A (fr) 1982-07-06
NO155699B (no) 1987-02-02
DK149003B (da) 1985-12-16
NO801775L (no) 1980-12-16
IL60219A (en) 1985-05-31
DE3062122D1 (en) 1983-03-31
EG16957A (en) 1990-06-30
FI801857A (fi) 1980-12-16
ES492384A0 (es) 1981-06-01
FI67231C (fi) 1985-02-11
IE49685B1 (en) 1985-11-27
NO155699C (no) 1987-05-13
PT71371B (en) 1981-10-21
FI67231B (fi) 1984-10-31
AU535944B2 (en) 1984-04-12
PL125843B1 (en) 1983-06-30
DK149003C (da) 1986-08-18
ES8105389A1 (es) 1981-06-01
ATE2620T1 (de) 1983-03-15
PT71371A (en) 1980-07-01

Similar Documents

Publication Publication Date Title
AR224008A1 (es) Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutirato
ES508453A0 (es) Procedimiento para preparar derivados de 2-amino-4-hidroxiquinazolina.
AR230989A1 (es) Procedimiento para preparar acilureidoalquil-bencen-sulfonilureas
AR228341A1 (es) Procedimiento para preparar 6-n-propil etil u 8-metoxi-metil,metil-mercaptometilergolinas,alil-8-metoximetil o metilmercapto metil o metilsulfonilmetil-ergolinas
MX154095A (es) Procedimiento para preparar polieteres sililados
ES476994A0 (es) Procedimiento para preparar perhalociclopropanocarboxilatos.
ES488593A0 (es) Procedimiento para preparar derivados de ciclopropano
ES492255A0 (es) Procedimiento para preparar aroilimidazol-2-onas
AR227766A1 (es) Procedimiento para preparar nuevas pirixolo-1,5-a-pirimidinas sustituidas
MX6600E (es) Procedimiento para preparar 2,3-diariltiofenos 5-sustituidos
ES488635A0 (es) Procedimiento para preparar derivados de pirimidina
ES494119A0 (es) Procedimiento para preparar derivados de 3-aminoproxiarilo
MX6816E (es) Procedimiento para preparar quinolonas
AR227284A1 (es) Procedimiento para preparar antraceno-9,10-bis-carbonil-hidrazonas
ES488772A0 (es) Procedimiento para preparar derivados de pirimidona
ES519006A0 (es) Procedimiento para preparar 2-(2-dimetilaminoetiltio)-3-fenilquinolina.
ES481478A0 (es) Procedimiento para preparar o-metaliloxifenol.
MX7642E (es) Procedimiento para preparar la 1-ciclo-hexenilmentil-2-cloroetil pirrolidina
ES489689A0 (es) Procedimiento para preparar compuestos de isotiourea
MX6141E (es) Procedimiento para preparar acil-ureas
MX6405E (es) Procedimiento para preparar tiazolilideno-oxo-propionitrilos
MX6024E (es) Procedimiento para preparar 2-cloro-4-hidroximetil-tiazoles-5-substituidos
ES493499A0 (es) Procedimiento para preparar compuestos de 3-metilemazetidina
ES494730A0 (es) Procedimiento de hidroformilacion para preparar aldehidos
ES493798A0 (es) Un procedimiento para preparar 7-alcoxicarbonil-6,8-dime- til-4-hidroximetil-1-ftalazona