EG16957A - Process for preparing of hypocholesteremic fermentation products - Google Patents

Process for preparing of hypocholesteremic fermentation products

Info

Publication number
EG16957A
EG16957A EG355/80A EG35580A EG16957A EG 16957 A EG16957 A EG 16957A EG 355/80 A EG355/80 A EG 355/80A EG 35580 A EG35580 A EG 35580A EG 16957 A EG16957 A EG 16957A
Authority
EG
Egypt
Prior art keywords
hypocholesteremic
preparing
fermentation products
fermentation
products
Prior art date
Application number
EG355/80A
Other languages
English (en)
Inventor
L Monghan Richard
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG16957(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/048,946 external-priority patent/US4231938A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of EG16957A publication Critical patent/EG16957A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus
EG355/80A 1979-06-15 1980-06-14 Process for preparing of hypocholesteremic fermentation products EG16957A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/048,946 US4231938A (en) 1979-06-15 1979-06-15 Hypocholesteremic fermentation products and process of preparation
US7780779A 1979-09-21 1979-09-21
US11445980A 1980-01-23 1980-01-23

Publications (1)

Publication Number Publication Date
EG16957A true EG16957A (en) 1990-06-30

Family

ID=27367450

Family Applications (1)

Application Number Title Priority Date Filing Date
EG355/80A EG16957A (en) 1979-06-15 1980-06-14 Process for preparing of hypocholesteremic fermentation products

Country Status (20)

Country Link
EP (1) EP0022478B1 (fr)
AR (1) AR224008A1 (fr)
AT (1) ATE2620T1 (fr)
AU (1) AU535944B2 (fr)
CA (1) CA1161380A (fr)
DD (1) DD157344A5 (fr)
DE (1) DE3062122D1 (fr)
DK (1) DK149003C (fr)
EG (1) EG16957A (fr)
ES (1) ES492384A0 (fr)
FI (1) FI67231C (fr)
GR (1) GR69216B (fr)
IE (1) IE49685B1 (fr)
IL (1) IL60219A (fr)
NO (1) NO155699C (fr)
NZ (1) NZ193922A (fr)
PL (1) PL125843B1 (fr)
PT (1) PT71371B (fr)
RO (1) RO79487A (fr)
ZW (1) ZW13480A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
DE8533814U1 (de) * 1985-11-30 1986-01-16 Beiersdorf Ag, 2000 Hamburg Vorrichtung zum Spülen des Darmes
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
DE3739882A1 (de) * 1987-11-25 1989-06-08 Bayer Ag Substituierte hydroxylamine
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
AU618158B2 (en) * 1989-01-07 1991-12-12 Bayer Aktiengesellschaft New substituted pyrido(2,3-d)pyrimidines
DE3911064A1 (de) * 1989-04-06 1990-10-11 Bayer Ag Substituierte 1,8-naphthyridine
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
CA2062023A1 (fr) 1992-02-10 1993-08-11 Jagroop S. Dahiya Nouvelles souches fongiques et leur utilisation pour la production d'antibiotiques
JPH07504568A (ja) * 1992-03-04 1995-05-25 藤沢薬品工業株式会社 ＨＭＧ−ＣｏＡレダクターゼ阻害物質としてのテトラリン誘導体
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
DE4244029A1 (de) * 1992-12-24 1994-06-30 Bayer Ag Neue substituierte Pyridine
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
TW474809B (en) * 1995-07-03 2002-02-01 Sankyo Co A pharmaceutical composition for arteriosclerosis or xanthoma consisting of HMG-CoA reductase inhibitors and insulin sensitizers
EP0795554A3 (fr) * 1996-03-05 1998-01-28 Takeda Chemical Industries, Ltd. Dérivés de (oxo-)xanthéne, leur préparation et leur utilisation comme immunomodulateurs
ATE327340T1 (de) * 1997-02-20 2006-06-15 Dsm Ip Assets Bv Fermentative herstellung von wertstoffen in industriellem umfang durch verwendung von chemisch definierten media
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
EA032476B1 (ru) 2006-07-05 2019-06-28 Астразенека Аб ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО, СОДЕРЖАЩЕЕ ИНГИБИТОРЫ HMG-CoA-РЕДУКТАЗЫ И ФОСФОДИЭСТЕРАЗЫ 4, ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ЛЕГКИХ
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent

Also Published As

Publication number Publication date
ZW13480A1 (en) 1982-02-03
EP0022478B1 (fr) 1983-02-23
ES8105389A1 (es) 1981-06-01
AU5901780A (en) 1980-12-18
FI67231B (fi) 1984-10-31
PT71371B (en) 1981-10-21
DD157344A5 (de) 1982-11-03
IL60219A (en) 1985-05-31
FI801857A (fi) 1980-12-16
PL125843B1 (en) 1983-06-30
NZ193922A (en) 1982-05-25
NO155699B (no) 1987-02-02
DK149003C (da) 1986-08-18
AU535944B2 (en) 1984-04-12
ATE2620T1 (de) 1983-03-15
DE3062122D1 (en) 1983-03-31
NO801775L (no) 1980-12-16
FI67231C (fi) 1985-02-11
ES492384A0 (es) 1981-06-01
EP0022478A1 (fr) 1981-01-21
GR69216B (fr) 1982-05-07
IE801232L (en) 1980-12-15
PL224920A1 (fr) 1981-03-27
RO79487A (fr) 1982-07-06
PT71371A (en) 1980-07-01
AR224008A1 (es) 1981-10-15
IL60219A0 (en) 1980-09-16
DK254180A (da) 1980-12-16
NO155699C (no) 1987-05-13
CA1161380A (fr) 1984-01-31
IE49685B1 (en) 1985-11-27
DK149003B (da) 1985-12-16

Similar Documents

Publication Publication Date Title
EG16957A (en) Process for preparing of hypocholesteremic fermentation products
GB2096878B (en) Process of preparing food products
ZA803545B (en) Hypocholesteremie fermentation products and process of preparation
PT71487A (en) Process for preparing microbial expression of quasi-synthetih genes
PT71936A (en) Process for the preparation of fermented type sausages
PH17945A (en) Process for manufacture of cheese like products
PT69202A (en) Process for preparing of 9-amino-dibenzopyrans
PT70086A (en) Process for preparing of novel spiro-oxazolidindiones
PL233258A1 (en) Process for preparing novel analogs of linkomycin and klinodamycin
YU43129B (en) Process for producing fermented alcohol products
ZA807768B (en) A process for the continuous production of fermentation alcohol
GB2040930B (en) Process for preparation of phenols
YU42987B (en) Process for preparing new derivatives of 1-oxadethiacephalosporin
ATA409380A (de) Vorrichtung zum speichern und umsetzen von formlingstraegerlagen
PT69212A (en) Process for preparing agrochemical products containing modified azulmic acids
HRP940098B1 (en) Process for the preparation of hypocholesteremic fermentation products
GB2066843B (en) Process for the continuous production of fermentation alcohol
PH16913A (en) Hypocholesteremic fermentation products and process of preparation
GB2031706B (en) Process for preparing fish products and product of the process
HU179621B (en) Process for preparing carbamete derivatives of mercapto-acyl-hydroxy-l-proline
HU182144B (en) Process for preparing compounds with hypocholesteremic activity by means of fermentation
PT71552A (en) Process for preparation of thienamycin and intermediates
YU152880A (en) Process for producing l-lysine process for obtainig hypocholesteremic fermentation produts
PH16652A (en) Hypocholesteremic fermentation products
GB2051797B (en) Process for production of beta-chloro-alanine