DD148050A5 - Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione - Google Patents

Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione Download PDF

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Publication number
DD148050A5
DD148050A5 DD77217954A DD21795477A DD148050A5 DD 148050 A5 DD148050 A5 DD 148050A5 DD 77217954 A DD77217954 A DD 77217954A DD 21795477 A DD21795477 A DD 21795477A DD 148050 A5 DD148050 A5 DD 148050A5
Authority
DD
German Democratic Republic
Prior art keywords
alkylene
group
preparation
general formula
application
Prior art date
Application number
DD77217954A
Other languages
German (de)
English (en)
Inventor
Herbert Koeppe
Anton Mentrup
Ernst-Otto Renth
Kurt Schromm
Wolfgang Hoefke
Gojko Muacevic
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of DD148050A5 publication Critical patent/DD148050A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/32One oxygen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/181,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
DD77217954A 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione DD148050A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762644833 DE2644833A1 (de) 1976-10-05 1976-10-05 Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DD148050A5 true DD148050A5 (de) 1981-05-06

Family

ID=5989679

Family Applications (5)

Application Number Title Priority Date Filing Date
DD77217954A DD148050A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl-bzw.benzimidazolione
DD77201314A DD134642A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer 1-aryloxy-2-hydroxy-3-alkylenaminopropane
DD77212491A DD143074A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl bzw.benzimidazolinone
DD77217956A DD148051A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte zur herstellung pharmazeutisch verwendbarer verbindungen
DD77217961A DD148052A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte von arzneimitteln

Family Applications After (4)

Application Number Title Priority Date Filing Date
DD77201314A DD134642A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer 1-aryloxy-2-hydroxy-3-alkylenaminopropane
DD77212491A DD143074A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer n-aryl bzw.benzimidazolinone
DD77217956A DD148051A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte zur herstellung pharmazeutisch verwendbarer verbindungen
DD77217961A DD148052A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung neuer zwischenprodukte von arzneimitteln

Country Status (33)

Country Link
US (7) US4212877A (cs)
JP (1) JPS5368775A (cs)
AT (15) AT361908B (cs)
AU (1) AU514600B2 (cs)
BE (1) BE859415A (cs)
BG (1) BG33153A3 (cs)
CA (4) CA1101859A (cs)
CS (1) CS197304B2 (cs)
DD (5) DD148050A5 (cs)
DE (1) DE2644833A1 (cs)
DK (1) DK439077A (cs)
ES (16) ES462868A1 (cs)
FI (1) FI69066C (cs)
FR (1) FR2394534A1 (cs)
GB (3) GB1592975A (cs)
GR (1) GR64229B (cs)
HK (1) HK19385A (cs)
HU (1) HU177173B (cs)
IE (3) IE46158B1 (cs)
IL (1) IL53043A (cs)
LU (1) LU78240A1 (cs)
MY (1) MY8500909A (cs)
NL (1) NL7710840A (cs)
NO (1) NO151411C (cs)
NZ (1) NZ185356A (cs)
PH (4) PH15763A (cs)
PL (1) PL113879B1 (cs)
PT (1) PT67107B (cs)
SE (1) SE442400B (cs)
SG (1) SG70884G (cs)
SU (1) SU665801A3 (cs)
YU (1) YU40484B (cs)
ZA (1) ZA775905B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404380A (en) * 1977-02-14 1983-09-13 Mead Johnson & Company Triazolopyrimidines
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
SE8003277L (sv) * 1979-05-04 1980-11-05 Continental Pharma Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivat
US4434174A (en) 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
EP0034116A3 (en) 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
US4379508A (en) * 1981-10-14 1983-04-12 Nestier Corporation Nesting tray with stacking keyed interlock
IT1193608B (it) * 1983-01-21 1988-07-21 Pierrel Spa Derivati di arilossipropanolamina,procedimento per la loro preparazione composizioni farmaceutiche che li contengono e loro impiego terapeutico
DE3324903A1 (de) * 1983-07-09 1985-01-17 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung substituierter ethylenharnstoffe sowie neue n-vinylethylenharnstoffe
GB8419797D0 (en) * 1984-08-03 1984-09-05 Beecham Group Plc Compounds
DE3807922A1 (de) * 1988-03-10 1989-09-21 Boehringer Mannheim Gmbh Substituierte heterocyclen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
TW203049B (cs) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
US6557907B2 (en) 1993-05-14 2003-05-06 William W. Rowley Polyethylene connectors
US6860524B1 (en) 1993-05-14 2005-03-01 William W. Rowley Polyolefin connectors
DE69942578D1 (de) 1998-05-22 2010-08-26 Univ R Bifunktionelle moleküle sowie darauf basierende therapien.
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6848719B2 (en) 2001-09-06 2005-02-01 William W. Rowley Bendable polymer-lined water heater connector
TWI316511B (en) * 2002-11-26 2009-11-01 Smithkline Beecham Corp Calcilytic compounds
WO2004058726A2 (en) * 2002-12-23 2004-07-15 Artesian Therapeutics, Inc. CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST β-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE
DE102004045648A1 (de) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
WO2006060122A2 (en) * 2004-11-30 2006-06-08 Artesian Therapeutics, Inc. Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白(rap)-缀合物对肝病症的治疗
PL3075401T3 (pl) * 2007-11-29 2024-08-19 Inolex Investment Corporation Środek konserwujący dla kompozycji kosmetycznych, toaletowych i farmaceutycznych
EP3395372B1 (en) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Glutathione-based drug delivery system
SG10201402069PA (en) 2009-05-06 2014-07-30 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL284529A (cs) * 1961-10-24
GB1066613A (en) * 1965-03-03 1967-04-26 Ici Ltd Naphthalene derivatives
DE2065365C3 (de) * 1969-11-28 1982-05-06 Teikoku Hormone Mfg. Co. Ltd., Tokyo 1,3-disubstituierte Azetidine sowie Verfahren zu deren Herstellung und ihre Anwendung
ZA71932B (en) * 1970-02-27 1971-10-27 Ici Ltd Organic compounds
BE787103A (fr) * 1971-08-04 1973-02-02 Pfizer Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant
US3818017A (en) * 1973-01-04 1974-06-18 Janssen Pharmaceutica Nv 1-{8 1-(2-hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
US3894030A (en) * 1973-01-04 1975-07-08 Janssen Pharmaceutica Nv 1-{8 1-(2-Hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
GB1456525A (en) * 1973-07-18 1976-11-24 Ici Ltd Process for the manufacture of alkanolamine derivatives
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH624395A5 (cs) * 1976-01-08 1981-07-31 Ciba Geigy Ag
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen

Also Published As

Publication number Publication date
US4296117A (en) 1981-10-20
DE2644833A1 (de) 1978-04-20
FR2394534B1 (cs) 1982-04-30
ZA775905B (en) 1979-06-27
GB1592976A (en) 1981-07-15
ES471807A1 (es) 1979-02-01
ATA58080A (de) 1981-04-15
ATA679377A (de) 1980-09-15
IE46158B1 (en) 1983-03-09
ATA57080A (de) 1980-09-15
AT363081B (de) 1981-07-10
AT361914B (de) 1981-04-10
ES462868A1 (es) 1978-12-16
CA1125751A (en) 1982-06-15
AT363082B (de) 1981-07-10
YU236977A (en) 1983-01-21
IE46160B1 (en) 1983-03-09
PT67107A (de) 1977-11-01
ES471805A1 (es) 1979-02-01
IE46158L (en) 1978-04-05
MY8500909A (en) 1985-12-31
AT364828B (de) 1981-11-25
SE442400B (sv) 1985-12-23
PH16053A (en) 1983-06-09
BE859415A (fr) 1978-04-05
AT363080B (de) 1981-07-10
AU2933377A (en) 1979-04-12
AT362365B (de) 1981-05-11
ES471795A1 (es) 1979-02-01
HK19385A (en) 1985-03-22
ES471803A1 (es) 1979-02-01
IL53043A0 (en) 1977-12-30
ATA57980A (de) 1980-12-15
NZ185356A (en) 1981-05-01
ATA57380A (de) 1980-10-15
ATA57880A (de) 1980-10-15
ATA57680A (de) 1980-12-15
DD148052A5 (de) 1981-05-06
ES471802A1 (es) 1979-02-01
IL53043A (en) 1982-01-31
SE7711168L (sv) 1978-05-18
ATA57280A (de) 1980-10-15
ATA56880A (de) 1980-09-15
IE822410L (en) 1978-04-05
ES471798A1 (es) 1979-02-01
ES471804A1 (es) 1979-02-01
AT362363B (de) 1981-05-11
ES471794A1 (es) 1979-02-01
PH15763A (en) 1983-03-22
NO151411B (no) 1984-12-27
AT361915B (de) 1981-04-10
GB1592977A (en) 1981-07-15
HU177173B (en) 1981-08-28
US4212877A (en) 1980-07-15
YU40484B (en) 1986-02-28
ES471808A1 (es) 1979-02-01
PL201286A1 (pl) 1978-12-04
PH19028A (en) 1985-12-06
FI69066C (fi) 1985-12-10
DD148051A5 (de) 1981-05-06
AT362362B (de) 1981-05-11
NO773384L (no) 1978-04-06
SU665801A3 (ru) 1979-05-30
US4381309A (en) 1983-04-26
FI772823A7 (fi) 1978-04-06
BG33153A3 (bg) 1982-12-15
IE46159B1 (en) 1983-03-09
ES471796A1 (es) 1979-02-01
ATA56780A (de) 1980-09-15
NO151411C (no) 1985-04-10
NL7710840A (nl) 1978-04-07
US4256756A (en) 1981-03-17
ATA56980A (de) 1980-09-15
GB1592975A (en) 1981-07-15
AT361908B (de) 1981-04-10
AT362364B (de) 1981-05-11
CA1127643A (en) 1982-07-13
AT361911B (de) 1981-04-10
ATA57580A (de) 1980-12-15
GR64229B (en) 1980-02-14
DK439077A (da) 1978-04-06
DD134642A5 (de) 1979-03-14
US4343800A (en) 1982-08-10
CS197304B2 (en) 1980-04-30
AT363079B (de) 1981-07-10
CA1126271A (en) 1982-06-22
PL113879B1 (en) 1981-01-31
SG70884G (en) 1985-04-04
ATA57480A (de) 1980-10-15
LU78240A1 (cs) 1979-02-02
ATA57180A (de) 1980-09-15
ES471800A1 (es) 1979-02-01
US4255430A (en) 1981-03-10
AT361912B (de) 1981-04-10
ATA57780A (de) 1980-12-15
ES471806A1 (es) 1979-02-01
FR2394534A1 (fr) 1979-01-12
PH18363A (en) 1985-06-13
ES471799A1 (es) 1979-02-01
JPS5368775A (en) 1978-06-19
DD143074A5 (de) 1980-07-30
CA1101859A (en) 1981-05-26
US4604468A (en) 1986-08-05
ES471797A1 (es) 1979-02-01
JPS6210988B2 (cs) 1987-03-10
IE822409L (en) 1978-04-05
ES471801A1 (es) 1979-02-01
PT67107B (de) 1980-04-07
AT361913B (de) 1981-04-10
FI69066B (fi) 1985-08-30
AU514600B2 (en) 1981-02-19

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