CY1118069T1 - Αντισωματα anti-bcma - Google Patents

Αντισωματα anti-bcma

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Publication number
CY1118069T1
CY1118069T1 CY20161100917T CY161100917T CY1118069T1 CY 1118069 T1 CY1118069 T1 CY 1118069T1 CY 20161100917 T CY20161100917 T CY 20161100917T CY 161100917 T CY161100917 T CY 161100917T CY 1118069 T1 CY1118069 T1 CY 1118069T1
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CY
Cyprus
Prior art keywords
cells
memory
plasma
bcma antibodies
bcma
Prior art date
Application number
CY20161100917T
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English (en)
Inventor
Susan L Kalled
Yen-Ming Hsu
Original Assignee
Biogen Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc. filed Critical Biogen Ma Inc.
Publication of CY1118069T1 publication Critical patent/CY1118069T1/el

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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]

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Abstract

Αυτή η εφεύρεση παρέχει αντισώματα που αναγνωρίζουν το Αντιγόνο Ωρίμανσης Κυττάρων Β (BCMA) και που δεσμεύουν μη-υποβληθέντα κατά το παρελθόν σε κατεργασία κύτταρα Β, κύτταρα πλάσματος, και/ή κύτταρα Β μνήμης. Η εφεύρεση παρέχει περαιτέρω μεθόδους για κένωση μη-υποβληθέντων κατά το παρελθόν κυττάρων πλάσματος και κυττάρων Β μνήμης, και για αγωγή των σχετικών με κύτταρα Β διαταραχών, συμπεριλαμβάνοντας λεμφώματα και αυτοάνοσες παθήσεις.
CY20161100917T 2009-03-10 2016-09-15 Αντισωματα anti-bcma CY1118069T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15894209P 2009-03-10 2009-03-10
US16292409P 2009-03-24 2009-03-24
PCT/US2010/026825 WO2010104949A2 (en) 2009-03-10 2010-03-10 Anti-bcma antibodies

Publications (1)

Publication Number Publication Date
CY1118069T1 true CY1118069T1 (el) 2017-06-28

Family

ID=42139515

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100917T CY1118069T1 (el) 2009-03-10 2016-09-15 Αντισωματα anti-bcma

Country Status (21)

Country Link
US (5) US9034324B2 (el)
EP (2) EP3141562A1 (el)
JP (2) JP6061469B2 (el)
KR (1) KR101589785B1 (el)
CN (2) CN102421801B (el)
AU (2) AU2010224160A1 (el)
CA (1) CA2754938C (el)
CY (1) CY1118069T1 (el)
DK (1) DK2406284T5 (el)
ES (1) ES2593583T3 (el)
HK (1) HK1166333A1 (el)
HR (1) HRP20161194T1 (el)
HU (1) HUE029619T4 (el)
IL (1) IL214996A (el)
LT (1) LT2406284T (el)
MX (2) MX341884B (el)
NZ (2) NZ594985A (el)
PL (1) PL2406284T3 (el)
PT (1) PT2406284T (el)
SI (1) SI2406284T1 (el)
WO (1) WO2010104949A2 (el)

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