CY1117830T1 - Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχων - Google Patents

Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχων

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Publication number
CY1117830T1
CY1117830T1 CY20161100713T CY161100713T CY1117830T1 CY 1117830 T1 CY1117830 T1 CY 1117830T1 CY 20161100713 T CY20161100713 T CY 20161100713T CY 161100713 T CY161100713 T CY 161100713T CY 1117830 T1 CY1117830 T1 CY 1117830T1
Authority
CY
Cyprus
Prior art keywords
treatment
acid derivatives
diseases
substituted tricyclic
autoimmune
Prior art date
Application number
CY20161100713T
Other languages
Greek (el)
English (en)
Inventor
Robert M Jones
Daniel J Buzard
Andrew M Kawasaki
Sun Hee Kim
Lars THORESEN
Juerg Lehmann
Xiuwen Zhu
Original Assignee
Arena Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharmaceuticals, Inc. filed Critical Arena Pharmaceuticals, Inc.
Publication of CY1117830T1 publication Critical patent/CY1117830T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Urology & Nephrology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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CY20161100713T 2008-08-27 2016-07-20 Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχων CY1117830T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19031108P 2008-08-27 2008-08-27
US26951909P 2009-06-24 2009-06-24
PCT/US2009/004851 WO2010027431A1 (en) 2008-08-27 2009-08-26 Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders

Publications (1)

Publication Number Publication Date
CY1117830T1 true CY1117830T1 (el) 2017-05-17

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CY20161100713T CY1117830T1 (el) 2008-08-27 2016-07-20 Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχων

Country Status (23)

Country Link
US (3) US8415484B2 (enExample)
EP (1) EP2342205B1 (enExample)
JP (2) JP5726737B2 (enExample)
KR (2) KR20110058849A (enExample)
CN (2) CN105816453B (enExample)
AU (1) AU2009288738B9 (enExample)
BR (1) BRPI0917923B1 (enExample)
CA (1) CA2733671C (enExample)
CY (1) CY1117830T1 (enExample)
EA (1) EA036955B1 (enExample)
ES (1) ES2583630T3 (enExample)
HR (1) HRP20160890T1 (enExample)
HU (1) HUE031479T2 (enExample)
IL (2) IL211107A0 (enExample)
MX (1) MX2011002199A (enExample)
NZ (1) NZ591001A (enExample)
PL (1) PL2342205T4 (enExample)
PT (1) PT2342205T (enExample)
RS (1) RS54970B1 (enExample)
SI (1) SI2342205T1 (enExample)
SM (1) SMT201600318B (enExample)
WO (1) WO2010027431A1 (enExample)
ZA (1) ZA201101524B (enExample)

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RU2519660C2 (ru) * 2008-03-17 2014-06-20 Актелион Фармасьютиклз Лтд Режим дозировки селективного агониста рецептора s1p1
HRP20161133T1 (hr) 2008-07-23 2016-12-02 Arena Pharmaceuticals, Inc. DERIVATI SUSPSTITUIRANE 1,2,3,4-TETRAHIDROCIKLOPENTA[b]INDOL-3-IL-OCTENE KISELINE KORISNI U LIJEČENJU AUTOIMUNIH I UPALNIH POREMEĆAJA
CN105816453B (zh) 2008-08-27 2021-03-05 艾尼纳制药公司 用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物
WO2011005295A1 (en) * 2009-06-24 2011-01-13 Arena Pharmaceuticals, Inc. Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto
EP2528894A1 (en) 2010-01-27 2012-12-05 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CA2789480A1 (en) * 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
CN104710426B (zh) * 2014-12-12 2017-08-01 常州大学 苯并吡咯里西啶生物碱及其制备方法和用途
CN104478885B (zh) * 2014-12-12 2017-08-01 常州大学 9‑氨基‑9a‑烯丙基苯并吡咯里西啶生物碱的制备方法
WO2016112075A1 (en) 2015-01-06 2016-07-14 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
KR102603199B1 (ko) 2015-06-22 2023-11-16 아레나 파마슈티칼스, 인크. Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염
MA47503A (fr) 2017-02-16 2021-04-21 Arena Pharm Inc Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
MA47504A (fr) 2017-02-16 2019-12-25 Arena Pharm Inc Composés et méthodes de traitement de l'angiocholite biliaire primitive
CN112601516A (zh) 2018-06-06 2021-04-02 艾尼纳制药公司 治疗与s1p1受体相关的病况的方法
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
CN111712484B (zh) * 2018-12-06 2021-05-28 上海济煜医药科技有限公司 作为免疫调节的芳环衍生物及其制备方法和应用
CN111410650B (zh) * 2019-01-04 2020-12-08 苏州亚盛药业有限公司 制备磺胺类药物的方法
CN113874009A (zh) * 2019-01-08 2021-12-31 艾尼纳制药公司 治疗与s1p1受体有关的病况的方法
CN115955970B (zh) * 2020-04-20 2025-07-11 斑马药业(广东)有限公司 使用Pelorol衍生物治疗SHIP1介导的疾病的方法
CN112812052B (zh) * 2021-02-02 2023-12-01 成都阿奇生物医药科技有限公司 一种治疗溃疡性结肠炎的化合物及其制备方法和用途

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