CY1111850T1 - Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντες - Google Patents
Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντεςInfo
- Publication number
- CY1111850T1 CY1111850T1 CY20111100894T CY111100894T CY1111850T1 CY 1111850 T1 CY1111850 T1 CY 1111850T1 CY 20111100894 T CY20111100894 T CY 20111100894T CY 111100894 T CY111100894 T CY 111100894T CY 1111850 T1 CY1111850 T1 CY 1111850T1
- Authority
- CY
- Cyprus
- Prior art keywords
- optionally substituted
- thumpty
- agents
- products
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004152000 | 2004-05-21 | ||
| EP05743594A EP1748985B1 (en) | 2004-05-21 | 2005-05-20 | Cyclic amide derivatives, and their production and use as antithrombotic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111850T1 true CY1111850T1 (el) | 2015-10-07 |
Family
ID=34968275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100894T CY1111850T1 (el) | 2004-05-21 | 2011-09-15 | Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντες |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US7745623B2 (enExample) |
| EP (2) | EP1748985B1 (enExample) |
| JP (2) | JP4129047B2 (enExample) |
| KR (1) | KR101248637B1 (enExample) |
| CN (2) | CN102093285B (enExample) |
| AT (1) | ATE513813T1 (enExample) |
| AU (1) | AU2005245298B2 (enExample) |
| BR (1) | BRPI0511186A (enExample) |
| CA (1) | CA2567506C (enExample) |
| CY (1) | CY1111850T1 (enExample) |
| DK (1) | DK1748985T3 (enExample) |
| ES (1) | ES2368155T3 (enExample) |
| HR (1) | HRP20110640T1 (enExample) |
| IL (1) | IL178896A (enExample) |
| MX (1) | MXPA06013243A (enExample) |
| MY (1) | MY154461A (enExample) |
| NO (1) | NO20065929L (enExample) |
| NZ (1) | NZ550985A (enExample) |
| PH (1) | PH12012501331A1 (enExample) |
| PL (1) | PL1748985T3 (enExample) |
| PT (1) | PT1748985E (enExample) |
| RS (1) | RS51925B (enExample) |
| RU (1) | RU2361861C2 (enExample) |
| SI (1) | SI1748985T1 (enExample) |
| TW (1) | TWI396686B (enExample) |
| WO (1) | WO2005113504A1 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1302462A4 (en) * | 2000-07-17 | 2007-07-18 | Takeda Pharmaceutical | SULFONATE DERIVATIVES, PROCESS FOR PRODUCTION AND USE THEREOF |
| US20070004736A1 (en) * | 2002-11-22 | 2007-01-04 | Keiji Kubo | Imidazole derivative, process for producing the same, and use |
| TWI396686B (zh) * | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| EP1960433A2 (en) * | 2005-11-28 | 2008-08-27 | Zymogenetics, Inc. | Il-21 receptor antagonists |
| JPWO2008066102A1 (ja) * | 2006-11-30 | 2010-03-11 | 武田薬品工業株式会社 | 徐放性製剤 |
| TW201014850A (en) | 2008-09-25 | 2010-04-16 | Takeda Pharmaceutical | Solid pharmaceutical composition |
| JP5535931B2 (ja) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| US8557805B2 (en) | 2008-12-29 | 2013-10-15 | Takeda Pharmaceutical Company Limited | Fused ring compound and use thereof |
| UY32395A (es) | 2009-01-27 | 2010-08-31 | Takeda Pharmaceutical | Compuesto con anillo fusionado y su uso |
| AU2010242308A1 (en) | 2009-04-30 | 2011-12-01 | Takeda Pharmaceutical Company Limited | Solid preparation |
| US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
| CN102548556A (zh) | 2009-07-28 | 2012-07-04 | 武田药品工业株式会社 | 片剂 |
| US8221489B2 (en) * | 2009-08-20 | 2012-07-17 | Stentys | Device and method for treating a body lumen |
| UY33354A (es) | 2010-04-27 | 2011-12-01 | Takeda Pharmaceutical | Compuesto biciclico como inhibidor acc |
| CN103068816B (zh) | 2010-06-16 | 2015-01-07 | 武田药品工业株式会社 | 酰胺化合物的结晶 |
| US9023858B2 (en) | 2010-07-23 | 2015-05-05 | Takeda Pharmaceutical Company Limited | Substituted pyrido[2,3-d]pyrimidines as delta-5-desaturase inhibitors |
| WO2012036293A1 (ja) | 2010-09-17 | 2012-03-22 | 武田薬品工業株式会社 | 糖尿病治療剤 |
| US8729102B2 (en) | 2010-11-30 | 2014-05-20 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| UY33913A (es) | 2011-02-17 | 2012-09-28 | Takeda Pharmaceutical | Método de producción de derivado de dihidrobenzofurano ópticamente activo |
| JPWO2013061962A1 (ja) | 2011-10-24 | 2015-04-02 | 武田薬品工業株式会社 | 二環性化合物 |
| US9365540B2 (en) | 2012-01-12 | 2016-06-14 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as MCH receptor antagonists |
| WO2013122029A1 (ja) | 2012-02-13 | 2013-08-22 | 武田薬品工業株式会社 | 芳香環化合物 |
| EP2816023A4 (en) | 2012-02-13 | 2015-09-09 | Takeda Pharmaceutical | AROMATIC RING CONNECTION |
| EP2814466B1 (en) | 2012-02-15 | 2018-12-26 | Takeda Pharmaceutical Company Limited | Tablet comprising 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamide or a salt thereof |
| JP6106179B2 (ja) | 2012-02-24 | 2017-03-29 | 武田薬品工業株式会社 | 芳香環化合物 |
| CN104350040B (zh) | 2012-03-29 | 2016-06-01 | 武田药品工业株式会社 | 芳环化合物 |
| US9505772B2 (en) | 2012-05-10 | 2016-11-29 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| WO2013168759A1 (ja) | 2012-05-10 | 2013-11-14 | 武田薬品工業株式会社 | 芳香環化合物 |
| JP6122879B2 (ja) | 2012-06-05 | 2017-04-26 | 武田薬品工業株式会社 | 固形製剤 |
| JP2015127299A (ja) | 2012-07-19 | 2015-07-09 | 武田薬品工業株式会社 | 固形製剤 |
| CA2882879A1 (en) | 2012-08-24 | 2014-02-27 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN103936763B (zh) * | 2013-01-18 | 2017-10-31 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
| US9605000B2 (en) | 2013-03-14 | 2017-03-28 | Takeda Pharmaceutical Company Limited | Spiro azetidine isoxazole derivatives and their use as SSTR antagonists |
| US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| UY35650A (es) | 2013-07-09 | 2015-02-27 | Takeda Pharmaceutical | Compuesto heterocíclico |
| ES2672992T3 (es) | 2013-08-09 | 2018-06-19 | Takeda Pharmaceutical Company Limited | Compuesto aromático |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| US10100027B2 (en) * | 2014-09-26 | 2018-10-16 | Changzhou Yinsheng Pharmaceutical Co., Ltd. | Benzofuran analogue as NS4B inhibitor |
| EP3524596B1 (en) | 2014-12-23 | 2020-09-09 | Crossing S.r.l. | Reagents comprising 2-halo-4,6-dialkoxy-1,3,5-triazines in the presence of amines and their use in a stabilization method. |
| US11186565B2 (en) | 2017-03-31 | 2021-11-30 | Takeda Pharmaceutical Company Limited | Aromatic compound |
| JOP20190211A1 (ar) | 2017-03-31 | 2019-09-15 | Takeda Pharmaceuticals Co | ببتيد منشط لمستقبل gip |
| AR111199A1 (es) | 2017-03-31 | 2019-06-12 | Takeda Pharmaceuticals Co | Compuesto aromático agonista de gpr40 |
| EP3654968B1 (en) | 2017-07-17 | 2023-08-16 | Merck Sharp & Dohme LLC | Metallo-beta-lactamase inhibitors and methods of use thereof |
| MX2020009950A (es) | 2018-03-23 | 2021-04-28 | Carmot Therapeutics Inc | Moduladores de receptores acoplados a proteina g. |
| EP3650440A4 (en) | 2018-08-27 | 2020-11-25 | Scohia Pharma, Inc. | BENZOIC ESTER COMPOUND |
| US20220016215A1 (en) | 2018-09-24 | 2022-01-20 | Takeda Phaarmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| EP3856768A2 (en) | 2018-09-24 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| PT4097099T (pt) | 2020-02-07 | 2024-07-19 | Gasherbrum Bio Inc | Agonistas heterocíclicos de glp-1 |
| IL296592A (en) | 2020-03-25 | 2022-11-01 | Takeda Pharmaceuticals Co | Qd dosing of gip receptor agonist peptide compounds and uses thereof |
| IL296219A (en) | 2020-03-25 | 2022-11-01 | Takeda Pharmaceuticals Co | Qw dosing of gip receptor agonist peptide compounds and uses thereof |
| WO2021219019A1 (en) | 2020-04-29 | 2021-11-04 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| KR20240007251A (ko) | 2021-05-13 | 2024-01-16 | 카모트 테라퓨틱스, 인크. | G-단백질 결합 수용체의 조절제 |
| EP4490155A1 (en) | 2022-03-09 | 2025-01-15 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| JP2025510741A (ja) | 2022-03-21 | 2025-04-15 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| US20250250269A1 (en) | 2022-04-14 | 2025-08-07 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN121002014A (zh) | 2022-12-15 | 2025-11-21 | 加舒布鲁姆生物公司 | 具有glp-1激动剂活性的化合物的盐和固体形式 |
| EP4638455A1 (en) | 2022-12-22 | 2025-10-29 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| JP2026501285A (ja) | 2022-12-22 | 2026-01-14 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| KR20250168210A (ko) | 2023-02-16 | 2025-12-02 | 가셔브룸 바이오, 인크. | 헤테로시클릭 glp-1 효능제 |
| US20250019389A1 (en) | 2023-06-30 | 2025-01-16 | Gasherbrum Bio, Inc. | Heterocyclic agonists |
| JP2026526054A (ja) | 2023-07-13 | 2026-08-04 | アコンカグア・バイオ・インコーポレイテッド | 化合物、組成物、および方法 |
| EP4743174A1 (en) | 2023-07-13 | 2026-05-20 | Aconcagua Bio, Inc. | CALCITONIN AND/OR AMYLIN RECEPTOR ACTIVITY MODULATORS |
| EP4771001A1 (en) | 2023-08-31 | 2026-07-08 | Gasherbrum Bio, Inc. | Heteroaryl-heterocycloalkyl-based glp-1 agonists |
| WO2025137307A1 (en) | 2023-12-20 | 2025-06-26 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| WO2025154020A1 (en) | 2024-01-19 | 2025-07-24 | Takeda Pharmaceutical Company Limited | Improved gip receptor agonist peptide compounds and uses thereof |
| WO2025154021A1 (en) | 2024-01-19 | 2025-07-24 | Takeda Pharmaceutical Company Limited | Improved gip receptor agonist peptide compounds and uses thereof |
| WO2025171340A1 (en) | 2024-02-08 | 2025-08-14 | Aconcagua Bio, Inc. | The treatment of calcitonin- and/or amylin-receptor associated conditions |
| WO2025171341A2 (en) | 2024-02-08 | 2025-08-14 | Aconcagua Bio, Inc. | Compounds and compositions for treating conditions associated with calcitonin receptor and/or amylin receptor activity |
| TW202600132A (zh) | 2024-03-08 | 2026-01-01 | 美商安尼波那生物公司 | 用於治療肥胖症及提高減重之方法 |
| WO2026041075A1 (en) | 2024-08-21 | 2026-02-26 | Gasherbrum Bio, Inc. | Gpl-1 agonists |
| WO2026051998A1 (en) | 2024-09-04 | 2026-03-12 | Aconcagua Bio, Inc. | Compounds, compositions, and methods |
| WO2026096926A1 (en) | 2024-11-01 | 2026-05-07 | Aconcagua Bio, Inc. | Compounds, compositions, and methods |
| WO2026156091A1 (en) | 2025-01-15 | 2026-07-23 | Aconcagua Bio, Inc. | Compounds and compositions for treating conditions associated with calcitonin receptor and/or amylin receptor activity |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US270488A (en) * | 1883-01-09 | Drilling apparatus | ||
| US2201270A (en) * | 1936-04-17 | 1940-05-21 | Mcintyre John Taylor | Apparatus for allaying dust from rock drills |
| US2946565A (en) * | 1953-06-16 | 1960-07-26 | Jersey Prod Res Co | Combination drilling and testing process |
| US2849214A (en) * | 1954-09-02 | 1958-08-26 | Gulf Research Development Co | Borehole drilling apparatus for preventing lost circulation |
| US3497020A (en) * | 1968-05-20 | 1970-02-24 | Archer W Kammerer Jr | System for reducing hydrostatic pressure on formations |
| JPS5011391B1 (enExample) * | 1970-07-21 | 1975-04-30 | ||
| SE355840B (enExample) * | 1971-09-08 | 1973-05-07 | Atlas Copco Ab | |
| FR2228301B1 (enExample) * | 1973-05-03 | 1977-10-14 | Ibm | |
| US4147786A (en) | 1976-02-02 | 1979-04-03 | Ciba-Geigy Corporation | 1-Indolylalkyl-3-or 4-trimethyleneurido-piperidines |
| EP0000485A1 (de) | 1977-07-08 | 1979-02-07 | Ciba-Geigy Ag | Piperidino-propanole, ihre Herstellung und pharmazeutische Präparate die diese enthalten |
| US4264599A (en) * | 1977-07-08 | 1981-04-28 | Ciba-Geigy Corporation | Piperidino-propanols |
| US4329348A (en) | 1979-02-26 | 1982-05-11 | Ciba-Geigy Corporation | N-Oxacyclic-alkylpiperidines as psychostimulants |
| US4630691A (en) * | 1983-05-19 | 1986-12-23 | Hooper David W | Annulus bypass peripheral nozzle jet pump pressure differential drilling tool and method for well drilling |
| US4534426A (en) * | 1983-08-24 | 1985-08-13 | Unique Oil Tools, Inc. | Packer weighted and pressure differential method and apparatus for Big Hole drilling |
| US4567954A (en) * | 1983-12-02 | 1986-02-04 | Norton Christensen, Inc. | Replaceable nozzles for insertion into a drilling bit formed by powder metallurgical techniques and a method for manufacturing the same |
| US4695575A (en) | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
| ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| US5902272A (en) | 1992-01-07 | 1999-05-11 | Arthrocare Corporation | Planar ablation probe and method for electrosurgical cutting and ablation |
| HU218419B (hu) | 1992-03-06 | 2000-08-28 | E.R. Squibb And Sons, Inc. | Mikroszomális triglicerid transzfer protein (MTP) nagy molekulatömegű alegységének rekombináns úton történő előállítására és a protein és inhibitorainak kimutatására szolgáló eljárások |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| US5355967A (en) * | 1992-10-30 | 1994-10-18 | Union Oil Company Of California | Underbalance jet pump drilling method |
| GB9321557D0 (en) * | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
| GB9312806D0 (en) | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| GB9317104D0 (en) * | 1993-08-17 | 1993-09-29 | Zeneca Ltd | Therapeutic heterocycles |
| TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5456326A (en) * | 1994-04-18 | 1995-10-10 | Exxon Production Research Company | Apparatus and method for installing open-ended tubular members axially into the earth |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| AU701127B2 (en) | 1994-10-27 | 1999-01-21 | Merck & Co., Inc. | Muscarine antagonists |
| NZ296210A (en) | 1994-12-02 | 1998-05-27 | Yamanouchi Pharma Co Ltd | Amidinonaphthyl derivatives to inhibit activated blood coagulation factor x |
| GB9508786D0 (en) | 1995-04-29 | 1995-06-21 | Zeneca Ltd | Substituted heterocycles |
| JP3133073B2 (ja) | 1995-05-29 | 2001-02-05 | ファイザー・インコーポレーテッド | 成長ホルモンの放出を促進するジペプチド類 |
| US5612353A (en) | 1995-06-07 | 1997-03-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
| US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| GB9602294D0 (en) | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
| SI0946185T2 (sl) | 1996-11-27 | 2010-08-31 | Aventis Pharma Inc | Farmacevtski sestavek, ki obsega spojino z anti-Xa-aktivnostjo in antagonistično spojino za agregacijo ploščic |
| US6359134B1 (en) | 1997-05-30 | 2002-03-19 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
| FR2764511B1 (fr) | 1997-06-13 | 2000-09-08 | Sanofi Sa | Compositions pour le traitement et la prevention de la thrombose arterielle et utilisation d'un inhibiteur du facteur xa seul et/ou en combinaison avec un antiagregant plaquettaire |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| US6348478B1 (en) | 1997-11-20 | 2002-02-19 | Teijin Limited | Biphenylamidine derivatives |
| NZ503757A (en) | 1997-11-21 | 2002-03-01 | Schering Corp | Substituted oximes as antagonists of tachykinin receptors |
| AU1692399A (en) | 1997-12-26 | 1999-07-19 | Mochida Pharmaceutical Co., Ltd. | Aromatic compounds having cyclic amino or salts thereof |
| CN1290254A (zh) | 1998-02-05 | 2001-04-04 | 武田药品工业株式会社 | 氨磺酰衍生物及其制备和用途 |
| SK15072000A3 (sk) | 1998-04-10 | 2001-08-06 | Japan Tobacco Inc. | Amidové zlúčeniny |
| US6129152A (en) * | 1998-04-29 | 2000-10-10 | Alpine Oil Services Inc. | Rotating bop and method |
| GB9809349D0 (en) | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Heterocyclic derivatives |
| US6423519B1 (en) * | 1998-07-15 | 2002-07-23 | Gpc Biotech Inc. | Compositions and methods for inhibiting fungal growth |
| EP1104754A1 (en) | 1998-08-11 | 2001-06-06 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
| JP2000080046A (ja) | 1998-09-03 | 2000-03-21 | Dai Ichi Seiyaku Co Ltd | 多臓器障害の予防・治療剤 |
| WO2000018398A1 (en) | 1998-09-25 | 2000-04-06 | Sunol Molecular Corporation | Pharmaceutically active compounds and methods of use thereof |
| US6204265B1 (en) | 1998-12-23 | 2001-03-20 | Schering Corporation | Substituted oximes and hydrazones as neurokinin antagonists |
| CO5160341A1 (es) | 1998-12-23 | 2002-05-30 | Schering Corp | Oximas e hidrazonas sustituidas como antagonistas de neuroquinina |
| US7217714B1 (en) * | 1998-12-23 | 2007-05-15 | Agouron Pharmaceuticals, Inc. | CCR5 modulators |
| ATE325114T1 (de) | 1999-06-22 | 2006-06-15 | Takeda Pharmaceutical | Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung |
| KR20020015061A (ko) | 1999-06-30 | 2002-02-27 | 모치다 에이 | 스피로 결합을 갖는 트리사이클릭 화합물 |
| KR20020087041A (ko) | 1999-07-28 | 2002-11-21 | 아벤티스 파마슈티칼스 프로덕츠 인크. | 치환된 옥소아자헤테로사이클릴 화합물 |
| WO2001017992A1 (en) | 1999-09-09 | 2001-03-15 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO2001044172A1 (en) | 1999-12-15 | 2001-06-21 | Axys Pharmaceuticals, Inc. | Salicylamides as serine protease and factor xa inhibitors |
| US6629974B2 (en) | 2000-02-22 | 2003-10-07 | Gyrus Medical Limited | Tissue treatment method |
| US6723091B2 (en) | 2000-02-22 | 2004-04-20 | Gyrus Medical Limited | Tissue resurfacing |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| EP1302462A4 (en) * | 2000-07-17 | 2007-07-18 | Takeda Pharmaceutical | SULFONATE DERIVATIVES, PROCESS FOR PRODUCTION AND USE THEREOF |
| JP2002201178A (ja) * | 2000-07-17 | 2002-07-16 | Takeda Chem Ind Ltd | スルホン誘導体、その製造法及び用途 |
| US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
| US20040082786A1 (en) | 2000-09-29 | 2004-04-29 | Bing-Yan Zhu | Piperazine based inhibitors of factor xa |
| AU2002222328A1 (en) | 2000-10-18 | 2002-04-29 | Gian Franco Bernabei | Method and apparatus for plasma skin resurfacing |
| FR2819511A1 (fr) | 2001-01-18 | 2002-07-19 | Servier Lab | Nouveaux composes azepane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2002068407A1 (en) | 2001-02-28 | 2002-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Benzimidazole compound |
| US7265121B2 (en) | 2001-07-26 | 2007-09-04 | Eli Lilly And Company | Chemical compounds |
| US6877571B2 (en) * | 2001-09-04 | 2005-04-12 | Sunstone Corporation | Down hole drilling assembly with independent jet pump |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| AU2002341693B2 (en) | 2001-09-21 | 2008-05-29 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors |
| WO2003031432A1 (en) * | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
| DE10155075A1 (de) | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Cyclische Sulfonamide |
| IL163923A0 (en) | 2002-03-28 | 2005-12-18 | Tanabe Seiyaku Co | Benzofuran derivatives |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| DE10229070A1 (de) | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
| US20040006490A1 (en) | 2002-07-08 | 2004-01-08 | Gingrich Mark A. | Prescription data exchange system |
| WO2004031145A2 (en) | 2002-10-02 | 2004-04-15 | Bristol-Myers Squibb Company | Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor xa inhibitors |
| WO2004035579A1 (ja) | 2002-10-15 | 2004-04-29 | Takeda Pharmaceutical Company Limited | イミダゾピリジン誘導体、その製造法および用途 |
| US20070004736A1 (en) | 2002-11-22 | 2007-01-04 | Keiji Kubo | Imidazole derivative, process for producing the same, and use |
| JP2006518368A (ja) | 2003-02-21 | 2006-08-10 | ファイザー・インク | プロテインキナーゼ阻害剤としてのｎ−ヘテロシクリル置換アミノチアゾール誘導体 |
| US6899188B2 (en) * | 2003-03-26 | 2005-05-31 | Sunstone Corporation | Down hole drilling assembly with concentric casing actuated jet pump |
| WO2005087266A1 (en) | 2004-03-05 | 2005-09-22 | Vddi Pharmaceuticals | Combination therapy for inhibition of platelet aggregation |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| US7988933B2 (en) | 2006-09-01 | 2011-08-02 | Siemens Healthcare Diagnostics Inc. | Identification system for a clinical sample container |
| KR100906250B1 (ko) | 2006-09-04 | 2009-07-07 | 주식회사 엘지화학 | 바인더로서 고중합도 폴리비닐알콜과 폴리비닐피롤리돈의혼합물을 포함하는 전극 합제 및 이를 포함하는 리튬이차전지 |
-
2005
- 2005-05-19 TW TW094116243A patent/TWI396686B/zh not_active IP Right Cessation
- 2005-05-20 WO PCT/JP2005/009711 patent/WO2005113504A1/en not_active Ceased
- 2005-05-20 PT PT05743594T patent/PT1748985E/pt unknown
- 2005-05-20 DK DK05743594.3T patent/DK1748985T3/da active
- 2005-05-20 KR KR1020067023942A patent/KR101248637B1/ko not_active Expired - Fee Related
- 2005-05-20 NZ NZ550985A patent/NZ550985A/en not_active IP Right Cessation
- 2005-05-20 MX MXPA06013243A patent/MXPA06013243A/es active IP Right Grant
- 2005-05-20 CN CN2010105739971A patent/CN102093285B/zh not_active Expired - Fee Related
- 2005-05-20 ES ES05743594T patent/ES2368155T3/es not_active Expired - Lifetime
- 2005-05-20 HR HR20110640T patent/HRP20110640T1/hr unknown
- 2005-05-20 RS RS20110371A patent/RS51925B/sr unknown
- 2005-05-20 SI SI200531321T patent/SI1748985T1/sl unknown
- 2005-05-20 EP EP05743594A patent/EP1748985B1/en not_active Expired - Lifetime
- 2005-05-20 AU AU2005245298A patent/AU2005245298B2/en not_active Ceased
- 2005-05-20 MY MYPI20052298A patent/MY154461A/en unknown
- 2005-05-20 RU RU2006145449/04A patent/RU2361861C2/ru not_active IP Right Cessation
- 2005-05-20 JP JP2007521014A patent/JP4129047B2/ja not_active Expired - Fee Related
- 2005-05-20 PL PL05743594T patent/PL1748985T3/pl unknown
- 2005-05-20 CA CA2567506A patent/CA2567506C/en not_active Expired - Fee Related
- 2005-05-20 CN CN2005800244522A patent/CN1989104B/zh not_active Expired - Fee Related
- 2005-05-20 US US11/596,089 patent/US7745623B2/en not_active Expired - Fee Related
- 2005-05-20 BR BRPI0511186-2A patent/BRPI0511186A/pt not_active Application Discontinuation
- 2005-05-20 EP EP10161428.7A patent/EP2208726B1/en not_active Expired - Lifetime
- 2005-05-20 PH PH1/2012/501331A patent/PH12012501331A1/en unknown
- 2005-05-20 AT AT05743594T patent/ATE513813T1/de active
-
2006
- 2006-10-26 IL IL178896A patent/IL178896A/en not_active IP Right Cessation
- 2006-12-20 NO NO20065929A patent/NO20065929L/no not_active Application Discontinuation
-
2008
- 2008-01-15 JP JP2008006003A patent/JP4362535B2/ja not_active Expired - Fee Related
- 2008-06-11 US US12/157,574 patent/US20080255352A1/en not_active Abandoned
- 2008-06-11 US US12/157,573 patent/US20080255362A1/en not_active Abandoned
-
2010
- 2010-03-02 US US12/715,930 patent/US8697865B2/en not_active Expired - Fee Related
-
2011
- 2011-09-15 CY CY20111100894T patent/CY1111850T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200600508A (en) | Cyclic amide derivative, and its production and use | |
| CY1115302T1 (el) | Ενωση οξαζολιου και φαρμακευτικη συνθεση | |
| CY1109309T1 (el) | Παραγωγα γλυκοπυρανοσυλοξυπυραζολης και χρηση αυτων σε φαρμακευτικα σκευασματα | |
| CY1112630T1 (el) | Αναστολεις πυριδυλιου της σηματοδοτησης hedgehog | |
| CY1114008T1 (el) | Θειενοπυριμιδινικες ενωσεις και χρηση τους | |
| CY1111706T1 (el) | Παραγωγα αρυλο- και ετεροαρυλο-πιπεριδινοκαρβοξυλικων αλατων, η παρασκευη τους και η εφαρμογη τους ως αναστολεις του ενζυμου faah | |
| CY1111867T1 (el) | Ενωση ενεργοποιησης ppar και φαρμακευτικη συνθεση που περιεχει αυτη | |
| CY1106237T1 (el) | Ετepοκυκλικα παραγωγα με 5 μελη στο δακτυλιο και εφαρμογη αυτων ως παρεμποδιστων της μονοαμινο οξυδασης | |
| ECSP088550A (es) | Nuevos compuestos que son inhibidores de erk | |
| IL185275A0 (en) | N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same | |
| AR088226A1 (es) | Derivados piperidinicos heterociclicos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades neurodegenerativas | |
| EA200701176A1 (ru) | Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их | |
| TW200602322A (en) | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs | |
| NO20052976L (no) | Fosfodiesterase-4-inhibitorer. | |
| BRPI0414792A (pt) | derivados de ácido 4-(1h-indol-3-il-metilidenoaminóxi-propóxi)-benzóico e compostos relacionados como inibidores de pai-1 para o tratamento de enfraquecimento do sistema fibrinolìtico e de trombose | |
| CY1105994T1 (el) | Aναδιαταγμενες πεντανολες, μεθοδος για την παραγωγη αυτων και η χρηση αυτων ως αντιφλεγμονωδων | |
| UY29312A1 (es) | Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones | |
| PE20100093A1 (es) | Derivados de acetileno | |
| CY1115256T1 (el) | Φαρμακευτικες ενωσεις | |
| CY1117753T1 (el) | Κρυσταλλικη μορφη του αλατος αργινινης της περινδοπριλης, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις οι οποιες την περιεχουν | |
| HRP20090474T1 (hr) | Postupak i intermedijeri za sintezu kaspofungina | |
| UY27825A1 (es) | Derivados de n-acilamino bencil eter | |
| DE60314381D1 (de) | Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren | |
| CY1108238T1 (el) | Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της | |
| AR041898A1 (es) | Derivados de 4(fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor y desordenes gastrointestinales |