AR055071A1 - Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas. - Google Patents

Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas.

Info

Publication number
AR055071A1
AR055071A1 ARP060102891A ARP060102891A AR055071A1 AR 055071 A1 AR055071 A1 AR 055071A1 AR P060102891 A ARP060102891 A AR P060102891A AR P060102891 A ARP060102891 A AR P060102891A AR 055071 A1 AR055071 A1 AR 055071A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
group
pharmaceutical compositions
pyrimidine
pirrolo
Prior art date
Application number
ARP060102891A
Other languages
English (en)
Inventor
S Imamura
Y Oguro
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR055071A1 publication Critical patent/AR055071A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Composiciones farmacéuticas que los comprenden. Reivindicacion1: Un compuesto caracterizado por la formula (1) en donde el anillo A es un anillo pirrol opcionalmente sustituido, X es CH opcionalmente sustituido, Y es CH opcionalmente sustituido o átomo de nitrogeno, Z es un grupo hidrocarbonado divalente opcionalmente sustituido o un grupo heterocíclico divalente opcionalmente sustituido, T es un enlace simple o un grupo alquileno C1-3 opcionalmente sustituido, y U es un grupo amido opcionalmente sustituido, un grupo sulfonamido opcionalmente sustituido, un grupo ureído opcionalmente sustituido, un grupo carbamoílo opcionalmente sustituido o un grupo tioureído opcionalmente sustituido o una de sus sales.
ARP060102891A 2005-07-05 2006-07-05 Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas. AR055071A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005196866 2005-07-05
JP2006054102 2006-02-28

Publications (1)

Publication Number Publication Date
AR055071A1 true AR055071A1 (es) 2007-08-01

Family

ID=37055938

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102891A AR055071A1 (es) 2005-07-05 2006-07-05 Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas.

Country Status (8)

Country Link
US (1) US20090137580A1 (es)
EP (1) EP1904498A1 (es)
JP (1) JP2009500295A (es)
AR (1) AR055071A1 (es)
PE (1) PE20070174A1 (es)
TW (1) TW200740820A (es)
UY (1) UY31674A1 (es)
WO (1) WO2007004749A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007014616A (es) 2005-05-20 2009-08-12 Methylgene Inc Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos.
CA2626350A1 (en) * 2005-10-28 2007-05-10 Irm Llc Compounds and compositions as protein kinase inhibitors
TW200730527A (en) * 2005-12-02 2007-08-16 Takeda Pharmaceuticals Co Fused heterocyclic compound
NZ551796A (en) * 2006-12-05 2009-07-31 Craig Robert Stuart Bump-resistant pin tumbler lock
EP2099444A4 (en) 2006-12-14 2012-11-07 Nps Pharma Inc USE OF D-SERIN DERIVATIVES FOR THE TREATMENT OF ANTIBODIES
PL2183254T3 (pl) 2007-08-29 2017-10-31 Methylgene Inc Inhibitory aktywności białkowej kinazy tyrozynowej
WO2009096435A1 (ja) * 2008-01-29 2009-08-06 Takeda Pharmaceutical Company Limited 縮合複素環誘導体およびその用途
RU2498988C2 (ru) * 2008-03-05 2013-11-20 Метилджин, Инк. Ингибиторы активности протеинтирозинкиназы
WO2009136663A1 (en) 2008-05-08 2009-11-12 Takeda Pharmaceutical Company Limited Fused heterocyclic derivatives and use thereof
WO2010108503A1 (en) 2009-03-24 2010-09-30 Life & Brain Gmbh Promotion of neuronal integration in neural stem cell grafts
US9951008B2 (en) * 2009-11-03 2018-04-24 University Of Notre Dame Du Lac Ionic liquids comprising heteraromatic anions
KR20130044382A (ko) * 2010-03-01 2013-05-02 마이렉시스 인코포레이티드 화합물 및 그의 치료 용도
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
KR20130012072A (ko) 2010-03-31 2013-01-31 액테리온 파마슈티칼 리미티드 항박테리아성 이소퀴놀린-３-일우레아 유도체
WO2012008564A1 (ja) * 2010-07-16 2012-01-19 協和発酵キリン株式会社 含窒素芳香族複素環誘導体
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
KR101993436B1 (ko) 2011-10-31 2019-06-26 노바르티스 아게 파조파닙 제형
EP2981526B1 (en) 2013-04-02 2021-11-03 Oxular Acquisitions Limited Intermediates useful in the preparation of naphthylurea derivatives useful as kinase inhibitors
PT3049417T (pt) * 2013-07-31 2019-01-24 Merck Patent Gmbh Piridinas, pirimidinas e pirazinas, como inibidores de btk e utilizações das mesmas
WO2015048765A1 (en) 2013-09-30 2015-04-02 University Of Notre Dame Du Lac Compounds, complexes, compositions, methods and systems for heating and cooling
US10086331B2 (en) 2013-11-05 2018-10-02 University Of Notre Dame Du Lac Carbon dioxide capture using phase change ionic liquids
EP3083604A1 (en) 2013-12-20 2016-10-26 Respivert Limited Urea derivatives useful as kinase inhibitors
MA40774A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
JPWO2017038873A1 (ja) * 2015-08-31 2018-06-14 東レ株式会社 尿素誘導体及びその用途
EA201892213A1 (ru) 2016-04-06 2019-05-31 Топайверт Фарма Лимитед Ингибиторы киназ
US10196378B2 (en) * 2016-08-25 2019-02-05 The Regents Of The University Of Michigan Inhibitors of BCR-ABL mutants and use thereof
CN109180677A (zh) * 2017-06-30 2019-01-11 厦门大学 取代芳基醚类化合物、其制备方法、药用组合物及其应用
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN110128299B (zh) * 2019-05-13 2020-11-10 浙江大学 一种二苯基脲类抗肿瘤小分子抑制剂及其制备方法
WO2020245208A1 (en) 2019-06-04 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN116789670A (zh) * 2022-03-17 2023-09-22 中国科学院合肥物质科学研究院 一种选择性csf1r抑制剂及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
AR004010A1 (es) * 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
EA199900021A1 (ru) * 1996-07-13 1999-08-26 Глаксо, Груп Лимитед Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы
CA2263566C (en) 1996-08-28 2003-09-09 Pfizer Inc. Substituted 6,5-hetero-bicyclic derivatives
ES2281591T3 (es) * 1999-01-22 2007-10-01 Kirin Beer Kabushiki Kaisha Derivados de n-((quinolinil)oxil)-fenil)-urea y de n-((quinazolinil)oxil)-fenil)-urea con actividad antitumoral.
WO2001083456A1 (fr) 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derives d'heteroaryle condenses
ES2282299T3 (es) * 2000-10-20 2007-10-16 EISAI R&D MANAGEMENT CO., LTD. Compuestos aromaticos con anillos de nitrogeno como agentes anticancerigenos.
PL209822B1 (pl) * 2001-04-27 2011-10-31 Kirin Pharma Kk Pochodna chinoliny lub chinazoliny, zawierająca ją kompozycja farmaceutyczna i zastosowanie
RU2389731C2 (ru) * 2004-06-02 2010-05-20 Такеда Фармасьютикал Компани Лимитед Конденсированное гетероциклическое соединение

Also Published As

Publication number Publication date
UY31674A1 (es) 2009-08-31
JP2009500295A (ja) 2009-01-08
EP1904498A1 (en) 2008-04-02
PE20070174A1 (es) 2007-03-12
WO2007004749A1 (en) 2007-01-11
US20090137580A1 (en) 2009-05-28
TW200740820A (en) 2007-11-01

Similar Documents

Publication Publication Date Title
AR055071A1 (es) Derivados de pirrolo (3,2 - b) pirimidina. composiciones farmaceuticas.
AR049418A1 (es) Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes.
EA200602060A1 (ru) Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
CO5640117A2 (es) Derivados de 2,4-diamonopirimidina
CY1115302T1 (el) Ενωση οξαζολιου και φαρμακευτικη συνθεση
RS52632B (en) S-TRIAZOLYL ALFA-MERCAPTOACETANILIDE AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE
CO5680403A2 (es) Antagonistas de mchr1r
UY29312A1 (es) Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones
AR025386A1 (es) Moduladores de los receptores activados del proliferador de peroxisomas
CR9234A (es) Derivados de 2,4(4,6) pirimidina
EA200500203A1 (ru) Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат
CO5601029A2 (es) Inhibidores no nucleosidos de transcriptasa inversa i para el tratamiento de enfermedades mediadas por vih
EA200700185A1 (ru) Производные хиназолиндиона в качестве ингибиторов parp
CO6220931A2 (es) Inhibidores de serina proteasas para el tratamiento de infecciones de vhc
CO5680435A2 (es) Derivados de quinazolina inhibidores de tirosina quinasa erbb y egb, su procedimiento de sintesis y composiciones farmaceuticas que los contienen
UY31604A1 (es) Compuestos tricíclicos y uso de los mismos
CO5690551A2 (es) Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo
BRPI0514372A (pt) inibidores de tiazol de frutose 1, 6-bisfosfatase
AR066669A1 (es) Derivados de imidazolona como inhibidores de bencimidazolona quimasa. composiciones farmaceuticas.
ECSP099335A (es) Compuestos heterocíclicos que contienen nitrógeno y métodos de uso de los mismos
AR053453A1 (es) Derivados de aminoalquil- y amidoalquil-benzopirano substituidos
EA201000101A1 (ru) Производные пиримидина 934
DE602007004740D1 (de) Antibiotische spiroderivate
AR066604A1 (es) Derivados de arilamida pirimidona, medicamentos que los contienen y usos terapeuticos para prevenir y/o tratar enfermedades neurodegenerativas fundamentalmente.
AR057961A1 (es) Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal