AR057961A1 - Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas. - Google Patents

Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas.

Info

Publication number
AR057961A1
AR057961A1 ARP060105330A ARP060105330A AR057961A1 AR 057961 A1 AR057961 A1 AR 057961A1 AR P060105330 A ARP060105330 A AR P060105330A AR P060105330 A ARP060105330 A AR P060105330A AR 057961 A1 AR057961 A1 AR 057961A1
Authority
AR
Argentina
Prior art keywords
atom
alkyl group
pharmaceutical compositions
thirosine
pirrolopirimidinas
Prior art date
Application number
ARP060105330A
Other languages
English (en)
Inventor
T Ishikawa
K Miwa
M Seto
H Banno
Y Kawakita
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR057961A1 publication Critical patent/AR057961A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

El compuesto de la presente tiene una accion inhibidora de la tirosina quinasa superior. Composiciones farmacéuticas que los comprenden. Reivindicacion 1: Un compuesto caracterizado por la formula (1) en donde R1a es un átomo de H; R2a es un grupo alquilo C1-6 sustituido con un grupo representado por alquilo C1-4 opcionalmente halogenado con -NR6a-CO-(CH2)n-SO2- en donde n es un numero entero de 1 a 4, R6a es un átomo de H o un grupo alquilo C1-4, y -(CH2)n-está opcionalmente sustituido con alquilo C1-4; R3a es un átomo de H o un grupo alquilo C1-6; R4a es un átomo de halogeno o un grupo alquilo C1-6; R5a es un átomo de halogeno o un grupo alquilo C1-6; y Xa es un átomo de H o un átomo de halogeno, o una de sus sales, con la condicion de que se excluya N-[2-(4-{[3-cloro-4-(3-clorofenoxi)fenil]amino}-5H-pirrolo[3,2-d]pirimidin-5-il)etil]-2-(metilsulfonil)acetamida.
ARP060105330A 2005-12-02 2006-12-01 Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas. AR057961A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005349858 2005-12-02
JP2006060648 2006-03-07

Publications (1)

Publication Number Publication Date
AR057961A1 true AR057961A1 (es) 2007-12-26

Family

ID=37897379

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105330A AR057961A1 (es) 2005-12-02 2006-12-01 Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas.

Country Status (15)

Country Link
US (1) US20100216788A1 (es)
EP (1) EP1957495A1 (es)
JP (1) JP2009517333A (es)
KR (1) KR20080084823A (es)
AR (1) AR057961A1 (es)
AU (1) AU2006319787A1 (es)
BR (1) BRPI0619911A2 (es)
CA (1) CA2631066A1 (es)
CR (1) CR10057A (es)
MA (1) MA30046B1 (es)
NO (1) NO20082870L (es)
PE (1) PE20071089A1 (es)
RU (1) RU2008126949A (es)
TW (1) TW200730527A (es)
WO (1) WO2007064045A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20105024B (en) * 2004-06-02 2010-06-25 Takeda Pharmaceuticals Co Fused heterocyclic compound
EP2103620A1 (en) * 2006-12-12 2009-09-23 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US7825127B2 (en) 2006-12-28 2010-11-02 Takeda Pharmaceutical Company, Limited Method for treating cancer
BRPI0813402A2 (pt) 2007-06-19 2014-12-30 Takeda Pharmaceutical Agente para evitar ou tratar um câncer resistente a trastuzumab, droga combinada, métodos para prevenir ou tratar câncer resistente a trastuzumab, para examinar a sensibilidade de um câncer expressando her2 a um inibidor de her2, para tratar um câncer em um animal julgado ter baixa sensibilidade a um inibidor de her2 e para triar uma droga para a profilaxia ou tratamento de um câncer resistente a trastuzumab, e, uso de um ou mais medicamentos.
UY31683A (es) * 2008-03-03 2009-11-10 Takeda Pharmaceutical Farmaco combinado
UY31704A (es) * 2008-03-12 2009-11-10 Takeda Pharmaceutical Compuesto heterociclico fusionado
CN103619818A (zh) 2011-06-20 2014-03-05 纳幕尔杜邦公司 用于治疗蠕虫感染的杂环化合物
US9321750B2 (en) 2012-04-20 2016-04-26 Innov17 Llc ROR modulators and their uses
CA2918242C (en) * 2013-07-31 2022-06-21 Merck Patent Gmbh Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof
GB201520499D0 (en) * 2015-11-20 2016-01-06 Medical Res Council Technology Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
GEP20105024B (en) * 2004-06-02 2010-06-25 Takeda Pharmaceuticals Co Fused heterocyclic compound
US7772247B2 (en) * 2004-07-30 2010-08-10 Methylgene Inc. Substituted thieno[3,2-d]pyridines as inhibitors of the VEGF receptor and HGF receptor
TW200740820A (en) * 2005-07-05 2007-11-01 Takeda Pharmaceuticals Co Fused heterocyclic derivatives and use thereof

Also Published As

Publication number Publication date
RU2008126949A (ru) 2010-01-10
MA30046B1 (fr) 2008-12-01
CA2631066A1 (en) 2007-06-07
WO2007064045A1 (en) 2007-06-07
BRPI0619911A2 (pt) 2016-08-30
AU2006319787A1 (en) 2007-06-07
CR10057A (es) 2008-07-29
PE20071089A1 (es) 2007-11-19
US20100216788A1 (en) 2010-08-26
NO20082870L (no) 2008-09-01
TW200730527A (en) 2007-08-16
JP2009517333A (ja) 2009-04-30
KR20080084823A (ko) 2008-09-19
EP1957495A1 (en) 2008-08-20

Similar Documents

Publication Publication Date Title
AR057961A1 (es) Derivados de pirrolopirimidinas con actividad inhibitoria de receptor de tirosina quinasa. composiciones farmaceuticas.
AR047456A1 (es) Derivados de amidas, procesos para su preparacion y uso como insecticidas
RS51548B (en) PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS
CR9459A (es) Derivados benzodioxano y benzodioxolano y usos de los mismos
CO6220855A2 (es) Compuesto a base de 54 -fenil-6-(2,2,2-trifluoro-1-feniletoxi)pirimidina y metodos para su empleo
AR053301A1 (es) Derivados de pirazina y su uso farmaceutico
AR055959A1 (es) Derivados espiro para la modulacion de actividad de crth2
DK1412354T3 (da) Derivater af triazolylimidazopyridin og af triazolylpurinerne, der er egnede som ligander for adenosin A2a?-receptoren og deres anvendelse som medikamenter
AR092289A1 (es) Derivados de aminoquinazolina y sus sales y metodos de uso
AR055613A1 (es) Formas cristalinas delta y epsilon de mesilato de imatinib
DK1817300T3 (da) Forstærkere af glutamat-receptorer
CR8505A (es) Derivados de (3-oxo-3,4-dihidroquinoxalin-2-il-amino)-benzamida y compuesto relacionado, como inhibidores de glucogeno fosforilasa para el tratamiento de la diabetes y obesidad
AR031627A1 (es) Activadores heteroaromaticos fusionados de la glucoquinasa
AR066669A1 (es) Derivados de imidazolona como inhibidores de bencimidazolona quimasa. composiciones farmaceuticas.
AR053895A1 (es) Aminopirimidinas como moduladores de quinasas
NO20060702L (no) Aminokinolinderivater og deres anvendelse som adenosin A3 ligander
CO5590895A2 (es) Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos
NO20033145L (no) Purinderivater som purinergiske reseptorantagonister
DK1611144T3 (da) Derivater af 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl-phosphonsyre og deres avendelse som n-methyl-D-aspartat (NMDA)-receptor-antagonister
DE60336267D1 (de) Uracilderivate mit herbizider wirkung
NO20073287L (no) 2,5 og 2,6-disubstituerte benzazol-analoger som proteinkinaseinhibitorer
ES2531159T3 (es) Compuestos y métodos para el tratamiento del cáncer
AR060810A1 (es) Moduladores de receptores metabotropicos de glutamato mglur5, composiciones farmaceuticas que los contienen y usos en procesos patofisiologicos y trastornos que afectan el scn
CO5570675A2 (es) Compuestos sustituidos de benzimidazolo y su uso para el tratamiento del cancer
AR069781A1 (es) Compuestos de n-(2,3-dihidro-inden-2-il) propanosulfonamida, composicion farmaceutica que los comprenden y su uso para el tratamiento de la ezquizofrenia.

Legal Events

Date Code Title Description
FB Suspension of granting procedure