CO5570675A2 - Compuestos sustituidos de benzimidazolo y su uso para el tratamiento del cancer - Google Patents
Compuestos sustituidos de benzimidazolo y su uso para el tratamiento del cancerInfo
- Publication number
- CO5570675A2 CO5570675A2 CO04028337A CO04028337A CO5570675A2 CO 5570675 A2 CO5570675 A2 CO 5570675A2 CO 04028337 A CO04028337 A CO 04028337A CO 04028337 A CO04028337 A CO 04028337A CO 5570675 A2 CO5570675 A2 CO 5570675A2
- Authority
- CO
- Colombia
- Prior art keywords
- aryl
- optionally substituted
- group
- alkoxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Compuestos de la fórmula (1)? donde A es una entidad aril o heteroaril? donde R se selecciona a partir de uno o más grupos similares seleccionados a partir de:- alquil, eventualmente sustituido por derivados de alcoxi, heteroalquil, áril, acil, acil, halógeno-alcoxi eventualmente sustituidos por un alquil, heteroalquil, aril, heteroaril, alcoxialquil, hidroxialquil amida o un grupo perfluoroalcoxi o un alquiltio eventualmente sustituido por una amida o un perfluoroalquiltio- aril o heteroaril eventualmente sustituidos por uno o más grupo alquil, grupo alcoxi, grupo nitro, grupo ciano, derivado de acil, grupo perfluoroalcoxi, grupo perfluoroalquil, grupo heteroaril, grupo, ariloxi, - halógeno- 4 NH2- 4 NH alquil o cicloalquil eventualmente sustituido con un grupo derivado de acil, un acil, un hidroxi, un amino, alcoxi, heterociclil o aril- 4 N imidazolil - 3 SO2 Me cuando A es fenil? donde R2 se selecciona a partir del grupo que consiste de - CO-alquil eventualmente sustituido por grupos amino, ácido, derivado de ácido, alcoxi, aril u OH- CO-aralquil eventualmente sustituidos por alcoxi, halógeno, amino, ácido o derivados de ácido- CO-aril eventualmente sustituido- CO-alcoxi eventualmente sustituido por aril- CO-amino, CO-NHR3, CO-NR3R4 donde R3 y R4 se seleccionan independientemente a partir de hidrógeno, alquil, hidroxialquil, alcoxialquil, fluoroalquil, alcinil, heteroalquil, alquilheteroalquil, aril, aralquil o conjuntamente forman una cadena alquilen que incluye eventualmente uno a 4 hetero átomos - aril o aralquil eventualmente sustituidos por heterocicloalquil, alquil, aril, alcoxi, amino, fluoroalquil, derivados de acil, halógenoo una sal farmacéuticamente aceptable o una pro-droga.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01402460A EP1298125A1 (en) | 2001-09-26 | 2001-09-26 | Substituted benzimidazole compounds and their use for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5570675A2 true CO5570675A2 (es) | 2005-10-31 |
Family
ID=8182891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04028337A CO5570675A2 (es) | 2001-09-26 | 2004-03-25 | Compuestos sustituidos de benzimidazolo y su uso para el tratamiento del cancer |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7041668B2 (es) |
| EP (2) | EP1298125A1 (es) |
| JP (1) | JP4510450B2 (es) |
| KR (1) | KR100891439B1 (es) |
| CN (1) | CN100346786C (es) |
| AR (1) | AR037096A1 (es) |
| AT (1) | ATE386517T1 (es) |
| AU (1) | AU2002337151B2 (es) |
| BR (1) | BR0212856A (es) |
| CA (1) | CA2461622C (es) |
| CO (1) | CO5570675A2 (es) |
| CY (1) | CY1107953T1 (es) |
| DE (1) | DE60225159T2 (es) |
| DK (1) | DK1432417T3 (es) |
| EA (1) | EA006802B1 (es) |
| ES (1) | ES2301682T3 (es) |
| GT (1) | GT200200190A (es) |
| HK (1) | HK1068551A1 (es) |
| HR (1) | HRPK20040293B3 (es) |
| HU (1) | HUP0401756A3 (es) |
| IL (1) | IL161059A0 (es) |
| ME (1) | MEP16808A (es) |
| MX (1) | MXPA04002042A (es) |
| MY (1) | MY135339A (es) |
| NO (1) | NO327008B1 (es) |
| NZ (1) | NZ531246A (es) |
| PA (1) | PA8555501A1 (es) |
| PE (1) | PE20030427A1 (es) |
| PL (1) | PL369527A1 (es) |
| PT (1) | PT1432417E (es) |
| RS (1) | RS50896B (es) |
| SI (1) | SI1432417T1 (es) |
| UY (1) | UY27452A1 (es) |
| WO (1) | WO2003028721A2 (es) |
| ZA (1) | ZA200401887B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| CA2542064A1 (en) * | 2003-10-24 | 2005-05-06 | Exelixis, Inc. | Tao kinase modulators and methods of use |
| DE102004010207A1 (de) | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| FR2868421B1 (fr) * | 2004-04-01 | 2008-08-01 | Aventis Pharma Sa | Nouveaux benzothiazoles et leur utilisation comme medicaments |
| EP1598348A1 (en) | 2004-05-18 | 2005-11-23 | Aventis Pharma Deutschland GmbH | Novel pyridazinone derivatives as inhibitors of CDK2 |
| AU2005326962A1 (en) | 2004-12-22 | 2006-08-17 | Bellus Health (International) Limited | Methods and compositions for treating amyloid-related diseases |
| CN101300251B (zh) * | 2005-09-06 | 2011-08-03 | 史密丝克莱恩比彻姆公司 | 作为plk抑制剂的苯并咪唑噻吩化合物 |
| FR2891273B1 (fr) * | 2005-09-27 | 2007-11-23 | Aventis Pharma Sa | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
| ES2533463T3 (es) | 2006-10-12 | 2015-04-10 | Bhi Limited Partnership | Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico |
| PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| PL2722046T3 (pl) * | 2007-10-12 | 2017-06-30 | Abbvie Ireland Unlimited Company | Postać krystaliczna 1 2-((R)-2-metylopirolidyn-2-ylo)-1H-benzoimidazolo-4-karboksyamidu |
| FR2922550B1 (fr) | 2007-10-19 | 2009-11-27 | Sanofi Aventis | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
| FR2941950B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941949B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941952B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941951B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| WO2011091152A1 (en) * | 2010-01-22 | 2011-07-28 | Pablo Gastaminza | Inhibitors of hepatitis c virus infection |
| WO2017035340A1 (en) | 2015-08-25 | 2017-03-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating a proprotein convertase subtilisin kexin (pcsk9) gene-associated disorder |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2441201C2 (de) * | 1974-08-28 | 1986-08-07 | Hoechst Ag, 6230 Frankfurt | Anthelminthisch wirksame 2-Carbalkoxyamino-5(6)-phenyl-sulfonyloxy-benzimidazole und Verfahren zu ihrer Herstellung |
| DE2541752A1 (de) | 1975-09-19 | 1977-03-24 | Hoechst Ag | Anthelminthisch wirksame 2-carbalkoxyamino-5(6)-phenyl-sulfonyloxy- benzimidazole und verfahren zu ihrer herstellung |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB9900752D0 (en) * | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
-
2001
- 2001-09-26 EP EP01402460A patent/EP1298125A1/en not_active Withdrawn
-
2002
- 2002-09-17 PE PE2002000913A patent/PE20030427A1/es not_active Application Discontinuation
- 2002-09-24 UY UY27452A patent/UY27452A1/es unknown
- 2002-09-25 GT GT200200190A patent/GT200200190A/es unknown
- 2002-09-25 MY MYPI20023586A patent/MY135339A/en unknown
- 2002-09-26 AU AU2002337151A patent/AU2002337151B2/en not_active Ceased
- 2002-09-26 SI SI200230686T patent/SI1432417T1/sl unknown
- 2002-09-26 WO PCT/EP2002/011353 patent/WO2003028721A2/en active IP Right Grant
- 2002-09-26 PT PT02772370T patent/PT1432417E/pt unknown
- 2002-09-26 ME MEP-168/08A patent/MEP16808A/xx unknown
- 2002-09-26 NZ NZ531246A patent/NZ531246A/en not_active IP Right Cessation
- 2002-09-26 DK DK02772370T patent/DK1432417T3/da active
- 2002-09-26 JP JP2003532053A patent/JP4510450B2/ja not_active Expired - Fee Related
- 2002-09-26 EA EA200400475A patent/EA006802B1/ru not_active IP Right Cessation
- 2002-09-26 ES ES02772370T patent/ES2301682T3/es not_active Expired - Lifetime
- 2002-09-26 RS YUP-214/04A patent/RS50896B/sr unknown
- 2002-09-26 CA CA002461622A patent/CA2461622C/en not_active Expired - Fee Related
- 2002-09-26 BR BR0212856-0A patent/BR0212856A/pt not_active IP Right Cessation
- 2002-09-26 HU HU0401756A patent/HUP0401756A3/hu unknown
- 2002-09-26 AT AT02772370T patent/ATE386517T1/de active
- 2002-09-26 PA PA20028555501A patent/PA8555501A1/es unknown
- 2002-09-26 MX MXPA04002042A patent/MXPA04002042A/es active IP Right Grant
- 2002-09-26 IL IL16105902A patent/IL161059A0/xx unknown
- 2002-09-26 EP EP02772370A patent/EP1432417B1/en not_active Expired - Lifetime
- 2002-09-26 KR KR1020047004365A patent/KR100891439B1/ko not_active IP Right Cessation
- 2002-09-26 PL PL02369527A patent/PL369527A1/xx not_active Application Discontinuation
- 2002-09-26 AR ARP020103629A patent/AR037096A1/es unknown
- 2002-09-26 DE DE60225159T patent/DE60225159T2/de not_active Expired - Lifetime
- 2002-09-26 CN CNB028187458A patent/CN100346786C/zh not_active Expired - Fee Related
-
2004
- 2004-03-08 ZA ZA200401887A patent/ZA200401887B/en unknown
- 2004-03-23 NO NO20041214A patent/NO327008B1/no not_active IP Right Cessation
- 2004-03-25 US US10/808,889 patent/US7041668B2/en not_active Expired - Fee Related
- 2004-03-25 HR HR20040293A patent/HRPK20040293B3/xx not_active IP Right Cessation
- 2004-03-25 CO CO04028337A patent/CO5570675A2/es not_active Application Discontinuation
-
2005
- 2005-02-07 HK HK05101028A patent/HK1068551A1/xx not_active IP Right Cessation
-
2008
- 2008-05-20 CY CY20081100526T patent/CY1107953T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |