AR045089A1 - "proceso para la preparacion de inhibidores de la cpla2" - Google Patents
"proceso para la preparacion de inhibidores de la cpla2"Info
- Publication number
- AR045089A1 AR045089A1 ARP040102620A ARP040102620A AR045089A1 AR 045089 A1 AR045089 A1 AR 045089A1 AR P040102620 A ARP040102620 A AR P040102620A AR P040102620 A ARP040102620 A AR P040102620A AR 045089 A1 AR045089 A1 AR 045089A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- group
- alkyl
- formula
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un proceso para la preparación de un compuesto de la fórmula (1) en la cual: n es un entero en el rango de 0-10; R1 representa un grupo alquilo C1-10 recto o ramificado o -CH2-fenilo, donde el grupo fenilo tiene optativamente hasta dos sustituyentes independientemente seleccionados del grupo formado por alquilo C1-4, alcoxi C1-4, halógeno y nitrilo, donde cada alquilo y alcoxi está optativamente sustituido con uno al máximo número de átomos de halógeno; cada uno de R2 y R3 es independientemente seleccionado del grupo formado por H, halógeno, nitrilo, alquilo C1-4 y alcoxi C1-4 y R4 representa un grupo alquilo C1-10 recto o ramificado, como se muestra en el grupo de fórmulas (2), donde cada uno de R2a y R3a es independientemente seleccionado del grupo formado por H, halógeno, nitrilo, alquilo C1-4 y alcoxi C1-4 donde dicho proceso comprende: a) la reacción del compuesto R1-SO2Cl con el compuesto HC:::C-(CH2)n-NH2 o una forma de sal del mismo, donde n representa un entero de 0-10, en condiciones alcalinas, para producir el compuesto intermedio de fórmula (3); b) y luego la reacción del compuesto de la fórmula (3) con el compuesto de la fórmula (4).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49000503P | 2003-07-25 | 2003-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045089A1 true AR045089A1 (es) | 2005-10-12 |
Family
ID=34115341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102620A AR045089A1 (es) | 2003-07-25 | 2004-07-23 | "proceso para la preparacion de inhibidores de la cpla2" |
Country Status (14)
Country | Link |
---|---|
US (2) | US6891065B2 (es) |
EP (1) | EP1648861B1 (es) |
JP (1) | JP4607877B2 (es) |
CN (1) | CN100577640C (es) |
AR (1) | AR045089A1 (es) |
AT (1) | ATE432918T1 (es) |
AU (1) | AU2004261567A1 (es) |
BR (1) | BRPI0412904A (es) |
CA (1) | CA2528174C (es) |
DE (1) | DE602004021388D1 (es) |
ES (1) | ES2325265T3 (es) |
MX (1) | MXPA06000406A (es) |
TW (1) | TW200510305A (es) |
WO (1) | WO2005012238A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
TW200510305A (en) | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
US7342119B2 (en) * | 2003-09-30 | 2008-03-11 | Wyeth Holdings Corporation | Process for the synthesis of a CPLA2 inhibitor |
HN2004000536A (es) * | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
AR053410A1 (es) | 2004-08-19 | 2007-05-09 | Wyeth Corp | Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios |
GT200600228A (es) | 2005-05-27 | 2006-12-26 | Inhibidores de la fosfolipasa a2 citosolica | |
KR100746342B1 (ko) | 2006-04-10 | 2007-08-03 | 한국과학기술원 | 구리 촉매 존재하에서 n―설포닐아미드 화합물의 제조방법 |
CN100363341C (zh) * | 2006-05-12 | 2008-01-23 | 北京化工大学 | 旋光性n-炔丙磺酰胺聚合物及其制备方法 |
EP2068829A2 (en) * | 2006-10-31 | 2009-06-17 | Wyeth | Semi-solid formulations of phospholipase enzyme inhibitors |
CL2007003143A1 (es) * | 2006-10-31 | 2008-01-25 | Wyeth Corp | Composicion farmaceutica que comprende un compuesto derivado de indol y un sistema portador que comprende 10-50% de un primer solubilizante, 5-50% de un segundo solubilizante, 10-30% de un primer diluyente y 1-15% de un segundo diluyente; proceso de prepracion; y forma de dosificacion. |
US8113207B2 (en) * | 2008-08-22 | 2012-02-14 | Kimberly-Clark Worldwide, Inc. | Self-conforming sound attenuation earplug |
CN102617558A (zh) * | 2012-03-26 | 2012-08-01 | 上海泛凯生物医药科技有限公司 | 一种维拉佐酮的制备方法 |
CN110437125B (zh) * | 2019-09-06 | 2021-03-12 | 苏州旺山旺水生物医药有限公司 | 一种Tezacaftor中间体II的制备方法 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5461075A (en) | 1988-06-17 | 1995-10-24 | The Procter & Gamble Company | Use of vanilloids for the prevention of lesions due to herpes simplex infections |
US5186736A (en) | 1988-08-02 | 1993-02-16 | Hoechst Aktiengesellschaft | Heterocyclic N-acylsulfonamides and their use as herbicides or growth regulators |
DE3826230A1 (de) | 1988-08-02 | 1990-02-08 | Hoechst Ag | Heterocyclische n-acylsufonamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren |
JPH02115157A (ja) * | 1988-10-24 | 1990-04-27 | Hokko Chem Ind Co Ltd | スルホニルグリシン誘導体および除草剤 |
CA2017383A1 (en) | 1989-06-08 | 1990-12-08 | Raymond R. Martodam | Use of vanilloids for the treatment of respiratory diseases or disorders |
DE3935277A1 (de) | 1989-10-24 | 1991-05-02 | Hoechst Ag | Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren |
GB9201755D0 (en) | 1992-01-28 | 1992-03-11 | British Bio Technology | Compounds |
CA2179292A1 (en) | 1993-12-20 | 1995-06-29 | Roland Andree | N-cyanoaryl nitrogen heterocycles with sulphur-containing groupings |
DE4431218A1 (de) | 1994-09-02 | 1996-03-07 | Bayer Ag | Substituierte Pyrimidin(thi)one |
DE19528305A1 (de) | 1995-08-02 | 1997-02-06 | Bayer Ag | Substituierte Phenyluracile |
DE19601626A1 (de) | 1996-01-18 | 1997-07-24 | Bayer Ag | Substituierte N-Aryl-Stickstoffheterocyclen |
DE19606594A1 (de) | 1996-02-22 | 1997-08-28 | Bayer Ag | Substituierte 2-Aryl-1,2,4-triazin-3,5-di(thi)one |
WO1998008818A1 (en) * | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
ID27280A (id) * | 1998-02-25 | 2001-03-22 | Genetics Inst | Inhibitor-inhibitor dari enzim-enzim fosfolipase |
GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
EP1316548A4 (en) * | 2000-07-05 | 2004-05-19 | Ajinomoto Kk | ACYLSULFONAMIDE DERIVATIVES |
DE10043790A1 (de) | 2000-09-06 | 2002-03-14 | Bayer Ag | Substituierte 1-Aryl-pyridin-2-(thi)one |
EP1339668A2 (en) | 2000-11-28 | 2003-09-03 | Guilford Pharmaceuticals Inc. | Bisubstituted carbocyclic cyclophilin binding compounds and theirus |
US6656971B2 (en) | 2001-01-25 | 2003-12-02 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
US20040242456A1 (en) | 2001-09-06 | 2004-12-02 | Christoph Luthy | Herbicidal n-alkysulfonamino derivatives |
US6797708B2 (en) * | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
KR100973665B1 (ko) * | 2001-12-03 | 2010-08-04 | 와이어쓰 엘엘씨 | 세포질 포스포리파제 a2의 억제제 |
US6635771B2 (en) * | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
TW200510305A (en) | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
US7582771B2 (en) | 2003-09-03 | 2009-09-01 | Wyeth | Process for the synthesis of cPLA2 inhibitors |
US7342119B2 (en) | 2003-09-30 | 2008-03-11 | Wyeth Holdings Corporation | Process for the synthesis of a CPLA2 inhibitor |
HN2004000536A (es) * | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
-
2004
- 2004-06-29 TW TW093119031A patent/TW200510305A/zh unknown
- 2004-07-19 CN CN200480018618A patent/CN100577640C/zh not_active Expired - Fee Related
- 2004-07-19 AU AU2004261567A patent/AU2004261567A1/en not_active Abandoned
- 2004-07-19 ES ES04778654T patent/ES2325265T3/es active Active
- 2004-07-19 WO PCT/US2004/023247 patent/WO2005012238A1/en active Application Filing
- 2004-07-19 JP JP2006521893A patent/JP4607877B2/ja not_active Expired - Fee Related
- 2004-07-19 EP EP04778654A patent/EP1648861B1/en active Active
- 2004-07-19 CA CA2528174A patent/CA2528174C/en active Active
- 2004-07-19 DE DE602004021388T patent/DE602004021388D1/de active Active
- 2004-07-19 MX MXPA06000406A patent/MXPA06000406A/es active IP Right Grant
- 2004-07-19 AT AT04778654T patent/ATE432918T1/de not_active IP Right Cessation
- 2004-07-19 BR BRPI0412904-0A patent/BRPI0412904A/pt not_active IP Right Cessation
- 2004-07-21 US US10/896,318 patent/US6891065B2/en not_active Expired - Fee Related
- 2004-07-23 AR ARP040102620A patent/AR045089A1/es unknown
-
2005
- 2005-03-08 US US11/076,117 patent/US7259277B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7259277B2 (en) | 2007-08-21 |
BRPI0412904A (pt) | 2006-09-26 |
JP4607877B2 (ja) | 2011-01-05 |
ATE432918T1 (de) | 2009-06-15 |
EP1648861A1 (en) | 2006-04-26 |
EP1648861B1 (en) | 2009-06-03 |
US20050020858A1 (en) | 2005-01-27 |
TW200510305A (en) | 2005-03-16 |
AU2004261567A1 (en) | 2005-02-10 |
CN1816522A (zh) | 2006-08-09 |
CA2528174C (en) | 2012-03-13 |
MXPA06000406A (es) | 2006-03-17 |
US6891065B2 (en) | 2005-05-10 |
US20050159613A1 (en) | 2005-07-21 |
CA2528174A1 (en) | 2005-02-10 |
JP2007500190A (ja) | 2007-01-11 |
ES2325265T3 (es) | 2009-08-31 |
DE602004021388D1 (de) | 2009-07-16 |
WO2005012238A1 (en) | 2005-02-10 |
CN100577640C (zh) | 2010-01-06 |
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Legal Events
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