AR082864A2 - Preparacion de compuestos de aminopirimidina - Google Patents

Preparacion de compuestos de aminopirimidina

Info

Publication number
AR082864A2
AR082864A2 ARP110103194A ARP110103194A AR082864A2 AR 082864 A2 AR082864 A2 AR 082864A2 AR P110103194 A ARP110103194 A AR P110103194A AR P110103194 A ARP110103194 A AR P110103194A AR 082864 A2 AR082864 A2 AR 082864A2
Authority
AR
Argentina
Prior art keywords
formula
group
aminopirimidine
compounds
preparation
Prior art date
Application number
ARP110103194A
Other languages
English (en)
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of AR082864A2 publication Critical patent/AR082864A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un método para preparar un compuesto de aminopirimidina que tiene la fórmula (1) donde R es un grupo hidrocarbilo, seleccionado de un grupo alquilo, cicloalquilo, aralquilo o un grupo arilo y cada uno de R1 y R2, independientemente, es un átomo de hidrógeno, un grupo alquilo, alquilsulfonilo, o un grupo arilsulfonilo, que comprende hacer reaccionar un compuesto de pirimidina 2-sustituido que tiene la fórmula (2) donde R es igual que anteriormente, y X es un átomo de halógeno o un grupo sulfoniloxi orgánico, con un compuesto de amina que tiene la fórmula (3) donde cada R1 y R2 es igual que anteriormente, en presencia de una base.
ARP110103194A 2001-07-13 2011-09-01 Preparacion de compuestos de aminopirimidina AR082864A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001213418 2001-07-13
JP2001213417 2001-07-13
JP2001310900 2001-10-09
JP2001360339 2001-11-27
JP2002007015 2002-01-16
JP2002042076 2002-02-19

Publications (1)

Publication Number Publication Date
AR082864A2 true AR082864A2 (es) 2013-01-16

Family

ID=27554967

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP020102617A AR034772A1 (es) 2001-07-13 2002-07-12 Preparacion de los compuestos de aminopirimidina
ARP110103194A AR082864A2 (es) 2001-07-13 2011-09-01 Preparacion de compuestos de aminopirimidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP020102617A AR034772A1 (es) 2001-07-13 2002-07-12 Preparacion de los compuestos de aminopirimidina

Country Status (28)

Country Link
US (4) US7304156B2 (es)
EP (1) EP1417180B1 (es)
JP (2) JP4359141B2 (es)
KR (1) KR100888408B1 (es)
CN (2) CN100349877C (es)
AR (2) AR034772A1 (es)
AT (1) ATE349431T1 (es)
AU (1) AU2002318041B2 (es)
BR (1) BR0211072A (es)
CA (1) CA2453505C (es)
CO (1) CO5560574A2 (es)
CY (1) CY1107551T1 (es)
DE (1) DE60217126T2 (es)
DK (1) DK1417180T3 (es)
EG (1) EG24848A (es)
ES (1) ES2278032T3 (es)
HK (1) HK1064384A1 (es)
HU (1) HUP0401248A3 (es)
IL (2) IL159741A0 (es)
IS (1) IS2399B (es)
MX (1) MXPA04000322A (es)
MY (1) MY133579A (es)
NO (1) NO326173B1 (es)
NZ (1) NZ531033A (es)
PL (1) PL366831A1 (es)
PT (1) PT1417180E (es)
SI (1) SI1417180T1 (es)
WO (1) WO2003006439A1 (es)

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WO2013185309A1 (zh) * 2012-06-13 2013-12-19 上海迪赛诺药业有限公司 瑞舒伐他汀钙及其中间体的制备方法
CN103483269B (zh) * 2012-06-13 2016-04-27 上海迪赛诺药业有限公司 瑞舒伐他汀钙及其中间体的制备方法
CN103864697A (zh) * 2012-12-11 2014-06-18 润泽制药(苏州)有限公司 瑞舒伐中间体主链醇的制备方法
CN104059024B (zh) * 2014-06-16 2016-04-06 浙江大学 瑞舒伐他汀中间体的制备方法及中间体化合物
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CN104817505A (zh) * 2015-04-23 2015-08-05 南京博优康远生物医药科技有限公司 一种制备n-[4-(4-氟苯基)-5-羟甲基-6-异丙基-嘧啶-2-基]-n-甲基甲磺酰胺的方法
CN109912522B (zh) * 2017-12-12 2021-04-13 北京颖泰嘉和生物科技股份有限公司 制备三唑啉硫酮化合物的方法
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KR20040030051A (ko) 2004-04-08
US20080058520A1 (en) 2008-03-06
IS2399B (is) 2008-09-15
US8614320B2 (en) 2013-12-24
US20040176401A1 (en) 2004-09-09
US7816528B2 (en) 2010-10-19
HK1064384A1 (en) 2005-01-28
US20110160455A1 (en) 2011-06-30
US7304156B2 (en) 2007-12-04
MXPA04000322A (es) 2005-09-08
US20120277432A1 (en) 2012-11-01
CN1301977C (zh) 2007-02-28
ATE349431T1 (de) 2007-01-15
CN100349877C (zh) 2007-11-21
US8222412B2 (en) 2012-07-17
DE60217126T2 (de) 2007-10-04
EG24848A (en) 2010-10-27
SI1417180T1 (sl) 2007-04-30
JP4359141B2 (ja) 2009-11-04
BR0211072A (pt) 2004-12-14
AU2002318041B2 (en) 2008-01-03
CA2453505A1 (en) 2003-01-23
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EP1417180A4 (en) 2004-10-27
CN1527821A (zh) 2004-09-08
NO20040122L (no) 2004-01-12
CA2453505C (en) 2011-04-19
CY1107551T1 (el) 2013-03-13
JP2009167167A (ja) 2009-07-30
PL366831A1 (en) 2005-02-07
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PT1417180E (pt) 2007-03-30
EP1417180A1 (en) 2004-05-12
IL159741A (en) 2009-06-15
CN1763016A (zh) 2006-04-26
CO5560574A2 (es) 2005-09-30
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