MEP16808A - Substituted benzimidazole compounds and their use for the treatment of cancer - Google Patents

Substituted benzimidazole compounds and their use for the treatment of cancer

Info

Publication number
MEP16808A
MEP16808A MEP-168/08A MEP16808A MEP16808A ME P16808 A MEP16808 A ME P16808A ME P16808 A MEP16808 A ME P16808A ME P16808 A MEP16808 A ME P16808A
Authority
ME
Montenegro
Prior art keywords
cancer
treatment
benzimidazole compounds
substituted benzimidazole
compounds
Prior art date
Application number
MEP-168/08A
Other languages
Bosnian (bs)
Inventor
Francois Clerc
Francois Hamy
Isabelle Depaty
Angouillant-Boniface
Stephanie Deprets
Manfred Carrez
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of MEP16808A publication Critical patent/MEP16808A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
    • C07D235/32Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nova jedinjenja benzoimidazola i njihova primjena kao inhibitorna jedinjenja ciklin -zavisnih kinaza kao i novi farmaceutski preparati koji sadrže ova jedinjenja.Novel benzoimidazole compounds and their use as inhibitors of cyclin-dependent kinases as well as new pharmaceutical preparations containing these compounds.

MEP-168/08A 2001-09-26 2002-09-26 Substituted benzimidazole compounds and their use for the treatment of cancer MEP16808A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01402460A EP1298125A1 (en) 2001-09-26 2001-09-26 Substituted benzimidazole compounds and their use for the treatment of cancer
YUP-214/04A RS50896B (en) 2001-09-26 2002-09-26 Substituted benzimidazole compounds and their use for the treatment of cancer
PCT/EP2002/011353 WO2003028721A2 (en) 2001-09-26 2002-09-26 Substituted benzimidazole compounds and their use for the treatment of cancer

Publications (1)

Publication Number Publication Date
MEP16808A true MEP16808A (en) 2010-06-10

Family

ID=8182891

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-168/08A MEP16808A (en) 2001-09-26 2002-09-26 Substituted benzimidazole compounds and their use for the treatment of cancer

Country Status (35)

Country Link
US (1) US7041668B2 (en)
EP (2) EP1298125A1 (en)
JP (1) JP4510450B2 (en)
KR (1) KR100891439B1 (en)
CN (1) CN100346786C (en)
AR (1) AR037096A1 (en)
AT (1) ATE386517T1 (en)
AU (1) AU2002337151B2 (en)
BR (1) BR0212856A (en)
CA (1) CA2461622C (en)
CO (1) CO5570675A2 (en)
CY (1) CY1107953T1 (en)
DE (1) DE60225159T2 (en)
DK (1) DK1432417T3 (en)
EA (1) EA006802B1 (en)
ES (1) ES2301682T3 (en)
GT (1) GT200200190A (en)
HK (1) HK1068551A1 (en)
HR (1) HRPK20040293B3 (en)
HU (1) HUP0401756A3 (en)
IL (1) IL161059A0 (en)
ME (1) MEP16808A (en)
MX (1) MXPA04002042A (en)
MY (1) MY135339A (en)
NO (1) NO327008B1 (en)
NZ (1) NZ531246A (en)
PA (1) PA8555501A1 (en)
PE (1) PE20030427A1 (en)
PL (1) PL369527A1 (en)
PT (1) PT1432417E (en)
RS (1) RS50896B (en)
SI (1) SI1432417T1 (en)
UY (1) UY27452A1 (en)
WO (1) WO2003028721A2 (en)
ZA (1) ZA200401887B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
AU2011250847B2 (en) * 2003-06-23 2013-06-20 Bhi Limited Partnership Methods and compositions for treating amyloid-related diseases
US20070208166A1 (en) * 2003-10-24 2007-09-06 Exelixis, Inc. Tao Kinase Modulators And Method Of Use
DE102004010207A1 (en) 2004-03-02 2005-09-15 Aventis Pharma S.A. New 4-benzimidazolyl-3(2H)-pyridazinone derivatives are kinase inhibitors, especially useful for treatment of cancer
FR2868421B1 (en) * 2004-04-01 2008-08-01 Aventis Pharma Sa NOVEL BENZOTHIAZOLES AND THEIR USE AS MEDICAMENTS
EP1598348A1 (en) 2004-05-18 2005-11-23 Aventis Pharma Deutschland GmbH Novel pyridazinone derivatives as inhibitors of CDK2
US8044100B2 (en) 2004-12-22 2011-10-25 Bellus Health Inc. Methods and compositions for treating amyloid-related diseases
UA92180C2 (en) * 2005-09-06 2010-10-11 Смиткляйн Бичам Корпорейшн Benzimidazole thiophene compounds as plk inhibitors
FR2891273B1 (en) * 2005-09-27 2007-11-23 Aventis Pharma Sa NOVEL BENZIMIDAZOLE AND BENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE, IN PARTICULAR AS CMET INHIBITORS
DK2089417T3 (en) 2006-10-12 2015-03-23 Bhi Ltd Partnership Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid
PA8792501A1 (en) 2007-08-09 2009-04-23 Sanofi Aventis NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS.
ES2620299T3 (en) * 2007-10-12 2017-06-28 Abbvie Ireland Unlimited Company Crystalline form 1 of 2 - ((R) -2-methylpyrrolidin-2-yl) -1H-benzimidazol-4-carboxamide
FR2922550B1 (en) 2007-10-19 2009-11-27 Sanofi Aventis NOVEL 6-ARYL / HETEROALKYLOXY BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, APPLICATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS CMET INHIBITORS
FR2941952B1 (en) 2009-02-06 2011-04-01 Sanofi Aventis 6- (6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) DERIVATIVES 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
FR2941950B1 (en) 2009-02-06 2011-04-01 Sanofi Aventis 6- (6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
FR2941949B1 (en) 2009-02-06 2011-04-01 Sanofi Aventis DERIVATIVES OF 6- (6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
FR2941951B1 (en) 2009-02-06 2011-04-01 Sanofi Aventis 6- (6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
WO2011091152A1 (en) * 2010-01-22 2011-07-28 Pablo Gastaminza Inhibitors of hepatitis c virus infection
IL257486B (en) 2015-08-25 2022-07-01 Alnylam Pharmaceuticals Inc Methods and compositions for treating a proprotein convertase subtilisin kexin (pcsk9) gene-associated disorder

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2441201C2 (en) * 1974-08-28 1986-08-07 Hoechst Ag, 6230 Frankfurt 2-Carbalkoxyamino-5 (6) -phenyl-sulfonyloxy-benzimidazoles and process for their preparation
DE2541752A1 (en) 1975-09-19 1977-03-24 Hoechst Ag ANTHELMINTHICALLY ACTIVE 2-CARBALCOXYAMINO-5 (6) -PHENYL-SULFONYLOXY- BENZIMIDAZOLE AND METHOD FOR THEIR PRODUCTION
DE3247615A1 (en) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt SUBSTITUTED PHENYLSULFONYLOXYBENZIMIDAZOLE CARBAMINATES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
GB9900752D0 (en) * 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
US6693125B2 (en) * 2001-01-24 2004-02-17 Combinatorx Incorporated Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders

Also Published As

Publication number Publication date
JP2005504112A (en) 2005-02-10
PA8555501A1 (en) 2003-06-30
CY1107953T1 (en) 2013-09-04
WO2003028721A2 (en) 2003-04-10
YU21404A (en) 2006-08-17
HK1068551A1 (en) 2005-04-29
UY27452A1 (en) 2003-02-28
KR20040048904A (en) 2004-06-10
EP1432417B1 (en) 2008-02-20
DE60225159T2 (en) 2009-02-19
HUP0401756A2 (en) 2005-01-28
PT1432417E (en) 2008-05-23
PE20030427A1 (en) 2003-06-20
PL369527A1 (en) 2005-05-02
ES2301682T3 (en) 2008-07-01
NO20041214L (en) 2004-06-24
EA006802B1 (en) 2006-04-28
CA2461622A1 (en) 2003-04-10
CA2461622C (en) 2008-12-02
DK1432417T3 (en) 2008-06-16
WO2003028721A3 (en) 2003-12-11
US20050014811A1 (en) 2005-01-20
NZ531246A (en) 2006-06-30
HUP0401756A3 (en) 2005-06-28
EP1432417A2 (en) 2004-06-30
SI1432417T1 (en) 2008-08-31
HRP20040293A2 (en) 2005-06-30
AR037096A1 (en) 2004-10-20
RS50896B (en) 2010-08-31
GT200200190A (en) 2003-11-11
EA200400475A1 (en) 2004-08-26
KR100891439B1 (en) 2009-04-03
ZA200401887B (en) 2005-05-31
MY135339A (en) 2008-03-31
CN1558761A (en) 2004-12-29
ATE386517T1 (en) 2008-03-15
HRPK20040293B3 (en) 2007-06-30
IL161059A0 (en) 2004-08-31
US7041668B2 (en) 2006-05-09
NO327008B1 (en) 2009-04-06
CN100346786C (en) 2007-11-07
DE60225159D1 (en) 2008-04-03
CO5570675A2 (en) 2005-10-31
EP1298125A1 (en) 2003-04-02
AU2002337151B2 (en) 2007-04-26
JP4510450B2 (en) 2010-07-21
BR0212856A (en) 2004-09-14
MXPA04002042A (en) 2004-06-07

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