AR037096A1 - Compuestos de benzimidazol sustituido,composicion farmacologica que los comprende y uso de los mismos para la preparacion de una droga - Google Patents
Compuestos de benzimidazol sustituido,composicion farmacologica que los comprende y uso de los mismos para la preparacion de una drogaInfo
- Publication number
- AR037096A1 AR037096A1 ARP020103629A ARP020103629A AR037096A1 AR 037096 A1 AR037096 A1 AR 037096A1 AR P020103629 A ARP020103629 A AR P020103629A AR P020103629 A ARP020103629 A AR P020103629A AR 037096 A1 AR037096 A1 AR 037096A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- optionally substituted
- group
- alkoxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuesto de benzimidazol sustituidos de fórmula (1), donde: A es una entidad arilo o heteroarilo; donde R1 se selecciona entre uno o más grupos similares seleccionados entre: alquilo, eventualmente sustituido por un alcoxi, heteroalquilo, arilo, acilo, derivados de acilo, halógeno; alcoxi eventualmente sustituido por un alquilo, heteroalquilo, arilo, heteroarilo, alcoxialquilo, hidroxialquilo amida o un grupo perfluoroalcoxi o un alquiltio eventualmente sustituido por una amida o un perfluoroalquiltio; arilo o heteroarilo eventualmente sustituido por uno o más grupos alquilo, grupo alcoxi, grupo nitro, grupo ciano, derivado de acilo, grupo perfluoroalcoxi, grupo perfluoroalquilo, grupo heteroarilo, grupo ariloxi; halógeno; 4 NH2; 4 NH alquilo o cicloalquilo eventualmente sustituido con un acilo, un aciloderivado, un hidroxi, un grupo amino, alcoxi, heterociclilo o arilo; 4 N imidazolilo; 3 SO2Me cuando A es fenilo; donde R2 se selecciona entre el grupo que consiste en: CO-alquilo eventualmente sustituido por amino, ácido, derivado ácido, alcoxi, arilo o grupos OH; CO-aralquilo eventualmente sustituido por alcoxi, halógeno, amino, ácido o derivados de ácidos; CO-arilo eventualmente sustituido; CO-alcoxi eventualmente sustituido por arilo; CO-amino, CO-NHR3 CO-NR3R4 donde R3 y R4 se selecciona independientemente entre hidrógeno, alquilo, hidroxialquilo, alcoxialquilo fluoroalquilo, alcinilo, heteroalquilo, alquiheteroalquilo, arilo, aralquilo o en forma combinada entre una cadena alquileno que incluye eventualmente de 1 a 4 heteroátomos; arilo o aralquilo eventualmente sustituido por heterocicloalquilo, alquilo, arilo, alcoxi, amino, fluoroalquilo, derivados de acilo, halógeno; o una sal farmacológicamente aceptable o una prodroga de los mismos. Composición farmacológica que comprende una cantidad terapéuticamente efectiva de un compuesto de la fórmula (1) en combinación con un portador farmacológicamente aceptable. Uso de los compuestos de fórmula (1) para la preparación de una droga. Los compuestos de fórmula (1) actúan como inhibidores de las cinasas dependientes de la ciclina y resultan de utilidad en el tratamiento de patologías surgidas de la proliferación celular o exacerbada por ella.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01402460A EP1298125A1 (en) | 2001-09-26 | 2001-09-26 | Substituted benzimidazole compounds and their use for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037096A1 true AR037096A1 (es) | 2004-10-20 |
Family
ID=8182891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103629A AR037096A1 (es) | 2001-09-26 | 2002-09-26 | Compuestos de benzimidazol sustituido,composicion farmacologica que los comprende y uso de los mismos para la preparacion de una droga |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7041668B2 (es) |
| EP (2) | EP1298125A1 (es) |
| JP (1) | JP4510450B2 (es) |
| KR (1) | KR100891439B1 (es) |
| CN (1) | CN100346786C (es) |
| AR (1) | AR037096A1 (es) |
| AT (1) | ATE386517T1 (es) |
| AU (1) | AU2002337151B2 (es) |
| BR (1) | BR0212856A (es) |
| CA (1) | CA2461622C (es) |
| CO (1) | CO5570675A2 (es) |
| CY (1) | CY1107953T1 (es) |
| DE (1) | DE60225159T2 (es) |
| DK (1) | DK1432417T3 (es) |
| EA (1) | EA006802B1 (es) |
| ES (1) | ES2301682T3 (es) |
| GT (1) | GT200200190A (es) |
| HK (1) | HK1068551A1 (es) |
| HR (1) | HRPK20040293B3 (es) |
| HU (1) | HUP0401756A3 (es) |
| IL (1) | IL161059A0 (es) |
| ME (1) | MEP16808A (es) |
| MX (1) | MXPA04002042A (es) |
| MY (1) | MY135339A (es) |
| NO (1) | NO327008B1 (es) |
| NZ (1) | NZ531246A (es) |
| PA (1) | PA8555501A1 (es) |
| PE (1) | PE20030427A1 (es) |
| PL (1) | PL369527A1 (es) |
| PT (1) | PT1432417E (es) |
| RS (1) | RS50896B (es) |
| SI (1) | SI1432417T1 (es) |
| UY (1) | UY27452A1 (es) |
| WO (1) | WO2003028721A2 (es) |
| ZA (1) | ZA200401887B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| US20070208166A1 (en) * | 2003-10-24 | 2007-09-06 | Exelixis, Inc. | Tao Kinase Modulators And Method Of Use |
| DE102004010207A1 (de) | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| FR2868421B1 (fr) * | 2004-04-01 | 2008-08-01 | Aventis Pharma Sa | Nouveaux benzothiazoles et leur utilisation comme medicaments |
| EP1598348A1 (en) | 2004-05-18 | 2005-11-23 | Aventis Pharma Deutschland GmbH | Novel pyridazinone derivatives as inhibitors of CDK2 |
| US8044100B2 (en) | 2004-12-22 | 2011-10-25 | Bellus Health Inc. | Methods and compositions for treating amyloid-related diseases |
| UA92180C2 (en) * | 2005-09-06 | 2010-10-11 | Смиткляйн Бичам Корпорейшн | Benzimidazole thiophene compounds as plk inhibitors |
| FR2891273B1 (fr) * | 2005-09-27 | 2007-11-23 | Aventis Pharma Sa | NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet |
| DK2089417T3 (en) | 2006-10-12 | 2015-03-23 | Bhi Ltd Partnership | Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid |
| PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| ES2620299T3 (es) * | 2007-10-12 | 2017-06-28 | Abbvie Ireland Unlimited Company | Forma cristalina 1 de 2-((R)-2-metilpirrolidin-2-il)-1H-bencimidazol-4-carboxamida |
| FR2922550B1 (fr) | 2007-10-19 | 2009-11-27 | Sanofi Aventis | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
| FR2941952B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941950B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941949B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941951B1 (fr) | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| WO2011091152A1 (en) * | 2010-01-22 | 2011-07-28 | Pablo Gastaminza | Inhibitors of hepatitis c virus infection |
| IL257486B (en) | 2015-08-25 | 2022-07-01 | Alnylam Pharmaceuticals Inc | Methods and preparations for treating disorders related to the pcsk9 gene |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2441201C2 (de) * | 1974-08-28 | 1986-08-07 | Hoechst Ag, 6230 Frankfurt | Anthelminthisch wirksame 2-Carbalkoxyamino-5(6)-phenyl-sulfonyloxy-benzimidazole und Verfahren zu ihrer Herstellung |
| DE2541752A1 (de) | 1975-09-19 | 1977-03-24 | Hoechst Ag | Anthelminthisch wirksame 2-carbalkoxyamino-5(6)-phenyl-sulfonyloxy- benzimidazole und verfahren zu ihrer herstellung |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB9900752D0 (en) * | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
-
2001
- 2001-09-26 EP EP01402460A patent/EP1298125A1/en not_active Withdrawn
-
2002
- 2002-09-17 PE PE2002000913A patent/PE20030427A1/es not_active Application Discontinuation
- 2002-09-24 UY UY27452A patent/UY27452A1/es unknown
- 2002-09-25 GT GT200200190A patent/GT200200190A/es unknown
- 2002-09-25 MY MYPI20023586A patent/MY135339A/en unknown
- 2002-09-26 DE DE60225159T patent/DE60225159T2/de not_active Expired - Lifetime
- 2002-09-26 DK DK02772370T patent/DK1432417T3/da active
- 2002-09-26 CA CA002461622A patent/CA2461622C/en not_active Expired - Fee Related
- 2002-09-26 BR BR0212856-0A patent/BR0212856A/pt not_active IP Right Cessation
- 2002-09-26 AU AU2002337151A patent/AU2002337151B2/en not_active Ceased
- 2002-09-26 AT AT02772370T patent/ATE386517T1/de active
- 2002-09-26 ME MEP-168/08A patent/MEP16808A/xx unknown
- 2002-09-26 EP EP02772370A patent/EP1432417B1/en not_active Expired - Lifetime
- 2002-09-26 PA PA20028555501A patent/PA8555501A1/es unknown
- 2002-09-26 CN CNB028187458A patent/CN100346786C/zh not_active Expired - Fee Related
- 2002-09-26 WO PCT/EP2002/011353 patent/WO2003028721A2/en active IP Right Grant
- 2002-09-26 HU HU0401756A patent/HUP0401756A3/hu unknown
- 2002-09-26 EA EA200400475A patent/EA006802B1/ru not_active IP Right Cessation
- 2002-09-26 SI SI200230686T patent/SI1432417T1/sl unknown
- 2002-09-26 KR KR1020047004365A patent/KR100891439B1/ko not_active IP Right Cessation
- 2002-09-26 NZ NZ531246A patent/NZ531246A/en not_active IP Right Cessation
- 2002-09-26 MX MXPA04002042A patent/MXPA04002042A/es active IP Right Grant
- 2002-09-26 RS YUP-214/04A patent/RS50896B/sr unknown
- 2002-09-26 IL IL16105902A patent/IL161059A0/xx unknown
- 2002-09-26 PT PT02772370T patent/PT1432417E/pt unknown
- 2002-09-26 AR ARP020103629A patent/AR037096A1/es unknown
- 2002-09-26 JP JP2003532053A patent/JP4510450B2/ja not_active Expired - Fee Related
- 2002-09-26 PL PL02369527A patent/PL369527A1/xx not_active Application Discontinuation
- 2002-09-26 ES ES02772370T patent/ES2301682T3/es not_active Expired - Lifetime
-
2004
- 2004-03-08 ZA ZA200401887A patent/ZA200401887B/en unknown
- 2004-03-23 NO NO20041214A patent/NO327008B1/no not_active IP Right Cessation
- 2004-03-25 CO CO04028337A patent/CO5570675A2/es not_active Application Discontinuation
- 2004-03-25 US US10/808,889 patent/US7041668B2/en not_active Expired - Fee Related
- 2004-03-25 HR HR20040293A patent/HRPK20040293B3/xx not_active IP Right Cessation
-
2005
- 2005-02-07 HK HK05101028A patent/HK1068551A1/xx not_active IP Right Cessation
-
2008
- 2008-05-20 CY CY20081100526T patent/CY1107953T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR037096A1 (es) | Compuestos de benzimidazol sustituido,composicion farmacologica que los comprende y uso de los mismos para la preparacion de una droga | |
| AR048642A1 (es) | Compuestos de metil-aril o heteroaril-amida sustituida utiles como antagonistas del receptor de prostaglandinas e2; composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento | |
| RU2498980C2 (ru) | Новое производное 1,2,3,4-тетрагидрохиноксалина, содержащее в качестве заместителя фенильную группу, имеющую структуру эфира сульфокислоты или амида сульфокислоты, и обладающее связывающей активностью в отношении рецептора глюкокортикоидов | |
| AR053232A1 (es) | Derivados de piridina condensadas, composiciones farmaceuticas que los contienen y su empleo en la fabricacion de agentes terapeuticos antiinflamatorios y para el tratamiento de enfermedades relacionadas con el sistema inmunologico. | |
| PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
| AR055057A1 (es) | Inhibidores heterociclicos de mek, formas cristalinas de los mismos, procesos para su preparacion y metodos de uso de los mismos en composiciones farmaceuticas y medicamentos para el tratamiento de un trastorno hiperproliferativo o de una condicion inflamatoria. | |
| AR072792A1 (es) | DERIVADOS DE PIRROLOPIRIDINILPIRIMIDIN-2-IL-AMINA, PROCEDIMIENTO DE PREPARACIoN Y COMPOSICIONES FARMACEUTICAS | |
| PE20071322A1 (es) | Derivados de 2-morfolinopirimidina como inhibidores de fosfatidinoinositol(pi) 3-quinasa | |
| PE20080404A1 (es) | Derivados bencil-amino-piperidina como inhibidores de cetp | |
| PE20081447A1 (es) | Compuestos y composiciones como inhibidores de la proteina cinasa | |
| AR048641A1 (es) | Compuestos de aril- o heteroarilamida ortosustituidos utiles como antago-nistas del receptor de prostaglandinas e2; composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicame | |
| AR054560A1 (es) | Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
| CL2012000999A1 (es) | Compuestos derivados de pirazoloespirocetona sustituida, inhibidores de acetil-coa carboxilasa; composicion farmaceutica que los comprende; uso para tratar o retrasar la progresion o el inicio de diabetes tipo 2, higado graso no alcoholico (hgna) o la resistencia hepatica a la insulina. | |
| PE20110150A1 (es) | Amidofenoxiindazoles como inhibidores de c-met | |
| PE20100737A1 (es) | Nuevos compuestos | |
| PE20080315A1 (es) | DERIVADOS DE PIRAZOLO-[3,4-d]-PIRIMIDINAS COMO INHIBIDORES DE CINASA PI-3 | |
| AR065937A2 (es) | Compuesto derivado indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de proteina quinasa | |
| PE20030762A1 (es) | Compuestos heterociclicos como antagonistas nk1 | |
| PE20081845A1 (es) | Nuevos derivados de aminopirimidina como inhibidores de plk1 | |
| AR041184A1 (es) | Derivados de benzopiranonas, inhibidores de las cinasas dependientes de ciclinas y su uso | |
| AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
| AR079497A1 (es) | Derivados fenilimidazol que comprenden un enlazante de etinileno como inhibidores de enzima pde10a | |
| CY1107677T1 (el) | Παραγωγα της 1-[indol-3-yl)carbonyl]piperazine | |
| AR054559A1 (es) | Derivados de purina como inhibidores del receptor a2a de adenosina | |
| PE20090880A1 (es) | Compuestos heterociclicos como inhibidores de fosfatidilinositol 3-cinasa |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |