CY1111281T1 - Παραγωγα πουρινης ως ανοσοτροποποιητες - Google Patents

Παραγωγα πουρινης ως ανοσοτροποποιητες

Info

Publication number
CY1111281T1
CY1111281T1 CY20111100214T CY111100214T CY1111281T1 CY 1111281 T1 CY1111281 T1 CY 1111281T1 CY 20111100214 T CY20111100214 T CY 20111100214T CY 111100214 T CY111100214 T CY 111100214T CY 1111281 T1 CY1111281 T1 CY 1111281T1
Authority
CY
Cyprus
Prior art keywords
heterocyclic ring
3alkoxy
het
membered saturated
saturated aliphatic
Prior art date
Application number
CY20111100214T
Other languages
English (en)
Inventor
Linos Lazarides
Stephen Allan Smith
Richard Stocker
Colin Jack Theobald
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CY1111281T1 publication Critical patent/CY1111281T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ενώσεις του τύπου (I): όπου: το R1 είναι C1-8αλκυλαμινο, C1-8αλκοξυ, C3-7κυκλοαλκυλοC1-6αλκυλαμινο, C3-7κυκλοαλκυλοC1-6 αλκοξυ, C1-3αλκοξυC2-3αλκοξυ, ή Ηetb-C1-3αλκοξυ· το Hetb είναι 5- ή 6-μελής κορεσμένος αλειφατικός ετεροκυκλικός δακτύλιος που περιέχει ένα άτομο οξυγόνου· το R2 είναι -(CH2)n-Het· το n είναι ακέραιος με τιμή 1 ως 4· το Het είναι 5- ή 6-μελής κορεσμένος αλειφατικός ετεροκυκλικός δακτύλιος που περιέχει ένα ετεροάτομο οξυγόνου, ο οποίος ετεροκυκλικός δακτύλιος μπορεί να είναι υποκατεστημένος με μια ή δύο C1-4αλκυλο ομάδες· κι άλατα κι επιδιαλυτωμένες μορφές αυτών, είναι επαγωγείς ανθρώπινης ιντερφερόνης και μπορούν να είναι χρήσιμες για τη θεραπεία διαφόρων διαταραχών και ιδιαίτερα μολυσματικών ασθενειών, καρκίνου, κι αλλεργικών ασθενειών κι άλλων φλεγμονωδών καταστάσεων για παράδειγμα αλλεργικής ρινίτιδας κι άσθματος, κι ως ανοσοενισχυτικά εμβολίων.
CY20111100214T 2007-02-19 2011-02-22 Παραγωγα πουρινης ως ανοσοτροποποιητες CY1111281T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89052307P 2007-02-19 2007-02-19
US97231307P 2007-09-14 2007-09-14
US2192108P 2008-01-18 2008-01-18
EP08716859A EP2125792B1 (en) 2007-02-19 2008-02-15 Purine derivatives as immunomodulators

Publications (1)

Publication Number Publication Date
CY1111281T1 true CY1111281T1 (el) 2015-08-05

Family

ID=39473324

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100214T CY1111281T1 (el) 2007-02-19 2011-02-22 Παραγωγα πουρινης ως ανοσοτροποποιητες

Country Status (15)

Country Link
US (4) US7977344B2 (el)
EP (1) EP2125792B1 (el)
JP (1) JP2010519186A (el)
AR (1) AR065372A1 (el)
AT (1) ATE490249T1 (el)
CL (1) CL2008000496A1 (el)
CY (1) CY1111281T1 (el)
DE (1) DE602008003764D1 (el)
DK (1) DK2125792T3 (el)
HR (1) HRP20110115T1 (el)
PL (1) PL2125792T3 (el)
PT (1) PT2125792E (el)
SI (1) SI2125792T1 (el)
TW (1) TW200843779A (el)
WO (1) WO2008101867A1 (el)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0509258A8 (pt) * 2004-03-26 2019-01-22 Astrazeneca Ab composto de 8-oxoadenina 9-substituída
WO2007034817A1 (ja) * 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
US7989459B2 (en) * 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
US20090281075A1 (en) * 2006-02-17 2009-11-12 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
WO2008004948A1 (en) * 2006-07-05 2008-01-10 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of tlr7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
TW200843779A (en) * 2007-02-19 2008-11-16 Smithkline Beecham Corp Compounds
ATE530549T1 (de) * 2007-03-19 2011-11-15 Astrazeneca Ab 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7)
US8067413B2 (en) * 2007-03-19 2011-11-29 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators
AR065784A1 (es) * 2007-03-20 2009-07-01 Dainippon Sumitomo Pharma Co Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
WO2008114819A1 (ja) * 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
EP2155743B1 (en) * 2007-05-08 2012-08-29 AstraZeneca AB Imidazoquinolines with immuno-modulating properties
PT2170888E (pt) * 2007-06-29 2015-08-21 Gilead Sciences Inc Purina derivados e sua utilização como moduladores de recetor de tipo toll 7
UY31531A1 (es) 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
JPWO2009091031A1 (ja) * 2008-01-17 2011-05-26 大日本住友製薬株式会社 アデニン化合物の製造方法
EP2246353A4 (en) 2008-01-17 2011-04-20 Dainippon Sumitomo Pharma Co PROCESS FOR PREPARING AN ADENINE COMPOUND
US8802684B2 (en) 2008-08-11 2014-08-12 Glaxosmithkline Llc Adenine derivatives
PT2320905T (pt) * 2008-08-11 2017-09-19 Glaxosmithkline Llc Novos derivados de adenina
WO2010018132A1 (en) * 2008-08-11 2010-02-18 Smithkline Beecham Corporation Compounds
WO2010018130A1 (en) * 2008-08-11 2010-02-18 Smithkline Beecham Corporation Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
JP2011530562A (ja) * 2008-08-11 2011-12-22 グラクソスミスクライン エルエルシー アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
CN102272134B (zh) 2008-12-09 2013-10-16 吉里德科学公司 Toll样受体调节剂
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
AU2010234241A1 (en) 2009-04-09 2011-09-08 Boehringer Ingelheim International Gmbh Inhibitors of HIV replication
MX2012002723A (es) 2009-09-02 2012-04-11 Novartis Ag Composiciones inmunogenicas que incluyen moduladores de la actividad de receptores tipo toll.
AU2010292102B2 (en) 2009-09-14 2015-04-09 Gilead Sciences, Inc. Modulators of Toll-like receptors
WO2011049825A1 (en) 2009-10-22 2011-04-28 Gilead Sciences, Inc. Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
WO2011068233A1 (en) * 2009-12-03 2011-06-09 Dainippon Sumitomo Pharma Co., Ltd. Imidazoquinolines which act via toll - like receptors (tlr)
US20110150836A1 (en) * 2009-12-22 2011-06-23 Gilead Sciences, Inc. Methods of treating hbv and hcv infection
US8575340B2 (en) 2010-02-10 2013-11-05 Glaxosmithkline Llc Purine derivatives and their pharmaceutical uses
CN102753553B (zh) 2010-02-10 2016-03-30 葛兰素史密丝克莱恩有限责任公司 6-氨基-2-{[(1s)-1-甲基丁基]氧基}-9-[5-(1-哌啶基)-7,9-二氢-8h-嘌呤-8-酮马来酸盐
US9050319B2 (en) 2010-04-30 2015-06-09 Telormedix, Sa Phospholipid drug analogs
US9173935B2 (en) 2010-04-30 2015-11-03 Telormedix Sa Phospholipid drug analogs
GB201012410D0 (en) 2010-07-23 2010-09-08 Medical Res Council Intracellular immunity
US20120177681A1 (en) 2010-09-01 2012-07-12 Manmohan Singh Formulation of immunopotentiators
ES2575688T3 (es) 2010-12-16 2016-06-30 Sumitomo Dainippon Pharma Co., Ltd. Derivado de imidazo[4,5-c]quinolin-1-ilo útil en terapia
JP5978226B2 (ja) 2010-12-17 2016-08-24 大日本住友製薬株式会社 プリン誘導体
RU2013144207A (ru) 2011-03-02 2015-04-10 Новартис Аг Комбинированные вакцины с пониженными дозами антигена и/или адъюванта
WO2012152741A1 (de) 2011-05-10 2012-11-15 Bayer Intellectual Property Gmbh Bicyclische (thio)carbonylamidine
LT2734186T (lt) 2011-07-22 2018-12-10 Glaxosmithkline Llc Kompozicija
KR20140066212A (ko) 2011-09-01 2014-05-30 노파르티스 아게 스타필로코쿠스 아우레우스 항원의 보조제 첨가된 조제물
WO2013131983A1 (en) 2012-03-07 2013-09-12 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
EP2822589A1 (en) 2012-03-07 2015-01-14 Novartis AG Adjuvanted formulations of rabies virus immunogens
JP6345603B2 (ja) 2012-03-08 2018-06-20 ノバルティス アーゲー 追加免疫ワクチンのアジュバント化された処方物
UY34987A (es) 2012-08-24 2014-03-31 Glaxosmithkline Llc ?nuevos compuestos inductores del interferón humano para el tratamiento de diversos trastornos?
JP6324961B2 (ja) 2012-09-06 2018-05-16 ノバルティス アーゲー 血清群ｂ髄膜炎菌とｄ／ｔ／ｐとの組み合わせワクチン
US9550785B2 (en) 2012-11-20 2017-01-24 Glaxosmithkline Llc Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
RS56233B1 (sr) 2012-11-20 2017-11-30 Glaxosmithkline Llc Nova jedinjenja
ES2625023T3 (es) 2012-11-20 2017-07-18 Glaxosmithkline Llc Compuestos novedosos
CN105189561B (zh) 2013-03-14 2021-02-26 宏观基因有限公司 与表达激活受体的免疫效应细胞和由被病毒感染的细胞表达的抗原具有免疫反应性的双特异性分子及其用途
AU2015287773B2 (en) 2014-07-11 2018-03-29 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of HIV
CN115043840A (zh) 2014-09-16 2022-09-13 吉利德科学公司 制备toll样受体调节剂的方法
CN106715431A (zh) 2014-09-16 2017-05-24 吉利德科学公司 Toll样受体调节剂的固体形式
MX2017004076A (es) 2014-09-29 2017-07-04 Univ Duke Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1.
JP2017533925A (ja) * 2014-11-13 2017-11-16 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム アレルギー性疾患又は他の炎症状態の治療に有用なアデニン誘導体
WO2017219931A1 (zh) * 2016-06-22 2017-12-28 四川科伦博泰生物医药股份有限公司 二氢蝶啶酮类衍生物、其制备方法及其用途
AR110963A1 (es) 2017-02-07 2019-05-22 Dae Woong Pharma Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende
CA3057813A1 (en) 2017-03-29 2018-10-04 Sumitomo Dainippon Pharma Co., Ltd. Vaccine adjuvant formulation
WO2019124500A1 (ja) 2017-12-21 2019-06-27 大日本住友製薬株式会社 Ｔｌｒ７アゴニストを含む併用薬
WO2020022272A1 (ja) 2018-07-23 2020-01-30 公益財団法人ヒューマンサイエンス振興財団 インフルエンザワクチンを含む組成物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
US7067664B1 (en) * 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
TW572758B (en) * 1997-12-22 2004-01-21 Sumitomo Pharma Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
CZ27399A3 (cs) * 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
AU3540101A (en) * 2000-01-07 2001-07-16 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
ES2387388T3 (es) 2002-09-27 2012-09-21 Dainippon Sumitomo Pharma Co., Ltd. Compuesto de adenina y uso del mismo
EP1646614A4 (en) * 2003-07-01 2008-09-10 Merck & Co Inc OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA
GEP20084545B (en) * 2003-09-05 2008-11-25 Anadys Pharmaceuticals Inc Introducing tlr7 ligands and prodrugs thereof for the treatment of hepatitis c viral infection
BRPI0509258A8 (pt) * 2004-03-26 2019-01-22 Astrazeneca Ab composto de 8-oxoadenina 9-substituída
US20060029642A1 (en) * 2004-08-03 2006-02-09 Dusan Miljkovic Methods and compositions for improved chromium complexes
MX2007013780A (es) * 2005-05-04 2008-02-05 Pfizer Ltd Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c.
EP1931352B1 (en) * 2005-08-22 2016-04-13 The Regents of The University of California Tlr agonists
JP4584335B2 (ja) 2005-09-02 2010-11-17 ファイザー・インク ヒドロキシ置換１ｈ−イミダゾピリジンおよび方法
TW200801003A (en) * 2005-09-16 2008-01-01 Astrazeneca Ab Novel compounds
US20080269240A1 (en) * 2005-09-22 2008-10-30 Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan Novel Adenine Compound
JPWO2007034916A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規アデニン化合物
JPWO2007034881A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規アデニン化合物
TW200745114A (en) * 2005-09-22 2007-12-16 Astrazeneca Ab Novel compounds
WO2007034917A1 (ja) * 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規なアデニン化合物
WO2007034817A1 (ja) * 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
CN1947717B (zh) 2005-10-14 2012-09-26 卓敏 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用
AU2007216247A1 (en) * 2006-02-17 2007-08-23 Pfizer Limited 3 -deazapurine derivatives as TLR7 modulators
WO2008004948A1 (en) * 2006-07-05 2008-01-10 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of tlr7
AU2007269557B2 (en) * 2006-07-07 2013-11-07 Gilead Sciences, Inc. Modulators of toll-like receptor 7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
TW200843779A (en) * 2007-02-19 2008-11-16 Smithkline Beecham Corp Compounds
ATE530549T1 (de) * 2007-03-19 2011-11-15 Astrazeneca Ab 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7)
US8067413B2 (en) * 2007-03-19 2011-11-29 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators
AR065784A1 (es) * 2007-03-20 2009-07-01 Dainippon Sumitomo Pharma Co Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
WO2008114819A1 (ja) * 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
PT2170888E (pt) * 2007-06-29 2015-08-21 Gilead Sciences Inc Purina derivados e sua utilização como moduladores de recetor de tipo toll 7
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
JP2011530562A (ja) * 2008-08-11 2011-12-22 グラクソスミスクライン エルエルシー アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体
PT2320905T (pt) * 2008-08-11 2017-09-19 Glaxosmithkline Llc Novos derivados de adenina
WO2010018132A1 (en) * 2008-08-11 2010-02-18 Smithkline Beecham Corporation Compounds
UA103195C2 (uk) * 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
WO2010018130A1 (en) * 2008-08-11 2010-02-18 Smithkline Beecham Corporation Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases

Also Published As

Publication number Publication date
EP2125792B1 (en) 2010-12-01
WO2008101867A1 (en) 2008-08-28
SI2125792T1 (sl) 2011-03-31
ATE490249T1 (de) 2010-12-15
US20120283438A1 (en) 2012-11-08
PL2125792T3 (pl) 2011-05-31
DK2125792T3 (da) 2011-03-07
HRP20110115T1 (hr) 2011-03-31
PT2125792E (pt) 2011-03-01
EP2125792A1 (en) 2009-12-02
DE602008003764D1 (de) 2011-01-13
US20100120799A1 (en) 2010-05-13
US7977344B2 (en) 2011-07-12
CL2008000496A1 (es) 2008-09-22
TW200843779A (en) 2008-11-16
AR065372A1 (es) 2009-06-03
JP2010519186A (ja) 2010-06-03
US20110269781A1 (en) 2011-11-03
US20090131458A1 (en) 2009-05-21

Similar Documents

Publication Publication Date Title
CY1111281T1 (el) Παραγωγα πουρινης ως ανοσοτροποποιητες
CY1119992T1 (el) Παραγωγα πουρινης για χρηση στη θεραπευτικη αγωγη αλλεργικων, φλεγμονωδων και λοιμωδων ασθενειων
CY1119368T1 (el) Νεα παραγωγα αδενινης
EA201100114A1 (ru) Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний
CY1124222T1 (el) Ενωσεις πυριδινονης-πυριδινυλιου υποκατεστημενες με μεθυλο/φθορο-πυριδινυλο-μεθοξυ και ενωσεις πυριδινονης-πυριδινυλιου υποκατεστημενες με φθορο-πυριδινυλο-μεθοξυ
CY1119557T1 (el) Νεες ενωσεις
CY1120238T1 (el) Κρυσταλλικες μορφες αναστολεα παραγοντα χια
CY1106881T1 (el) (3-οξο-3,4-διυδρο-κινοξαλιν-2-υλο-αμινο) - βενζαμιδικα παραγωγα και σχετικες ενωσεις ως αναστολεις της φωσφορυλασης γλυκογονου για την αντιμετωπιση του διαβητη και της παχυσαρκιας.
CY1114141T1 (el) Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτητα
CY1116298T1 (el) Ενωσεις 3,4-διυποκατεστημενου 1η-πυραζολιου και χρηση αυτων ως ρυθμιστες κινασων που εξαρτωνται απο κυκλινη (cdk) και κινασης-3 συνθασης γλυκογονου (gsk-3)
PE20061436A1 (es) Derivados de amida sustituida como inhibidores de proteina quinasa
CY1117197T1 (el) Ενωσεις τριαζολοπυριδινης ως αναστολεις της κινασης ριμ
HRP20231048T1 (hr) Derivati bipirazola kao jak inhibitori
JP2009532453A5 (el)
CY1110419T1 (el) Τρικυκλικες ενωσεις με βαση το 1,6-διυδρο-1,3,5,6-tetpaaza-as-ινδακενιο και φαρμακευτικες συνθεσεις που τις περιεχουν ως αναστολεις της ενζυμικης ενεργοτητας της ικκ
NO20090595L (no) Ny pyridazinforbindelse og anvendelse derav
CY1110363T1 (el) Παραγωγα (1-4-πιπεριδινυλ)βενζιμιδαζολιου χρησιμα σαν ανταγωνιστες η3 ισταμινης
EA201590189A1 (ru) Пиразолопиримидиновые соединения
RU2008112691A (ru) Азотсодержащее гетероциклическое соединение и его фармацевтическое применение
CY1123285T1 (el) Ενωσεις 6-αρυλ-4-(μορφολιν-4-υλ)-1η-πυριδιν-2-ονης χρησιμες για τη θεραπεια καρκινου και διαβητη
AR107738A1 (es) Amidas de ácido n-(5-halógen-1,3,4-oxadiazol-2-il)arilcarboxílico y su uso como herbicidas
CY1119289T1 (el) Παραγωγα 1,3-διυδρο-2η-βενζιμιδαζολ-2-ονης υποκατεστημενα με ετεροκυκλικους δακτυλιους ως αντι-ιικοι παραγοντες αναπνευστικου συγκυτιακου ιου
PE20070212A1 (es) Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen
AR066063A1 (es) Derivados de triazol que son antagonistas de smo
EA201170237A1 (ru) Производные карбаматов алкилтиазолов, их получение и их применение в терапии