CY1119368T1 - Νεα παραγωγα αδενινης - Google Patents
Νεα παραγωγα αδενινηςInfo
- Publication number
- CY1119368T1 CY1119368T1 CY20171100953T CY171100953T CY1119368T1 CY 1119368 T1 CY1119368 T1 CY 1119368T1 CY 20171100953 T CY20171100953 T CY 20171100953T CY 171100953 T CY171100953 T CY 171100953T CY 1119368 T1 CY1119368 T1 CY 1119368T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- adenin
- producers
- new
- het
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Ενώσεις του τύπου (I) όπου R1 είναι C1-6αλκυλάμινο ή C1-6αλκόξυ· R2 είναι ομάδα που έχει τη σύνταξη (II): n είναι ακέραιος που έχει τιμή 1 έως 6· Het είναι 6-μελής κορεσμένος ετερόκυκλος που περιέχει ένα άτομο αζώτου όπου Het συνδέεται προς την -(CH2)n- χαρακτηριστική ομάδα σε οποιοδήποτε άτομο άνθρακα του ετερόκυκλου· R3 είναι υδρογόνο, C1-8αλκύλ ή C3-7κυκλοαλκυλC0-6αλκύλ· και άλατα αυτών είναι διεγέρτες ανθρώπινης ιντερφερόνης. Ενώσεις οι οποίες διεγείρουν ανθρώπινη ιντερφερόνη μπορεί να είναι χρήσιμες στη θεραπεία διαφόρων διαταραχών, για παράδειγμα στη θεραπεία αλλεργικών ασθενειών και άλλων φλεγμονωδών καταστάσεων, για παράδειγμα αλλεργικής ρινίτιδας και άσθματος, τη θεραπεία μολυσματωδών ασθενειών και καρκίνου και μπορεί επίσης να είναι χρήσιμες ως ανοσοενισχυτικά εμβολίου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8777308P | 2008-08-11 | 2008-08-11 | |
PCT/EP2009/060267 WO2010018134A1 (en) | 2008-08-11 | 2009-08-07 | Novel adenine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119368T1 true CY1119368T1 (el) | 2018-02-14 |
Family
ID=41152355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100953T CY1119368T1 (el) | 2008-08-11 | 2017-09-08 | Νεα παραγωγα αδενινης |
Country Status (23)
Country | Link |
---|---|
US (1) | US8563717B2 (el) |
EP (2) | EP2320905B1 (el) |
JP (2) | JP5785078B2 (el) |
KR (2) | KR101616396B1 (el) |
CN (2) | CN102176911B (el) |
AU (1) | AU2009281198B2 (el) |
BR (1) | BRPI0917013A2 (el) |
CA (1) | CA2733750C (el) |
CY (1) | CY1119368T1 (el) |
DK (1) | DK2320905T3 (el) |
EA (1) | EA019204B1 (el) |
ES (1) | ES2640535T3 (el) |
HR (1) | HRP20171398T1 (el) |
HU (1) | HUE033645T2 (el) |
IL (1) | IL210855A (el) |
LT (1) | LT2320905T (el) |
MX (1) | MX2011001663A (el) |
PL (1) | PL2320905T3 (el) |
PT (1) | PT2320905T (el) |
SG (1) | SG193149A1 (el) |
SI (1) | SI2320905T1 (el) |
WO (1) | WO2010018134A1 (el) |
ZA (1) | ZA201101104B (el) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ539064A (en) * | 2002-09-27 | 2007-09-28 | Dainippon Sumitomo Pharma Co | Novel adenine compound and use thereof |
RU2397171C2 (ru) | 2004-03-26 | 2010-08-20 | ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. | 9-замещенное производное 8-оксоаденина и лекарственное средство |
WO2008004948A1 (en) * | 2006-07-05 | 2008-01-10 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of tlr7 |
TW200831105A (en) * | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
AR065372A1 (es) * | 2007-02-19 | 2009-06-03 | Smithkline Beecham Corp | Derivados de purina |
SI2132209T1 (sl) * | 2007-03-19 | 2014-05-30 | Astrazeneca Ab | Spojine 9-substituiranega-8-okso-adenina, kot modulatorji Toll-like receptorja (TLR7) |
EP2139894B1 (en) * | 2007-03-19 | 2011-10-26 | AstraZeneca AB | 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators |
JPWO2008114819A1 (ja) * | 2007-03-20 | 2010-07-08 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
AR065784A1 (es) * | 2007-03-20 | 2009-07-01 | Dainippon Sumitomo Pharma Co | Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas. |
AR067182A1 (es) * | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Moduladores del receptor 7 tipo toll |
EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
US8802684B2 (en) * | 2008-08-11 | 2014-08-12 | Glaxosmithkline Llc | Adenine derivatives |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
US8575181B2 (en) | 2008-08-11 | 2013-11-05 | Glaxosmithkline Llc | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
ES2640535T3 (es) * | 2008-08-11 | 2017-11-03 | Glaxosmithkline Llc | Derivados novedosos de adenina |
WO2010054083A2 (en) * | 2008-11-05 | 2010-05-14 | Pharmacaribe | Inhalation formulation for treating and prophylatic use in bacteria, mycobacterial and fungal respiratory infections |
ES2467108T3 (es) | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
IN2012DN02984A (el) | 2009-10-22 | 2015-07-31 | Gilead Sciences Inc | |
WO2011098451A1 (en) | 2010-02-10 | 2011-08-18 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
CA2841361A1 (en) | 2011-07-22 | 2013-01-31 | Glaxosmithkline Llc | Composition for the treatment of allergic diseases and inflammatory conditions |
GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
SG11201500787YA (en) | 2012-08-24 | 2015-03-30 | Glaxosmithkline Llc | Pyrazolopyrimidine compounds |
US9550785B2 (en) | 2012-11-20 | 2017-01-24 | Glaxosmithkline Llc | Pyrrolopyrimidines as therapeutic agents for the treatment of diseases |
SI2922549T1 (sl) | 2012-11-20 | 2017-10-30 | Glaxosmithkline Llc Corporation Service Company | Nove spojine |
ES2625023T3 (es) | 2012-11-20 | 2017-07-18 | Glaxosmithkline Llc | Compuestos novedosos |
EA201790024A1 (ru) | 2014-07-11 | 2017-07-31 | Джилид Сайэнс, Инк. | Модуляторы toll-подобных рецепторов для лечения вич |
EA201790369A1 (ru) | 2014-09-16 | 2017-10-31 | Джилид Сайэнс, Инк. | Твердые формы модулятора толл-подобного рецептора |
CN107108628A (zh) * | 2014-11-13 | 2017-08-29 | 葛兰素史密丝克莱恩生物有限公司 | 可用于治疗变应性疾病或其它炎性病症的腺嘌呤衍生物 |
WO2016142880A1 (en) | 2015-03-10 | 2016-09-15 | Glaxosmithkline Biologicals Sa | Compositions and uses |
WO2017021912A1 (en) | 2015-08-06 | 2017-02-09 | Glaxosmithkline Intellectual Property Development Limited | Combined tlrs modulators with anti ox40 antibodies |
TW201802093A (zh) * | 2016-06-02 | 2018-01-16 | 西建公司 | 動物及人類抗錐蟲及抗利什曼原蟲藥劑 |
JP6744622B2 (ja) * | 2016-06-16 | 2020-08-19 | 学校法人上智学院 | ピペリジン化合物の製造方法 |
AR110963A1 (es) * | 2017-02-07 | 2019-05-22 | Dae Woong Pharma | Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende |
JP7169968B2 (ja) | 2017-03-29 | 2022-11-11 | 住友ファーマ株式会社 | ワクチンアジュバント製剤 |
US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
CA3085424A1 (en) | 2017-12-21 | 2019-06-27 | Sumitomo Dainippon Pharma Co., Ltd. | Combination drug including tlr7 agonist |
US20210371440A1 (en) | 2018-04-13 | 2021-12-02 | Glaxosmithkline Biologicals Sa | Tlr7 and / or tlr8 agonists |
US20210353737A1 (en) | 2018-07-23 | 2021-11-18 | Japan As Represented By Director General Of National Institute Of Infectious Diseases | Composition containing influenza vaccine |
EP4232094A1 (en) | 2020-10-21 | 2023-08-30 | Univerza V Ljubljani | Conjugated tlr7 and nod2 agonists |
AU2022274469A1 (en) * | 2021-05-13 | 2023-09-21 | Daewoong Pharmaceutical Co., Ltd. | Pharmaceutical composition for prevention or treatment of fibrosis |
AU2022272111A1 (en) * | 2021-05-13 | 2023-09-21 | Daewoong Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing or treating fibrosis |
KR20230092630A (ko) * | 2021-12-17 | 2023-06-26 | 주식회사 대웅제약 | (2R, 3S)-2-(벤조[d]이미다졸일프로필)피페리딘-3-올 유도체의 제조 방법 |
WO2023113540A1 (ko) * | 2021-12-17 | 2023-06-22 | 주식회사 대웅제약 | (2r, 3s)-2-(3-(4,5-디클로로-1h-벤조[d]이미다졸-1-일)프로필)피페리딘-3-올의 신규한 산부가염 및 결정형 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU679511B2 (en) | 1993-03-17 | 1997-07-03 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid |
TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
US6403599B1 (en) | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
TW572758B (en) | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
CA2310896A1 (en) | 1999-07-02 | 2001-01-02 | Japan Tobacco Inc. | Hcv polymerase suitable for crystal structure analysis and method for using the enzyme |
CZ20013424A3 (cs) | 1999-12-27 | 2002-02-13 | Japan Tobacco Inc. | Sloučeniny s fúzovanými kruhy a jejich pouľití jako léčiva |
CA2396276A1 (en) | 2000-01-07 | 2001-07-12 | Universitaire Instelling Antwerpen | Purine derivatives, process for their preparation and use thereof |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US6310224B1 (en) | 2001-01-19 | 2001-10-30 | Arco Chemical Technology, L.P. | Epoxidation catalyst and process |
PL207405B1 (pl) | 2001-01-22 | 2010-12-31 | Isis Pharmaceuticals Inc | Pochodne nukleozydów, zawierająca je kompozycja farmaceutyczna i ich zastosowanie |
KR20030093248A (ko) | 2001-03-19 | 2003-12-06 | 오노 야꾸힝 고교 가부시키가이샤 | 트리아자스피로[5.5]운데칸 유도체를 유효성분으로서함유하는 약제 |
GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
US6841566B2 (en) | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
EP1497469A4 (en) | 2002-04-04 | 2005-06-08 | Achillion Pharmaceuticals Inc | TEST FOR ASSESSING THE ACTIVITY OF COMPOUNDS AGAINST HCV USING A NOVEL DETECTION SYSTEM IN THE HCV REPLICIC |
DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
ATE418554T1 (de) | 2002-10-24 | 2009-01-15 | Glaxo Group Ltd | 1-acyl-pyrrolidin-derivate für die behandlung von viralen infektionen |
ES2309400T3 (es) | 2002-12-13 | 2008-12-16 | Smithkline Beecham Corporation | Compuestos de pirrolidina y azetidina como antagonistas de ccr5. |
US7589207B2 (en) | 2002-12-13 | 2009-09-15 | Smithkline Beecham Corporation | Cyclohexyl compounds as CCR5 antagonists |
US7645771B2 (en) | 2002-12-13 | 2010-01-12 | Smithkline Beecham Corp. | CCR5 antagonists as therapeutic agents |
US7569579B2 (en) | 2002-12-13 | 2009-08-04 | Smithkline Beecham Corporation | Cyclopropyl compounds as ccr5 antagonists |
AU2003300952A1 (en) | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Indane compounds as ccr5 antagonists |
EP1569931B1 (en) | 2002-12-13 | 2008-10-08 | Smithkline Beecham Corporation | Heterocyclic compounds as ccr5 antagonists |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
JP2007521296A (ja) | 2003-07-01 | 2007-08-02 | メルク エンド カムパニー インコーポレーテッド | 高眼圧の治療のための眼科用組成物 |
WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
WO2005020892A2 (en) | 2003-08-08 | 2005-03-10 | Mitochroma Research, Inc. | Pharmaceutical compositions and methods for metabolic modulation |
DE602004026891D1 (de) | 2003-09-05 | 2010-06-10 | Anadys Pharmaceuticals Inc | Tlr7-liganden zur behandlung von hepatitis c |
PT1699512E (pt) | 2003-11-03 | 2012-09-11 | Glaxo Group Ltd | Dispositivo distribuidor de fluido |
RS52931B (en) | 2004-02-20 | 2014-02-28 | Boehringer Ingelheim International Gmbh | VIRAL POLYMERASE INHIBITORS |
AU2005238270A1 (en) | 2004-04-28 | 2005-11-10 | Arrow Therapeutics Limited | Morpholinylanilinoquinazo- line derivatives for use as antiviral agents |
US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
CN101538268B (zh) | 2004-08-18 | 2011-07-27 | 辉瑞有限公司 | C型肝炎病毒rna依赖型rna聚合酶的抑制剂、以及使用该抑制剂的组合物和治疗剂 |
WO2006026394A2 (en) | 2004-08-27 | 2006-03-09 | 3M Innovative Properties Company | Method of eliciting an immune response against hiv |
GB0423673D0 (en) | 2004-10-25 | 2004-11-24 | Glaxo Group Ltd | Compounds |
JP2008540396A (ja) | 2005-05-04 | 2008-11-20 | ファイザー・リミテッド | 癌およびc型肝炎などのウイルス感染を治療するためのトール様受容体調節薬としての2−アミド−6−アミノ−8−オキソプリン誘導体 |
NZ563866A (en) | 2005-05-09 | 2011-03-31 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use |
AU2006287157A1 (en) | 2005-09-02 | 2007-03-08 | Pfizer Inc. | Hydroxy substituted 1H-imidazopyridines and methods |
TW200745114A (en) * | 2005-09-22 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
WO2007034882A1 (ja) * | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | 新規アデニン化合物 |
WO2007034881A1 (ja) * | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | 新規アデニン化合物 |
CN1947717B (zh) | 2005-10-14 | 2012-09-26 | 卓敏 | 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用 |
KR20080085232A (ko) | 2006-02-17 | 2008-09-23 | 화이자 리미티드 | Tlr7 조절제로서 3-데아자퓨린 유도체 |
GB0610666D0 (en) | 2006-05-30 | 2006-07-05 | Glaxo Group Ltd | Fluid dispenser |
WO2007142755A2 (en) * | 2006-05-31 | 2007-12-13 | The Regents Of The University Of California | Purine analogs |
AR065372A1 (es) * | 2007-02-19 | 2009-06-03 | Smithkline Beecham Corp | Derivados de purina |
SI2132209T1 (sl) * | 2007-03-19 | 2014-05-30 | Astrazeneca Ab | Spojine 9-substituiranega-8-okso-adenina, kot modulatorji Toll-like receptorja (TLR7) |
JPWO2008114819A1 (ja) * | 2007-03-20 | 2010-07-08 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
CA2733743A1 (en) | 2008-08-11 | 2010-02-18 | Glaxosmithkline Llc | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
ES2640535T3 (es) * | 2008-08-11 | 2017-11-03 | Glaxosmithkline Llc | Derivados novedosos de adenina |
WO2010018132A1 (en) | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Compounds |
US8575181B2 (en) | 2008-08-11 | 2013-11-05 | Glaxosmithkline Llc | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
JP5759992B2 (ja) * | 2009-08-07 | 2015-08-05 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 脂質付加オキソアデニン誘導体 |
WO2011098451A1 (en) * | 2010-02-10 | 2011-08-18 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
-
2009
- 2009-08-07 ES ES09781608.6T patent/ES2640535T3/es active Active
- 2009-08-07 WO PCT/EP2009/060267 patent/WO2010018134A1/en active Application Filing
- 2009-08-07 BR BRPI0917013A patent/BRPI0917013A2/pt not_active Application Discontinuation
- 2009-08-07 LT LTEP09781608.6T patent/LT2320905T/lt unknown
- 2009-08-07 HU HUE09781608A patent/HUE033645T2/en unknown
- 2009-08-07 KR KR1020117005861A patent/KR101616396B1/ko active IP Right Grant
- 2009-08-07 AU AU2009281198A patent/AU2009281198B2/en not_active Ceased
- 2009-08-07 SG SG2013056569A patent/SG193149A1/en unknown
- 2009-08-07 US US13/058,465 patent/US8563717B2/en active Active
- 2009-08-07 SI SI200931724T patent/SI2320905T1/sl unknown
- 2009-08-07 PT PT97816086T patent/PT2320905T/pt unknown
- 2009-08-07 EP EP09781608.6A patent/EP2320905B1/en active Active
- 2009-08-07 CN CN200980141082.9A patent/CN102176911B/zh not_active Expired - Fee Related
- 2009-08-07 KR KR1020157036139A patent/KR101649881B1/ko active IP Right Grant
- 2009-08-07 DK DK09781608.6T patent/DK2320905T3/en active
- 2009-08-07 JP JP2011522487A patent/JP5785078B2/ja not_active Expired - Fee Related
- 2009-08-07 CA CA2733750A patent/CA2733750C/en not_active Expired - Fee Related
- 2009-08-07 EP EP17177351.8A patent/EP3246030A1/en not_active Withdrawn
- 2009-08-07 PL PL09781608T patent/PL2320905T3/pl unknown
- 2009-08-07 MX MX2011001663A patent/MX2011001663A/es active IP Right Grant
- 2009-08-07 EA EA201100115A patent/EA019204B1/ru not_active IP Right Cessation
- 2009-08-07 CN CN201410643782.0A patent/CN104530048B/zh not_active Expired - Fee Related
-
2011
- 2011-01-25 IL IL210855A patent/IL210855A/en active IP Right Grant
- 2011-02-10 ZA ZA2011/01104A patent/ZA201101104B/en unknown
-
2015
- 2015-07-23 JP JP2015145367A patent/JP2016006072A/ja active Pending
-
2017
- 2017-09-08 CY CY20171100953T patent/CY1119368T1/el unknown
- 2017-09-15 HR HRP20171398TT patent/HRP20171398T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1119368T1 (el) | Νεα παραγωγα αδενινης | |
CY1111281T1 (el) | Παραγωγα πουρινης ως ανοσοτροποποιητες | |
EA201100114A1 (ru) | Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний | |
EA201100113A1 (ru) | Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний | |
CY1122863T1 (el) | Φαρμακευτικη συνθεση που περιεχει γλυκοπυρρολικο και εναν αγωνιστη βητα2 αδρενοϋποδοχεα | |
EA201591000A1 (ru) | Пирролобензодиазепины | |
CY1107008T1 (el) | Παραγωγο βενζιμιδαζολης και χρηση ως ανταγωνιστου υποδοχεα aii | |
HRP20050628A2 (en) | Substituted benzoyl derivatives uses as herbicides | |
CY1113736T1 (el) | Ετεροαρυλ-ουριες και η χρηση τους ως ενεργοποιητες γλυκοκινασης | |
NO20053614L (no) | Nye pyridazin-3(2H)-on-derivater | |
CY1111069T1 (el) | Παραγωγα διυδροπυραζολοπυριμιδινονης | |
HUP0303897A2 (hu) | Eljárások p38 kinázzal összafüggő esetek kezelésére, kináz inhibitorokként alkalmazható pirrolotriazin vegyületek és ezeket tartalmazó gyógyszerkészítmények | |
CY1107677T1 (el) | Παραγωγα της 1-[indol-3-yl)carbonyl]piperazine | |
EA201171386A1 (ru) | ПРОИЗВОДНЫЕ ЦИКЛОПЕНТА[c]ПИРРОЛ-2-КАРБОКСИЛАТОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ | |
CY1105899T1 (el) | Πυριδινοϋλοπιπepιδινες ως 5-ht1f αγωνιστες | |
EA200801968A1 (ru) | Пирролопиримидиновые производные, используемые в качестве ингибиторов hsp90 | |
DE60311821D1 (de) | Dibenzylaminverbindung und deren medizinische verwendung | |
CY1114240T1 (el) | Παραγωγα σουλφοναμιδιου τετραϋδροϊσοκινολινης, η παρασκευη τους και η χρηση τους στη θεραπευτικη | |
CY1115536T1 (el) | Νεες υδροξυ-6-ετεροαρυλφαινανθριδινες και χρηση αυτων ως αναστολεις pde4 | |
DE60211343D1 (de) | Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente | |
EA201190119A1 (ru) | ПРОИЗВОДНЫЕ ТРИАЗОЛОПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ МАР-КИНАЗЫ p38 | |
EA201170237A1 (ru) | Производные карбаматов алкилтиазолов, их получение и их применение в терапии | |
PE20070212A1 (es) | Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen | |
CO6321269A2 (es) | Derivados de benzoxazinona que actuan como agonistas de receptores adrenergicos beta 2 para el tratamiento de transtornos respiratorios | |
NO20054721L (no) | Substituerte anilinderivater |