CY1120238T1 - Κρυσταλλικες μορφες αναστολεα παραγοντα χια - Google Patents

Κρυσταλλικες μορφες αναστολεα παραγοντα χια

Info

Publication number
CY1120238T1
CY1120238T1 CY20181100522T CY181100522T CY1120238T1 CY 1120238 T1 CY1120238 T1 CY 1120238T1 CY 20181100522 T CY20181100522 T CY 20181100522T CY 181100522 T CY181100522 T CY 181100522T CY 1120238 T1 CY1120238 T1 CY 1120238T1
Authority
CY
Cyprus
Prior art keywords
chia
factors
crystal forms
crystalline forms
forms suspended
Prior art date
Application number
CY20181100522T
Other languages
English (en)
Inventor
Marta Dabros
Chenkou Wei
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1120238T1 publication Critical patent/CY1120238T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει κρυσταλλικές μορφές του (S,Ε)-4-(2-(3-(3-χλωρο-2-φθορο-6-(1Η-τετραζολ-1 -υλ)φαινυλ)ακρυλοϋλ)-5-(4-μεθυλ-2-οξοπιπεραζιν-1-υλ)-1,2,3,4-τετραϋδροϊσοκινολινο-1-καρβοξαμιδο)βενζοϊκού οξέος και διαλυτωμάτων αυτού· μεθόδους για την παρασκευή τέτοιων κρυσταλλικών μορφών· φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες κρυσταλλικές μορφές· και μεθόδους θεραπείας θρομβοεμβολικών διαταραχών με τέτοιες κρυσταλλικές μορφές ή τέτοιες φαρμακευτικές συνθέσεις.
CY20181100522T 2012-10-12 2018-05-18 Κρυσταλλικες μορφες αναστολεα παραγοντα χια CY1120238T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712850P 2012-10-12 2012-10-12
PCT/US2013/064423 WO2014059203A1 (en) 2012-10-12 2013-10-11 Crystalline forms of a factor xia inhibitor

Publications (1)

Publication Number Publication Date
CY1120238T1 true CY1120238T1 (el) 2019-07-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100522T CY1120238T1 (el) 2012-10-12 2018-05-18 Κρυσταλλικες μορφες αναστολεα παραγοντα χια

Country Status (34)

Country Link
US (1) US9920034B2 (el)
EP (1) EP2906551B1 (el)
JP (1) JP6154473B2 (el)
KR (1) KR102143257B1 (el)
CN (1) CN104837833B (el)
AU (1) AU2013329125B2 (el)
BR (1) BR112015007937A2 (el)
CA (1) CA2888100A1 (el)
CL (1) CL2015000916A1 (el)
CO (1) CO7350621A2 (el)
CY (1) CY1120238T1 (el)
DK (1) DK2906551T3 (el)
EA (1) EA032092B1 (el)
ES (1) ES2668318T3 (el)
HK (1) HK1212333A1 (el)
HR (1) HRP20180465T1 (el)
HU (1) HUE038272T2 (el)
IL (1) IL238089B (el)
LT (1) LT2906551T (el)
MA (1) MA38071B1 (el)
MX (1) MX351848B (el)
MY (1) MY173058A (el)
NO (1) NO2819265T3 (el)
NZ (1) NZ707990A (el)
PE (1) PE20150639A1 (el)
PH (1) PH12015500678A1 (el)
PL (1) PL2906551T3 (el)
PT (1) PT2906551T (el)
RS (1) RS57039B1 (el)
SG (1) SG11201502605PA (el)
SI (1) SI2906551T1 (el)
TR (1) TR201807316T4 (el)
WO (1) WO2014059203A1 (el)
ZA (1) ZA201503238B (el)

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DK2906551T3 (en) 2018-05-22
HK1212333A1 (en) 2016-06-10
MX2015004328A (es) 2015-06-10
CO7350621A2 (es) 2015-08-10
CA2888100A1 (en) 2014-04-17
EA032092B1 (ru) 2019-04-30
NO2819265T3 (el) 2018-07-28
CN104837833B (zh) 2017-07-14
EA201590548A1 (ru) 2015-07-30
JP6154473B2 (ja) 2017-06-28
PL2906551T3 (pl) 2018-07-31
AU2013329125A1 (en) 2015-05-28
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