MX351848B - Formas cristalinas de inhibidor del factor xia. - Google Patents

Formas cristalinas de inhibidor del factor xia.

Info

Publication number
MX351848B
MX351848B MX2015004328A MX2015004328A MX351848B MX 351848 B MX351848 B MX 351848B MX 2015004328 A MX2015004328 A MX 2015004328A MX 2015004328 A MX2015004328 A MX 2015004328A MX 351848 B MX351848 B MX 351848B
Authority
MX
Mexico
Prior art keywords
crystalline forms
factor xia
xia inhibitor
pharmaceutical compositions
inhibitor
Prior art date
Application number
MX2015004328A
Other languages
English (en)
Other versions
MX2015004328A (es
Inventor
Wei Chenkou
Dabros Marta
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2015004328A publication Critical patent/MX2015004328A/es
Publication of MX351848B publication Critical patent/MX351848B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención se refiere a formas cristalinas de ácido (S,E)-4-(2-(3-(3-cloro-2-fluoro-6-(1H- tetrazol-1-il)fenil)acriloi l)-6.-(4-metil-2-oxopiperazin-1- il) -1,2,3,4-tetrahidroisoquinoli na-1-carboxamida) benzoico y sus solvatos del mismo; procesos para la producción de tales formas cristalinas; composiciones farmacéuticas que comprenden tales formas cristalinas; y métodos para tratar trastornos tromboembólicos con tales formas cristalinas o tales composiciones farmacéuticas.
MX2015004328A 2012-10-12 2013-10-11 Formas cristalinas de inhibidor del factor xia. MX351848B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712850P 2012-10-12 2012-10-12
PCT/US2013/064423 WO2014059203A1 (en) 2012-10-12 2013-10-11 Crystalline forms of a factor xia inhibitor

Publications (2)

Publication Number Publication Date
MX2015004328A MX2015004328A (es) 2015-06-10
MX351848B true MX351848B (es) 2017-10-31

Family

ID=49474724

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004328A MX351848B (es) 2012-10-12 2013-10-11 Formas cristalinas de inhibidor del factor xia.

Country Status (34)

Country Link
US (1) US9920034B2 (es)
EP (1) EP2906551B1 (es)
JP (1) JP6154473B2 (es)
KR (1) KR102143257B1 (es)
CN (1) CN104837833B (es)
AU (1) AU2013329125B2 (es)
BR (1) BR112015007937A2 (es)
CA (1) CA2888100A1 (es)
CL (1) CL2015000916A1 (es)
CO (1) CO7350621A2 (es)
CY (1) CY1120238T1 (es)
DK (1) DK2906551T3 (es)
EA (1) EA032092B1 (es)
ES (1) ES2668318T3 (es)
HK (1) HK1212333A1 (es)
HR (1) HRP20180465T1 (es)
HU (1) HUE038272T2 (es)
IL (1) IL238089B (es)
LT (1) LT2906551T (es)
MA (1) MA38071B1 (es)
MX (1) MX351848B (es)
MY (1) MY173058A (es)
NO (1) NO2819265T3 (es)
NZ (1) NZ707990A (es)
PE (1) PE20150639A1 (es)
PH (1) PH12015500678A1 (es)
PL (1) PL2906551T3 (es)
PT (1) PT2906551T (es)
RS (1) RS57039B1 (es)
SG (1) SG11201502605PA (es)
SI (1) SI2906551T1 (es)
TR (1) TR201807316T4 (es)
WO (1) WO2014059203A1 (es)
ZA (1) ZA201503238B (es)

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Also Published As

Publication number Publication date
ES2668318T3 (es) 2018-05-17
JP2015533168A (ja) 2015-11-19
MA38071B1 (fr) 2017-01-31
WO2014059203A1 (en) 2014-04-17
HUE038272T2 (hu) 2018-10-29
SG11201502605PA (en) 2015-05-28
MY173058A (en) 2019-12-23
JP6154473B2 (ja) 2017-06-28
TR201807316T4 (tr) 2018-06-21
PH12015500678A1 (en) 2015-05-18
CN104837833B (zh) 2017-07-14
HK1212333A1 (en) 2016-06-10
CA2888100A1 (en) 2014-04-17
RS57039B1 (sr) 2018-05-31
LT2906551T (lt) 2018-04-25
NO2819265T3 (es) 2018-07-28
MX2015004328A (es) 2015-06-10
ZA201503238B (en) 2017-11-29
CL2015000916A1 (es) 2015-08-14
BR112015007937A2 (pt) 2017-07-04
AU2013329125B2 (en) 2017-03-30
SI2906551T1 (en) 2018-05-31
PT2906551T (pt) 2018-05-10
DK2906551T3 (en) 2018-05-22
IL238089B (en) 2019-03-31
CO7350621A2 (es) 2015-08-10
US20150266855A1 (en) 2015-09-24
EA032092B1 (ru) 2019-04-30
PL2906551T3 (pl) 2018-07-31
AU2013329125A1 (en) 2015-05-28
HRP20180465T1 (hr) 2018-05-04
EP2906551B1 (en) 2018-02-28
PE20150639A1 (es) 2015-05-11
US9920034B2 (en) 2018-03-20
CN104837833A (zh) 2015-08-12
EA201590548A1 (ru) 2015-07-30
NZ707990A (en) 2018-07-27
CY1120238T1 (el) 2019-07-10
EP2906551A1 (en) 2015-08-19
MA38071A1 (fr) 2016-06-30
KR20150065189A (ko) 2015-06-12
KR102143257B1 (ko) 2020-08-10

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