MX2011006560A - Derivados heterociclicos fucionados con oxadiazola utiles para el tratamiento de esclerosis multiple. - Google Patents

Derivados heterociclicos fucionados con oxadiazola utiles para el tratamiento de esclerosis multiple.

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Publication number
MX2011006560A
MX2011006560A MX2011006560A MX2011006560A MX2011006560A MX 2011006560 A MX2011006560 A MX 2011006560A MX 2011006560 A MX2011006560 A MX 2011006560A MX 2011006560 A MX2011006560 A MX 2011006560A MX 2011006560 A MX2011006560 A MX 2011006560A
Authority
MX
Mexico
Prior art keywords
treatment
multiple sclerosis
oxadiazole
fused heterocyclic
derivatives useful
Prior art date
Application number
MX2011006560A
Other languages
English (en)
Inventor
Anna Quattropani
Jerome Dorbais
Cyril Montagne
Mathilde Muzerelle
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of MX2011006560A publication Critical patent/MX2011006560A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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Abstract

La invención proporciona los compuestos de la fórmula (I) para el tratamiento de la esclerosis múltiple y otras enfermedades. ( ver formula (I)).
MX2011006560A 2008-12-18 2009-12-15 Derivados heterociclicos fucionados con oxadiazola utiles para el tratamiento de esclerosis multiple. MX2011006560A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08172177 2008-12-18
US23826109P 2009-08-31 2009-08-31
PCT/EP2009/067171 WO2010069949A1 (en) 2008-12-18 2009-12-15 Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis

Publications (1)

Publication Number Publication Date
MX2011006560A true MX2011006560A (es) 2011-08-03

Family

ID=40564893

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011006560A MX2011006560A (es) 2008-12-18 2009-12-15 Derivados heterociclicos fucionados con oxadiazola utiles para el tratamiento de esclerosis multiple.

Country Status (15)

Country Link
US (1) US8741923B2 (es)
EP (1) EP2376484B1 (es)
JP (1) JP5855942B2 (es)
KR (1) KR20110100624A (es)
CN (1) CN102245602B (es)
AR (1) AR074700A1 (es)
AU (1) AU2009327133B2 (es)
BR (1) BRPI0923178A2 (es)
CA (1) CA2743397C (es)
EA (1) EA201170828A1 (es)
ES (1) ES2543205T3 (es)
IL (1) IL213590A0 (es)
MX (1) MX2011006560A (es)
WO (1) WO2010069949A1 (es)
ZA (1) ZA201103405B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042998A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
WO2010043000A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
JP2013544811A (ja) * 2010-11-03 2013-12-19 ブリストル−マイヤーズ スクイブ カンパニー 自己免疫疾患および血管疾患の治療用のｓ１ｐ１アゴニストとしての複素環式化合物
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
PL2958913T3 (pl) 2013-02-20 2019-03-29 Lg Chem, Ltd. Agoniści receptora sfingozyno-1-fosforanowego, sposoby ich przygotowania i zawierające je jako środek aktywny farmaceutyczne kompozycje
TWI613182B (zh) 2013-02-21 2018-02-01 必治妥美雅史谷比公司 雙環化合物
EP2970177A1 (en) 2013-03-15 2016-01-20 Pfizer Inc. Indole compounds that activate ampk
TWI689487B (zh) 2014-08-20 2020-04-01 美商必治妥美雅史谷比公司 經取代雙環化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05012460A (es) * 2003-05-19 2006-05-25 Irm Llc Compuestos y composiciones inmunosupresoras.
WO2004103309A2 (en) * 2003-05-19 2004-12-02 Irm Llc Immunosuppressant compounds and compositions
WO2006047195A2 (en) 2004-10-22 2006-05-04 Merck & Co., Inc. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists
MX356221B (es) * 2006-04-03 2018-05-18 Astellas Pharma Inc Heterocompuesto.
JO2701B1 (en) * 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
AU2008240773B2 (en) 2007-04-19 2013-10-03 Glaxo Group Limited Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (S1P) agonists

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EP2376484A1 (en) 2011-10-19
CN102245602A (zh) 2011-11-16
KR20110100624A (ko) 2011-09-14
WO2010069949A1 (en) 2010-06-24
JP2012512829A (ja) 2012-06-07
AU2009327133A1 (en) 2010-06-24
IL213590A0 (en) 2011-07-31
CA2743397A1 (en) 2010-06-24
AR074700A1 (es) 2011-02-02
JP5855942B2 (ja) 2016-02-09
ES2543205T3 (es) 2015-08-17
AU2009327133B2 (en) 2016-04-14
US8741923B2 (en) 2014-06-03
ZA201103405B (en) 2012-08-29
US20110230518A1 (en) 2011-09-22
EP2376484B1 (en) 2015-04-22
CN102245602B (zh) 2014-09-10
EA201170828A1 (ru) 2011-12-30
CA2743397C (en) 2017-02-28
BRPI0923178A2 (pt) 2016-02-16

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