SG11201502605PA - Crystalline forms of a factor xia inhibitor - Google Patents
Crystalline forms of a factor xia inhibitorInfo
- Publication number
- SG11201502605PA SG11201502605PA SG11201502605PA SG11201502605PA SG11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA
- Authority
- SG
- Singapore
- Prior art keywords
- crystalline forms
- factor xia
- xia inhibitor
- inhibitor
- factor
- Prior art date
Links
- 229940122036 Factor XIa inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712850P | 2012-10-12 | 2012-10-12 | |
| PCT/US2013/064423 WO2014059203A1 (en) | 2012-10-12 | 2013-10-11 | Crystalline forms of a factor xia inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201502605PA true SG11201502605PA (en) | 2015-05-28 |
Family
ID=49474724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502605PA SG11201502605PA (en) | 2012-10-12 | 2013-10-11 | Crystalline forms of a factor xia inhibitor |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9920034B2 (en) |
| EP (1) | EP2906551B1 (en) |
| JP (1) | JP6154473B2 (en) |
| KR (1) | KR102143257B1 (en) |
| CN (1) | CN104837833B (en) |
| AU (1) | AU2013329125B2 (en) |
| BR (1) | BR112015007937A2 (en) |
| CA (1) | CA2888100A1 (en) |
| CL (1) | CL2015000916A1 (en) |
| CO (1) | CO7350621A2 (en) |
| CY (1) | CY1120238T1 (en) |
| DK (1) | DK2906551T3 (en) |
| EA (1) | EA032092B1 (en) |
| ES (1) | ES2668318T3 (en) |
| HK (1) | HK1212333A1 (en) |
| HR (1) | HRP20180465T1 (en) |
| HU (1) | HUE038272T2 (en) |
| IL (1) | IL238089B (en) |
| LT (1) | LT2906551T (en) |
| MA (1) | MA38071B1 (en) |
| MX (1) | MX351848B (en) |
| MY (1) | MY173058A (en) |
| NO (1) | NO2819265T3 (en) |
| NZ (1) | NZ707990A (en) |
| PE (1) | PE20150639A1 (en) |
| PH (1) | PH12015500678A1 (en) |
| PL (1) | PL2906551T3 (en) |
| PT (1) | PT2906551T (en) |
| RS (1) | RS57039B1 (en) |
| SG (1) | SG11201502605PA (en) |
| SI (1) | SI2906551T1 (en) |
| TR (1) | TR201807316T4 (en) |
| WO (1) | WO2014059203A1 (en) |
| ZA (1) | ZA201503238B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201319068A (en) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | Cyclic P1 linkers as factor XIa inhibitors |
| TW201311689A (en) | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | Novel macrocycles as factor XIa inhibitors |
| TWI586651B (en) | 2011-10-14 | 2017-06-11 | 必治妥美雅史谷比公司 | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| WO2014059202A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9738655B2 (en) | 2013-03-25 | 2017-08-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors |
| NO2760821T3 (en) | 2014-01-31 | 2018-03-10 | ||
| CN110845498B (en) | 2014-01-31 | 2023-02-17 | 百时美施贵宝公司 | Macrocyclic compounds having heterocyclic P2' groups as factor XIA inhibitors |
| WO2016036893A1 (en) | 2014-09-04 | 2016-03-10 | Bristol-Myers Squibb Company | Diamide macrocycles that are fxia inhibitors |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| JP6742348B2 (en) | 2015-06-19 | 2020-08-19 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Diamide macrocycles as factor XIA inhibitors |
| CN107849026B (en) | 2015-07-29 | 2021-01-01 | 百时美施贵宝公司 | Factor XIA macrocyclic inhibitors bearing alkyl or cycloalkyl P2' moieties |
| ES2871111T3 (en) | 2015-07-29 | 2021-10-28 | Bristol Myers Squibb Co | Macrocyclic factor XIa inhibitors containing a non-aromatic P2 'group |
| CN106496249B (en) * | 2015-09-07 | 2019-12-13 | 江苏恒瑞医药股份有限公司 | Oxazoloindole derivative, preparation method and medical application thereof |
| WO2017074833A1 (en) | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
| TW201808908A (en) | 2016-08-22 | 2018-03-16 | 美商默沙東藥廠 | Factor XIa inhibitors |
| CN109867660A (en) * | 2017-12-01 | 2019-06-11 | 四川科伦博泰生物医药股份有限公司 | Tetrahydroisoquinoline amide compound and its medicinal usage containing quaternary ammonium ion |
| WO2019184744A1 (en) | 2018-03-28 | 2019-10-03 | 四川科伦博泰生物医药股份有限公司 | Tetrahydroisoquinoline derivative, preparation method therefor and uses thereof |
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| US7129264B2 (en) | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
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| WO2006076575A2 (en) | 2005-01-13 | 2006-07-20 | Bristol-Myers Squibb Company | Substituted biaryl compounds as factor xia inhibitors |
| WO2006089005A2 (en) | 2005-02-17 | 2006-08-24 | Bristol-Myers Squibb Company | Combination of selective factor viia and/or xia and plasma kallikrein inhibitors |
| CA2627426A1 (en) * | 2005-11-11 | 2007-05-18 | Markus Boehringer | Carbocyclic fused cyclic amines as inhibitors of the coagulation factor xa |
| EP1966141A1 (en) | 2005-12-14 | 2008-09-10 | Brystol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| US8466295B2 (en) | 2005-12-14 | 2013-06-18 | Bristol-Myers Squibb Company | Thiophene derivatives as factor XIa inhibitors |
| CA2633252A1 (en) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
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| CN101605779B (en) | 2006-12-15 | 2013-11-20 | 百时美施贵宝公司 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
| PE20081775A1 (en) | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | MACROCYCLIC COMPOUNDS AS INHIBITORS OF FACTOR VIIA |
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| JP5841547B2 (en) | 2010-02-11 | 2016-01-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Macrocycles as factor XIA inhibitors |
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| TWI586651B (en) | 2011-10-14 | 2017-06-11 | 必治妥美雅史谷比公司 | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
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-
2013
- 2013-10-11 WO PCT/US2013/064423 patent/WO2014059203A1/en active Application Filing
- 2013-10-11 TR TR2018/07316T patent/TR201807316T4/en unknown
- 2013-10-11 SI SI201330987T patent/SI2906551T1/en unknown
- 2013-10-11 BR BR112015007937A patent/BR112015007937A2/en not_active Application Discontinuation
- 2013-10-11 MX MX2015004328A patent/MX351848B/en active IP Right Grant
- 2013-10-11 DK DK13780287.2T patent/DK2906551T3/en active
- 2013-10-11 PL PL13780287T patent/PL2906551T3/en unknown
- 2013-10-11 RS RS20180328A patent/RS57039B1/en unknown
- 2013-10-11 AU AU2013329125A patent/AU2013329125B2/en not_active Ceased
- 2013-10-11 EA EA201590548A patent/EA032092B1/en not_active IP Right Cessation
- 2013-10-11 US US14/434,507 patent/US9920034B2/en active Active
- 2013-10-11 HU HUE13780287A patent/HUE038272T2/en unknown
- 2013-10-11 EP EP13780287.2A patent/EP2906551B1/en active Active
- 2013-10-11 MY MYPI2015701150A patent/MY173058A/en unknown
- 2013-10-11 PT PT137802872T patent/PT2906551T/en unknown
- 2013-10-11 LT LTEP13780287.2T patent/LT2906551T/en unknown
- 2013-10-11 CN CN201380064797.5A patent/CN104837833B/en active Active
- 2013-10-11 KR KR1020157011941A patent/KR102143257B1/en active IP Right Grant
- 2013-10-11 JP JP2015536906A patent/JP6154473B2/en active Active
- 2013-10-11 SG SG11201502605PA patent/SG11201502605PA/en unknown
- 2013-10-11 NZ NZ707990A patent/NZ707990A/en not_active IP Right Cessation
- 2013-10-11 CA CA2888100A patent/CA2888100A1/en not_active Abandoned
- 2013-10-11 PE PE2015000477A patent/PE20150639A1/en not_active Application Discontinuation
- 2013-10-11 ES ES13780287.2T patent/ES2668318T3/en active Active
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2014
- 2014-05-21 NO NO14169333A patent/NO2819265T3/no unknown
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2015
- 2015-03-26 PH PH12015500678A patent/PH12015500678A1/en unknown
- 2015-04-01 IL IL238089A patent/IL238089B/en active IP Right Grant
- 2015-04-10 CL CL2015000916A patent/CL2015000916A1/en unknown
- 2015-05-07 MA MA38071A patent/MA38071B1/en unknown
- 2015-05-07 CO CO15104857A patent/CO7350621A2/en unknown
- 2015-05-11 ZA ZA2015/03238A patent/ZA201503238B/en unknown
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2016
- 2016-01-07 HK HK16100130.3A patent/HK1212333A1/en not_active IP Right Cessation
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2018
- 2018-03-20 HR HRP20180465TT patent/HRP20180465T1/en unknown
- 2018-05-18 CY CY20181100522T patent/CY1120238T1/en unknown
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