SG11201502605PA - Crystalline forms of a factor xia inhibitor - Google Patents
Crystalline forms of a factor xia inhibitorInfo
- Publication number
- SG11201502605PA SG11201502605PA SG11201502605PA SG11201502605PA SG11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA SG 11201502605P A SG11201502605P A SG 11201502605PA
- Authority
- SG
- Singapore
- Prior art keywords
- crystalline forms
- factor xia
- xia inhibitor
- inhibitor
- factor
- Prior art date
Links
- 229940122036 Factor XIa inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712850P | 2012-10-12 | 2012-10-12 | |
| PCT/US2013/064423 WO2014059203A1 (en) | 2012-10-12 | 2013-10-11 | Crystalline forms of a factor xia inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201502605PA true SG11201502605PA (en) | 2015-05-28 |
Family
ID=49474724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502605PA SG11201502605PA (en) | 2012-10-12 | 2013-10-11 | Crystalline forms of a factor xia inhibitor |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9920034B2 (en) |
| EP (1) | EP2906551B1 (en) |
| JP (1) | JP6154473B2 (en) |
| KR (1) | KR102143257B1 (en) |
| CN (1) | CN104837833B (en) |
| AU (1) | AU2013329125B2 (en) |
| BR (1) | BR112015007937A2 (en) |
| CA (1) | CA2888100A1 (en) |
| CL (1) | CL2015000916A1 (en) |
| CO (1) | CO7350621A2 (en) |
| CY (1) | CY1120238T1 (en) |
| DK (1) | DK2906551T3 (en) |
| EA (1) | EA032092B1 (en) |
| ES (1) | ES2668318T3 (en) |
| HK (1) | HK1212333A1 (en) |
| HR (1) | HRP20180465T1 (en) |
| HU (1) | HUE038272T2 (en) |
| IL (1) | IL238089B (en) |
| LT (1) | LT2906551T (en) |
| MA (1) | MA38071B1 (en) |
| MX (1) | MX351848B (en) |
| MY (1) | MY173058A (en) |
| NO (1) | NO2819265T3 (en) |
| NZ (1) | NZ707990A (en) |
| PE (1) | PE20150639A1 (en) |
| PH (1) | PH12015500678A1 (en) |
| PL (1) | PL2906551T3 (en) |
| PT (1) | PT2906551T (en) |
| RS (1) | RS57039B1 (en) |
| SG (1) | SG11201502605PA (en) |
| SI (1) | SI2906551T1 (en) |
| TR (1) | TR201807316T4 (en) |
| WO (1) | WO2014059203A1 (en) |
| ZA (1) | ZA201503238B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201311689A (en) | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | Novel macrocycles as factor XIa inhibitors |
| TW201319068A (en) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | Cyclic P1 linkers as factor XIa inhibitors |
| PL2766346T3 (en) | 2011-10-14 | 2017-09-29 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9315519B2 (en) | 2012-10-12 | 2016-04-19 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
| EP2978751B1 (en) | 2013-03-25 | 2018-12-05 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| HUE040226T2 (en) | 2014-01-31 | 2019-02-28 | Bristol Myers Squibb Co | Macrocycles with hetrocyclic p2' groups as factor xia inhibitors |
| NO2760821T3 (en) | 2014-01-31 | 2018-03-10 | ||
| WO2016036893A1 (en) | 2014-09-04 | 2016-03-10 | Bristol-Myers Squibb Company | Diamide macrocycles that are fxia inhibitors |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| EP3310777B1 (en) | 2015-06-19 | 2019-10-09 | Bristol-Myers Squibb Company | Diamide macrocycles as factor xia inhibitors |
| ES2937156T3 (en) | 2015-07-29 | 2023-03-24 | Bristol Myers Squibb Co | Macrocyclic factor XIa inhibitors bearing a non-aromatic P2' group |
| ES2803659T3 (en) | 2015-07-29 | 2021-01-28 | Bristol Myers Squibb Co | Macrocyclic factor xia inhibitors containing p2 alkyl or cycloalkyl moieties |
| CN106496249B (en) * | 2015-09-07 | 2019-12-13 | 江苏恒瑞医药股份有限公司 | Oxazoloindole derivative, preparation method and medical application thereof |
| EP3371162B1 (en) | 2015-10-29 | 2022-01-26 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
| US10143681B2 (en) | 2016-08-22 | 2018-12-04 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| CN109867660A (en) * | 2017-12-01 | 2019-06-11 | 四川科伦博泰生物医药股份有限公司 | Tetrahydroisoquinoline amide compound and its medicinal usage containing quaternary ammonium ion |
| JP7458984B2 (en) | 2018-03-28 | 2024-04-01 | 四川科倫博泰生物医薬股▲フン▼有限公司 | Tetrahydroisoquinoline derivatives, their production methods and uses |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7155E (en) | 1906-03-16 | 1907-05-23 | Rene Gabriel Poncet | Rotary dryer |
| FR1525186A (en) | 1967-03-29 | 1968-05-17 | Roussel Uclaf | New penicillins and method of preparation |
| ATA937274A (en) | 1973-12-17 | 1978-02-15 | Thomae Gmbh Dr K | PROCESS FOR PRODUCING NEW ARALIPHATIC KETONES |
| DE4034829A1 (en) | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | CYCLOPEPTIDE |
| JP3190431B2 (en) | 1991-07-01 | 2001-07-23 | 三菱化学株式会社 | Ketone derivatives |
| GB9206757D0 (en) | 1992-03-27 | 1992-05-13 | Ferring Bv | Novel peptide receptor ligands |
| US5624936A (en) | 1995-03-29 | 1997-04-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1996034010A2 (en) | 1995-03-29 | 1996-10-31 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5869682A (en) | 1996-04-03 | 1999-02-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP2000507597A (en) | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | Farnesyl protein transferase inhibitor |
| TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
| PT1064298E (en) | 1998-03-19 | 2009-01-02 | Vertex Pharma | Inhibitors of caspases |
| AU763839B2 (en) | 1998-05-26 | 2003-07-31 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
| KR20010101355A (en) | 1999-01-02 | 2001-11-14 | 로버트 흐라이탁, 미쉘 베스트 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them(inhibition of factor XA activity) |
| EP1016663A1 (en) | 1999-01-02 | 2000-07-05 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
| HUP0203167A3 (en) | 1999-04-09 | 2003-09-29 | Basf Ag | Peptidic substances, their preparations and their use as complement protease inhibitors |
| EP1125925A1 (en) | 2000-02-15 | 2001-08-22 | Applied Research Systems ARS Holding N.V. | Amine derivatives for the treatment of apoptosis |
| DE60115227T2 (en) | 2000-05-11 | 2006-08-24 | Bristol-Myers Squibb Co. | TETRAHYDROISOCHINOLINE ANALOGUE AS GROWTH HORMONE SECRETAGOGA |
| SV2003000617A (en) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M |
| WO2003011222A2 (en) | 2001-07-27 | 2003-02-13 | Merck & Co., Inc. | Thrombin inhibitors |
| WO2003041641A2 (en) | 2001-11-09 | 2003-05-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
| US7138412B2 (en) | 2003-03-11 | 2006-11-21 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives useful as serine protease inhibitors |
| US7129264B2 (en) | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
| JP2007501844A (en) | 2003-08-08 | 2007-02-01 | トランス テック ファーマ，インコーポレイテッド | Aryl and heteroaryl compounds, compositions and methods of use |
| US7417063B2 (en) | 2004-04-13 | 2008-08-26 | Bristol-Myers Squibb Company | Bicyclic heterocycles useful as serine protease inhibitors |
| US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| WO2006017295A2 (en) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
| WO2006076575A2 (en) | 2005-01-13 | 2006-07-20 | Bristol-Myers Squibb Company | Substituted biaryl compounds as factor xia inhibitors |
| US20060183771A1 (en) | 2005-02-17 | 2006-08-17 | Seiffert Dietmar A | Novel combination of selective factor VIIa and/or factor XIa inhibitors and selective plasma kallikrein inhibitors |
| CN101304989A (en) * | 2005-11-11 | 2008-11-12 | 弗·哈夫曼-拉罗切有限公司 | Carbocyclic fused cyclic amines as inhibitors of the coagulation factor XA |
| US8466295B2 (en) | 2005-12-14 | 2013-06-18 | Bristol-Myers Squibb Company | Thiophene derivatives as factor XIa inhibitors |
| EP1966141A1 (en) | 2005-12-14 | 2008-09-10 | Brystol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| KR20080087817A (en) | 2005-12-14 | 2008-10-01 | 브리스톨-마이어스 스큅 컴퍼니 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
| TW200745062A (en) | 2005-12-23 | 2007-12-16 | Bristol Myers Squibb Co | Macrocyclic factor VIIA inhibitors useful as anticoagulants |
| EP2102189B1 (en) | 2006-12-15 | 2015-07-29 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
| PE20081775A1 (en) | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | MACROCYCLIC COMPOUNDS AS INHIBITORS OF FACTOR VIIA |
| AR067329A1 (en) | 2007-06-13 | 2009-10-07 | Bristol Myers Squibb Co | ANALOGS DIPEPTIDOS AS INHIBITORS OF THE COAGULATION FACTOR |
| CN102026996B (en) * | 2008-03-13 | 2015-01-07 | 百时美施贵宝公司 | Pyridazine derivatives as factor XIA inhibitors |
| WO2010151317A1 (en) | 2009-06-22 | 2010-12-29 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2011002520A2 (en) | 2009-07-02 | 2011-01-06 | Angion Biomedica Corp. | Small molecule inhibitors of parp activity |
| EP2462123B1 (en) | 2009-08-04 | 2013-10-02 | Merck Sharp & Dohme Corp. | 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors |
| TWI577665B (en) | 2010-02-11 | 2017-04-11 | 必治妥美雅史谷比公司 | Macrocycles as factor xia inhibitors |
| EP2729150B1 (en) | 2011-07-08 | 2016-09-14 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
| TW201311689A (en) | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | Novel macrocycles as factor XIa inhibitors |
| TW201319068A (en) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | Cyclic P1 linkers as factor XIa inhibitors |
| CN103987696B (en) | 2011-10-14 | 2016-12-21 | 百时美施贵宝公司 | Substituted tetrahydro isoquinoline compound as factor XI, plasma thromboplastin antecedent A inhibitor |
| PL2766346T3 (en) * | 2011-10-14 | 2017-09-29 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| ES2699226T3 (en) | 2011-10-14 | 2019-02-08 | Bristol Myers Squibb Co | Substituted tetrahydroisoquinoline compounds as inhibitors of factor XIa |
| EP3290413B9 (en) | 2011-12-21 | 2020-04-29 | ONO Pharmaceutical Co., Ltd. | Pyridinone and pyrimidinone derivatives as factor xia inhibitors |
| EP2807156A1 (en) | 2012-01-27 | 2014-12-03 | Novartis AG | Aminopyridine derivatives as plasma kallikrein inhibitors |
| WO2013111108A1 (en) | 2012-01-27 | 2013-08-01 | Novartis Ag | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| JP2015083542A (en) | 2012-02-08 | 2015-04-30 | 大日本住友製薬株式会社 | Three substituted proline derivative |
| LT2847228T (en) | 2012-05-10 | 2018-11-12 | Bayer Pharma Aktiengesellschaft | ANTIBODIES CAPABLE OF BINDING TO THE COAGULATION FACTOR XI AND/OR ITS ACTIVATED FORM FACTOR XIa AND USES THEREOF |
| GB201209138D0 (en) | 2012-05-24 | 2012-07-04 | Ono Pharmaceutical Co | Compounds |
| TW201416362A (en) | 2012-07-19 | 2014-05-01 | Dainippon Sumitomo Pharma Co | 1-(cycloalkylcarbonyl)proline derivatives |
| CN108250199B (en) | 2012-08-03 | 2021-07-16 | 百时美施贵宝公司 | Dihydropyridone P1 as factor XIA inhibitor |
| UY34959A (en) | 2012-08-03 | 2014-01-31 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | DIHYDROPIRIDONE P1 AS INHIBITORS OF THE XIA FACTOR |
| US9315519B2 (en) | 2012-10-12 | 2016-04-19 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| WO2014120346A1 (en) | 2012-12-19 | 2014-08-07 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
| GB201300304D0 (en) | 2013-01-08 | 2013-02-20 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
| GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
| EP2978751B1 (en) | 2013-03-25 | 2018-12-05 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
-
2013
- 2013-10-11 SI SI201330987T patent/SI2906551T1/en unknown
- 2013-10-11 SG SG11201502605PA patent/SG11201502605PA/en unknown
- 2013-10-11 PE PE2015000477A patent/PE20150639A1/en not_active Application Discontinuation
- 2013-10-11 WO PCT/US2013/064423 patent/WO2014059203A1/en active Application Filing
- 2013-10-11 HU HUE13780287A patent/HUE038272T2/en unknown
- 2013-10-11 NZ NZ707990A patent/NZ707990A/en not_active IP Right Cessation
- 2013-10-11 EA EA201590548A patent/EA032092B1/en not_active IP Right Cessation
- 2013-10-11 DK DK13780287.2T patent/DK2906551T3/en active
- 2013-10-11 KR KR1020157011941A patent/KR102143257B1/en active IP Right Grant
- 2013-10-11 BR BR112015007937A patent/BR112015007937A2/en not_active Application Discontinuation
- 2013-10-11 RS RS20180328A patent/RS57039B1/en unknown
- 2013-10-11 MY MYPI2015701150A patent/MY173058A/en unknown
- 2013-10-11 AU AU2013329125A patent/AU2013329125B2/en not_active Ceased
- 2013-10-11 LT LTEP13780287.2T patent/LT2906551T/en unknown
- 2013-10-11 US US14/434,507 patent/US9920034B2/en active Active
- 2013-10-11 PT PT137802872T patent/PT2906551T/en unknown
- 2013-10-11 MX MX2015004328A patent/MX351848B/en active IP Right Grant
- 2013-10-11 TR TR2018/07316T patent/TR201807316T4/en unknown
- 2013-10-11 JP JP2015536906A patent/JP6154473B2/en active Active
- 2013-10-11 CA CA2888100A patent/CA2888100A1/en not_active Abandoned
- 2013-10-11 CN CN201380064797.5A patent/CN104837833B/en active Active
- 2013-10-11 EP EP13780287.2A patent/EP2906551B1/en active Active
- 2013-10-11 PL PL13780287T patent/PL2906551T3/en unknown
- 2013-10-11 ES ES13780287.2T patent/ES2668318T3/en active Active
-
2014
- 2014-05-21 NO NO14169333A patent/NO2819265T3/no unknown
-
2015
- 2015-03-26 PH PH12015500678A patent/PH12015500678A1/en unknown
- 2015-04-01 IL IL238089A patent/IL238089B/en active IP Right Grant
- 2015-04-10 CL CL2015000916A patent/CL2015000916A1/en unknown
- 2015-05-07 MA MA38071A patent/MA38071B1/en unknown
- 2015-05-07 CO CO15104857A patent/CO7350621A2/en unknown
- 2015-05-11 ZA ZA2015/03238A patent/ZA201503238B/en unknown
-
2016
- 2016-01-07 HK HK16100130.3A patent/HK1212333A1/en not_active IP Right Cessation
-
2018
- 2018-03-20 HR HRP20180465TT patent/HRP20180465T1/en unknown
- 2018-05-18 CY CY20181100522T patent/CY1120238T1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1212333A1 (en) | Crystalline forms of a factor xia inhibitor xia | |
| HRP20181751T1 (en) | Crystalline forms of a prolyl hydroxylase inhibitor | |
| HRP20170784T8 (en) | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors | |
| HK1211921A1 (en) | Inhibitor compounds | |
| SI2882734T1 (en) | Dihydropyridone as factor xia inhibitors | |
| HK1200454A1 (en) | Crystalline form of a succinate salt | |
| GB201211019D0 (en) | Inhibitor compounds | |
| EP2900240A4 (en) | Crystalline form of a reverse transcriptase inhibitor |