PL2906551T3 - Postacie krystaliczne inhibitora czynnika xia - Google Patents

Postacie krystaliczne inhibitora czynnika xia

Info

Publication number
PL2906551T3
PL2906551T3 PL13780287T PL13780287T PL2906551T3 PL 2906551 T3 PL2906551 T3 PL 2906551T3 PL 13780287 T PL13780287 T PL 13780287T PL 13780287 T PL13780287 T PL 13780287T PL 2906551 T3 PL2906551 T3 PL 2906551T3
Authority
PL
Poland
Prior art keywords
xia
crystalline forms
factor inhibitor
inhibitor
factor
Prior art date
Application number
PL13780287T
Other languages
English (en)
Inventor
Marta Dabros
Chenkou Wei
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of PL2906551T3 publication Critical patent/PL2906551T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL13780287T 2012-10-12 2013-10-11 Postacie krystaliczne inhibitora czynnika xia PL2906551T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261712850P 2012-10-12 2012-10-12
PCT/US2013/064423 WO2014059203A1 (en) 2012-10-12 2013-10-11 Crystalline forms of a factor xia inhibitor
EP13780287.2A EP2906551B1 (en) 2012-10-12 2013-10-11 Crystalline forms of a factor xia inhibitor

Publications (1)

Publication Number Publication Date
PL2906551T3 true PL2906551T3 (pl) 2018-07-31

Family

ID=49474724

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13780287T PL2906551T3 (pl) 2012-10-12 2013-10-11 Postacie krystaliczne inhibitora czynnika xia

Country Status (34)

Country Link
US (1) US9920034B2 (pl)
EP (1) EP2906551B1 (pl)
JP (1) JP6154473B2 (pl)
KR (1) KR102143257B1 (pl)
CN (1) CN104837833B (pl)
AU (1) AU2013329125B2 (pl)
BR (1) BR112015007937A2 (pl)
CA (1) CA2888100A1 (pl)
CL (1) CL2015000916A1 (pl)
CO (1) CO7350621A2 (pl)
CY (1) CY1120238T1 (pl)
DK (1) DK2906551T3 (pl)
EA (1) EA032092B1 (pl)
ES (1) ES2668318T3 (pl)
HR (1) HRP20180465T1 (pl)
HU (1) HUE038272T2 (pl)
IL (1) IL238089B (pl)
LT (1) LT2906551T (pl)
MA (1) MA38071B1 (pl)
MX (1) MX351848B (pl)
MY (1) MY173058A (pl)
NO (1) NO2819265T3 (pl)
NZ (1) NZ707990A (pl)
PE (1) PE20150639A1 (pl)
PH (1) PH12015500678A1 (pl)
PL (1) PL2906551T3 (pl)
PT (1) PT2906551T (pl)
RS (1) RS57039B1 (pl)
SG (1) SG11201502605PA (pl)
SI (1) SI2906551T1 (pl)
SM (1) SMT201800262T1 (pl)
TR (1) TR201807316T4 (pl)
WO (1) WO2014059203A1 (pl)
ZA (1) ZA201503238B (pl)

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TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
CN103974938B (zh) 2011-10-14 2016-11-09 百时美施贵宝公司 作为因子xia抑制剂的经取代的四氢异喹啉化合物
US9315519B2 (en) 2012-10-12 2016-04-19 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
WO2014059214A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
NO2760821T3 (pl) 2014-01-31 2018-03-10
TWI688564B (zh) 2014-01-31 2020-03-21 美商必治妥美雅史谷比公司 作為凝血因子ｘｉａ抑制劑之具有雜環p2'基團之巨環化合物
WO2016036893A1 (en) 2014-09-04 2016-03-10 Bristol-Myers Squibb Company Diamide macrocycles that are fxia inhibitors
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CN106496249B (zh) * 2015-09-07 2019-12-13 江苏恒瑞医药股份有限公司 噁唑并吲哚类衍生物、其制备方法及其在医药上的应用
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CN109867660A (zh) * 2017-12-01 2019-06-11 四川科伦博泰生物医药股份有限公司 含季铵离子的四氢异喹啉酰胺化合物及其药物用途
WO2019184744A1 (zh) 2018-03-28 2019-10-03 四川科伦博泰生物医药股份有限公司 四氢异喹啉类衍生物及其制备方法和用途

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Also Published As

Publication number Publication date
CY1120238T1 (el) 2019-07-10
CA2888100A1 (en) 2014-04-17
SMT201800262T1 (it) 2018-07-17
CN104837833A (zh) 2015-08-12
AU2013329125B2 (en) 2017-03-30
NZ707990A (en) 2018-07-27
KR20150065189A (ko) 2015-06-12
CO7350621A2 (es) 2015-08-10
BR112015007937A2 (pt) 2017-07-04
ZA201503238B (en) 2017-11-29
EA032092B1 (ru) 2019-04-30
EP2906551A1 (en) 2015-08-19
MX2015004328A (es) 2015-06-10
JP2015533168A (ja) 2015-11-19
NO2819265T3 (pl) 2018-07-28
TR201807316T4 (tr) 2018-06-21
PE20150639A1 (es) 2015-05-11
EP2906551B1 (en) 2018-02-28
US9920034B2 (en) 2018-03-20
DK2906551T3 (en) 2018-05-22
IL238089B (en) 2019-03-31
SI2906551T1 (en) 2018-05-31
CL2015000916A1 (es) 2015-08-14
MA38071A1 (fr) 2016-06-30
JP6154473B2 (ja) 2017-06-28
HK1212333A1 (en) 2016-06-10
KR102143257B1 (ko) 2020-08-10
PH12015500678A1 (en) 2015-05-18
US20150266855A1 (en) 2015-09-24
ES2668318T3 (es) 2018-05-17
RS57039B1 (sr) 2018-05-31
MA38071B1 (fr) 2017-01-31
CN104837833B (zh) 2017-07-14
HUE038272T2 (hu) 2018-10-29
WO2014059203A1 (en) 2014-04-17
AU2013329125A1 (en) 2015-05-28
LT2906551T (lt) 2018-04-25
PT2906551T (pt) 2018-05-10
SG11201502605PA (en) 2015-05-28
HRP20180465T1 (hr) 2018-05-04
MY173058A (en) 2019-12-23
MX351848B (es) 2017-10-31
EA201590548A1 (ru) 2015-07-30

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