CY1119557T1 - Νεες ενωσεις - Google Patents

Νεες ενωσεις

Info

Publication number
CY1119557T1
CY1119557T1 CY20171100898T CY171100898T CY1119557T1 CY 1119557 T1 CY1119557 T1 CY 1119557T1 CY 20171100898 T CY20171100898 T CY 20171100898T CY 171100898 T CY171100898 T CY 171100898T CY 1119557 T1 CY1119557 T1 CY 1119557T1
Authority
CY
Cyprus
Prior art keywords
integer
useful
treatment
human interferon
compounds
Prior art date
Application number
CY20171100898T
Other languages
English (en)
Inventor
Diane Mary Coe
Stephen Allan Smith
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CY1119557T1 publication Critical patent/CY1119557T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ενώσεις του τύπου (I) κι άλατα αυτών: όπου το R1 είναι n-C4-6αλκυλο ή C1-2αλκοξυC1-2αλκυλο- · το R2 είναι υδρογόνο ή μέθυλο· κάθε R3 είναι υδροξυ, αλογονο ή n-C1-3αλκυλο· το m είναι ακέραιος με τιμή 2 ως 4· το n είναι ακέραιος με τιμή 0 ως 3· και το p είναι ακέραιος με τιμή 0 ως 2, είναι επαγωγείς της ανθρώπινης ιντερφερόνης. Ενώσεις που επάγουν την ανθρώπινη ιντερφερόνη μπορεί να είναι χρήσιμες για τη θεραπεία διαφόρων διαταραχών, για παράδειγμα για τη θεραπεία αλλεργικών νόσων κι άλλων φλεγμονωδών καταστάσεων, για παράδειγμα αλλεργικής ρινίτιδας κι άσθματος, μολυσματικών νόσων και καρκίνου, και μπορούν επίσης να είναι χρήσιμες ως ανοσοενισχυτικά εμβολίων.
CY20171100898T 2012-11-20 2017-08-24 Νεες ενωσεις CY1119557T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728390P 2012-11-20 2012-11-20
US201361774087P 2013-03-07 2013-03-07
PCT/US2013/070472 WO2014081645A1 (en) 2012-11-20 2013-11-18 Novel compounds

Publications (1)

Publication Number Publication Date
CY1119557T1 true CY1119557T1 (el) 2018-03-07

Family

ID=50776485

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100898T CY1119557T1 (el) 2012-11-20 2017-08-24 Νεες ενωσεις

Country Status (32)

Country Link
US (3) US9540383B2 (el)
EP (1) EP2922549B1 (el)
JP (1) JP6228223B2 (el)
KR (1) KR20150085055A (el)
CN (1) CN104780922B (el)
AU (1) AU2013348218B2 (el)
BR (1) BR112015011400A8 (el)
CA (1) CA2892218A1 (el)
CL (1) CL2015001342A1 (el)
CR (1) CR20150268A (el)
CY (1) CY1119557T1 (el)
DK (1) DK2922549T3 (el)
DO (1) DOP2015000121A (el)
EA (1) EA028480B1 (el)
ES (1) ES2639789T3 (el)
HK (1) HK1208826A1 (el)
HR (1) HRP20171150T1 (el)
HU (1) HUE13857477T2 (el)
IL (1) IL238800B (el)
LT (1) LT2922549T (el)
ME (1) ME02867B (el)
MX (1) MX358025B (el)
NZ (1) NZ707319A (el)
PE (1) PE20151086A1 (el)
PH (1) PH12015501100A1 (el)
PL (1) PL2922549T3 (el)
PT (1) PT2922549T (el)
RS (1) RS56233B1 (el)
SG (1) SG11201503282RA (el)
SI (1) SI2922549T1 (el)
UA (1) UA114645C2 (el)
WO (1) WO2014081645A1 (el)

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JP6452711B2 (ja) * 2014-02-20 2019-01-16 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ ヒトインターフェロンの誘導物質としてのピロロ［３，２］ピリミジン誘導体
EA032824B1 (ru) * 2014-08-15 2019-07-31 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. Пирролопиримидиновые соединения, используемые в качестве агониста tlr7
CN105732635A (zh) * 2014-12-29 2016-07-06 南京明德新药研发股份有限公司 一类Toll样受体7激动剂
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EA035116B1 (ru) * 2015-11-05 2020-04-29 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. 7-(тиазол-5-ил)пирролопиримидин в качестве агониста рецептора tlr7
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CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
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KR20150085081A (ko) 2012-11-20 2015-07-22 글락소스미스클라인 엘엘씨 신규 화합물
EP2922550B1 (en) 2012-11-20 2017-04-19 Glaxosmithkline LLC Novel compounds
JP6452711B2 (ja) 2014-02-20 2019-01-16 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ ヒトインターフェロンの誘導物質としてのピロロ［３，２］ピリミジン誘導体

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