CY1114141T1 - Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτητα - Google Patents
Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτηταInfo
- Publication number
- CY1114141T1 CY1114141T1 CY20121100744T CY121100744T CY1114141T1 CY 1114141 T1 CY1114141 T1 CY 1114141T1 CY 20121100744 T CY20121100744 T CY 20121100744T CY 121100744 T CY121100744 T CY 121100744T CY 1114141 T1 CY1114141 T1 CY 1114141T1
- Authority
- CY
- Cyprus
- Prior art keywords
- competiting
- units
- crth2 activity
- crth2
- activity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
Abstract
Ενώσεις του γενικού χημικού τύπου (Ι) όπου το R είναι φαινύλιο προαιρετικώς υποκατεστημένο με ένα ή περισσότερα αλο- υποκατάστατα· και τα φαρμακευτικώς αποδεκτά άλατα, ένυδρα άλατα, επιδιαλυτωμένα άλατα, σύμπλοκα ή προφάρμακα αυτών είναι χρήσιμα στις εκ του στόματος δυνάμενες χορήγησης συνθέσεις για την αγωγή αλλεργικών παθήσεων όπως είναι το άσθμα, η αλλεργική ρινίτιδα και η ατοπική δερματίτιδα.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0614608A GB0614608D0 (en) | 2006-07-22 | 2006-07-22 | Compounds having CRTH2 antagonist activity |
GB0624176A GB0624176D0 (en) | 2006-12-04 | 2006-12-04 | Compounds having CRTH2 antagonist activity |
EP07766323A EP2046740B1 (en) | 2006-07-22 | 2007-07-20 | Compounds having crth2 antagonist activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114141T1 true CY1114141T1 (el) | 2016-07-27 |
Family
ID=38566827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100744T CY1114141T1 (el) | 2006-07-22 | 2012-08-20 | Ενωσεις που εχουν ανταγωνιστικη του crth2 δραστηριοτητα |
Country Status (20)
Country | Link |
---|---|
US (2) | US7999119B2 (el) |
EP (2) | EP2492268A1 (el) |
JP (1) | JP5270542B2 (el) |
KR (1) | KR20090042808A (el) |
AU (1) | AU2007279079A1 (el) |
BR (1) | BRPI0714840A2 (el) |
CA (1) | CA2658496A1 (el) |
CY (1) | CY1114141T1 (el) |
DK (1) | DK2046740T3 (el) |
ES (1) | ES2391671T3 (el) |
HK (1) | HK1130256A1 (el) |
IL (1) | IL196640A (el) |
MX (1) | MX2009000801A (el) |
NO (1) | NO20090216L (el) |
NZ (1) | NZ574375A (el) |
PL (1) | PL2046740T3 (el) |
PT (1) | PT2046740E (el) |
RU (1) | RU2458918C2 (el) |
SI (1) | SI2046740T1 (el) |
WO (1) | WO2008012511A1 (el) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0324763D0 (en) * | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
GB0505048D0 (en) * | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
WO2007149312A2 (en) | 2006-06-16 | 2007-12-27 | The Trustees Of The University Of Pennsylvania | Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and bph |
SI2049478T1 (sl) * | 2006-07-06 | 2012-08-31 | Glaxo Group Ltd | Substituirani N-fenilmetil-5-okso-prolin-2-amidi kot antagonisti receptorja P2X7 in postopki za njihovo uporabo |
PL2046740T3 (pl) | 2006-07-22 | 2012-10-31 | Oxagen Ltd | Związki o aktywności antagonisty CRTH2 |
GB0722216D0 (en) * | 2007-11-13 | 2007-12-27 | Oxagen Ltd | Use of crth2 antagonist compounds |
US20110124683A1 (en) * | 2007-11-13 | 2011-05-26 | Oxagen Limited | Use of CRTH2 Antagonist Compounds |
GB0722203D0 (en) * | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
DK2327693T3 (da) | 2007-12-14 | 2012-08-13 | Pulmagen Therapeutics Asthma Ltd | Indoler og terapeutisk anvendelse deraf |
MY155133A (en) * | 2008-01-18 | 2015-09-15 | Atopix Therapeutics Ltd | Compounds having crth2 antagonist activity |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
JP2011509990A (ja) * | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
GB2457040A (en) * | 2008-01-30 | 2009-08-05 | Oxagen Ltd | 1-Acetic acid indole derivatives with PGD2 activity |
WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
US20110312945A1 (en) * | 2008-10-01 | 2011-12-22 | James Jia | Crth2 modulators |
JP2012508768A (ja) | 2008-11-13 | 2012-04-12 | リンク・メディスン・コーポレーション | アザキノリノン誘導体及びその使用 |
WO2010142934A1 (en) * | 2009-06-12 | 2010-12-16 | Pulmagen Therapeutics (Asthma) Limited | Indole derivatives as ligands of crth2 receptors |
JP5731538B2 (ja) | 2009-12-23 | 2015-06-10 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Crth2モジュレーター |
RU2562255C2 (ru) | 2010-03-22 | 2015-09-10 | Актелион Фармасьютиклз Лтд | Производные 3-(гетероариламино)-1,2,3,4-тетрагидро-9н-карбазола и их применение в качестве модуляторов рецепторов простагландина d2 |
US20130216552A1 (en) * | 2010-07-12 | 2013-08-22 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
US20140187795A1 (en) * | 2010-12-08 | 2014-07-03 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators and preparation thereof |
GB201103837D0 (en) | 2011-03-07 | 2011-04-20 | Oxagen Ltd | Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid |
KR101928595B1 (ko) | 2011-04-14 | 2018-12-12 | 이도르시아 파마슈티컬스 리미티드 | 7-(헤테로아릴-아미노)-6,7,8,9-테트라히드로피리도[1,2-a]인돌 아세트산 유도체 및 프로스타글란딘 d2 수용체 조절자로서의 이의 용도 |
EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
WO2013078422A2 (en) | 2011-11-23 | 2013-05-30 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
GB201121557D0 (en) | 2011-12-15 | 2012-01-25 | Oxagen Ltd | Process |
AU2012351342A1 (en) | 2011-12-16 | 2014-07-24 | Atopix Therapeutics Limited | Combination of CRTH2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
CA2867901A1 (en) * | 2012-03-21 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
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- 2007-07-20 KR KR1020097003615A patent/KR20090042808A/ko active IP Right Grant
- 2007-07-20 EP EP12168896A patent/EP2492268A1/en not_active Withdrawn
- 2007-07-20 WO PCT/GB2007/002761 patent/WO2008012511A1/en active Search and Examination
- 2007-07-20 DK DK07766323.5T patent/DK2046740T3/da active
- 2007-07-20 ES ES07766323T patent/ES2391671T3/es active Active
- 2007-07-20 BR BRPI0714840-2A patent/BRPI0714840A2/pt not_active IP Right Cessation
- 2007-07-20 EP EP07766323A patent/EP2046740B1/en active Active
- 2007-07-20 PT PT07766323T patent/PT2046740E/pt unknown
- 2007-07-20 SI SI200730995T patent/SI2046740T1/sl unknown
- 2007-07-20 RU RU2009101297/04A patent/RU2458918C2/ru active
- 2007-07-20 AU AU2007279079A patent/AU2007279079A1/en not_active Abandoned
- 2007-07-20 NZ NZ574375A patent/NZ574375A/en not_active IP Right Cessation
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- 2007-07-20 JP JP2009520057A patent/JP5270542B2/ja not_active Expired - Fee Related
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CA2658496A1 (en) | 2008-01-31 |
JP5270542B2 (ja) | 2013-08-21 |
WO2008012511A1 (en) | 2008-01-31 |
IL196640A (en) | 2013-01-31 |
RU2009101297A (ru) | 2010-08-27 |
US8268878B2 (en) | 2012-09-18 |
DK2046740T3 (da) | 2012-08-20 |
EP2492268A1 (en) | 2012-08-29 |
US20110268693A1 (en) | 2011-11-03 |
BRPI0714840A2 (pt) | 2013-05-21 |
AU2007279079A1 (en) | 2008-01-31 |
MX2009000801A (es) | 2009-02-03 |
HK1130256A1 (en) | 2009-12-24 |
ES2391671T3 (es) | 2012-11-28 |
PT2046740E (pt) | 2012-08-28 |
JP2010500966A (ja) | 2010-01-14 |
SI2046740T1 (sl) | 2012-12-31 |
US20100035956A1 (en) | 2010-02-11 |
IL196640A0 (en) | 2009-11-18 |
EP2046740A1 (en) | 2009-04-15 |
KR20090042808A (ko) | 2009-04-30 |
EP2046740B1 (en) | 2012-05-23 |
NO20090216L (no) | 2009-03-12 |
PL2046740T3 (pl) | 2012-10-31 |
NZ574375A (en) | 2011-06-30 |
RU2458918C2 (ru) | 2012-08-20 |
US7999119B2 (en) | 2011-08-16 |
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