CY1114418T1 - Αλατα προσθηκης αμινων που περιεχουν υδροξυλικες ή/και καρβοξυλικες ομαδες με παραγωγα αμινονικοτινικου οξεως ως αναστολεις της dhodh - Google Patents
Αλατα προσθηκης αμινων που περιεχουν υδροξυλικες ή/και καρβοξυλικες ομαδες με παραγωγα αμινονικοτινικου οξεως ως αναστολεις της dhodhInfo
- Publication number
- CY1114418T1 CY1114418T1 CY20131100818T CY131100818T CY1114418T1 CY 1114418 T1 CY1114418 T1 CY 1114418T1 CY 20131100818 T CY20131100818 T CY 20131100818T CY 131100818 T CY131100818 T CY 131100818T CY 1114418 T1 CY1114418 T1 CY 1114418T1
- Authority
- CY
- Cyprus
- Prior art keywords
- groups
- aminicotinic
- dodh
- suspensions
- carboxylic groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αφορά καινοτόμα, υδατοδιαλυτά φαρμακευτικά αποδεκτά κρυσταλλικά άλατα προσθήκης (i) μιας αμίνης που περιέχει μία ή περισσότερες υδροξυλικές ή/και καρβοξυλικές ομάδες με (ii) παράγωγα αμινονικοτινικού οξέως του χημικού τύπου (Ι), όπου τα Ra, Rb, Rc και Rd αντιπροσωπεύουν ανεξάρτητα το καθένα ομάδες που επιλέγονται από άτομα υδρογόνου, άτομα αλογόνου, αλκυλομάδες C1-4 οι οποίες μπορεί να είναι προαιρετικά υποκατεστημένες με 1, 2 ή 3 υποκατάστατα που επιλέγονται από άτομα αλογόνου και υδροξυομάδες, και αλκοξυομάδες C1-4 οι οποίες μπορεί να είναι προαιρετικά υποκατεστημένες με 1, 2 ή 3 υποκατάστατα που επιλέγονται από άτομα αλογόνου και υδροξυομάδες, καθώς και τα φαρμακευτικά αποδεκτά διαλυτώματα αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382031A EP2228367A1 (en) | 2009-03-13 | 2009-03-13 | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
| EP10708932.8A EP2406225B1 (en) | 2009-03-13 | 2010-03-11 | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as dhodh inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114418T1 true CY1114418T1 (el) | 2016-08-31 |
Family
ID=40677683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100818T CY1114418T1 (el) | 2009-03-13 | 2013-09-18 | Αλατα προσθηκης αμινων που περιεχουν υδροξυλικες ή/και καρβοξυλικες ομαδες με παραγωγα αμινονικοτινικου οξεως ως αναστολεις της dhodh |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US20120014918A1 (el) |
| EP (2) | EP2228367A1 (el) |
| JP (1) | JP5674685B2 (el) |
| KR (1) | KR101674699B1 (el) |
| CN (1) | CN102348689B (el) |
| AR (1) | AR075738A1 (el) |
| AU (1) | AU2010223528B2 (el) |
| BR (1) | BRPI1006766B8 (el) |
| CA (1) | CA2754804C (el) |
| CL (1) | CL2011002216A1 (el) |
| CO (1) | CO6420337A2 (el) |
| CY (1) | CY1114418T1 (el) |
| DK (1) | DK2406225T3 (el) |
| EA (1) | EA022350B1 (el) |
| EC (1) | ECSP11011365A (el) |
| ES (1) | ES2428746T3 (el) |
| HK (1) | HK1162487A1 (el) |
| HR (1) | HRP20130851T1 (el) |
| IL (1) | IL214519A (el) |
| ME (1) | ME01564B (el) |
| MX (1) | MX2011009146A (el) |
| MY (1) | MY155140A (el) |
| NZ (1) | NZ594493A (el) |
| PE (1) | PE20120171A1 (el) |
| PL (1) | PL2406225T3 (el) |
| PT (1) | PT2406225E (el) |
| RS (1) | RS52949B (el) |
| SG (1) | SG173823A1 (el) |
| SI (1) | SI2406225T1 (el) |
| SM (1) | SMT201300104B (el) |
| TW (1) | TWI428127B (el) |
| UA (1) | UA105786C2 (el) |
| UY (1) | UY32467A (el) |
| WO (1) | WO2010102826A1 (el) |
| ZA (1) | ZA201105744B (el) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) * | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
| EP2314577A1 (en) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
| EP2444088A1 (en) * | 2010-10-22 | 2012-04-25 | Almirall, S.A. | Amino derivatives for the treatment of proliferative skin disorders |
| EP2594271A1 (en) * | 2011-11-21 | 2013-05-22 | Almirall, S.A. | 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid for the treatment of psoriasis. |
| KR101251851B1 (ko) | 2011-11-30 | 2013-04-10 | 현대자동차주식회사 | Ｉｓｇ 시스템 및 이의 제어방법 |
| TW201350467A (zh) * | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| TW201400117A (zh) * | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| US20160051679A1 (en) * | 2013-04-12 | 2016-02-25 | Actavis Group Ptc Ehf. | Pemetrexed Formulation |
| WO2018136009A1 (en) | 2017-01-20 | 2018-07-26 | Aslan Pharmaceuticals Pte Ltd | Combination therapy |
| WO2018136010A1 (en) | 2017-01-20 | 2018-07-26 | Aslan Pharmaceuticals Pte Ltd | Combination therapy |
| WO2018157843A1 (zh) * | 2017-03-02 | 2018-09-07 | 中国科学院上海药物研究所 | 2-(取代苯杂基)芳香甲酸类fto抑制剂，其制备方法及其应用 |
| EP3864014B1 (en) | 2018-10-09 | 2023-07-05 | ASLAN Pharmaceuticals Pte Ltd | Malonate salt of varlitinib |
| CA3124401A1 (en) * | 2018-12-21 | 2020-06-25 | Les Laboratoires Servier | Crystalline and salt forms of an organic compound and pharmaceutical compositions thereof |
| EP4228640A1 (en) * | 2020-10-15 | 2023-08-23 | ASLAN Pharmaceuticals Pte Ltd | Treatment of autoimmune diseases with a dihydroorotate hehydrogenase (dhodh) inhibitor |
| CN114907267A (zh) * | 2021-02-08 | 2022-08-16 | 中国科学院上海药物研究所 | 用于抗肿瘤的药物组合 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3839344A (en) * | 1973-03-28 | 1974-10-01 | Schering Corp | N-methyl d-glucamine salt of 2(2'-methyl-3'-trifluoromethylanilino)nicotinic acid |
| GB9804343D0 (en) | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| WO2000076489A2 (en) * | 1999-06-10 | 2000-12-21 | Warner-Lambert Company | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
| CA2443285C (en) | 2001-04-05 | 2007-08-21 | Aventis Pharmaceuticals Inc. | Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| WO2003006424A1 (en) * | 2001-07-10 | 2003-01-23 | 4Sc Ag | Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| JP2004099586A (ja) * | 2002-05-21 | 2004-04-02 | Sumitomo Pharmaceut Co Ltd | ジヒドロオロテートデヒドロゲナーゼ阻害剤 |
| WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| WO2004056747A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Dhodh-inhibitors and method for their identification |
| EP1763346A4 (en) | 2004-05-21 | 2009-03-04 | Uab Research Foundation | COMPOSITION AND METHODS RELATING TO INHIBITORS OF PYRIMIDINE SYNTHESIS |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| JP2008517059A (ja) | 2004-10-19 | 2008-05-22 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 炎症性腸疾患を治療するための（ｚ）−２−シアノ−３−ヒドロキシ−ブタ−２−エン酸−（４’−トリフルオロメチルフェニル）−アミドの使用 |
| JP2007015952A (ja) * | 2005-07-06 | 2007-01-25 | Shionogi & Co Ltd | ナフタレン誘導体 |
| ES2303758B1 (es) | 2006-02-20 | 2009-08-13 | Laboratorios Almirall S.A. | Nuevos derivados de piridin-3-amina. |
| ES2301380B1 (es) | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | Nuevos derivados de 1,7-naftiridina. |
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| UY31272A1 (es) * | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
-
2009
- 2009-03-13 EP EP09382031A patent/EP2228367A1/en not_active Withdrawn
-
2010
- 2010-02-24 UY UY0001032467A patent/UY32467A/es active IP Right Grant
- 2010-03-08 TW TW099106617A patent/TWI428127B/zh active
- 2010-03-11 PE PE2011001599A patent/PE20120171A1/es active IP Right Grant
- 2010-03-11 PT PT107089328T patent/PT2406225E/pt unknown
- 2010-03-11 MX MX2011009146A patent/MX2011009146A/es active IP Right Grant
- 2010-03-11 BR BRPI1006766A patent/BRPI1006766B8/pt active IP Right Grant
- 2010-03-11 ME MEP-2013-106A patent/ME01564B/me unknown
- 2010-03-11 CA CA2754804A patent/CA2754804C/en active Active
- 2010-03-11 RS RS20130394A patent/RS52949B/en unknown
- 2010-03-11 MY MYPI2011004300A patent/MY155140A/en unknown
- 2010-03-11 CN CN201080011530.6A patent/CN102348689B/zh active Active
- 2010-03-11 AU AU2010223528A patent/AU2010223528B2/en active Active
- 2010-03-11 KR KR1020117021314A patent/KR101674699B1/ko active IP Right Grant
- 2010-03-11 SI SI201030344T patent/SI2406225T1/sl unknown
- 2010-03-11 UA UAA201111802A patent/UA105786C2/uk unknown
- 2010-03-11 DK DK10708932.8T patent/DK2406225T3/da active
- 2010-03-11 ES ES10708932T patent/ES2428746T3/es active Active
- 2010-03-11 US US13/256,349 patent/US20120014918A1/en not_active Abandoned
- 2010-03-11 PL PL10708932T patent/PL2406225T3/pl unknown
- 2010-03-11 WO PCT/EP2010/001550 patent/WO2010102826A1/en active Application Filing
- 2010-03-11 SG SG2011060811A patent/SG173823A1/en unknown
- 2010-03-11 AR ARP100100741A patent/AR075738A1/es not_active Application Discontinuation
- 2010-03-11 JP JP2011553360A patent/JP5674685B2/ja active Active
- 2010-03-11 NZ NZ594493A patent/NZ594493A/xx unknown
- 2010-03-11 EA EA201101297A patent/EA022350B1/ru unknown
- 2010-03-11 EP EP10708932.8A patent/EP2406225B1/en active Active
-
2011
- 2011-08-04 ZA ZA2011/05744A patent/ZA201105744B/en unknown
- 2011-08-08 IL IL214519A patent/IL214519A/en active IP Right Grant
- 2011-09-01 CO CO11112338A patent/CO6420337A2/es not_active Application Discontinuation
- 2011-09-08 CL CL2011002216A patent/CL2011002216A1/es unknown
- 2011-09-30 EC EC2011011365A patent/ECSP11011365A/es unknown
-
2012
- 2012-03-21 HK HK12102865.4A patent/HK1162487A1/xx unknown
-
2013
- 2013-09-11 HR HRP20130851AT patent/HRP20130851T1/hr unknown
- 2013-09-18 CY CY20131100818T patent/CY1114418T1/el unknown
- 2013-09-23 SM SM201300104T patent/SMT201300104B/xx unknown
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