CY1107659T1 - Μεθοδος για την παρασκευη στειρας θεραπευτικως αποδεκτης διπροπιονικης μπεκλομεθαζονης - Google Patents

Μεθοδος για την παρασκευη στειρας θεραπευτικως αποδεκτης διπροπιονικης μπεκλομεθαζονης

Info

Publication number
CY1107659T1
CY1107659T1 CY20071100437T CY071100437T CY1107659T1 CY 1107659 T1 CY1107659 T1 CY 1107659T1 CY 20071100437 T CY20071100437 T CY 20071100437T CY 071100437 T CY071100437 T CY 071100437T CY 1107659 T1 CY1107659 T1 CY 1107659T1
Authority
CY
Cyprus
Prior art keywords
preparation
sterile
biplomethone
therapeutic medicine
suspensions
Prior art date
Application number
CY20071100437T
Other languages
English (en)
Inventor
Eva Bernini
Chiara Malvolti
Raffaella Garzia
Gaetano Brambilla
Paolo Chiesi
Original Assignee
Chiesi Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of CY1107659T1 publication Critical patent/CY1107659T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Η εφεύρεση αφορά μια μέθοδο για την παραγωγή εναιωρημάτων σωματιδίων φαρμάκου για εισπνοές, και η οποία μέθοδος, παρέχει σωματίδια με βελτιστοποιημένο σωματιδιακό μέγεθος και κατανομή, ομογενώς κατανεμημένα στο φορέα. Η μέθοδος, που είναι επίσης κατάλληλη για τη παρασκευή στείρων εναιωρημάτων, περιλαμβάνει το στάδιο της ομογενοποίησης και της παραγωγής μικροσκοπικών σωματιδίων του σκευάσματος, σε στροβιλογαλακτωματοποιητή, εξοπλισμένο με στρόβιλο υψηλής ισχύος, και εναλλακτικά, ακολουθεί κατεργασία σε ομογενοποιητή υψηλής πίεσης. Μια περαιτέρω άποψη της εφεύρεσης απευθύνεται σε μια μέθοδο για τη παρασκευή μικρόκοκκης στείρας διπροπιονικής μπεκλομεθαζόνης με ακτινοβολία γάμμα.
CY20071100437T 1998-11-03 2007-03-29 Μεθοδος για την παρασκευη στειρας θεραπευτικως αποδεκτης διπροπιονικης μπεκλομεθαζονης CY1107659T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002364A IT1303692B1 (it) 1998-11-03 1998-11-03 Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
EP99955895A EP1126823B1 (en) 1998-11-03 1999-10-28 A process for the preparation of sterile therapeutically acceptable beclomethasone dipropionate

Publications (1)

Publication Number Publication Date
CY1107659T1 true CY1107659T1 (el) 2013-04-18

Family

ID=11380994

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071100437T CY1107659T1 (el) 1998-11-03 2007-03-29 Μεθοδος για την παρασκευη στειρας θεραπευτικως αποδεκτης διπροπιονικης μπεκλομεθαζονης
CY20151100651T CY1116943T1 (el) 1998-11-03 2015-07-23 Μεθοδος για την παρασκευη εναιωρηματων σωματιδιων δραστικης ουσιας για χορηγηση δια εισπνοης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20151100651T CY1116943T1 (el) 1998-11-03 2015-07-23 Μεθοδος για την παρασκευη εναιωρηματων σωματιδιων δραστικης ουσιας για χορηγηση δια εισπνοης

Country Status (26)

Country Link
US (1) US6464958B1 (el)
EP (2) EP1832279B1 (el)
JP (1) JP2002528484A (el)
KR (1) KR100783096B1 (el)
CN (1) CN1158997C (el)
AT (1) ATE352288T1 (el)
AU (1) AU762367B2 (el)
BR (2) BRPI9917701B1 (el)
CA (2) CA2614633C (el)
CY (2) CY1107659T1 (el)
CZ (2) CZ300650B6 (el)
DE (1) DE69935002T2 (el)
DK (2) DK1832279T3 (el)
EA (1) EA003228B1 (el)
ES (1) ES2281197T3 (el)
HU (2) HU226734B1 (el)
IT (1) IT1303692B1 (el)
NO (1) NO20012175L (el)
NZ (1) NZ511305A (el)
PL (1) PL195908B1 (el)
PT (1) PT1126823E (el)
SI (1) SI1126823T1 (el)
SK (2) SK288316B6 (el)
TR (1) TR200101209T2 (el)
WO (1) WO2000025746A2 (el)
ZA (1) ZA200103526B (el)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4990696A (en) * 1995-02-24 1996-09-11 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
JP4613275B2 (ja) 1998-11-02 2011-01-12 エラン ファーマ インターナショナル，リミティド 多粒子改質放出組成物
AUPQ573300A0 (en) * 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
NZ523693A (en) * 2000-07-10 2004-08-27 Chiron Corp Macrolide formulations for inhalation and methods of treatment of endobronchial infections
SG98420A1 (en) * 2000-07-13 2003-09-19 Purzer Pharmaceutical Co Ltd Method for transferring one or more active ingredients between different phase carriers
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030091513A1 (en) * 2001-10-03 2003-05-15 Mohsen Nahed M. Method to generate water soluble or nonwater soluble in nanoparticulates directly in suspension or dispersion media
US20030129242A1 (en) * 2002-01-04 2003-07-10 Bosch H. William Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer
WO2003070285A1 (en) 2002-02-19 2003-08-28 Resolution Chemicals Limited Solvent-based sterilisation of pharmaceuticals
ITMI20020808A1 (it) * 2002-04-17 2003-10-17 Chiesi Farma Spa Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
AU2003268380A1 (en) * 2002-10-04 2004-05-04 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
ITMI20022674A1 (it) 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
WO2004073685A1 (en) * 2003-02-20 2004-09-02 Constant Research & Development Limited Dexamethasone-containing formulations for oral administration as well the process for manufacturing required therefor
EP1454636A1 (en) * 2003-03-04 2004-09-08 Dompé S.P.A. Sterilization of glucocorticoid drug particles for pulmonary delivery
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) * 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
WO2004105809A1 (en) * 2003-05-22 2004-12-09 Elan Pharma International Ltd. Sterilization of dispersions of nanoparticulate active agents with gamma radiation
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
GB0319500D0 (en) * 2003-08-19 2003-09-17 Resolution Chemicals Ltd Particle-size reduction apparatus,and use thereof
ITMI20032054A1 (it) 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
KR20060116833A (ko) * 2003-11-18 2006-11-15 얀송 샨 건강에 좋은 유쾌한 흡입장치
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
EP1574222B1 (en) * 2004-03-12 2011-02-09 Cipla Ltd. Sterilization process for steroids
KR20120091378A (ko) 2004-03-23 2012-08-17 노파르티스 아게 제약 조성물
GB0406515D0 (en) * 2004-03-23 2004-04-28 Novartis Ag Organic compounds
ITMI20040795A1 (it) * 2004-04-23 2004-07-23 Eratech S R L Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa
GB0410995D0 (en) 2004-05-17 2004-06-23 Norton Healthcare Ltd Heat sterilization of glucocorticosteroids
GB0425266D0 (en) * 2004-11-16 2004-12-15 Norton Healthcare Ltd Pharmaceutical manufacturing process
JP5324098B2 (ja) * 2004-11-16 2013-10-23 アルケルメス ファーマ アイルランド リミテッド 注射可能なナノ粒子のオランザピン製剤
GB0427568D0 (en) * 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
ES2388287T3 (es) 2005-01-20 2012-10-11 Eratech S.R.L. Procedimiento para la preparación de suspensiones concentradas de fármacos y kit correspondiente
US20090252801A1 (en) * 2005-11-29 2009-10-08 Farmbios S.P.A. Process for the Preparation of Micronised Sterile Steroids
KR20090031618A (ko) * 2006-07-12 2009-03-26 엘란 코포레이션, 피엘씨 나노입자형 모다피닐 제제
KR20100095587A (ko) * 2007-12-13 2010-08-31 노파르티스 아게 유기 화합물
JP2012527490A (ja) * 2009-05-25 2012-11-08 シエシー ファルマセウティチィ ソシエタ ペル アチオニ 肺表面活性物質およびステロイドを有する治療的組み合わせ
ES2612257T3 (es) 2011-05-03 2017-05-16 Chiesi Farmaceutici S.P.A. Formulación de suspensión mejorada de dipropionato de beclometasona para administración mediante inhalación
BR112013027390A2 (pt) 2011-05-04 2017-01-17 Chiesi Farma Spa formulação farmacêutica
CN104739811A (zh) * 2015-02-27 2015-07-01 上海臣邦医药科技有限公司 一种糖皮质激素雾化吸入混悬液及其制备方法
TWI773641B (zh) * 2015-05-08 2022-08-11 日商活效製藥股份有限公司 含有糖皮質類固醇（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ）之奈米微粒子之水性懸浮液劑
WO2023136787A1 (en) * 2022-01-17 2023-07-20 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Process for the preparation of a sterile, homogeneous suspension for inhalation by nebulization

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2024872C (en) * 1989-09-08 2002-07-09 James Barry Douglas Palmer Medicaments
US5126123A (en) * 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
JPH0486921A (ja) * 1990-07-31 1992-03-19 Omron Corp 近似推論のための知識ベース形成方法および装置
US5046326A (en) * 1990-10-24 1991-09-10 Thermo King Corporation Transport refrigeration system
IT1243911B (it) * 1990-11-19 1994-06-28 Zambon Spa Composizioni per la terapia mucolitica
GB9202519D0 (en) * 1992-02-06 1992-03-25 Glaxo Group Ltd Medicaments
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
UY24147A1 (es) * 1995-01-20 1996-02-02 Gruenenthal Chemie Procedimiento y dispositivo para preparar composiciones dispersables por aspersion de aerosoles
US6135628A (en) * 1995-10-13 2000-10-24 Boehringer Ingelheim Pharmceuticals, Inc. Method and apparatus for homogenizing aerosol formulations
IT1286496B1 (it) * 1996-11-20 1998-07-15 Leetrim Ltd Dublin Composizione farmaceutica orale ad attivita' antipiretica,analgesica ed antiinfiammatoria
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter

Also Published As

Publication number Publication date
BR9915251A (pt) 2001-10-30
CA2349268C (en) 2009-03-31
ATE352288T1 (de) 2007-02-15
NZ511305A (en) 2003-07-25
DE69935002D1 (de) 2007-03-15
EP1832279A2 (en) 2007-09-12
NO20012175L (no) 2001-07-02
KR100783096B1 (ko) 2007-12-07
SI1126823T1 (sl) 2007-04-30
EA003228B1 (ru) 2003-02-27
BRPI9915251B8 (pt) 2021-05-25
WO2000025746A3 (en) 2000-10-26
SK5932001A3 (en) 2001-11-06
NO20012175D0 (no) 2001-05-02
AU1266600A (en) 2000-05-22
DK1832279T3 (en) 2015-10-05
TR200101209T2 (tr) 2001-09-21
EP1832279B1 (en) 2015-07-01
CA2614633A1 (en) 2000-05-11
AU762367B2 (en) 2003-06-26
ITMI982364A1 (it) 2000-05-03
SK288316B6 (sk) 2015-11-03
PL347908A1 (en) 2002-04-22
PT1126823E (pt) 2007-04-30
SK285487B6 (sk) 2007-02-01
CA2614633C (en) 2010-12-21
KR20010075656A (ko) 2001-08-09
ZA200103526B (en) 2002-06-03
CA2349268A1 (en) 2000-05-11
EP1126823A2 (en) 2001-08-29
PL195908B1 (pl) 2007-11-30
DK1126823T3 (da) 2007-05-21
DE69935002T2 (de) 2007-07-19
EP1126823B1 (en) 2007-01-24
CN1158997C (zh) 2004-07-28
US6464958B1 (en) 2002-10-15
EP1832279A3 (en) 2008-03-05
WO2000025746A2 (en) 2000-05-11
CZ20011541A3 (cs) 2001-09-12
CZ300650B6 (cs) 2009-07-08
HUP0104230A3 (en) 2006-07-28
EA200100397A1 (ru) 2001-10-22
HU0700446D0 (en) 2007-08-28
HU230121B1 (hu) 2015-08-28
BRPI9915251B1 (pt) 2015-09-01
HU226734B1 (en) 2009-08-28
CZ306939B6 (cs) 2017-09-27
CN1335766A (zh) 2002-02-13
ES2281197T3 (es) 2007-09-16
HUP0104230A2 (hu) 2002-03-28
CZ2007211A3 (cs) 2017-09-27
CY1116943T1 (el) 2017-04-05
BRPI9917701B1 (pt) 2016-07-19
JP2002528484A (ja) 2002-09-03
IT1303692B1 (it) 2001-02-23

Similar Documents

Publication Publication Date Title
CY1107659T1 (el) Μεθοδος για την παρασκευη στειρας θεραπευτικως αποδεκτης διπροπιονικης μπεκλομεθαζονης
US4736745A (en) Laser treatment of cancerization of the oral cavity and apparatus for use therewith
Boldrini et al. Biomechanical effect of one session of low-level laser on the bone–titanium implant interface
US5976066A (en) Neutron capture therapies
Toida et al. Usefulness of low-level laser for control of painful stomatitis in patients with hand-foot-and-mouth disease
CN107362359A (zh) 通过离子植入形成用于中子俘获治疗的组成物
Suresh et al. Applications of cold atmospheric pressure plasma in dentistry—A review
Madsen et al. Comparing the effects of light-or sonic-activated drug delivery: photochemical/sonochemical internalization
Ward The palatal flap
Holt Increase in X-ray sensitivity of cancer after exposure to 434 MHz electromagnetic radiation
Fromont-Colson et al. Efficiency of low-level laser therapy for orthodontic tooth movement: a review
Pourparvar et al. Evaluation and Comparison of the Dose Received by the Mandible, Maxilla, and Teeth in Two Methods of Three-dimensional Conformal Radiation Therapy and Helical Tomotherapy
Babincova et al. Photodynamic therapy of pigmented melanoma B16 using sterically stabilized fullerenosomes
Meng et al. Radioactive seed implantation combined with prosthesis denture in treatment of oral and maxillofacial malignancy
Chitroda et al. Photodynamic therapy-a review
Gopal et al. The Efficacy of Low-Level Laser Therapy on the Healing of Oral Wounds: A Systematic Review
JP3242026B2 (ja) 細胞破壊装置
Nam The validity of oral prosthetic stents for maxillofacial cancer during radiation therapy: case report
Özsoylu Treatment of Kasabach-Merritt syndrome by megadose methylprednisolone
Betenya et al. RADIATION IN MEDICINE AND METHODS OF RADIOLOGICAL PROTECTION
Tajima Targeted Electron Radiation Theranostics of COVID-19 by Laser Wakefield Accelerators (LFWA)
He et al. Cyanoacrylate-nano drug: A bone-targeted therapy
Maruyama et al. Cf-252 neutron brachytherapy of short duration for bulky neck tumors
Cao et al. Radiosensitizing Pancreatic Cancer Xenografts by an Implantable Micro-Oxygen Generator
Olson et al. Interstitial treatment of brain tumors with iridium-192