HUP0104230A2 - Eljárás inhalációs adagolásra alkalmas hatóanyagszemcsék szuszpenzióinak előállítására - Google Patents

Eljárás inhalációs adagolásra alkalmas hatóanyagszemcsék szuszpenzióinak előállítására

Info

Publication number
HUP0104230A2
HUP0104230A2 HU0104230A HUP0104230A HUP0104230A2 HU P0104230 A2 HUP0104230 A2 HU P0104230A2 HU 0104230 A HU0104230 A HU 0104230A HU P0104230 A HUP0104230 A HU P0104230A HU P0104230 A2 HUP0104230 A2 HU P0104230A2
Authority
HU
Hungary
Prior art keywords
suspensions
production
preparation
drug particles
inhalation delivery
Prior art date
Application number
HU0104230A
Other languages
English (en)
Inventor
Eva Bernini
Gaetano Brambilla
Paolo Chiesi
Raffaella Garzia
Chiara Malvolti
Original Assignee
Chiesi Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of HUP0104230A2 publication Critical patent/HUP0104230A2/hu
Publication of HUP0104230A3 publication Critical patent/HUP0104230A3/hu
Publication of HU226734B1 publication Critical patent/HU226734B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

A találmány eljárást ismertet inhalációs alkalmazású gyógyszerszemcsékszuszpenzióinak előállítására; a szóban forgó eljárás soránoptimalizált szemcseméretű és eloszlású, a hordozóban homogén módondiszpergált szemcséket állítanak elő. Az eljárás - amely sterilszuszpenziók előállítására is alkalmas - első lépésébennagyteljesítményű turbinával felszerelt turboemulgeátorbanhomogenizálják és mikronizálják a hatóanyagot, majd adott esetbennagynyomású homogenizátorban kezelik azt. A találmány továbbá eljárástismertet mikronizált steril beklometazon-dipropionát gamma-sugárzássaltörténő előállítására. Ó
HU0104230A 1998-11-03 1999-10-28 Process for the preparation of suspension containing micronised form of beclometasone dipropionate for inhalation use HU226734B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002364A IT1303692B1 (it) 1998-11-03 1998-11-03 Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
PCT/EP1999/008176 WO2000025746A2 (en) 1998-11-03 1999-10-28 A process for the preparation of suspensions of drug particles for inhalation delivery

Publications (3)

Publication Number Publication Date
HUP0104230A2 true HUP0104230A2 (hu) 2002-03-28
HUP0104230A3 HUP0104230A3 (en) 2006-07-28
HU226734B1 HU226734B1 (en) 2009-08-28

Family

ID=11380994

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0104230A HU226734B1 (en) 1998-11-03 1999-10-28 Process for the preparation of suspension containing micronised form of beclometasone dipropionate for inhalation use
HU0700446A HU230121B1 (hu) 1998-11-03 1999-10-28 Eljárás inhalációs adagolásra alkalmas hatóanyagszemcsék szuszpenzióinak előállítására

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0700446A HU230121B1 (hu) 1998-11-03 1999-10-28 Eljárás inhalációs adagolásra alkalmas hatóanyagszemcsék szuszpenzióinak előállítására

Country Status (26)

Country Link
US (1) US6464958B1 (hu)
EP (2) EP1832279B1 (hu)
JP (1) JP2002528484A (hu)
KR (1) KR100783096B1 (hu)
CN (1) CN1158997C (hu)
AT (1) ATE352288T1 (hu)
AU (1) AU762367B2 (hu)
BR (2) BRPI9915251B8 (hu)
CA (2) CA2349268C (hu)
CY (2) CY1107659T1 (hu)
CZ (2) CZ300650B6 (hu)
DE (1) DE69935002T2 (hu)
DK (2) DK1832279T3 (hu)
EA (1) EA003228B1 (hu)
ES (1) ES2281197T3 (hu)
HU (2) HU226734B1 (hu)
IT (1) IT1303692B1 (hu)
NO (1) NO20012175L (hu)
NZ (1) NZ511305A (hu)
PL (1) PL195908B1 (hu)
PT (1) PT1126823E (hu)
SI (1) SI1126823T1 (hu)
SK (2) SK285487B6 (hu)
TR (1) TR200101209T2 (hu)
WO (1) WO2000025746A2 (hu)
ZA (1) ZA200103526B (hu)

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ITMI20022674A1 (it) * 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
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ATE497787T1 (de) * 2004-03-12 2011-02-15 Cipla Ltd Sterilisationsprozess für steroide
JP5138362B2 (ja) 2004-03-23 2013-02-06 ノバルティス アーゲー 医薬組成物
GB0406515D0 (en) * 2004-03-23 2004-04-28 Novartis Ag Organic compounds
ITMI20040795A1 (it) * 2004-04-23 2004-07-23 Eratech S R L Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa
GB0410995D0 (en) 2004-05-17 2004-06-23 Norton Healthcare Ltd Heat sterilization of glucocorticosteroids
US7910577B2 (en) * 2004-11-16 2011-03-22 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
GB0425266D0 (en) * 2004-11-16 2004-12-15 Norton Healthcare Ltd Pharmaceutical manufacturing process
GB0427568D0 (en) * 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
EP1683514B1 (en) 2005-01-20 2012-05-23 Eratech S.r.l. Process for the preparation of concentrated suspensions of drugs and kit thereof
US20090252801A1 (en) * 2005-11-29 2009-10-08 Farmbios S.P.A. Process for the Preparation of Micronised Sterile Steroids
JP2009543803A (ja) * 2006-07-12 2009-12-10 エラン・ファルマ・インターナショナル・リミテッド モダフィニルのナノ粒子製剤
CA2707594C (en) * 2007-12-13 2015-08-18 Novartis Ag Process for preparing particulates of crystalline drug substance
EP2435081B1 (en) * 2009-05-25 2013-04-17 Chiesi Farmaceutici S.p.A. A therapeutic combination comprising a pulmonary surfactant and a steroid
SI2704724T1 (sl) 2011-05-03 2017-01-31 Chiesi Farmaceutici S.P.A. Izboljšana formulacija suspenzije beklometazon dipropionata za dajanje z inhalacijo
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CN104739811A (zh) * 2015-02-27 2015-07-01 上海臣邦医药科技有限公司 一种糖皮质激素雾化吸入混悬液及其制备方法
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Also Published As

Publication number Publication date
EP1832279A3 (en) 2008-03-05
BRPI9915251B1 (pt) 2015-09-01
DE69935002D1 (de) 2007-03-15
IT1303692B1 (it) 2001-02-23
DK1126823T3 (da) 2007-05-21
SK285487B6 (sk) 2007-02-01
ATE352288T1 (de) 2007-02-15
CZ306939B6 (cs) 2017-09-27
JP2002528484A (ja) 2002-09-03
CA2349268A1 (en) 2000-05-11
BR9915251A (pt) 2001-10-30
CA2614633C (en) 2010-12-21
NO20012175L (no) 2001-07-02
CA2614633A1 (en) 2000-05-11
EP1832279A2 (en) 2007-09-12
BRPI9915251B8 (pt) 2021-05-25
EP1126823B1 (en) 2007-01-24
CZ20011541A3 (cs) 2001-09-12
HUP0104230A3 (en) 2006-07-28
CA2349268C (en) 2009-03-31
CZ300650B6 (cs) 2009-07-08
DK1832279T3 (en) 2015-10-05
KR100783096B1 (ko) 2007-12-07
ZA200103526B (en) 2002-06-03
AU762367B2 (en) 2003-06-26
NO20012175D0 (no) 2001-05-02
US6464958B1 (en) 2002-10-15
AU1266600A (en) 2000-05-22
HU226734B1 (en) 2009-08-28
WO2000025746A2 (en) 2000-05-11
DE69935002T2 (de) 2007-07-19
ES2281197T3 (es) 2007-09-16
PL195908B1 (pl) 2007-11-30
TR200101209T2 (tr) 2001-09-21
BRPI9917701B1 (pt) 2016-07-19
KR20010075656A (ko) 2001-08-09
PT1126823E (pt) 2007-04-30
CY1107659T1 (el) 2013-04-18
NZ511305A (en) 2003-07-25
CN1158997C (zh) 2004-07-28
CY1116943T1 (el) 2017-04-05
ITMI982364A1 (it) 2000-05-03
SI1126823T1 (sl) 2007-04-30
EA200100397A1 (ru) 2001-10-22
HU0700446D0 (en) 2007-08-28
EA003228B1 (ru) 2003-02-27
HU230121B1 (hu) 2015-08-28
EP1832279B1 (en) 2015-07-01
PL347908A1 (en) 2002-04-22
CN1335766A (zh) 2002-02-13
SK5932001A3 (en) 2001-11-06
WO2000025746A3 (en) 2000-10-26
EP1126823A2 (en) 2001-08-29
CZ2007211A3 (cs) 2017-09-27
SK288316B6 (sk) 2015-11-03

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