BR9915251A - Um processo para a preparação de suspensões departìculas de medicamentos para seremadministradas por inalação - Google Patents

Um processo para a preparação de suspensões departìculas de medicamentos para seremadministradas por inalação

Info

Publication number
BR9915251A
BR9915251A BR9915251-7A BR9915251A BR9915251A BR 9915251 A BR9915251 A BR 9915251A BR 9915251 A BR9915251 A BR 9915251A BR 9915251 A BR9915251 A BR 9915251A
Authority
BR
Brazil
Prior art keywords
suspensions
inhalation
preparation
medicines
administered
Prior art date
Application number
BR9915251-7A
Other languages
English (en)
Other versions
BRPI9915251B8 (pt
BRPI9915251B1 (pt
Inventor
Paolo Chiesi
Gaetano Brambilla
Raffaella Garzia
Eva Bernini
Hiara Malvotti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BR9915251A publication Critical patent/BR9915251A/pt
Publication of BRPI9915251B1 publication Critical patent/BRPI9915251B1/pt
Publication of BRPI9915251B8 publication Critical patent/BRPI9915251B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

"UM PROCESSO PARA A PREPARAçãO DE SUSPENSõES DEPARTìCULAS DE MEDICAMENTOS PARA SEREMADMINISTRADAS POR INALAçãO". A invenção diz respeito aum processo para a preparação de suspensões de partículas demedicamentos para aplicação por inalação, oferecendo partículasde tamanho e distribuição otimizados, dispersadoshomogeneamente no veículo. O processo, que é tambémadequado para a preparação de suspensões estéreis, inclui opasso de homogeneização e micronização da formulação por meiode um turbo emulsificador provido de uma turbina de alta potência,opcionalmente seguido de um tratamento em um homogeneizadorde alta pressão. Ainda um outro aspecto da invenção é dirigido aum processo para a preparação de dipropionato de beclometasonamicronizado e estéril, por meio de irradiação gama.
BRPI9915251A 1998-11-03 1999-10-28 um processo para a preparação de suspensões de partículas de medicamentos para serem administradas por inalação BRPI9915251B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002364A IT1303692B1 (it) 1998-11-03 1998-11-03 Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
PCT/EP1999/008176 WO2000025746A2 (en) 1998-11-03 1999-10-28 A process for the preparation of suspensions of drug particles for inhalation delivery

Publications (3)

Publication Number Publication Date
BR9915251A true BR9915251A (pt) 2001-10-30
BRPI9915251B1 BRPI9915251B1 (pt) 2015-09-01
BRPI9915251B8 BRPI9915251B8 (pt) 2021-05-25

Family

ID=11380994

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9917701A BRPI9917701B1 (pt) 1998-11-03 1999-10-28 processo para a esterilização do dipropionato de beclometasona micronizado e dipropionato de beclometasona micronizado estéril terapeuticamente aceitável
BRPI9915251A BRPI9915251B8 (pt) 1998-11-03 1999-10-28 um processo para a preparação de suspensões de partículas de medicamentos para serem administradas por inalação

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI9917701A BRPI9917701B1 (pt) 1998-11-03 1999-10-28 processo para a esterilização do dipropionato de beclometasona micronizado e dipropionato de beclometasona micronizado estéril terapeuticamente aceitável

Country Status (26)

Country Link
US (1) US6464958B1 (pt)
EP (2) EP1832279B1 (pt)
JP (1) JP2002528484A (pt)
KR (1) KR100783096B1 (pt)
CN (1) CN1158997C (pt)
AT (1) ATE352288T1 (pt)
AU (1) AU762367B2 (pt)
BR (2) BRPI9917701B1 (pt)
CA (2) CA2614633C (pt)
CY (2) CY1107659T1 (pt)
CZ (2) CZ300650B6 (pt)
DE (1) DE69935002T2 (pt)
DK (2) DK1832279T3 (pt)
EA (1) EA003228B1 (pt)
ES (1) ES2281197T3 (pt)
HU (2) HU226734B1 (pt)
IT (1) IT1303692B1 (pt)
NO (1) NO20012175L (pt)
NZ (1) NZ511305A (pt)
PL (1) PL195908B1 (pt)
PT (1) PT1126823E (pt)
SI (1) SI1126823T1 (pt)
SK (2) SK288316B6 (pt)
TR (1) TR200101209T2 (pt)
WO (1) WO2000025746A2 (pt)
ZA (1) ZA200103526B (pt)

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ITMI20022674A1 (it) 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
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ITMI20032054A1 (it) 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
KR20060116833A (ko) * 2003-11-18 2006-11-15 얀송 샨 건강에 좋은 유쾌한 흡입장치
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
EP1574222B1 (en) * 2004-03-12 2011-02-09 Cipla Ltd. Sterilization process for steroids
KR20120091378A (ko) 2004-03-23 2012-08-17 노파르티스 아게 제약 조성물
GB0406515D0 (en) * 2004-03-23 2004-04-28 Novartis Ag Organic compounds
ITMI20040795A1 (it) * 2004-04-23 2004-07-23 Eratech S R L Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa
GB0410995D0 (en) 2004-05-17 2004-06-23 Norton Healthcare Ltd Heat sterilization of glucocorticosteroids
GB0425266D0 (en) * 2004-11-16 2004-12-15 Norton Healthcare Ltd Pharmaceutical manufacturing process
JP5324098B2 (ja) * 2004-11-16 2013-10-23 アルケルメス ファーマ アイルランド リミテッド 注射可能なナノ粒子のオランザピン製剤
GB0427568D0 (en) * 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
ES2388287T3 (es) 2005-01-20 2012-10-11 Eratech S.R.L. Procedimiento para la preparación de suspensiones concentradas de fármacos y kit correspondiente
US20090252801A1 (en) * 2005-11-29 2009-10-08 Farmbios S.P.A. Process for the Preparation of Micronised Sterile Steroids
KR20090031618A (ko) * 2006-07-12 2009-03-26 엘란 코포레이션, 피엘씨 나노입자형 모다피닐 제제
KR20100095587A (ko) * 2007-12-13 2010-08-31 노파르티스 아게 유기 화합물
JP2012527490A (ja) * 2009-05-25 2012-11-08 シエシー ファルマセウティチィ ソシエタ ペル アチオニ 肺表面活性物質およびステロイドを有する治療的組み合わせ
ES2612257T3 (es) 2011-05-03 2017-05-16 Chiesi Farmaceutici S.P.A. Formulación de suspensión mejorada de dipropionato de beclometasona para administración mediante inhalación
BR112013027390A2 (pt) 2011-05-04 2017-01-17 Chiesi Farma Spa formulação farmacêutica
CN104739811A (zh) * 2015-02-27 2015-07-01 上海臣邦医药科技有限公司 一种糖皮质激素雾化吸入混悬液及其制备方法
TWI773641B (zh) * 2015-05-08 2022-08-11 日商活效製藥股份有限公司 含有糖皮質類固醇（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ）之奈米微粒子之水性懸浮液劑
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Also Published As

Publication number Publication date
CA2349268C (en) 2009-03-31
ATE352288T1 (de) 2007-02-15
NZ511305A (en) 2003-07-25
DE69935002D1 (de) 2007-03-15
EP1832279A2 (en) 2007-09-12
NO20012175L (no) 2001-07-02
KR100783096B1 (ko) 2007-12-07
SI1126823T1 (sl) 2007-04-30
EA003228B1 (ru) 2003-02-27
BRPI9915251B8 (pt) 2021-05-25
WO2000025746A3 (en) 2000-10-26
SK5932001A3 (en) 2001-11-06
NO20012175D0 (no) 2001-05-02
AU1266600A (en) 2000-05-22
DK1832279T3 (en) 2015-10-05
TR200101209T2 (tr) 2001-09-21
EP1832279B1 (en) 2015-07-01
CA2614633A1 (en) 2000-05-11
AU762367B2 (en) 2003-06-26
ITMI982364A1 (it) 2000-05-03
SK288316B6 (sk) 2015-11-03
PL347908A1 (en) 2002-04-22
PT1126823E (pt) 2007-04-30
SK285487B6 (sk) 2007-02-01
CA2614633C (en) 2010-12-21
KR20010075656A (ko) 2001-08-09
ZA200103526B (en) 2002-06-03
CA2349268A1 (en) 2000-05-11
EP1126823A2 (en) 2001-08-29
PL195908B1 (pl) 2007-11-30
DK1126823T3 (da) 2007-05-21
DE69935002T2 (de) 2007-07-19
EP1126823B1 (en) 2007-01-24
CN1158997C (zh) 2004-07-28
US6464958B1 (en) 2002-10-15
EP1832279A3 (en) 2008-03-05
WO2000025746A2 (en) 2000-05-11
CZ20011541A3 (cs) 2001-09-12
CZ300650B6 (cs) 2009-07-08
HUP0104230A3 (en) 2006-07-28
EA200100397A1 (ru) 2001-10-22
HU0700446D0 (en) 2007-08-28
HU230121B1 (hu) 2015-08-28
BRPI9915251B1 (pt) 2015-09-01
HU226734B1 (en) 2009-08-28
CZ306939B6 (cs) 2017-09-27
CY1107659T1 (el) 2013-04-18
CN1335766A (zh) 2002-02-13
ES2281197T3 (es) 2007-09-16
HUP0104230A2 (hu) 2002-03-28
CZ2007211A3 (cs) 2017-09-27
CY1116943T1 (el) 2017-04-05
BRPI9917701B1 (pt) 2016-07-19
JP2002528484A (ja) 2002-09-03
IT1303692B1 (it) 2001-02-23

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15G Petition not considered as such [chapter 15.7 patent gazette]

Free format text: NAO CONHECIDA A PETICAO NO 018080046131/SP DE 21/07/2008 EM VIRTUDE DO EXPOSTO NO ART. 219 INCISO II DA LPI, UMA VEZ QUE JA CONSTA PETICAO DE EXAME, VALIDA E ANTERIOR, DOS AUTOS DO PROCESSO.

B09B Patent application refused [chapter 9.2 patent gazette]

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B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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