TR200101209T2 - Teneffüs yoluyla uygulanan ilaç parçacıklarının süspansiyonlarının hazırlanması için bir işlem - Google Patents
Teneffüs yoluyla uygulanan ilaç parçacıklarının süspansiyonlarının hazırlanması için bir işlemInfo
- Publication number
- TR200101209T2 TR200101209T2 TR2001/01209T TR200101209T TR200101209T2 TR 200101209 T2 TR200101209 T2 TR 200101209T2 TR 2001/01209 T TR2001/01209 T TR 2001/01209T TR 200101209 T TR200101209 T TR 200101209T TR 200101209 T2 TR200101209 T2 TR 200101209T2
- Authority
- TR
- Turkey
- Prior art keywords
- preparation
- suspensions
- inhalation
- drug particles
- directed
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000002245 particle Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000000725 suspension Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 abstract 1
- 229950000210 beclometasone dipropionate Drugs 0.000 abstract 1
- 238000009826 distribution Methods 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
Abstract
Bulus, teneffüs yoluyla uygulanmak üzere ilaç parçaciklarinin süspansiyonlarinin hazirlanmasi için bir isleme yönelik olup, bahsedilen islem optimize parçacik boyutu ve tasiyici içinde homojen olarak dagilma dagilimi olan parçaciklari saglar. Steril süspansiyonlarin hazirlanmasi için de uygun olan bu islem, formülasyonun yüksek güçlü türbin ile donatilmis bir turbo-emülsiflestirici içinde homojenlestirme ve mikronlastirma adimini ve opsiyonel olarak ardindan bir yüksek basinçli homojenlestirici içinde bir islem adimini içerir. Bulusun diger bir amaci ise mikronlastirilmis steril beklometason dipropionatin gama isimasi ile hazirlanmasi için olan bir isleme de yöneliktir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI002364A IT1303692B1 (it) | 1998-11-03 | 1998-11-03 | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200101209T2 true TR200101209T2 (tr) | 2001-09-21 |
Family
ID=11380994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/01209T TR200101209T2 (tr) | 1998-11-03 | 1999-10-28 | Teneffüs yoluyla uygulanan ilaç parçacıklarının süspansiyonlarının hazırlanması için bir işlem |
Country Status (26)
Country | Link |
---|---|
US (1) | US6464958B1 (tr) |
EP (2) | EP1126823B1 (tr) |
JP (1) | JP2002528484A (tr) |
KR (1) | KR100783096B1 (tr) |
CN (1) | CN1158997C (tr) |
AT (1) | ATE352288T1 (tr) |
AU (1) | AU762367B2 (tr) |
BR (2) | BRPI9917701B1 (tr) |
CA (2) | CA2349268C (tr) |
CY (2) | CY1107659T1 (tr) |
CZ (2) | CZ2007211A3 (tr) |
DE (1) | DE69935002T2 (tr) |
DK (2) | DK1126823T3 (tr) |
EA (1) | EA003228B1 (tr) |
ES (1) | ES2281197T3 (tr) |
HU (2) | HU230121B1 (tr) |
IT (1) | IT1303692B1 (tr) |
NO (1) | NO20012175L (tr) |
NZ (1) | NZ511305A (tr) |
PL (1) | PL195908B1 (tr) |
PT (1) | PT1126823E (tr) |
SI (1) | SI1126823T1 (tr) |
SK (2) | SK288316B6 (tr) |
TR (1) | TR200101209T2 (tr) |
WO (1) | WO2000025746A2 (tr) |
ZA (1) | ZA200103526B (tr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69633222T2 (de) * | 1995-02-24 | 2005-09-08 | Elan Pharma International Ltd. | Nanopartikel-dispersionen enthaltende aerosole |
CZ303495B6 (cs) | 1998-11-02 | 2012-10-24 | Elan Pharma International Limited | Mnohocásticový modifikovane uvolnující prostredek a jeho použití, pevná orální dávkovací forma |
AUPQ573300A0 (en) * | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
NZ523693A (en) * | 2000-07-10 | 2004-08-27 | Chiron Corp | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
SG98420A1 (en) * | 2000-07-13 | 2003-09-19 | Purzer Pharmaceutical Co Ltd | Method for transferring one or more active ingredients between different phase carriers |
US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
US20030091513A1 (en) * | 2001-10-03 | 2003-05-15 | Mohsen Nahed M. | Method to generate water soluble or nonwater soluble in nanoparticulates directly in suspension or dispersion media |
US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
EP1476201B1 (en) | 2002-02-19 | 2008-12-24 | Resolution Chemicals Limited | Solvent-based sterilisation of steroids |
ITMI20020808A1 (it) * | 2002-04-17 | 2003-10-17 | Chiesi Farma Spa | Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione |
EP1556091A1 (en) * | 2002-10-04 | 2005-07-27 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
ITMI20022674A1 (it) * | 2002-12-18 | 2004-06-19 | Chiesi Farma Spa | Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione. |
US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
EP1594471B1 (en) * | 2003-02-20 | 2009-03-25 | Constant Research & Development Limited | Process for manufacturing a dexamethasone-containing formulation for oral administration |
EP1454636A1 (en) * | 2003-03-04 | 2004-09-08 | Dompé S.P.A. | Sterilization of glucocorticoid drug particles for pulmonary delivery |
US9808471B2 (en) * | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
US8912174B2 (en) * | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
US7811606B2 (en) * | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
WO2004105809A1 (en) * | 2003-05-22 | 2004-12-09 | Elan Pharma International Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
GB0319500D0 (en) * | 2003-08-19 | 2003-09-17 | Resolution Chemicals Ltd | Particle-size reduction apparatus,and use thereof |
ITMI20032054A1 (it) | 2003-10-22 | 2005-04-23 | Monteres S R L | Processo per la preparazione di sospensioni farmaceutiche da inalare. |
MXPA06005604A (es) * | 2003-11-18 | 2007-01-30 | Yansong Shan | Dispositivo de inhalacion saludable yagradable. |
PE20050941A1 (es) | 2003-12-16 | 2005-11-08 | Nycomed Gmbh | Suspensiones acuosas de ciclesonida para nebulizacion |
ATE497787T1 (de) * | 2004-03-12 | 2011-02-15 | Cipla Ltd | Sterilisationsprozess für steroide |
WO2005089718A2 (en) | 2004-03-23 | 2005-09-29 | Novartis Ag | Pharmaceutical compositions |
GB0406515D0 (en) * | 2004-03-23 | 2004-04-28 | Novartis Ag | Organic compounds |
ITMI20040795A1 (it) * | 2004-04-23 | 2004-07-23 | Eratech S R L | Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa |
GB0410995D0 (en) * | 2004-05-17 | 2004-06-23 | Norton Healthcare Ltd | Heat sterilization of glucocorticosteroids |
EA200701065A1 (ru) * | 2004-11-16 | 2007-12-28 | Элан Фарма Интернэшнл Лтд. | Инъецируемые составы, содержащие нанодисперсный оланзапин |
GB0425266D0 (en) | 2004-11-16 | 2004-12-15 | Norton Healthcare Ltd | Pharmaceutical manufacturing process |
GB0427568D0 (en) | 2004-12-16 | 2005-01-19 | Resolution Chemicals Ltd | Particle-size reduction apparatus, and the use thereof |
ES2388287T3 (es) | 2005-01-20 | 2012-10-11 | Eratech S.R.L. | Procedimiento para la preparación de suspensiones concentradas de fármacos y kit correspondiente |
EP1968547A1 (en) * | 2005-11-29 | 2008-09-17 | Farmabios S.p.A. | Process for the preparation of micronised sterile steroids |
BRPI0714173A2 (pt) * | 2006-07-12 | 2012-12-25 | Elan Pharma Int Ltd | composiÇço nanoparticulada estÁvel,mÉtodos para preparar a composiÇço, para prevenir e/ou tratar estados de doenÇas, sintomas, sÍndromes e condiÇÕes do sistema nervoso central, para melhorar ou manter a biodisponibilidade de modafinil, e para tratar distérbio com base neurolàgica, composiÇço farmacÊutica, e forma de dosagem |
CA2707594C (en) * | 2007-12-13 | 2015-08-18 | Novartis Ag | Process for preparing particulates of crystalline drug substance |
AU2010252354B2 (en) * | 2009-05-25 | 2016-05-19 | Chiesi Farmaceutici S.P.A. | A therapeutic combination comprising a pulmonary surfactant and a steroid |
HUE030016T2 (en) | 2011-05-03 | 2017-04-28 | Chiesi Farm Spa | An improved suspension beclomethasone dipropionate formulation for inhalation administration |
DK2704687T3 (en) | 2011-05-04 | 2015-10-05 | Chiesi Farma Spa | Topical formulation having a corticosteroid as an active ingredient |
CN104739811A (zh) * | 2015-02-27 | 2015-07-01 | 上海臣邦医药科技有限公司 | 一种糖皮质激素雾化吸入混悬液及其制备方法 |
TWI773641B (zh) * | 2015-05-08 | 2022-08-11 | 日商活效製藥股份有限公司 | 含有糖皮質類固醇(glucocorticoids)之奈米微粒子之水性懸浮液劑 |
WO2023136787A1 (en) * | 2022-01-17 | 2023-07-20 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Process for the preparation of a sterile, homogeneous suspension for inhalation by nebulization |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69002718T2 (de) * | 1989-09-08 | 1993-12-23 | Glaxo Group Ltd | Medikamente. |
US5126123A (en) * | 1990-06-28 | 1992-06-30 | Glaxo, Inc. | Aerosol drug formulations |
JPH0486921A (ja) * | 1990-07-31 | 1992-03-19 | Omron Corp | 近似推論のための知識ベース形成方法および装置 |
US5046326A (en) | 1990-10-24 | 1991-09-10 | Thermo King Corporation | Transport refrigeration system |
IT1243911B (it) * | 1990-11-19 | 1994-06-28 | Zambon Spa | Composizioni per la terapia mucolitica |
GB9202519D0 (en) * | 1992-02-06 | 1992-03-25 | Glaxo Group Ltd | Medicaments |
IL101387A (en) * | 1992-03-26 | 1999-11-30 | Pharmos Ltd | Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets |
UY24147A1 (es) * | 1995-01-20 | 1996-02-02 | Gruenenthal Chemie | Procedimiento y dispositivo para preparar composiciones dispersables por aspersion de aerosoles |
US6135628A (en) * | 1995-10-13 | 2000-10-24 | Boehringer Ingelheim Pharmceuticals, Inc. | Method and apparatus for homogenizing aerosol formulations |
IT1286496B1 (it) | 1996-11-20 | 1998-07-15 | Leetrim Ltd Dublin | Composizione farmaceutica orale ad attivita' antipiretica,analgesica ed antiinfiammatoria |
SE9704186D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
-
1998
- 1998-11-03 IT IT1998MI002364A patent/IT1303692B1/it active
-
1999
- 1999-10-28 PL PL99347908A patent/PL195908B1/pl unknown
- 1999-10-28 BR BRPI9917701A patent/BRPI9917701B1/pt not_active IP Right Cessation
- 1999-10-28 BR BRPI9915251A patent/BRPI9915251B8/pt not_active IP Right Cessation
- 1999-10-28 CZ CZ2007-211A patent/CZ2007211A3/cs not_active IP Right Cessation
- 1999-10-28 WO PCT/EP1999/008176 patent/WO2000025746A2/en active Application Filing
- 1999-10-28 EA EA200100397A patent/EA003228B1/ru not_active IP Right Cessation
- 1999-10-28 SI SI9930948T patent/SI1126823T1/sl unknown
- 1999-10-28 TR TR2001/01209T patent/TR200101209T2/tr unknown
- 1999-10-28 AU AU12666/00A patent/AU762367B2/en not_active Ceased
- 1999-10-28 AT AT99955895T patent/ATE352288T1/de active
- 1999-10-28 HU HU0700446A patent/HU230121B1/hu unknown
- 1999-10-28 SK SK94-2006A patent/SK288316B6/sk not_active IP Right Cessation
- 1999-10-28 DK DK99955895T patent/DK1126823T3/da active
- 1999-10-28 KR KR1020017005023A patent/KR100783096B1/ko active IP Right Grant
- 1999-10-28 SK SK593-2001A patent/SK285487B6/sk not_active IP Right Cessation
- 1999-10-28 DK DK06017746.6T patent/DK1832279T3/en active
- 1999-10-28 CA CA002349268A patent/CA2349268C/en not_active Expired - Lifetime
- 1999-10-28 HU HU0104230A patent/HU226734B1/hu unknown
- 1999-10-28 CN CNB998129348A patent/CN1158997C/zh not_active Expired - Lifetime
- 1999-10-28 PT PT99955895T patent/PT1126823E/pt unknown
- 1999-10-28 DE DE69935002T patent/DE69935002T2/de not_active Expired - Lifetime
- 1999-10-28 NZ NZ511305A patent/NZ511305A/en unknown
- 1999-10-28 EP EP99955895A patent/EP1126823B1/en not_active Expired - Lifetime
- 1999-10-28 JP JP2000579190A patent/JP2002528484A/ja active Pending
- 1999-10-28 ES ES99955895T patent/ES2281197T3/es not_active Expired - Lifetime
- 1999-10-28 CA CA2614633A patent/CA2614633C/en not_active Expired - Lifetime
- 1999-10-28 US US09/830,884 patent/US6464958B1/en not_active Expired - Lifetime
- 1999-10-28 EP EP06017746.6A patent/EP1832279B1/en not_active Expired - Lifetime
- 1999-10-28 CZ CZ20011541A patent/CZ300650B6/cs not_active IP Right Cessation
-
2001
- 2001-05-02 NO NO20012175A patent/NO20012175L/no not_active Application Discontinuation
- 2001-05-02 ZA ZA200103526A patent/ZA200103526B/en unknown
-
2007
- 2007-03-29 CY CY20071100437T patent/CY1107659T1/el unknown
-
2015
- 2015-07-23 CY CY20151100651T patent/CY1116943T1/el unknown
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