EA200100397A1 - Способ приготовления суспензий лекарственных частиц для доставки путем ингаляции - Google Patents

Способ приготовления суспензий лекарственных частиц для доставки путем ингаляции

Info

Publication number
EA200100397A1
EA200100397A1 EA200100397A EA200100397A EA200100397A1 EA 200100397 A1 EA200100397 A1 EA 200100397A1 EA 200100397 A EA200100397 A EA 200100397A EA 200100397 A EA200100397 A EA 200100397A EA 200100397 A1 EA200100397 A1 EA 200100397A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhalation
delivery
preparing
particles
suspensions
Prior art date
Application number
EA200100397A
Other languages
English (en)
Other versions
EA003228B1 (ru
Inventor
Эва Бернини
Кьяра Мальвольти
Раффаэлла Гарция
Гаэтано Брамбилла
Паоло Кьези
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA200100397A1 publication Critical patent/EA200100397A1/ru
Publication of EA003228B1 publication Critical patent/EA003228B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Данное изобретение относится к способу приготовления суспензий лекарственных частиц для доставки путем ингаляции, причем указанный способ обеспечивает частицы с оптимальным размером частиц и распределением, гомогенно диспергированные в носителе. Указанный способ, который также подходит для приготовления стерильных суспензий, включает в себя стадию гомогенизации и микронизации препарата в турбоэмульгаторе, оснащенном турбиной высокой мощности, возможно с последующей обработкой в гомогенизаторе высокого давления. Еще один аспект данного изобретения относится к способу приготовления микронизированного стерилизованного с помощью гамма-облучения дипропионата беклометазона.Отчет о международном поиске был опубликован 2000.10.26.
EA200100397A 1998-11-03 1999-10-28 Способ приготовления суспензий лекарственных частиц для доставки путем ингаляции EA003228B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002364A IT1303692B1 (it) 1998-11-03 1998-11-03 Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
PCT/EP1999/008176 WO2000025746A2 (en) 1998-11-03 1999-10-28 A process for the preparation of suspensions of drug particles for inhalation delivery

Publications (2)

Publication Number Publication Date
EA200100397A1 true EA200100397A1 (ru) 2001-10-22
EA003228B1 EA003228B1 (ru) 2003-02-27

Family

ID=11380994

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100397A EA003228B1 (ru) 1998-11-03 1999-10-28 Способ приготовления суспензий лекарственных частиц для доставки путем ингаляции

Country Status (26)

Country Link
US (1) US6464958B1 (ru)
EP (2) EP1832279B1 (ru)
JP (1) JP2002528484A (ru)
KR (1) KR100783096B1 (ru)
CN (1) CN1158997C (ru)
AT (1) ATE352288T1 (ru)
AU (1) AU762367B2 (ru)
BR (2) BRPI9917701B1 (ru)
CA (2) CA2614633C (ru)
CY (2) CY1107659T1 (ru)
CZ (2) CZ306939B6 (ru)
DE (1) DE69935002T2 (ru)
DK (2) DK1126823T3 (ru)
EA (1) EA003228B1 (ru)
ES (1) ES2281197T3 (ru)
HU (2) HU226734B1 (ru)
IT (1) IT1303692B1 (ru)
NO (1) NO20012175L (ru)
NZ (1) NZ511305A (ru)
PL (1) PL195908B1 (ru)
PT (1) PT1126823E (ru)
SI (1) SI1126823T1 (ru)
SK (2) SK288316B6 (ru)
TR (1) TR200101209T2 (ru)
WO (1) WO2000025746A2 (ru)
ZA (1) ZA200103526B (ru)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0810853B1 (en) * 1995-02-24 2004-08-25 Elan Pharma International Limited Aerosols containing nanoparticle dispersions
CA2348871C (en) 1998-11-02 2009-04-14 John G. Devane Multiparticulate modified release composition
AUPQ573300A0 (en) * 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
NZ523693A (en) * 2000-07-10 2004-08-27 Chiron Corp Macrolide formulations for inhalation and methods of treatment of endobronchial infections
SG98420A1 (en) * 2000-07-13 2003-09-19 Purzer Pharmaceutical Co Ltd Method for transferring one or more active ingredients between different phase carriers
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030091513A1 (en) * 2001-10-03 2003-05-15 Mohsen Nahed M. Method to generate water soluble or nonwater soluble in nanoparticulates directly in suspension or dispersion media
US20030129242A1 (en) * 2002-01-04 2003-07-10 Bosch H. William Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer
US8541399B2 (en) 2002-02-19 2013-09-24 Resolution Chemicals Limited Solvent-based sterilisation of pharmaceuticals
ITMI20020808A1 (it) * 2002-04-17 2003-10-17 Chiesi Farma Spa Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
CA2500908A1 (en) * 2002-10-04 2004-04-22 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
ITMI20022674A1 (it) * 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
DE602004020187D1 (de) * 2003-02-20 2009-05-07 Constant Res & Dev Ltd Prozess zur Herstellung einer Dexamethason enthaltenden Formulierung zur oralen Anwendung
EP1454636A1 (en) * 2003-03-04 2004-09-08 Dompé S.P.A. Sterilization of glucocorticoid drug particles for pulmonary delivery
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) * 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
CA2523035C (en) * 2003-05-22 2011-04-26 Elan Pharma International Ltd. Sterilization of dispersions of nanoparticulate active agents with gamma radiation
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
GB0319500D0 (en) * 2003-08-19 2003-09-17 Resolution Chemicals Ltd Particle-size reduction apparatus,and use thereof
ITMI20032054A1 (it) 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
CA2546454A1 (en) * 2003-11-18 2005-06-02 Yansong Shan Healthy pleasurable inhalation device
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
DE602005026225D1 (de) * 2004-03-12 2011-03-24 Cipla Ltd Sterilisationsprozess für Steroide
GB0406515D0 (en) * 2004-03-23 2004-04-28 Novartis Ag Organic compounds
KR20120091378A (ko) 2004-03-23 2012-08-17 노파르티스 아게 제약 조성물
ITMI20040795A1 (it) * 2004-04-23 2004-07-23 Eratech S R L Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa
GB0410995D0 (en) 2004-05-17 2004-06-23 Norton Healthcare Ltd Heat sterilization of glucocorticosteroids
EP2623095A1 (en) * 2004-11-16 2013-08-07 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
GB0425266D0 (en) * 2004-11-16 2004-12-15 Norton Healthcare Ltd Pharmaceutical manufacturing process
GB0427568D0 (en) * 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
EP1683514B1 (en) 2005-01-20 2012-05-23 Eratech S.r.l. Process for the preparation of concentrated suspensions of drugs and kit thereof
US20090252801A1 (en) * 2005-11-29 2009-10-08 Farmbios S.P.A. Process for the Preparation of Micronised Sterile Steroids
CA2657409A1 (en) * 2006-07-12 2008-01-17 Elan Corporation, Plc Nanoparticulate formulations of modafinil
AU2008334547B2 (en) * 2007-12-13 2011-06-30 Novartis Ag Organic compounds
CN105169399A (zh) * 2009-05-25 2015-12-23 奇斯药制品公司 包括肺表面活性物质和类固醇的治疗组合
EP2704724B1 (en) 2011-05-03 2016-10-26 Chiesi Farmaceutici S.p.A. Improved suspension formulation of beclometasone dipropionate for administration by inhalation
WO2012150130A1 (en) 2011-05-04 2012-11-08 Chiesi Farmaceutici S.P.A. A topical formulation comprising a corticosteroid as active ingredient
CN104739811A (zh) * 2015-02-27 2015-07-01 上海臣邦医药科技有限公司 一种糖皮质激素雾化吸入混悬液及其制备方法
TWI773641B (zh) * 2015-05-08 2022-08-11 日商活效製藥股份有限公司 含有糖皮質類固醇（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ）之奈米微粒子之水性懸浮液劑
WO2023136787A1 (en) * 2022-01-17 2023-07-20 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Process for the preparation of a sterile, homogeneous suspension for inhalation by nebulization

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3042866B2 (ja) * 1989-09-08 2000-05-22 グラクソ・グループ・リミテッド 呼吸疾患治療薬
US5126123A (en) * 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
JPH0486921A (ja) * 1990-07-31 1992-03-19 Omron Corp 近似推論のための知識ベース形成方法および装置
US5046326A (en) * 1990-10-24 1991-09-10 Thermo King Corporation Transport refrigeration system
IT1243911B (it) * 1990-11-19 1994-06-28 Zambon Spa Composizioni per la terapia mucolitica
GB9202519D0 (en) * 1992-02-06 1992-03-25 Glaxo Group Ltd Medicaments
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
UY24147A1 (es) * 1995-01-20 1996-02-02 Gruenenthal Chemie Procedimiento y dispositivo para preparar composiciones dispersables por aspersion de aerosoles
US6135628A (en) * 1995-10-13 2000-10-24 Boehringer Ingelheim Pharmceuticals, Inc. Method and apparatus for homogenizing aerosol formulations
IT1286496B1 (it) * 1996-11-20 1998-07-15 Leetrim Ltd Dublin Composizione farmaceutica orale ad attivita' antipiretica,analgesica ed antiinfiammatoria
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter

Also Published As

Publication number Publication date
HUP0104230A3 (en) 2006-07-28
EP1832279A2 (en) 2007-09-12
SI1126823T1 (sl) 2007-04-30
PL347908A1 (en) 2002-04-22
KR100783096B1 (ko) 2007-12-07
TR200101209T2 (tr) 2001-09-21
EA003228B1 (ru) 2003-02-27
SK288316B6 (sk) 2015-11-03
AU762367B2 (en) 2003-06-26
CN1335766A (zh) 2002-02-13
CY1116943T1 (el) 2017-04-05
WO2000025746A2 (en) 2000-05-11
BRPI9915251B8 (pt) 2021-05-25
ITMI982364A1 (it) 2000-05-03
HUP0104230A2 (hu) 2002-03-28
DE69935002T2 (de) 2007-07-19
PL195908B1 (pl) 2007-11-30
CZ2007211A3 (cs) 2017-09-27
ES2281197T3 (es) 2007-09-16
NO20012175D0 (no) 2001-05-02
BRPI9915251B1 (pt) 2015-09-01
NZ511305A (en) 2003-07-25
JP2002528484A (ja) 2002-09-03
KR20010075656A (ko) 2001-08-09
IT1303692B1 (it) 2001-02-23
EP1126823A2 (en) 2001-08-29
HU0700446D0 (en) 2007-08-28
CZ300650B6 (cs) 2009-07-08
DE69935002D1 (de) 2007-03-15
WO2000025746A3 (en) 2000-10-26
SK285487B6 (sk) 2007-02-01
CA2614633A1 (en) 2000-05-11
CZ20011541A3 (cs) 2001-09-12
CY1107659T1 (el) 2013-04-18
HU226734B1 (en) 2009-08-28
EP1832279A3 (en) 2008-03-05
CZ306939B6 (cs) 2017-09-27
BRPI9917701B1 (pt) 2016-07-19
AU1266600A (en) 2000-05-22
ZA200103526B (en) 2002-06-03
CA2614633C (en) 2010-12-21
DK1126823T3 (da) 2007-05-21
CN1158997C (zh) 2004-07-28
DK1832279T3 (en) 2015-10-05
SK5932001A3 (en) 2001-11-06
EP1832279B1 (en) 2015-07-01
US6464958B1 (en) 2002-10-15
BR9915251A (pt) 2001-10-30
PT1126823E (pt) 2007-04-30
NO20012175L (no) 2001-07-02
HU230121B1 (hu) 2015-08-28
ATE352288T1 (de) 2007-02-15
EP1126823B1 (en) 2007-01-24
CA2349268C (en) 2009-03-31
CA2349268A1 (en) 2000-05-11

Similar Documents

Publication Publication Date Title
EA200100397A1 (ru) Способ приготовления суспензий лекарственных частиц для доставки путем ингаляции
CA2481520A1 (en) Process for preparation of a sterile suspension of corticosteroid particles for administration by inhalation
KR101226856B1 (ko) 당질코르티코스테로이드 멸균 현탁액의 제조방법
Harwood et al. T2 glottic cancer: an analysis of dose-time-volume factors
US20100197779A1 (en) Phytoestrogenic isoflavone compositions, their preparation and use thereof for protection against and treatment of radiation injury
Schwartz et al. The relationship of polycythemia vera to leukemia; a critical review
Dergin et al. Direct current electric stimulation in implant osseointegration: an experimental animal study with sheep
Vaughan The effects of radiation on bone
EP1124544A1 (en) Dry powder pharmaceutical formulation
La Scala et al. Radiation-induced craniofacial bone growth inhibition: efficacy of cytoprotection following a fractionated dose regimen
AU2001271310A1 (en) Phytoestrogenic Isoflavone Compositions, Their Preparation and Use Thereof for Protection Against and Treatment of Radiation Injury
EP1683514B1 (en) Process for the preparation of concentrated suspensions of drugs and kit thereof
Donneys et al. Translational treatment paradigm for managing non‐unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy
DAHLLÖF et al. Craniofacial growth in bone marrow transplant recipients treated with growth hormone after total body irradiation
EP1767215A1 (en) Isoflavones against radiation-induced mortality
US4212857A (en) Method for stimulating the production of immunoglobulin and total complement
Maruyama et al. Cf-252 neutron brachytherapy of short duration for bulky neck tumors
Jia et al. The position and course of mandibular canal through mandibular ramus in patients with prognathism.
Green et al. Evaluation of combination chemotherapy in Wistar/Furth rats bearing transplantable Wilms’ tumor
Ayhan et al. The Effects of Corona Stimulation on the Osseointegration of Dental Implants: An Experimental Study
Inoue et al. High dose Steroid for Diamond-blackfan Anemia

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): RU