CS276903B6 - Therapeutically active acyclic nucleosides - Google Patents

Therapeutically active acyclic nucleosides Download PDF

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Publication number
CS276903B6
CS276903B6 CS885594A CS559488A CS276903B6 CS 276903 B6 CS276903 B6 CS 276903B6 CS 885594 A CS885594 A CS 885594A CS 559488 A CS559488 A CS 559488A CS 276903 B6 CS276903 B6 CS 276903B6
Authority
CS
Czechoslovakia
Prior art keywords
compound
formula
group
amino
pharmaceutically acceptable
Prior art date
Application number
CS885594A
Other languages
Czech (cs)
English (en)
Other versions
CS8805594A2 (en
Inventor
Thomas Anthony Krenitsky
Lilia Marie Beauchamp
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS276903(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878719367A external-priority patent/GB8719367D0/en
Priority claimed from GB878725939A external-priority patent/GB8725939D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of CS8805594A2 publication Critical patent/CS8805594A2/cs
Publication of CS276903B6 publication Critical patent/CS276903B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CS885594A 1987-08-15 1988-08-12 Therapeutically active acyclic nucleosides CS276903B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719367A GB8719367D0 (en) 1987-08-15 1987-08-15 Therapeutic compounds
GB878725939A GB8725939D0 (en) 1987-11-05 1987-11-05 Therapeutic compounds

Publications (2)

Publication Number Publication Date
CS8805594A2 CS8805594A2 (en) 1990-06-13
CS276903B6 true CS276903B6 (en) 1992-09-16

Family

ID=26292613

Family Applications (1)

Application Number Title Priority Date Filing Date
CS885594A CS276903B6 (en) 1987-08-15 1988-08-12 Therapeutically active acyclic nucleosides

Country Status (30)

Country Link
EP (2) EP0308065B1 (lv)
JP (2) JPH0662623B2 (lv)
KR (2) KR960002849B1 (lv)
CN (1) CN1033701C (lv)
AP (2) AP55A (lv)
AT (1) ATE138660T1 (lv)
AU (1) AU612393C (lv)
CS (1) CS276903B6 (lv)
CY (1) CY1833A (lv)
DE (1) DE3855333T2 (lv)
DK (2) DK170045B1 (lv)
ES (1) ES2087639T3 (lv)
FI (1) FI89713C (lv)
GR (1) GR3020372T3 (lv)
HU (1) HU201071B (lv)
IE (1) IE65551B1 (lv)
IL (1) IL87434A (lv)
LU (1) LU88746I2 (lv)
LV (1) LV5264A3 (lv)
MC (1) MC1968A1 (lv)
MX (1) MX9203418A (lv)
MY (1) MY103760A (lv)
NL (1) NL960001I2 (lv)
NO (2) NO167805C (lv)
NZ (1) NZ225809A (lv)
PL (1) PL158285B1 (lv)
PT (1) PT88261B (lv)
SA (1) SA95160244B1 (lv)
SG (1) SG26346G (lv)
SU (1) SU1634138A3 (lv)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
CA2005815C (en) * 1988-12-19 1999-08-03 Wellcome Foundation Limited (The) Antiviral acyclic nucleoside derivatives
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
EP0702682B1 (en) * 1993-06-10 2001-03-14 Rolabo Sl Process for the preparation of amino acid esters of nucleoside analogues
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (lv) * 1993-11-18 1996-08-01 Ajinomoto Kk
DE69513313T2 (de) * 1994-02-01 2000-07-13 Ajinomoto Co., Inc. Verfahren zur Herstellung von Nukleinsäurebasenderivaten
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
GB9501142D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Compounds for use in medicine
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
CA2243237C (en) * 1996-01-19 2008-09-02 Glaxo Group Limited Use of valaciclovir for the manufacture of a medicament for the treatment of genital herpes by a single daily application
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
CN1064683C (zh) * 1996-01-26 2001-04-18 弗·哈夫曼-拉罗切有限公司 制备嘌呤衍生物的方法
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
KR20000070223A (ko) * 1997-01-17 2000-11-25 에가시라 구니오 신규한 ｚ-발라사이클로비르 결정
CA2332961A1 (en) * 1998-05-21 1999-11-25 Michael Zasloff A method for stimulation of defensin production by exposure to isoleucine
WO2003022209A2 (en) * 2001-09-07 2003-03-20 Teva Pharmaceutical Industries Ltd. Crystalline forms of valacyclovir hydrochloride
WO2004000265A2 (en) 2002-06-24 2003-12-31 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) * 2002-10-28 2007-04-11 南京长澳医药科技有限公司 6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
CA2527708A1 (en) * 2003-06-02 2005-01-06 Teva Pharmaceutical Industries Ltd. Crystalline forms of valacyclovir hydrochloride
CN1331471C (zh) * 2003-09-22 2007-08-15 陈云芳 盐酸万乃洛韦软胶囊组合物
MXPA06008197A (es) * 2004-01-21 2007-04-02 Teva Pharma Proceso para la preparacion de clorhidrato de valaciclovir.
GB2413017A (en) * 2004-04-06 2005-10-12 Ford Global Tech Llc An electrical connector for a vehicle
WO2006035452A1 (en) * 2004-09-27 2006-04-06 Matrix Laboratories Ltd Novel pseudomorph of valaciclovir hydrochloride
EP1891071B1 (en) 2005-05-25 2012-02-22 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
EP1746098A1 (en) 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
CN101456859B (zh) * 2009-01-06 2011-07-20 华南理工大学 抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
CN102850354B (zh) * 2012-10-10 2014-07-23 山东金城医药化工股份有限公司 高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) * 2016-12-27 2017-05-10 河南康达制药有限公司 一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) * 2020-05-18 2021-07-05 Александр Сергеевич Самойлов Производные гуанина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3534774A1 (de) * 1985-09-30 1987-04-02 Robugen Gmbh Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides

Also Published As

Publication number Publication date
KR960002849B1 (ko) 1996-02-27
CN1032538A (zh) 1989-04-26
JPS6468373A (en) 1989-03-14
DK170045B1 (da) 1995-05-08
FI883757A0 (fi) 1988-08-12
NZ225809A (en) 1991-07-26
AU2097888A (en) 1989-02-16
DK170803B1 (da) 1996-01-22
MC1968A1 (fr) 1989-09-29
EP0308065B1 (en) 1995-01-04
NO883612D0 (no) 1988-08-12
EP0596542A1 (en) 1994-05-11
AU612393B2 (en) 1991-07-11
MY103760A (en) 1993-09-30
AP160A (en) 1991-11-18
NO167805B (no) 1991-09-02
GR3020372T3 (en) 1996-09-30
IE65551B1 (en) 1995-11-01
KR960004940B1 (ko) 1996-04-18
FI89713C (fi) 1993-11-10
PL274215A1 (en) 1990-02-19
HU201071B (en) 1990-09-28
CY1833A (en) 1995-12-01
PT88261B (pt) 1995-03-01
NO167805C (no) 1991-12-11
CN1033701C (zh) 1997-01-01
MX9203418A (es) 1992-07-01
JPH03115284A (ja) 1991-05-16
DE3855333T2 (de) 1996-12-05
SU1634138A3 (ru) 1991-03-07
IL87434A0 (en) 1989-01-31
NO1996015I1 (no) 1996-12-17
DK451388A (da) 1989-02-16
ATE138660T1 (de) 1996-06-15
FI883757A (fi) 1989-02-16
DK451388D0 (da) 1988-08-12
EP0308065A3 (en) 1989-09-27
KR890003761A (ko) 1989-04-17
CS8805594A2 (en) 1990-06-13
ES2087639T3 (es) 1996-07-16
AP8800099A0 (en) 1988-08-01
FI89713B (fi) 1993-07-30
PL158285B1 (en) 1992-08-31
SG26346G (en) 1995-09-01
EP0596542B1 (en) 1996-05-29
IE882463L (en) 1989-02-15
IL87434A (en) 1993-06-10
AU612393C (en) 2006-08-17
PT88261A (pt) 1989-06-30
NL960001I2 (nl) 1996-11-01
LU88746I2 (fr) 1996-10-04
SA95160244B1 (ar) 2006-10-02
LV5264A3 (lv) 1993-10-10
JPH0662623B2 (ja) 1994-08-17
EP0308065A2 (en) 1989-03-22
DE3855333D1 (de) 1996-07-04
AP55A (en) 1989-09-26
HUT47935A (en) 1989-04-28
NL960001I1 (nl) 1996-03-01
DK82694A (da) 1994-07-08
NO883612L (no) 1989-02-16
JPH07113025B2 (ja) 1995-12-06

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20080812