CS253564B2 - Vaginal ring - Google Patents
Vaginal ring Download PDFInfo
- Publication number
- CS253564B2 CS253564B2 CS817905A CS790581A CS253564B2 CS 253564 B2 CS253564 B2 CS 253564B2 CS 817905 A CS817905 A CS 817905A CS 790581 A CS790581 A CS 790581A CS 253564 B2 CS253564 B2 CS 253564B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- layer
- active substance
- ring
- active agent
- active
- Prior art date
Links
- 239000006213 vaginal ring Substances 0.000 title claims abstract description 19
- 229940044953 vaginal ring Drugs 0.000 title claims abstract description 14
- 239000013543 active substance Substances 0.000 claims abstract description 22
- 150000003431 steroids Chemical class 0.000 claims abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 14
- 229920002379 silicone rubber Polymers 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 27
- 239000000203 mixture Substances 0.000 description 20
- -1 polyethylene Polymers 0.000 description 14
- 229910052697 platinum Inorganic materials 0.000 description 13
- 239000004205 dimethyl polysiloxane Substances 0.000 description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 8
- 239000003054 catalyst Substances 0.000 description 6
- 229920001971 elastomer Polymers 0.000 description 5
- 239000000806 elastomer Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- MVHWAHJQDRBRIX-UHFFFAOYSA-N carbonic acid;platinum Chemical compound [Pt].OC(O)=O MVHWAHJQDRBRIX-UHFFFAOYSA-N 0.000 description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- 229960004400 levonorgestrel Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VMAWODUEPLAHOE-UHFFFAOYSA-N 2,4,6,8-tetrakis(ethenyl)-2,4,6,8-tetramethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane Chemical compound C=C[Si]1(C)O[Si](C)(C=C)O[Si](C)(C=C)O[Si](C)(C=C)O1 VMAWODUEPLAHOE-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 208000035217 Ring chromosome 1 syndrome Diseases 0.000 description 1
- 206010047786 Vulvovaginal discomfort Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003057 platinum Chemical class 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002631 room-temperature vulcanizate silicone Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000003698 tetramethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- General Induction Heating (AREA)
- Control And Safety Of Cranes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803040978 DE3040978A1 (de) | 1980-10-28 | 1980-10-28 | Vaginalring |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS253564B2 true CS253564B2 (en) | 1987-11-12 |
Family
ID=6115593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS817905A CS253564B2 (en) | 1980-10-28 | 1981-10-28 | Vaginal ring |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4822616A (ro) |
| EP (1) | EP0050867B1 (ro) |
| JP (2) | JPS5799954A (ro) |
| AT (1) | ATE31875T1 (ro) |
| AU (1) | AU7670981A (ro) |
| BG (1) | BG42182A3 (ro) |
| CA (1) | CA1165239A (ro) |
| CS (1) | CS253564B2 (ro) |
| DD (1) | DD201645A5 (ro) |
| DE (2) | DE3040978A1 (ro) |
| DK (1) | DK151529C (ro) |
| EG (1) | EG15347A (ro) |
| ES (2) | ES261058U (ro) |
| FI (1) | FI78389C (ro) |
| GR (1) | GR75367B (ro) |
| HU (1) | HU183646B (ro) |
| IE (1) | IE54581B1 (ro) |
| IL (1) | IL64139A (ro) |
| NO (1) | NO153753C (ro) |
| PL (1) | PL127941B1 (ro) |
| PT (1) | PT73886B (ro) |
| RO (1) | RO88674A (ro) |
| SU (1) | SU1440326A3 (ro) |
| YU (1) | YU252281A (ro) |
| ZA (1) | ZA817477B (ro) |
| ZW (1) | ZW26081A1 (ro) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3347125A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrstufenkombinationspraeparat und seine verwendung zur oralen kontrazeption |
| GB8430703D0 (en) * | 1984-12-05 | 1985-01-16 | Lrc Products | Drug release devices |
| FR2618329B1 (fr) * | 1987-07-22 | 1997-03-28 | Dow Corning Sa | Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede |
| US5295984A (en) | 1989-12-07 | 1994-03-22 | Ultrafem, Inc. | Vaginal discharge collection device and intravaginal drug delivery system |
| US6264638B1 (en) | 1989-12-07 | 2001-07-24 | Ultrafem, Inc. | Intravaginal drug delivery system and discharge collection device |
| AU1797592A (en) * | 1991-04-12 | 1992-11-17 | Upjohn Company, The | Vaginal drug delivery device |
| FI95768C (fi) * | 1993-06-17 | 1996-03-25 | Leiras Oy | Emättimensisäinen antosysteemi |
| GB9326255D0 (en) * | 1993-12-23 | 1994-02-23 | Roussel Lab Ltd | Medical device for the prevention and treatment of cancer |
| DE69616551T2 (de) | 1995-07-04 | 2002-05-29 | Akzo Nobel N.V., Arnheim/Arnhem | Ringförmige vorrichtung |
| GB9522403D0 (en) * | 1995-11-01 | 1996-01-03 | Hoechst Roussel Ltd | Intravaginal drug delivery device |
| US5988169A (en) * | 1996-03-29 | 1999-11-23 | Iotek, Inc. | Vaginal insert and method for treating urogenital disorders |
| US5816248A (en) * | 1996-03-29 | 1998-10-06 | Iotek, Inc. | Channeled vaginal insert and method for treating urogenital disorders |
| US6030375A (en) * | 1996-03-29 | 2000-02-29 | Iotek, Inc. | Compressible vaginal insert and method for treating urogenital disorders |
| IL127880A0 (en) | 1996-07-03 | 1999-10-28 | Ultrafem Inc | Method and system for manufacturing elastomeric articles |
| US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| IL123813A0 (en) * | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| AU748653B2 (en) | 1998-05-01 | 2002-06-06 | John F. Cline | Method for injection molding manufacture of controlled release devices |
| WO2002015832A1 (en) | 2000-08-24 | 2002-02-28 | Cornell Research Foundation, Inc. | Non-hormonal vaginal contraceptive |
| DE60116520T2 (de) * | 2000-10-10 | 2006-08-31 | Microchips, Inc., Bedford | Microchip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten |
| CN1289064C (zh) * | 2001-08-31 | 2006-12-13 | 先灵有限责任公司 | 药物输送体系 |
| US7497855B2 (en) * | 2002-09-04 | 2009-03-03 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
| US7357046B2 (en) | 2002-12-16 | 2008-04-15 | N. V. Organon | Method for dissolution testing of a pharmaceutical delivery device |
| WO2004096151A2 (en) * | 2003-04-29 | 2004-11-11 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| TWI336627B (en) | 2003-05-23 | 2011-02-01 | Organon Nv | Drug delivery system,and use and manufacturing method thereof |
| US8481079B2 (en) | 2004-03-24 | 2013-07-09 | Merck Sharp & Dohme B.V. | Drug delivery system based on polyethylene vinylacetate copolymers |
| US7488316B2 (en) * | 2005-01-25 | 2009-02-10 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
| US20080076975A1 (en) * | 2005-01-25 | 2008-03-27 | Microchips, Inc. | Method and implantable device with reservoir array for pre-clinical in vivo testing |
| CN1899643B (zh) * | 2005-07-20 | 2010-12-29 | 上海市计划生育科学研究所 | 含有抗雌激素和抗孕激素复合制剂的阴道环或宫内释药装置及其制药用途 |
| US8399012B2 (en) | 2006-04-17 | 2013-03-19 | Kimberly-Clark Worldwide, Inc. | Degradable therapeutic delivery device |
| TW200930343A (en) | 2007-09-21 | 2009-07-16 | Organon Nv | Drug delivery system |
| TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| NZ611268A (en) | 2008-02-04 | 2015-03-27 | Teva Women’S Health Inc | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
| US20100040671A1 (en) * | 2008-08-12 | 2010-02-18 | Ahmed Salah U | Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof |
| US8419793B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| US8420153B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| EP4108216A1 (en) | 2009-06-03 | 2022-12-28 | Forsight Vision5, Inc. | Anterior segment drug delivery |
| US8753667B2 (en) | 2009-07-21 | 2014-06-17 | The Population Council, Inc. | Multi-layered gradient vaginal ring |
| MX2012012695A (es) | 2010-05-05 | 2013-02-26 | Teva Womens Health Inc | Metodos para reducir sintomas en sujetos utilizando formas de dosificacion individuales con velocidades de liberacion que disminuyen gradualmente. |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| DE202012012713U1 (de) | 2011-03-04 | 2014-01-23 | Arstat, Inc. | Intravaginale Arzneimittelabgabevorrichtung |
| DE202011110355U1 (de) | 2011-03-09 | 2014-01-15 | Arstat, Inc. | Behandlung von Uterusmyomen durch intravaginale Verabreichung einer niedrigen Dosis eines selektiven Progesteronrezeptormodulators, eines Antigestagens oder eines Antigestagen-Wirkstoffes |
| WO2012121778A1 (en) | 2011-03-10 | 2012-09-13 | Arstat, Inc. | Treatment of endometriosis by intravaginal administration of selective progesterone receptor modulator (sprm), anti-progestin, or anti-progestational agent |
| WO2012138542A1 (en) * | 2011-04-07 | 2012-10-11 | Arstat, Inc. | Treatment of menstrual pain and excessive menstrual blood loss by intravaginal administration of a low dose of antifibrinolytic or hemostatic agent in combination with non- steroidal anti-inflammatory drug |
| JP6068454B2 (ja) * | 2011-06-06 | 2017-01-25 | オーク・クレスト・インスティテュート・オブ・サイエンスＯａｋ Ｃｒｅｓｔ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｓｃｉｅｎｃｅ | ウィッキング放出ウィンドウを利用した薬剤デリバリーデバイス |
| KR102071083B1 (ko) | 2011-09-14 | 2020-01-29 | 포사이트 비젼5, 인크. | 안내 삽입물 장치 및 방법 |
| LT2782584T (lt) | 2011-11-23 | 2021-09-10 | Therapeuticsmd, Inc. | Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| PT2911623T (pt) | 2012-10-26 | 2019-11-21 | Forsight Vision5 Inc | Sistema oftálmico para libertação prolongada de fármaco no olho |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2015055789A1 (en) | 2013-10-17 | 2015-04-23 | Bayer Pharma Aktiengesellschaft | INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| US10413504B2 (en) | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
| EP3079659B1 (en) | 2013-12-11 | 2020-10-28 | Merck Sharp & Dohme B.V. | Drug delivery system for delivery of anti-virals |
| DE102014004388A1 (de) * | 2014-03-26 | 2015-10-01 | Angela Kayser | Verfahren und System zum intravaginalen Verabreichen von Progesteron |
| US10206932B2 (en) | 2014-05-22 | 2019-02-19 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2016168141A1 (en) | 2015-04-13 | 2016-10-20 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
| CA2985717A1 (en) | 2015-05-13 | 2016-11-17 | Bayer Oy | A long acting drug delivery device and its use in contraception |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017165624A1 (en) * | 2016-03-23 | 2017-09-28 | The University Of North Carolina At Chapel Hill | Geometrically complex intravaginal rings, systems and methods of making the same |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| JP2019513709A (ja) | 2016-04-01 | 2019-05-30 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | ステロイドホルモン薬学的組成物 |
| WO2018202574A1 (en) | 2017-05-04 | 2018-11-08 | Bayer Oy | Intravaginal drug delivery system, method for manufacturing such system and its use in gynecological therapies and contraception |
| DE102017113166A1 (de) | 2017-06-14 | 2018-12-20 | Amw Gmbh | Depotform zur Abgabe eines Östrogen-Wirkstoffs |
| EP4628016A3 (en) | 2017-10-27 | 2025-12-17 | Axena Health, Inc. | Devices, systems, and methods for training pelvic floor muscles |
| US20220395456A1 (en) * | 2019-11-12 | 2022-12-15 | Poly-Med, Inc. | Contraceptive medical devices |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| CA988849A (en) * | 1969-06-16 | 1976-05-11 | Antonio Scommegna | Anti-fertility device |
| GB1264731A (ro) * | 1969-11-10 | 1972-02-23 | ||
| US3845761A (en) * | 1970-06-02 | 1974-11-05 | Alza Corp | Intrauterine contraceptive anti-fertility device for the management of reproduction |
| US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| US3851648A (en) * | 1973-10-11 | 1974-12-03 | Mead Johnson & Co | Zero-order release device |
| FR2270899A1 (en) * | 1974-05-16 | 1975-12-12 | Groves Harvey | Vaginal medicator with long medicament-carrying stem - having anchor to correctly position stem |
| DE2445971A1 (de) * | 1974-09-24 | 1976-04-08 | Schering Ag | Arzneimittelwirkstofftraeger ii |
| DE2450107A1 (de) * | 1974-10-18 | 1976-04-29 | Schering Ag | Vaginalring |
| US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
| US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
-
1980
- 1980-10-28 DE DE19803040978 patent/DE3040978A1/de not_active Withdrawn
-
1981
- 1981-10-22 AU AU76709/81A patent/AU7670981A/en not_active Abandoned
- 1981-10-22 DD DD81234288A patent/DD201645A5/de not_active IP Right Cessation
- 1981-10-22 YU YU02522/81A patent/YU252281A/xx unknown
- 1981-10-23 GR GR66351A patent/GR75367B/el unknown
- 1981-10-24 EP EP81108872A patent/EP0050867B1/en not_active Expired
- 1981-10-24 AT AT81108872T patent/ATE31875T1/de active
- 1981-10-24 DE DE8181108872T patent/DE3176606D1/de not_active Expired
- 1981-10-26 JP JP56170262A patent/JPS5799954A/ja active Pending
- 1981-10-26 DK DK471481A patent/DK151529C/da not_active IP Right Cessation
- 1981-10-27 ES ES1981261058U patent/ES261058U/es active Pending
- 1981-10-27 IE IE2503/81A patent/IE54581B1/en not_active IP Right Cessation
- 1981-10-27 NO NO813625A patent/NO153753C/no unknown
- 1981-10-27 EG EG81625A patent/EG15347A/xx active
- 1981-10-27 SU SU813347855A patent/SU1440326A3/ru active
- 1981-10-27 ES ES527301A patent/ES527301A0/es active Granted
- 1981-10-27 FI FI813360A patent/FI78389C/fi not_active IP Right Cessation
- 1981-10-27 HU HU813156A patent/HU183646B/hu unknown
- 1981-10-27 PT PT73886A patent/PT73886B/pt not_active IP Right Cessation
- 1981-10-27 CA CA000388832A patent/CA1165239A/en not_active Expired
- 1981-10-28 PL PL1981233606A patent/PL127941B1/pl unknown
- 1981-10-28 ZW ZW260/81A patent/ZW26081A1/xx unknown
- 1981-10-28 ZA ZA817477A patent/ZA817477B/xx unknown
- 1981-10-28 IL IL64139A patent/IL64139A/xx not_active IP Right Cessation
- 1981-10-28 BG BG053982A patent/BG42182A3/xx unknown
- 1981-10-28 RO RO81105663A patent/RO88674A/ro unknown
- 1981-10-28 CS CS817905A patent/CS253564B2/cs unknown
-
1987
- 1987-02-13 US US07/014,316 patent/US4822616A/en not_active Expired - Fee Related
-
1990
- 1990-02-19 JP JP1990014821U patent/JPH048893Y2/ja not_active Expired
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