CS241036B2 - Method of pyrimidone derivatives production - Google Patents

Method of pyrimidone derivatives production Download PDF

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Publication number
CS241036B2
CS241036B2 CS824800A CS480082A CS241036B2 CS 241036 B2 CS241036 B2 CS 241036B2 CS 824800 A CS824800 A CS 824800A CS 480082 A CS480082 A CS 480082A CS 241036 B2 CS241036 B2 CS 241036B2
Authority
CS
Czechoslovakia
Prior art keywords
pyridyl
formula
methyl
methylpyrid
histamine
Prior art date
Application number
CS824800A
Other languages
Czech (cs)
English (en)
Other versions
CS480082A2 (en
Inventor
George S Sach
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Priority to CS845999A priority Critical patent/CS241049B2/cs
Priority to CS833563A priority patent/CS241040B2/cs
Publication of CS480082A2 publication Critical patent/CS480082A2/cs
Publication of CS241036B2 publication Critical patent/CS241036B2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
CS824800A 1981-06-27 1982-06-25 Method of pyrimidone derivatives production CS241036B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS845999A CS241049B2 (cs) 1981-06-27 1982-06-25 Způsob výroby pyrimidonových derivátů
CS833563A CS241040B2 (cs) 1981-06-27 1982-06-25 Způsob výroby pyrimidonových derivátů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8119906 1981-06-27

Publications (2)

Publication Number Publication Date
CS480082A2 CS480082A2 (en) 1985-06-13
CS241036B2 true CS241036B2 (en) 1986-03-13

Family

ID=10522859

Family Applications (1)

Application Number Title Priority Date Filing Date
CS824800A CS241036B2 (en) 1981-06-27 1982-06-25 Method of pyrimidone derivatives production

Country Status (27)

Country Link
US (4) US4444772A (de)
EP (2) EP0068834B1 (de)
JP (4) JPS588080A (de)
KR (1) KR880001475B1 (de)
AT (2) ATE21900T1 (de)
AU (2) AU8535282A (de)
BG (1) BG38163A3 (de)
CS (1) CS241036B2 (de)
DD (1) DD202291A5 (de)
DE (2) DE3273782D1 (de)
DK (2) DK286982A (de)
ES (1) ES8305755A1 (de)
FI (1) FI822281L (de)
GR (2) GR74925B (de)
HU (1) HU190396B (de)
IE (1) IE53348B1 (de)
IL (1) IL66125A (de)
JO (1) JO1185B1 (de)
NO (1) NO822120L (de)
NZ (1) NZ201077A (de)
PH (1) PH19680A (de)
PL (3) PL138524B1 (de)
PT (1) PT75074B (de)
SU (1) SU1232145A3 (de)
YU (1) YU138982A (de)
ZA (2) ZA824537B (de)
ZW (1) ZW13082A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (de) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
DE3376422D1 (en) * 1982-03-25 1988-06-01 Smith Kline French Lab Process for preparing 3,5-disubstituted 2-pyridylalkyl amines
GR78463B (de) * 1982-03-25 1984-09-27 Smith Kline French Lab
PT77287B (en) * 1982-10-01 1986-02-04 Smith Kline French Lab Compound
GB8319874D0 (en) * 1983-07-23 1983-08-24 Smith Kline French Lab Compounds
CA1286297C (en) * 1985-06-13 1991-07-16 George S. Sach Pyridine derivatives
GB8601816D0 (en) * 1986-01-25 1986-02-26 Smith Kline French Lab Pyridine derivatives
GB8610867D0 (en) * 1986-05-02 1986-06-11 Smith Kline French Lab 3-hydroxypyridines
JP2679977B2 (ja) * 1986-09-19 1997-11-19 株式会社日立製作所 半導体集積回路
WO1989010124A1 (en) * 1988-04-27 1989-11-02 Kievsky Nauchno-Issledovatelsky Institut Farmakolo Antidote for organic phosphorus compound poisoning
US5216170A (en) * 1989-01-26 1993-06-01 Bayer Aktiengesellschaft (2-aminopropyl) pyridines useful as intermediates
KR100498005B1 (ko) * 2002-07-26 2005-07-01 주식회사 소하드 기능성 액상비료 및 그 제조방법
JP4426527B2 (ja) * 2002-12-20 2010-03-03 エクソンモービル・ケミカル・パテンツ・インク 重合プロセス
US7443103B2 (en) * 2005-06-24 2008-10-28 General Electric Company High pressure lamp with lamp flicker suppression and lamp voltage control
WO2010003976A1 (en) * 2008-07-10 2010-01-14 Novartis Ag Cyclic sulfones with aminobenzyl substitution useful as bace inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN146736B (de) * 1975-10-02 1979-08-25 Smith Kline French Lab
US4216318A (en) * 1975-12-29 1980-08-05 Smith Kline & French Laboratories Limited Heterocyclic alkyl 4-pyrimidones
MW5076A1 (en) * 1975-12-29 1978-02-08 Smith Kline French Lab Pharmacologicalle active compounds
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
US4227000A (en) * 1978-04-11 1980-10-07 Smith Kline & French Laboratories Limited Intermediates in the process for making histamine antagonists
ZA792608B (en) * 1978-05-30 1980-06-25 Smith Kline French Lab Nitro compounds
US4255428A (en) * 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55133379A (en) * 1979-04-05 1980-10-17 Smith Kline French Lab Pyrimidone compound
EP0017680B1 (de) * 1979-04-11 1982-04-21 Smith Kline & French Laboratories Limited Pyrimidon-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative

Also Published As

Publication number Publication date
NZ201077A (en) 1985-09-13
DE3273782D1 (en) 1986-11-20
PT75074B (en) 1986-02-26
SU1232145A3 (ru) 1986-05-15
ZA824537B (en) 1983-05-25
JPH0345073B2 (de) 1991-07-09
KR880001475B1 (ko) 1988-08-13
EP0068834A2 (de) 1983-01-05
DK287082A (da) 1982-12-28
ATE22891T1 (de) 1986-11-15
EP0068834A3 (en) 1983-04-06
US4486434A (en) 1984-12-04
EP0068834B1 (de) 1986-09-03
IE53348B1 (en) 1988-10-26
IL66125A0 (en) 1982-09-30
JPS6328424B2 (de) 1988-06-08
KR840000533A (ko) 1984-02-25
DE3273019D1 (en) 1986-10-09
AU8535282A (en) 1983-01-06
US4444772A (en) 1984-04-24
ZW13082A1 (en) 1982-09-29
PL240628A1 (en) 1983-10-10
PL137627B1 (en) 1986-07-31
YU138982A (en) 1985-03-20
JPS61233616A (ja) 1986-10-17
IE821533L (en) 1982-12-27
JPS61233670A (ja) 1986-10-17
DK286982A (da) 1982-12-28
GR74926B (de) 1984-07-12
PL138524B1 (en) 1986-09-30
ES513469A0 (es) 1983-05-01
DD202291A5 (de) 1983-09-07
JPS588079A (ja) 1983-01-18
ZA824580B (en) 1983-05-25
JPS588080A (ja) 1983-01-18
PT75074A (en) 1982-07-01
EP0068833B1 (de) 1986-10-15
NO822120L (no) 1982-12-28
AU551066B2 (en) 1986-04-17
IL66125A (en) 1986-01-31
HU190396B (en) 1986-08-28
FI822281A0 (fi) 1982-06-24
JO1185B1 (en) 1983-11-30
EP0068833A2 (de) 1983-01-05
EP0068833A3 (en) 1983-03-30
ATE21900T1 (de) 1986-09-15
PL237110A1 (en) 1983-06-20
BG38163A3 (en) 1985-10-15
CS480082A2 (en) 1985-06-13
PH19680A (en) 1986-06-13
JPH0244812B2 (de) 1990-10-05
US4584381A (en) 1986-04-22
GR74925B (de) 1984-07-12
AU8535182A (en) 1983-01-06
FI822281L (fi) 1982-12-28
PL137600B1 (en) 1986-07-31
US4535163A (en) 1985-08-13
ES8305755A1 (es) 1983-05-01

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