CS227012B2 - Method of preparing 2-amino-3-benzoyl-phenylacetamide - Google Patents

Method of preparing 2-amino-3-benzoyl-phenylacetamide Download PDF

Info

Publication number
CS227012B2
CS227012B2 CS806196A CS619680A CS227012B2 CS 227012 B2 CS227012 B2 CS 227012B2 CS 806196 A CS806196 A CS 806196A CS 619680 A CS619680 A CS 619680A CS 227012 B2 CS227012 B2 CS 227012B2
Authority
CS
Czechoslovakia
Prior art keywords
amino
solution
mol
added
formula
Prior art date
Application number
CS806196A
Other languages
Czech (cs)
English (en)
Inventor
James R Shanklin
Dwight A Shamblee
David A Walsh
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of CS227012B2 publication Critical patent/CS227012B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS806196A 1979-09-26 1980-09-11 Method of preparing 2-amino-3-benzoyl-phenylacetamide CS227012B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7886079A 1979-09-26 1979-09-26

Publications (1)

Publication Number Publication Date
CS227012B2 true CS227012B2 (en) 1984-04-16

Family

ID=22146633

Family Applications (1)

Application Number Title Priority Date Filing Date
CS806196A CS227012B2 (en) 1979-09-26 1980-09-11 Method of preparing 2-amino-3-benzoyl-phenylacetamide

Country Status (36)

Country Link
JP (1) JPS5657751A (fr)
KR (1) KR840000763B1 (fr)
AT (1) AT374170B (fr)
AU (1) AU532359B2 (fr)
BE (1) BE885393A (fr)
BR (1) BR8006042A (fr)
CA (1) CA1128512A (fr)
CH (1) CH646138A5 (fr)
CS (1) CS227012B2 (fr)
DE (1) DE3035688A1 (fr)
DK (1) DK154136C (fr)
EG (1) EG15020A (fr)
ES (2) ES495329A0 (fr)
FI (1) FI72967C (fr)
FR (1) FR2465710A1 (fr)
GB (1) GB2059963B (fr)
GR (1) GR70049B (fr)
HK (1) HK59383A (fr)
HU (1) HU183215B (fr)
IE (1) IE50268B1 (fr)
IL (1) IL60999A (fr)
IN (3) IN151313B (fr)
IT (1) IT1133823B (fr)
KE (1) KE3307A (fr)
LU (1) LU82797A1 (fr)
MX (1) MX7159E (fr)
NL (1) NL8005346A (fr)
NO (1) NO152128C (fr)
NZ (1) NZ195061A (fr)
PH (1) PH22628A (fr)
PL (1) PL128998B1 (fr)
PT (1) PT71839B (fr)
SE (1) SE448626B (fr)
SG (1) SG42983G (fr)
YU (3) YU41734B (fr)
ZA (1) ZA805476B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
US8084447B2 (en) 2001-09-03 2011-12-27 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use
EP1438956A1 (fr) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Dérivés alpha-aminoamides en tant qu'agents antimigraine
CZ2009367A3 (cs) * 2009-06-08 2010-06-16 Farmak, A.S. Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu
CN112794809B (zh) * 2019-11-14 2023-12-29 南京济群医药科技股份有限公司 一种高纯度奈帕芬胺中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (fr) * 1967-07-31 1971-03-24
SE400966B (sv) * 1975-08-13 1978-04-17 Robins Co Inc A H Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI72967B (fi) 1987-04-30
DK405780A (da) 1981-03-27
ES503019A0 (es) 1982-05-01
JPH0141616B2 (fr) 1989-09-06
JPS5657751A (en) 1981-05-20
GB2059963A (en) 1981-04-29
NO152128C (no) 1985-08-07
IE50268B1 (en) 1986-03-19
YU245080A (en) 1983-09-30
IE801946L (en) 1981-03-26
SE8006668L (sv) 1981-03-27
GR70049B (fr) 1982-07-26
IN156255B (fr) 1985-06-08
MX7159E (es) 1987-12-02
FR2465710B1 (fr) 1984-10-12
SG42983G (en) 1985-01-11
PT71839A (en) 1980-10-01
HU183215B (en) 1984-04-28
NZ195061A (en) 1984-04-27
BE885393A (fr) 1981-01-16
GB2059963B (en) 1983-04-20
NO802834L (no) 1981-03-27
HK59383A (en) 1983-12-02
AU532359B2 (en) 1983-09-29
DE3035688C2 (fr) 1990-05-17
ES8200329A1 (es) 1981-10-16
ATA474580A (de) 1983-08-15
SE448626B (sv) 1987-03-09
IT1133823B (it) 1986-07-24
YU43305B (en) 1989-06-30
FR2465710A1 (fr) 1981-03-27
KR840000763B1 (ko) 1984-06-08
YU73083A (en) 1983-12-31
CA1128512A (fr) 1982-07-27
CH646138A5 (fr) 1984-11-15
PH22628A (en) 1988-10-28
NO152128B (no) 1985-04-29
YU41734B (en) 1987-12-31
YU43306B (en) 1989-06-30
BR8006042A (pt) 1981-04-07
AU6211680A (en) 1981-04-02
ES495329A0 (es) 1981-10-16
YU73183A (en) 1983-12-31
DE3035688A1 (de) 1981-04-16
IN156254B (fr) 1985-06-08
PT71839B (en) 1981-06-25
IT8024948A0 (it) 1980-09-26
ZA805476B (en) 1981-11-25
IL60999A (en) 1984-05-31
IL60999A0 (en) 1980-11-30
PL128998B1 (en) 1984-03-31
KR830004210A (ko) 1983-07-06
FI803002A (fi) 1981-03-27
EG15020A (en) 1985-03-31
DK154136B (da) 1988-10-17
FI72967C (fi) 1987-08-10
KE3307A (en) 1983-08-19
ES8204715A1 (es) 1982-05-01
NL8005346A (nl) 1981-03-30
AT374170B (de) 1984-03-26
DK154136C (da) 1989-03-06
LU82797A1 (fr) 1982-05-10
IN151313B (fr) 1983-03-26
PL226919A1 (fr) 1982-02-01

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