GB2059963B - 2-amino-3-benzoyl-phenylacet-amides and cyclic homologues - Google Patents

2-amino-3-benzoyl-phenylacet-amides and cyclic homologues

Info

Publication number
GB2059963B
GB2059963B GB8030955A GB8030955A GB2059963B GB 2059963 B GB2059963 B GB 2059963B GB 8030955 A GB8030955 A GB 8030955A GB 8030955 A GB8030955 A GB 8030955A GB 2059963 B GB2059963 B GB 2059963B
Authority
GB
United Kingdom
Prior art keywords
phenylacet
benzoyl
amides
amino
cyclic homologues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8030955A
Other languages
English (en)
Other versions
GB2059963A (en
Inventor
J R Shanklin
D A Shamblee
D A Walsh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of GB2059963A publication Critical patent/GB2059963A/en
Application granted granted Critical
Publication of GB2059963B publication Critical patent/GB2059963B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8030955A 1979-09-26 1980-09-25 2-amino-3-benzoyl-phenylacet-amides and cyclic homologues Expired GB2059963B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7886079A 1979-09-26 1979-09-26

Publications (2)

Publication Number Publication Date
GB2059963A GB2059963A (en) 1981-04-29
GB2059963B true GB2059963B (en) 1983-04-20

Family

ID=22146633

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8030955A Expired GB2059963B (en) 1979-09-26 1980-09-25 2-amino-3-benzoyl-phenylacet-amides and cyclic homologues

Country Status (36)

Country Link
JP (1) JPS5657751A (fr)
KR (1) KR840000763B1 (fr)
AT (1) AT374170B (fr)
AU (1) AU532359B2 (fr)
BE (1) BE885393A (fr)
BR (1) BR8006042A (fr)
CA (1) CA1128512A (fr)
CH (1) CH646138A5 (fr)
CS (1) CS227012B2 (fr)
DE (1) DE3035688A1 (fr)
DK (1) DK154136C (fr)
EG (1) EG15020A (fr)
ES (2) ES495329A0 (fr)
FI (1) FI72967C (fr)
FR (1) FR2465710A1 (fr)
GB (1) GB2059963B (fr)
GR (1) GR70049B (fr)
HK (1) HK59383A (fr)
HU (1) HU183215B (fr)
IE (1) IE50268B1 (fr)
IL (1) IL60999A (fr)
IN (3) IN151313B (fr)
IT (1) IT1133823B (fr)
KE (1) KE3307A (fr)
LU (1) LU82797A1 (fr)
MX (1) MX7159E (fr)
NL (1) NL8005346A (fr)
NO (1) NO152128C (fr)
NZ (1) NZ195061A (fr)
PH (1) PH22628A (fr)
PL (1) PL128998B1 (fr)
PT (1) PT71839B (fr)
SE (1) SE448626B (fr)
SG (1) SG42983G (fr)
YU (3) YU41734B (fr)
ZA (1) ZA805476B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
US8084447B2 (en) 2001-09-03 2011-12-27 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use
EP1438956A1 (fr) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Dérivés alpha-aminoamides en tant qu'agents antimigraine
CZ2009367A3 (cs) * 2009-06-08 2010-06-16 Farmak, A.S. Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu
CN112794809B (zh) * 2019-11-14 2023-12-29 南京济群医药科技股份有限公司 一种高纯度奈帕芬胺中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (fr) * 1967-07-31 1971-03-24
SE400966B (sv) * 1975-08-13 1978-04-17 Robins Co Inc A H Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI72967B (fi) 1987-04-30
DK405780A (da) 1981-03-27
ES503019A0 (es) 1982-05-01
JPH0141616B2 (fr) 1989-09-06
JPS5657751A (en) 1981-05-20
GB2059963A (en) 1981-04-29
NO152128C (no) 1985-08-07
IE50268B1 (en) 1986-03-19
YU245080A (en) 1983-09-30
IE801946L (en) 1981-03-26
SE8006668L (sv) 1981-03-27
GR70049B (fr) 1982-07-26
IN156255B (fr) 1985-06-08
MX7159E (es) 1987-12-02
FR2465710B1 (fr) 1984-10-12
SG42983G (en) 1985-01-11
PT71839A (en) 1980-10-01
HU183215B (en) 1984-04-28
NZ195061A (en) 1984-04-27
BE885393A (fr) 1981-01-16
NO802834L (no) 1981-03-27
CS227012B2 (en) 1984-04-16
HK59383A (en) 1983-12-02
AU532359B2 (en) 1983-09-29
DE3035688C2 (fr) 1990-05-17
ES8200329A1 (es) 1981-10-16
ATA474580A (de) 1983-08-15
SE448626B (sv) 1987-03-09
IT1133823B (it) 1986-07-24
YU43305B (en) 1989-06-30
FR2465710A1 (fr) 1981-03-27
KR840000763B1 (ko) 1984-06-08
YU73083A (en) 1983-12-31
CA1128512A (fr) 1982-07-27
CH646138A5 (fr) 1984-11-15
PH22628A (en) 1988-10-28
NO152128B (no) 1985-04-29
YU41734B (en) 1987-12-31
YU43306B (en) 1989-06-30
BR8006042A (pt) 1981-04-07
AU6211680A (en) 1981-04-02
ES495329A0 (es) 1981-10-16
YU73183A (en) 1983-12-31
DE3035688A1 (de) 1981-04-16
IN156254B (fr) 1985-06-08
PT71839B (en) 1981-06-25
IT8024948A0 (it) 1980-09-26
ZA805476B (en) 1981-11-25
IL60999A (en) 1984-05-31
IL60999A0 (en) 1980-11-30
PL128998B1 (en) 1984-03-31
KR830004210A (ko) 1983-07-06
FI803002A (fi) 1981-03-27
EG15020A (en) 1985-03-31
DK154136B (da) 1988-10-17
FI72967C (fi) 1987-08-10
KE3307A (en) 1983-08-19
ES8204715A1 (es) 1982-05-01
NL8005346A (nl) 1981-03-30
AT374170B (de) 1984-03-26
DK154136C (da) 1989-03-06
LU82797A1 (fr) 1982-05-10
IN151313B (fr) 1983-03-26
PL226919A1 (fr) 1982-02-01

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19920925