CS214699B2 - Method of making the 9-aminoalcylfluorenes - Google Patents

Method of making the 9-aminoalcylfluorenes Download PDF

Info

Publication number
CS214699B2
CS214699B2 CS807588A CS758880A CS214699B2 CS 214699 B2 CS214699 B2 CS 214699B2 CS 807588 A CS807588 A CS 807588A CS 758880 A CS758880 A CS 758880A CS 214699 B2 CS214699 B2 CS 214699B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
alkyl
carbon atoms
hydrogen
amine
Prior art date
Application number
CS807588A
Other languages
Czech (cs)
English (en)
Inventor
William B Lacefield
Richard L Simon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS214699B2 publication Critical patent/CS214699B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/10—Impermeable to liquids, e.g. waterproof; Liquid-repellent
    • A41D31/102—Waterproof and breathable
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/18—Elastic
    • A41D31/185—Elastic using layered materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Textile Engineering (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS807588A 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes CS214699B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1953379A 1979-03-12 1979-03-12

Publications (1)

Publication Number Publication Date
CS214699B2 true CS214699B2 (en) 1982-05-28

Family

ID=21793707

Family Applications (4)

Application Number Title Priority Date Filing Date
CS807589A CS214700B2 (en) 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes
CS801664A CS214696B2 (en) 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes
CS807588A CS214699B2 (en) 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes
CS807587A CS214698B2 (en) 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CS807589A CS214700B2 (en) 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes
CS801664A CS214696B2 (en) 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS807587A CS214698B2 (en) 1979-03-12 1980-03-11 Method of making the 9-aminoalcylfluorenes

Country Status (40)

Country Link
US (1) US4277495A (xx)
EP (1) EP0018076B1 (xx)
JP (1) JPS55124743A (xx)
KR (2) KR840000279B1 (xx)
AR (6) AR228851A1 (xx)
AT (4) AT370407B (xx)
AU (1) AU527992B2 (xx)
BE (1) BE882166A (xx)
CA (1) CA1136624A (xx)
CH (1) CH643234A5 (xx)
CS (4) CS214700B2 (xx)
CY (1) CY1345A (xx)
DD (1) DD149511A5 (xx)
DE (1) DE3064872D1 (xx)
DK (1) DK158658C (xx)
EG (1) EG14592A (xx)
ES (5) ES8104186A1 (xx)
FI (3) FI67211C (xx)
FR (2) FR2460287A1 (xx)
GB (1) GB2046257B (xx)
GR (1) GR68035B (xx)
GT (1) GT198062477A (xx)
HK (1) HK101086A (xx)
HU (1) HU179837B (xx)
IE (1) IE49553B1 (xx)
IL (1) IL59558A (xx)
IT (1) IT1140772B (xx)
LU (1) LU82236A1 (xx)
MA (1) MA18763A1 (xx)
MY (1) MY8700080A (xx)
NZ (1) NZ193078A (xx)
OA (1) OA06486A (xx)
PH (1) PH15594A (xx)
PL (1) PL122643B1 (xx)
PT (1) PT70927A (xx)
RO (2) RO79822A (xx)
SG (1) SG72286G (xx)
SU (2) SU1022656A3 (xx)
YU (1) YU65680A (xx)
ZA (1) ZA801422B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212337A (en) * 1978-03-31 1980-07-15 Union Carbide Corporation Closure fastening device
US4452745A (en) * 1981-02-06 1984-06-05 Eli Lilly And Company 9-Aminoalkylfluorenes
US4484352A (en) * 1983-02-07 1984-11-20 Katzin Lawrence F Reclosable plastic bag
US4552982A (en) * 1983-08-01 1985-11-12 Eli Lilly And Company Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes
US4508735A (en) * 1983-09-21 1985-04-02 Eli Lilly And Company Anti-arrhythmic N-alkanoylaminoalkyl fluorenes
US4585894A (en) * 1983-10-19 1986-04-29 Eli Lilly And Company Process for producing 9-carbamoyl fluorene derivatives
IL73261A (en) * 1983-10-19 1988-03-31 Lilly Co Eli Process for producing 9-carbamoyl-9-aminoalkyl fluorene derivatives,and certain intermediates thereof
US4486592A (en) * 1983-10-19 1984-12-04 Eli Lilly And Company 9-Carbamoylfluorene derivatives
DE3444837A1 (de) * 1984-12-08 1986-06-12 Basf Ag, 6700 Ludwigshafen 10,11-dihydro-5h-dibenzo(a,d)cycloheptadien- derivate, ihre herstellung und verwendung
GB9304189D0 (en) * 1993-03-02 1993-04-21 Sturmey Archer Ltd Epicyclic change speed gear hubs
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5631203A (en) * 1995-05-04 1997-05-20 Phillips Petroleum Company Metallocene compounds and preparation thereof containing terminal alkynes
PL328094A1 (en) * 1996-01-16 1999-01-04 Bristol Myers Squibb Co Conformingly restricted aromatic inhibitors triglycerides carrying chromosome protein and method of obtaining such inhibitors
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB736372A (en) * 1953-05-06 1955-09-07 Miles Lab Fluorene derivatives
NL287095A (xx) 1962-12-21 1965-02-25
FR1345419A (fr) * 1962-12-21 1963-12-06 Boehringer & Soehne Gmbh Procédé pour la préparation de dérivés basiques du fluorène et des sels de ces dérivés
DE1203253B (de) * 1963-02-09 1965-10-21 Boehringer & Soehne Gmbh Verfahren zur Herstellung basischer Fluorenderivate und ihrer Salze
FR1482727A (fr) * 1965-06-10 1967-05-26 Upjohn Co 9-(2-amino-1-méthyléthyl) fluoren-9-ols et leur procédé de fabrication
GB1211459A (en) * 1967-05-10 1970-11-04 Abbott Lab Hydroxy amines
US3660485A (en) * 1970-10-05 1972-05-02 Searle & Co Fluorene-9-carboxylic acid hydrazides
US3843657A (en) * 1972-12-08 1974-10-22 Searle & Co 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides

Also Published As

Publication number Publication date
FI70006B (fi) 1986-01-31
ES497300A0 (es) 1982-01-01
AT368131B (de) 1982-09-10
KR840001836B1 (ko) 1984-10-22
KR840000279B1 (ko) 1984-03-13
ES497303A0 (es) 1982-01-01
FR2460287A1 (fr) 1981-01-23
FI840920A (fi) 1984-03-07
IT1140772B (it) 1986-10-10
ES497301A0 (es) 1982-01-01
ES489470A0 (es) 1981-04-16
ATA114181A (de) 1982-01-15
ES8201943A1 (es) 1982-01-01
MA18763A1 (fr) 1980-10-01
PL222600A1 (xx) 1980-12-15
IL59558A0 (en) 1980-06-30
ES8104186A1 (es) 1981-04-16
FR2457278A1 (fr) 1980-12-19
GB2046257A (en) 1980-11-12
FI840921A (fi) 1984-03-07
SU1022656A3 (ru) 1983-06-07
ATA114081A (de) 1982-01-15
DK158658B (da) 1990-07-02
FR2460287B1 (xx) 1983-03-11
CS214700B2 (en) 1982-05-28
GT198062477A (es) 1981-09-02
IE800494L (en) 1980-09-12
DD149511A5 (de) 1981-07-15
DK103380A (da) 1980-09-13
FI69299C (fi) 1986-01-10
GB2046257B (en) 1983-10-19
AR227318A1 (es) 1982-10-15
AR225526A1 (es) 1982-03-31
CY1345A (en) 1987-01-16
GR68035B (xx) 1981-10-27
FI70006C (fi) 1986-09-12
NZ193078A (en) 1981-11-19
CH643234A5 (fr) 1984-05-30
IE49553B1 (en) 1985-10-30
BE882166A (fr) 1980-09-11
PH15594A (en) 1983-02-28
EP0018076B1 (en) 1983-09-21
JPS55124743A (en) 1980-09-26
JPS6314702B2 (xx) 1988-04-01
EG14592A (en) 1985-03-31
RO85074A (ro) 1984-08-17
MY8700080A (en) 1987-12-31
EP0018076A1 (en) 1980-10-29
FI67211C (fi) 1985-02-11
FI67211B (fi) 1984-10-31
AR228851A1 (es) 1983-04-29
AT370407B (de) 1983-03-25
ATA113981A (de) 1982-01-15
FI840921A0 (fi) 1984-03-07
LU82236A1 (fr) 1980-06-06
AR229402A1 (es) 1983-08-15
FI800735A (fi) 1980-09-13
CS214696B2 (en) 1982-05-28
FR2457278B1 (xx) 1984-06-29
ES8201945A1 (es) 1982-01-01
AT368125B (de) 1982-09-10
ES8201946A1 (es) 1982-01-01
IT8020502A0 (it) 1980-03-11
PL122643B1 (en) 1982-08-31
AR228059A1 (es) 1983-01-14
US4277495A (en) 1981-07-07
DK158658C (da) 1990-12-31
IL59558A (en) 1984-05-31
HU179837B (en) 1982-12-28
ES8201947A1 (es) 1982-01-01
SU1015820A3 (ru) 1983-04-30
ES497302A0 (es) 1982-01-01
HK101086A (en) 1987-01-02
OA06486A (fr) 1981-07-31
CA1136624A (en) 1982-11-30
AR230983A1 (es) 1984-08-31
PT70927A (en) 1980-04-01
AU527992B2 (en) 1983-03-31
YU65680A (en) 1983-02-28
ZA801422B (en) 1981-10-28
FI840920A0 (fi) 1984-03-07
DE3064872D1 (en) 1983-10-27
AU5630180A (en) 1980-09-18
KR830001860A (ko) 1983-05-19
RO79822A (ro) 1983-02-01
CS214698B2 (en) 1982-05-28
ATA134480A (de) 1982-08-15
SG72286G (en) 1987-03-27
FI69299B (fi) 1985-09-30
AT368130B (de) 1982-09-10

Similar Documents

Publication Publication Date Title
US5352703A (en) Antitussive and mucus regulating agent, a process for the preparation thereof and pharmaceutical compositions containing it
CS214699B2 (en) Method of making the 9-aminoalcylfluorenes
IE50186B1 (en) 3-aminopropoxy derivatives,their preparation and pharmaceutical compositions containing them
PT1727817E (pt) Derivados de azabiciclooctan-3-ona e seu uso
PT99394A (pt) Processo para a preparacao de uma combinacao sinergistica de inibidores da transcriptase reversa de hiv, contendo aminopiridonas e nucleosideos
DE69935331T2 (de) Verfahren und verbindungen zur behandlung der depression
RU2282627C2 (ru) Кумариновые производные с подавляющей комт активностью
US5036062A (en) Novel esters
EP0325406B1 (en) Diamine compounds
US5488151A (en) {(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino)-2-hydroxyethylamino]5,} acetic acid and its pharmaceutically acceptable salts
KR100352899B1 (ko) 새로운3-페닐설포닐-3,7-디아자바이사이클로[3,3,1]노난-화합물을함유하는약제
EP0007184B1 (en) Urea derivatives, processes for preparing them and compositions containing them
FI67077B (fi) Analogifoerfarande foer framstaellning av antidepressivt verksamma aralkylamider av aminosyror
IL43218A (en) 2-n-phenyl-n-aminoalkyl-aminoindanes their preparation and pharmaceutical compositions containing them
US4237311A (en) 2-Methyl-1-(substituted)phenyl-2-propyl esters of 2-aminopropanoic acid
JPH0633247B2 (ja) ３―アミノプロポキシフェニル誘導体およびその製法ならび用途
JPH0441149B2 (xx)
HU187706B (en) Process for preparing n-/aryl-oxy.alkyl/-n'-/amino-alkyl/-carbamide derivatives
US4016284A (en) Derivatives of 1,3-benzodioxole, the preparation and use thereof
JPH02258749A (ja) ポリヒドロキシベンジルオキシプロパノールアミン
US4153696A (en) Dihydroxyphenylethylaminoalkyl theophyllines
JPH0222252A (ja) ５―ヒドロキシトリプタミン―１ａ―受容体結合化合物
KR20030002304A (ko) 3-페닐-3,7-디아자비시클로[3.3.1]노난 화합물들과 이들의제조방법 및 이러한 화합물들을 포함하는 약제들
US3976771A (en) Glycylglycine amide preparations and method of use antiarrhythmic
KR820000520B1 (ko) N-＜3-알킬아미노프로필＞-n′-＜(치환된)페닐＞-요소의 제조방법